Lee J Martin

Professor

1984 …2019
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Research Output 1984 2019

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Article
2011
Ischemia
Inflammation
Wounds and Injuries
Necrosis
Cell Death

Neuronal cell death in neonatal hypoxia-ischemia

Northington, F., Chavez-Valdez, R. & Martin, L. J., May 2011, In : Annals of Neurology. 69, 5, p. 743-758 16 p.

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Cell Death
Ischemia
Necrosis
Animal Models

Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia-ischemia in newborn piglet striatum

Yang, Z. J., Ni, X., Carter, E. L., Kibler, K., Martin, L. J. & Koehler, R. C., Aug 2011, In : Neurobiology of Disease. 43, 2, p. 446-454 9 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channel Blockers
Acid Sensing Ion Channels
Neuroprotective Agents
Putamen
Ischemia

Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone

Ni, X., Yang, Z. J., Carter, E. L., Martin, L. J. & Koehler, R. C., Oct 2011, In : Developmental Neuroscience. 33, 3-4, p. 299-311 13 p.

Research output: Contribution to journalArticle

Corpus Striatum
Ischemia
Antioxidants
Neurons
Oxidative Stress

The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation

Martin, L. J., Adams, N. A., Pan, Y., Price, A. & Wong, M., Jan 5 2011, In : Journal of Neuroscience. 31, 1, p. 359-370 12 p.

Research output: Contribution to journalArticle

Geniculate Bodies
Nitric Oxide
Apoptosis
Neurons
Voltage-Dependent Anion Channels
2010
Schwann Cells
Amyotrophic Lateral Sclerosis
Motor Neurons
Nitric Oxide Synthase Type II
Mitochondria
Amyotrophic Lateral Sclerosis
Parkinson Disease
Mitochondria
Neurodegenerative Diseases
Neurons

Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis

Martin, L. J., Aug 2010, In : IDrugs. 13, 8, p. 568-580 13 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Neuroprotective Agents
Permeability
Cholesterol
Motor Neurons
sigma Receptors
Post-Synaptic Density
Corpus Striatum
Nerve Degeneration
Nitric Oxide Synthase Type I

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice

Wong, M. & Martin, L. J., Mar 10 2010, In : Human Molecular Genetics. 19, 11, p. 2284-2302 19 p., ddq106.

Research output: Contribution to journalArticle

Nerve Degeneration
Motor Neurons
Transgenic Mice
Amyotrophic Lateral Sclerosis
Skeletal Muscle

Synphilin-1 attenuates neuronal degeneration in the A53T α-synuclein transgenic mouse model

Smith, W., Liu, Z., Liang, Y., Masuda, N., Swing, D. A., Jenkins, N. A., Copeland, N. G., Troncoso, J. C., Pletnikov, M., Dawson, T. M., Martin, L. J., Moran, T. H., Lee, M. K., Borchelt, D. R. & Ross, C. A., Feb 25 2010, In : Human Molecular Genetics. 19, 11, p. 2087-2098 12 p., ddq086.

Research output: Contribution to journalArticle

Synucleins
Transgenic Mice
Parkinson Disease
Parkinsonian Disorders
Caspase 3
Amyotrophic Lateral Sclerosis
Permeability
Mitochondria
Cell Death
Motor Neurons
2009
Amyotrophic Lateral Sclerosis
Motor Neurons
Glycine Plasma Membrane Transport Proteins
Glutamate Decarboxylase
Choline O-Acetyltransferase

Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex

Martin, L. J., Liu, Z., Pipino, J., Chestnut, B. & Landek, M. A., Jun 2009, In : Cerebral Cortex. 19, 6, p. 1273-1293 21 p.

