Lee J Martin

Professor

1984 …2019
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Research Output 1984 2019

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2002

DNA damage profiling in motor neurons: A single-cell analysis by comet assay

Martin, L. J. & Liu, Z., Oct 1 2002, In : Neurochemical Research. 27, 10, p. 1093-1104 12 p.

Research output: Contribution to journalArticle

Single-Cell Analysis
Comet Assay
DNA Fingerprinting
Motor Neurons
DNA Damage
Mitogen-Activated Protein Kinases
Caspase 3
Neurons
Apoptosis
MAP Kinase Kinase Kinase 1

Injury-induced spinal motor neuron apoptosis is preceded by DNA single-strand breaks and is p53- and Bax-dependent

Martin, L. J. & Liu, Z., Feb 15 2002, In : Journal of Neurobiology. 50, 3, p. 181-197 17 p.

Research output: Contribution to journalArticle

Single-Stranded DNA Breaks
Spinal Injuries
Motor Neurons
Apoptosis
DNA Damage

Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death

Lesuisse, C. & Martin, L. J., 2002, In : Journal of Neurobiology. 51, 1, p. 9-23 15 p.

Research output: Contribution to journalArticle

Neurons
Synucleins
Proteins
AMPA Receptors
Presynaptic Terminals
Retrograde Degeneration
Geniculate Bodies
Interneurons
Atrophy
Apoptosis
Endonucleases
Caspase 3
Corpus Striatum
Apoptosis
Brain

Thalamic neuron apoptosis emerges rapidly after cortical damage in immature mice

Natale, J. E., Cheng, Y. & Martin, L. J., Jul 5 2002, In : Neuroscience. 112, 3, p. 665-676 12 p.

Research output: Contribution to journalArticle

Geniculate Bodies
Occipital Lobe
Apoptosis
Neurons
Axotomy
2001

Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis

Northington, F., Ferriero, D. M., Flock, D. L. & Martin, L. J., Mar 15 2001, In : Journal of Neuroscience. 21, 6, p. 1931-1938 8 p.

Research output: Contribution to journalArticle

Thalamus
Death Domain Receptors
Ischemia
Brain Injuries
Apoptosis

Early neurodegeneration after hypoxia-ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis

Northington, F., Ferriero, D. M., Graham, E. M., Traystman, R. J. & Martin, L. J., 2001, In : Neurobiology of Disease. 8, 2, p. 207-219 13 p.

Research output: Contribution to journalArticle

Necrosis
Ischemia
Apoptosis
Wounds and Injuries
Thalamus

Failure to sustain recovery of Na,K-ATPase function is a possible mechanism for striatal neurodegeneration in hypoxic-ischemic newborn piglets

Golden, W. C., Brambrink, A. M., Traystman, R. J. & Martin, L. J., Mar 31 2001, In : Molecular Brain Research. 88, 1-2, p. 94-102 9 p.

Research output: Contribution to journalArticle

Corpus Striatum
Ischemia
Neurons
Protein Isoforms
Necrosis

Injury-induced apoptosis of neurons in adult brain is mediated by p53-dependent and p53-independent pathways and requires Bax

Martin, L. J., Kaiser, A., Yu, J. W., Natale, J. E. & Al-Abdulla, N. A., May 7 2001, In : Journal of Comparative Neurology. 433, 3, p. 299-311 13 p.

Research output: Contribution to journalArticle

Geniculate Bodies
Apoptosis
Neurons
Wounds and Injuries
Brain

Involvement of apolipoprotein E in herpes simplex encephalitis

Nicoll, J. A. R., Martin, L. J., Stewart, J., Murray, L. S., Love, S. & Kennedy, P. G. E., Mar 26 2001, In : NeuroReport. 12, 4, p. 695-698 4 p.

Research output: Contribution to journalArticle

Herpes Simplex Encephalitis
Apolipoproteins E
Genotype
Brain Injuries
Herpes Labialis
Single-Cell Analysis
Comet Assay
Motor Neurons
DNA Damage
Axotomy

Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice

Gabrielson, K. L., Hogue, B. A., Bohr, V. A., Cardounel, A. J., Nakajima, W., Kofler, J., Zweier, J. L., Rodriguez, E. R., Martin, L. J., De Souza-Pinto, N. C. & Bressler, J., 2001, In : American Journal of Pathology. 159, 4, p. 1507-1520 14 p.

Research output: Contribution to journalArticle

Succinate Dehydrogenase
Heart Mitochondria
Cardiac Myocytes
Necrosis
Mitochondrial Swelling
Single-Stranded DNA Breaks
Axotomy
Peroxynitrous Acid
Motor Neurons
Nitric Oxide

Neurodegeneration in the thalamus following neonatal hypoxia-ischemia is programmed cell death

Northington, F., Ferriero, D. M. & Martin, L. J., 2001, In : Developmental Neuroscience. 23, 3, p. 186-191 6 p.

Research output: Contribution to journalArticle

Thalamus
Cell Death
Ischemia
Death Domain Receptors
Prosencephalon

Neuronal cell death in nervous system development, disease, and injury (Review).

Martin, L. J., May 2001, In : International Journal of Molecular Medicine. 7, 5, p. 455-478 24 p.

Research output: Contribution to journalArticle

Nervous System Trauma
Nervous System Diseases
Cell Death
Apoptosis
Necrosis

N-Methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease

Sze, C. I., Bi, H., Kleinschmidt-DeMasters, B. K., Filley, C. M. & Martin, L. J., Jan 1 2001, In : Journal of the Neurological Sciences. 182, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

Protein Subunits
N-Methyl-D-Aspartate Receptors
Alzheimer Disease
Phosphorylation
Entorhinal Cortex
2000
Metabotropic Glutamate Receptors
Purkinje Cells
Cerebellum
Pyramidal Cells
Hippocampus

Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat

Nakajima, W., Ishida, A., Lange, M. S., Gabrielson, K. L., Wilson, M. A. A., Martin, L. J., Blue, M. E. & Johnston, M. V., Nov 1 2000, In : Journal of Neuroscience. 20, 21, p. 7994-8004 11 p.

Research output: Contribution to journalArticle

Ischemia
Apoptosis
Caspase 3
Thalamus
Neurons

Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death (Review).

Martin, L. J., Price, A. C., Kaiser, A., Shaikh, A. Y. & Liu, Z., Jan 2000, In : International Journal of Molecular Medicine. 5, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
Motor Neuron Disease
Cell Death
Muscular Atrophy

Neuronal death in newborn striatum after hypoxia-ischemia is necrosis and evolves with oxidative stress

Martin, L. J., Brambrink, A. M., Price, A. C., Kaiser, A., Agnew, D. M., Ichord, R. N. & Traystman, R. J., Jun 2000, In : Neurobiology of Disease. 7, 3, p. 169-191 23 p.

Research output: Contribution to journalArticle

Oxidative Stress
Necrosis
Ischemia
Corpus Striatum
Neurons

p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis

Martin, L. J., 2000, In : Neurobiology of Disease. 7, 6, p. 613-622 10 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
Nerve Degeneration
Apoptosis
DNA

Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains

Sze, C. I., Bi, H., Kleinschmidt-Demasters, B. K., Filley, C. M. & Martin, L. J., Apr 15 2000, In : Journal of the Neurological Sciences. 175, 2, p. 81-90 10 p.

Research output: Contribution to journalArticle

R-SNARE Proteins
Synaptotagmins
Alzheimer Disease
Brain
Synapsins

The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease

West, M. J., Kawas, C. H., Martin, L. J. & Troncoso, J. C., 2000, In : Annals of the New York Academy of Sciences. 908, p. 255-259 5 p.

Research output: Contribution to journalArticle

Hippocampus
Alzheimer Disease
Neurons
Cell Aging
Pathologic Processes
1999

Effects of the AMPA receptor antagonist NBQX on outcome of newborn pigs after asphyxic cardiac arrest

Brambrink, A. M., Martin, L. J., Hanley, D. F., Becker, K. J., Koehler, R. C. & Traystman, R. J., 1999, In : Journal of Cerebral Blood Flow and Metabolism. 19, 8, p. 927-938 12 p.