Research output: Contribution to journalArticle

Cerebral Cortex
DNA Damage
Apoptosis
Neurons
Ataxia Telangiectasia

Neuropathologic studies of the Baltimore longitudinal study of aging (BLSA)

O'Brien, R. J., Resnick, S. M., Zonderman, A. B., Ferrucci, L., Crain, B. J., Pletnikova, O., Rudow, G., Iacono, D., Riudavets, M. A., Driscoll, I., Price, D. L., Martin, L. J. & Troncoso, J. C., 2009, In : Journal of Alzheimer's Disease. 18, 3, p. 665-675 11 p.

Research output: Contribution to journalArticle

Baltimore
Longitudinal Studies
Alzheimer Disease
Autopsy
Neuronal Plasticity

The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice

Martin, L. J., Gertz, B., Pan, Y., Price, A. C., Molkentin, J. D. & Chang, Q., Aug 2009, In : Experimental Neurology. 218, 2, p. 333-346 14 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
Mitochondria
Nerve Degeneration
Adenine Nucleotides
2008

Delayed neural network degeneration after neonatal hypoxia-ischemia

Stone, B. S., Zhang, J., Mack, D. W., Mori, S., Martin, L. J. & Northington, F., Nov 2008, In : Annals of Neurology. 64, 5, p. 535-546 12 p.

Research output: Contribution to journalArticle

Diffusion Tensor Imaging
Ischemia
Wounds and Injuries
Brain
Axons

DNA damage and repair: Relevance to mechanisms of neurodegeneration

Martin, L. J., May 2008, In : Journal of Neuropathology and Experimental Neurology. 67, 5, p. 377-387 11 p.

Research output: Contribution to journalArticle

DNA Repair
DNA Damage
Neurons
DNA Repair-Deficiency Disorders
Amyotrophic Lateral Sclerosis

Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking

Laird, F. M., Farah, M. H., Ackerley, S., Hoke, A., Maragakis, N. J., Rothstein, J. D., Griffin, J., Price, D. L., Martin, L. J. & Wong, P. C., Feb 27 2008, In : Journal of Neuroscience. 28, 9, p. 1997-2005 9 p.

Research output: Contribution to journalArticle

Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Motor Neurons
Muscle Spasticity
Muscular Atrophy
Corpus Striatum
N-Methyl-D-Aspartate Receptors
Hypothermia
Oxidative Stress
Ischemia
2007
Nerve Degeneration
Olfactory Bulb
Amyotrophic Lateral Sclerosis
Motor Neurons
Transplants

Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets

Yang, Z. J., Torbey, M., Li, X., Bernardy, J., Golden, W. C., Martin, L. J. & Koehler, R. C., Jul 27 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 7, p. 1339-1351 13 p.

Research output: Contribution to journalArticle

Sulpiride
Dopamine Receptors
Dopamine and cAMP-Regulated Phosphoprotein 32
Putamen
Wounds and Injuries

Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as "continuum" phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain

Northington, F., Zelaya, M. E., O'Riordan, D. P., Blomgren, K., Flock, D. L., Hagberg, H., Ferriero, D. M. & Martin, L. J., Nov 23 2007, In : Neuroscience. 149, 4, p. 822-833 12 p.

Research output: Contribution to journalArticle

Prosencephalon
Rodentia
Cell Death
Ischemia
Caspase 3

Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: Mechanisms of mitochondriopathy and cell death

Martin, L. J., Liu, Z., Chen, K., Price, A. C., Yan, P., Swaby, J. A. & Golden, W. C., Jan 1 2007, In : Journal of Comparative Neurology. 500, 1, p. 20-46 27 p.

Research output: Contribution to journalArticle

Nerve Degeneration
Amyotrophic Lateral Sclerosis
Motor Neurons
Transgenic Mice
Cell Death

Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons

Riudavets, M. A., Iacono, D., Resnick, S. M., O'Brien, R., Zonderman, A. B., Martin, L. J., Rudow, G., Pletnikova, O. & Troncoso, J. C., Oct 2007, In : Neurobiology of Aging. 28, 10, p. 1484-1492 9 p.

Research output: Contribution to journalArticle

Hypertrophy
Alzheimer Disease
Pathology
Neurons
Asymptomatic Diseases
Amyotrophic Lateral Sclerosis
Motor Neurons
Transgenic Mice
Parkinson Disease
Genes
2006

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

Lai, C., Xie, C., McCormack, S. G., Chiang, H. C., Michalak, M. K., Lin, X., Chandran, J., Shim, H., Shimoji, M., Cookson, M. R., Huganir, R. L., Rothstein, J. D., Price, D. L., Wong, P. C., Martin, L. J., Zhu, J. J. & Cai, H., Nov 8 2006, In : Journal of Neuroscience. 26, 45, p. 11798-11806 9 p.

Research output: Contribution to journalArticle

AMPA Receptors
Amyotrophic Lateral Sclerosis
Glutamate Receptors
Receptor-Interacting Protein Serine-Threonine Kinases
Motor Neurons

Low-dose ouabain protects against excitotoxic apoptosis and up-regulates nuclear Bcl-2 in vivo

Golden, W. C. & Martin, L. J., 2006, In : Neuroscience. 137, 1, p. 133-144 12 p.

Research output: Contribution to journalArticle

Ouabain
Cardiac Glycosides
Up-Regulation
Apoptosis
Injections

Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis

Martin, L. J., Dec 2006, In : Journal of Neuropathology and Experimental Neurology. 65, 12, p. 1103-1110 8 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Parkinson Disease
Mitochondria
Molecular Biology
Cell Death

Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death

Martin, L. J., Pan, Y., Price, A. C., Sterling, W., Copeland, N. G., Jenkins, N. A., Price, D. L. & Lee, M. K., Jan 4 2006, In : Journal of Neuroscience. 26, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

Synucleins
Transgenic Mice
Parkinson Disease
Cell Death
Motor Neurons

The adult neural stem and progenitor cell niche is altered in amyotrophic lateral sclerosis mouse brain

Liu, Z. & Martin, L. J., Jul 20 2006, In : Journal of Comparative Neurology. 497, 3, p. 468-488 21 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Adult Stem Cells
Neural Stem Cells
Amyotrophic Lateral Sclerosis
Stem Cells
2005

Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation

Martin, L. J., Chen, K. & Liu, Z., Jul 6 2005, In : Journal of Neuroscience. 25, 27, p. 6449-6459 11 p.

Research output: Contribution to journalArticle

CD95 Antigens
Death Domain Receptors
Motor Neurons
DNA Damage
Nitric Oxide
Brain Injuries
Apoptosis
Ischemia
Stroke
Therapeutics

Effect of glutamine synthetase inhibition on astrocyte swelling and altered astroglial protein expression during hyperammonemia in rats

Tanigami, H., Rebel, A., Martin, L. J., Chen, T. Y., Brusilow, S. W., Traystman, R. J. & Koehler, R. C., 2005, In : Neuroscience. 131, 2, p. 437-449 13 p.

Research output: Contribution to journalArticle

Hyperammonemia
Glutamate-Ammonia Ligase
Astrocytes
Glutamine
Proteins
Brain
Amino Acid Transport System X-AG
HSP70 Heat-Shock Proteins
Glial Fibrillary Acidic Protein
Proteins

Moral issues of human-non-human primate neural grafting

Greene, M., Schill, K., Takahashi, S., Bateman-House, A., Beauchamp, T., Bok, H., Cheney, D., Coyle, J., Deacon, T., Dennett, D., Donovan, P., Flanagan, O., Goldman, S., Greely, H., Martin, L. J., Miller, E., Mueller, D., Siegel, A., Solter, D., Gearhart, J. & 2 others, McKhann, G. & Faden, R. R., Jul 15 2005, In : Science. 309, 5733, p. 385-386 2 p.