Research output: Contribution to journalArticle

Heart Arrest
Swine
Asphyxia
Seizures
Neurologic Manifestations

Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in the septum

Ginsberg, S. D., Portera-Cailliau, C. & Martin, L. J., Feb 1999, In : Neuroscience. 88, 4, p. 1059-1071 13 p.

Research output: Contribution to journalArticle

Brain Fornix
Septal Nuclei
Neurons
Axotomy
Wounds and Injuries
Amino Acid Transport System X-AG
Neuroglia
Astrocytes
Sheep
Neurons
Neocortex
Glutamate Receptors
Cerebral Cortex
AMPA Receptors
Kainic Acid Receptors

Motor neuron degeneration after sciatic nerve avulsion in adult rat evolves with oxidative stress and is apoptosis

Martin, L. J., Kaiser, A. & Price, A. C., 1999, In : Journal of Neurobiology. 40, 2, p. 185-201 17 p.

Research output: Contribution to journalArticle

Nerve Degeneration
Motor Neurons
Sciatic Nerve
Oxidative Stress
Apoptosis
Amyotrophic Lateral Sclerosis
Cell Death
Apoptosis
Cytosol
Motor Cortex
Craniocerebral Trauma
Brain Injuries
Brain
Ischemia
Newborn Infant
1998

AMPA receptor protein in developing rat brain: Glutamate receptor-1 expression and localization change at regional, cellular, and subcellular levels with maturation

Martin, L. J., Furuta, A. & Blackstone, C. D., Jan 5 1998, In : Neuroscience. 83, 3, p. 917-928 12 p.

Research output: Contribution to journalArticle

AMPA Receptors
Glutamate Receptors
Brain
Proteins
Isoxazoles

Animal models and degenerative disorders of the human brain

Martin, L. J., Portera-Cailliau, C., Ginsberg, S. D. & Al-Abdulla, N. A., Nov 1998, In : Lab Animal. 27, 10, p. 18-25 8 p.

Research output: Contribution to journalArticle

nervous system diseases
Brain Diseases
Nervous System Diseases
Brain
Animals
Mitochondria
Apoptosis
Neurons
Geniculate Bodies
Axotomy

Cognitive decline strongly correlates with cortical atrophy in Alzheimer's dementia

Mouton, P. R., Martin, L. J., Calhoun, M. E., Dal Forno, G. & Price, D. L., Sep 1998, In : Neurobiology of Aging. 19, 5, p. 371-377 7 p.

Research output: Contribution to journalArticle

Atrophy
Alzheimer Disease
Dementia
Autopsy
Cognitive Dysfunction

Familial amyotrophic lateral sclerosis and Alzheimer's disease: Transgenic models

Wong, P. C., Borchelt, D. R., Lee, M. K., Pardo-Villamizar, C. A., Thinakaran, G., Martin, L. J., Sisodia, S. S. & Price, D. L., 1998, In : Advances in Experimental Medicine and Biology. 446, p. 145-159 15 p.

Research output: Contribution to journalArticle

Mutagenesis
Inborn Genetic Diseases
Amyloid beta-Protein Precursor
Amyotrophic Lateral Sclerosis
Transgenic Mice

Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis

Martin, L. J., Al-Abdulla, N. A., Brambrink, A. M., Kiesch, J. R., Sieber, F. & Portera-Cailliau, C., Jul 1 1998, In : Brain Research Bulletin. 46, 4, p. 281-309 29 p.

Research output: Contribution to journalArticle

Brain Ischemia
Necrosis
Apoptosis
Cell Death
Neurons

Neuropathology of preclinical and clinical late-onset Alzheimer's disease

Troncoso, J. C., Cataldo, A. M., Nixon, R. A., Barnett, J. L., Lee, M. K., Checler, F., Fowler, D. R., Smialek, J. E., Crain, B., Martin, L. J. & Kawas, C. H., May 1998, In : Annals of Neurology. 43, 5, p. 673-676 4 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Nuclear Family
Amyloid
Brain
Neuroglia

Occipital cortex ablation in adult rat causes retrograde neuronal death in the lateral geniculate nucleus that resembles apoptosis

Al-Abdulla, N. A., Portera-Cailliau, C. & Martin, L. J., May 21 1998, In : Neuroscience. 86, 1, p. 191-209 19 p.