Research output: Contribution to journalArticle

Transplantation Chimera
Moral Obligations
Research Ethics
Mental Processes
Heterologous Transplantation

Transplanted human embryonic germ cell-derived neural stem cells replace neurons and oligodendrocytes in the forebrain of neonatal mice with excitotoxic brain damage

Mueller, D., Shamblott, M. J., Fox, H. E., Gearhart, J. D. & Martin, L. J., Dec 1 2005, In : Journal of Neuroscience Research. 82, 5, p. 592-608 17 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Oligodendroglia
Prosencephalon
Neurons
Brain
2004

Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice

Kofler, J., Hattori, K., Sawada, M., DeVries, A. C., Martin, L. J., Hurn, P. D. & Traystman, R. J., Jun 15 2004, In : Journal of Neuroscience Methods. 136, 1, p. 33-44 12 p.

Research output: Contribution to journalArticle

Cardiopulmonary Resuscitation
Heart Arrest
Locomotion
Resuscitation Orders
Avoidance Learning

Neonatal mice lacking functional Fas death receptors are resistant to hypoxic-ischemic brain injury

Graham, E. M., Sheldon, R. A., Flock, D. L., Ferriero, D. M., Martin, L. J., O'Riordan, D. P. & Northington, F., Oct 2004, In : Neurobiology of Disease. 17, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

CD95 Antigens
Death Domain Receptors
Brain Injuries
Ischemia
Inbred MRL lpr Mouse

Opportunities for neuroprotection in ALS using cell death mechanism rationales

Martin, L. J. & Liu, Z., Nov 2004, In : Drug Discovery Today: Disease Models. 1, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Cell Death
Motor Neurons
Nerve Degeneration
Motor Neuron Disease

Pluripotent fates and tissue regenerative potential of adult olfactory bulb neural stem and progenitor cells

Liu, Z. & Martin, L. J., Oct 2004, In : Journal of Neurotrauma. 21, 10, p. 1479-1499 21 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Olfactory Bulb
Stem Cells
Skeletal Muscle
Neurons
2003

Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: Oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins

Martin, L. J., Price, A. C., McClendon, K. B., Al-Abdulla, N. A., Subramaniam, J. R., Wong, P. C. & Liu, Z., Apr 2003, In : Journal of Neurochemistry. 85, 1, p. 234-247 14 p.

Research output: Contribution to journalArticle

Axotomy
Phosphorylation
Oxidative stress
DNA Damage
Oxidative Stress

Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming

Agnew, D. M., Koehler, R. C., Guerguerian, A. M., Shaffner, D. H., Traystman, R. J., Martin, L. J. & Ichord, R. N., Aug 1 2003, In : Pediatric Research. 54, 2, p. 253-262 10 p.

Research output: Contribution to journalArticle

Corpus Striatum
Rewarming
Heart Arrest
Hypothermia
Putamen
Nitration
Corpus Striatum
Peroxynitrous Acid
Adenosine Triphosphatases
Brain

Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human

Liu, Z. & Martin, L. J., May 12 2003, In : Journal of Comparative Neurology. 459, 4, p. 368-391 24 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Olfactory Bulb
Rodentia
Stem Cells
Nestin
2002

Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia - Ischemia

Guerguerian, A. M., Brambrink, A. M., Traystman, R. J., Huganir, R. L. & Martin, L. J., Jul 15 2002, In : Molecular Brain Research. 104, 1-2, p. 66-80 15 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Ischemia
Phosphorylation
Corpus Striatum
Nerve Degeneration

Axonal transection in adult rat brain induces transsynaptic apoptosis and persistent atrophy of target neurons

Ginsberg, S. D. & Martin, L. J., 2002, In : Journal of Neurotrauma. 19, 1, p. 99-109 11 p.

Research output: Contribution to journalArticle

Brain Fornix
Atrophy
Apoptosis
Neurons
Brain
DNA-(Apurinic or Apyrimidinic Site) Lyase
Amyotrophic Lateral Sclerosis
DNA Repair
Oxidation-Reduction
Spinal Cord