Research output: Contribution to journalArticle

Geniculate Bodies
Occipital Lobe
Apoptosis
Neurons
Rough Endoplasmic Reticulum

Protein kinase C expression and activity after global incomplete cerebral ischemia in dogs

Sieber, F., Traystman, R. J., Brown, P. R. & Martin, L. J., Jul 1998, In : Stroke. 29, 7, p. 1445-1453 9 p.

Research output: Contribution to journalArticle

Brain Ischemia
Protein Kinase C
Dogs
Cerebellum
Hippocampus
Amino Acid Transport System X-AG
Neuroglia
Sheep
Brain
Proteins

The competitive NMDA antagonist GPI 3000 (GPI) does not improve outcome after cardiac arrest in dog

Hetfaer, M., Chord, R., Martin, L. J., Hum, P., Castro, J. & Traystman, R. J., 1998, In : Critical Care Medicine. 26, 1 SUPPL.

Research output: Contribution to journalArticle

N-Methylaspartate
Heart Arrest
Dogs
Animal Care Committees
Neocortex

Treatment with the competitive NMDA antagonist GPI 3000 does not improve outcome after cardiac arrest in dogs

Helfaer, M. A., Ichord, R. N., Martin, L. J., Hurn, P. D., Castro, A. & Traystman, R. J., Apr 1998, In : Stroke. 29, 4, p. 824-829 6 p.

Research output: Contribution to journalArticle

N-Methylaspartate
Heart Arrest
Dogs
Resuscitation
Therapeutics

Ultrastructural analysis of the progression of neurodegeneration in the septum following fimbria-fornix transection

Ginsberg, S. D. & Martin, L. J., Jun 18 1998, In : Neuroscience. 86, 4, p. 1259-1272 14 p.

Research output: Contribution to journalArticle

Brain Fornix
Septal Nuclei
Presynaptic Terminals
Neurons
Afferent Neurons
1997

Amyotrophic lateral sclerosis and Alzheimer's disease. Lessons from model systems

Price, D. L., Wong, P. C., Borchelt, D. R., Pardo-Villamizar, C. A., Thinakaran, G., Doan, A. P., Lee, M. K., Martin, L. J. & Sisodia, S. S., Sep 1997, In : Revue Neurologique. 153, 8-9, p. 484-495 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
Alzheimer Disease
Motor Neuron Disease
Amyloid beta-Protein Precursor

Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4

Furuta, A., Martin, L. J., Lin, C. L. G., Dykes-Hoberg, M. & Rothstein, J. D., Oct 10 1997, In : Neuroscience. 81, 4, p. 1031-1042 12 p.

Research output: Contribution to journalArticle

Excitatory Amino Acid Transporter 4
Excitatory Amino Acid Transporter 3
Amino Acid Transport System X-AG
Glutamate Plasma Membrane Transport Proteins
Purkinje Cells

Characterization of metabotropic glutamate receptor-mediated nitric oxide production in vivo

Bhardwaj, A., Northington, F., Martin, L. J., Hanley, D. F., Traystman, R. J. & Koehler, R. C., Feb 1997, In : Journal of Cerebral Blood Flow and Metabolism. 17, 2, p. 153-160 8 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Citrulline
Nitric Oxide
Acids
Dantrolene
Type C Phospholipases
Ischemia
Dogs
Proteins
Hippocampus

Excitotoxic neuronal death in the immature brain is an apoptosis- necrosis morphological continuum

Portera-Cailliau, C., Price, D. L. & Martin, L. J., Feb 3 1997, In : Journal of Comparative Neurology. 378, 1, p. 70-87 18 p.

Research output: Contribution to journalArticle

Necrosis
Apoptosis
Cell Death
Brain
Neurons