Lee J Martin

Professor

1984 …2019
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Research Output 1984 2019

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Aberrant Regulation of DNA Methylation in Amyotrophic Lateral Sclerosis: A New Target of Disease Mechanisms

Martin, L. J. & Wong, M., Oct 2013, In : Neurotherapeutics. 10, 4, p. 722-733 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
DNA Methylation
Motor Neurons
Nerve Degeneration
Epigenomics

Additive Neuroprotection of a 20-HETE Inhibitor with Delayed Therapeutic Hypothermia after Hypoxia-Ischemia in Neonatal Piglets

Zhu, J., Wang, B., Lee, J. H., Armstrong, J. S., Kulikowicz, E., Bhalala, U. S., Martin, L. J., Koehler, R. C. & Yang, Z. J., Jul 25 2015, In : Developmental Neuroscience. 37, 4-5, p. 376-389 14 p.

Research output: Contribution to journalArticle

Induced Hypothermia
Hypothermia
Ischemia
Putamen
Thalamus

Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet

Yang, Z. J., Wang, B., Kwansa, H., Heitmiller, K. D., Hong, G., Carter, E. L., Jamrogowicz, J. L., Larson, A. C., Martin, L. J. & Koehler, R. C., Oct 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 10, p. 1612-1620 9 p.

Research output: Contribution to journalArticle

Adenosine A2A Receptors
Neurons
Ischemia
Cyclic AMP-Dependent Protein Kinases
Brain

Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation

Martin, L. J., Chen, K. & Liu, Z., Jul 6 2005, In : Journal of Neuroscience. 25, 27, p. 6449-6459 11 p.

Research output: Contribution to journalArticle

CD95 Antigens
Death Domain Receptors
Motor Neurons
DNA Damage
Nitric Oxide
Nerve Degeneration
Olfactory Bulb
Amyotrophic Lateral Sclerosis
Motor Neurons
Transplants

Age-associated inclusions in normal and transgenic mouse brain

Jucker, M., Walker, L. C., Martin, L. J., Kitt, C. A., Kleinman, H. K., Ingram, D. K., Price, D. L., Wirak, D., Bayney, R., Ramabhadran, T. V., Fracasso, R. P., Hart, J. T., Hauer, P. E., Hsiau, P., Pekar, S. K., Scangos, G. A., Trapp, B. D. & Unterbeck, A. J., 1992, In : Science. 255, 5050, p. 1443-1445 3 p.

Research output: Contribution to journalArticle

Amyloid beta-Peptides
Inbred C57BL Mouse
Transgenic Mice
Brain

Aged non-human primates: An animal model of age-associated neurodegenerative disease

Price, D. L., Martin, L. J., Sisodia, S. S., Wagster, M. V., Koo, E. H., Walker, L. C., Koliatsos, V. E. & Cork, L. C., 1991, In : Brain Pathology. 1, 4, p. 287-296 10 p.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Primates
Animal Models
Amyloid Plaques
Nerve Growth Factor

Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia - Ischemia

Guerguerian, A. M., Brambrink, A. M., Traystman, R. J., Huganir, R. L. & Martin, L. J., Jul 15 2002, In : Molecular Brain Research. 104, 1-2, p. 66-80 15 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Ischemia
Phosphorylation
Corpus Striatum
Nerve Degeneration

Alzheimer's disease-type brain abnormalities in animal models.

Price, D. L., Martin, L. J., Sisodia, S. S., Walker, L. C. & Cork, L. C., 1992, In : Progress in Clinical and Biological Research. 379, p. 271-287 17 p.

Research output: Contribution to journalArticle

Animal Disease Models
Amyloid beta-Peptides
Macaca mulatta
Transgenic Mice
Alzheimer Disease

AMPA glutamate receptor subunits are differentially distributed in rat brain

Martin, L. J., Blackstone, C. D., Levey, A. I., Huganir, R. L. & Price, D. L., 1993, In : Neuroscience. 53, 2, p. 327-358 32 p.

Research output: Contribution to journalArticle

AMPA Receptors
Glutamate Receptors
Brain
Neurons
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

AMPA receptor protein in developing rat brain: Glutamate receptor-1 expression and localization change at regional, cellular, and subcellular levels with maturation

Martin, L. J., Furuta, A. & Blackstone, C. D., Jan 5 1998, In : Neuroscience. 83, 3, p. 917-928 12 p.

Research output: Contribution to journalArticle

AMPA Receptors
Glutamate Receptors
Brain
Proteins
Isoxazoles

Amyloidosis in aging and Alzheimer's disease

Price, D. L., Walker, L. C., Martin, L. J. & Sisodia, S. S., 1992, In : American Journal of Pathology. 141, 4, p. 767-772 6 p.

Research output: Contribution to journalArticle

Animal Disease Models
Genetically Modified Animals
Amyloid beta-Protein Precursor
Amyloidosis
Macaca mulatta

Amyloid precursor protein in aged nonhuman primates

Martin, L. J., Sisodia, S. S., Koo, E. H., Cork, L. C., Dellovade, T. L., Weidemann, A., Beyreuther, K., Masters, C. & Price, D. L., 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 4, p. 1461-1465 5 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Primates
Amyloid Plaques
Axons
Neurites

Amyloid-related proteins and nerve growth factor in Alzheimer's disease and animal models

Price, D. L., Koliatsos, V. E., Sisodia, S. S., Koo, E. H., Martin, L. J., Walker, L. C., Applegate, M. D. & Cork, L. C., 1991, In : Clinical Neuropharmacology. 14, SUPPL. 1

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Cholinergic Neurons
Nerve Growth Factor
Amyloid
Alzheimer Disease

Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques

Kageyama, Y., Saito, A., Pletnikova, O., Rudow, G. L., Irie, Y., An, Y., Murakami, K., Irie, K., Resnick, S. M., Fowler, D. R., Martin, L. J. & Troncoso, J. C., Dec 1 2018, In : Scientific Reports. 8, 1, 16895.

Research output: Contribution to journalArticle

Parietal Lobe
Poisons
Amyloid Plaques
Extracellular Space
Amyloid

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

Lai, C., Xie, C., McCormack, S. G., Chiang, H. C., Michalak, M. K., Lin, X., Chandran, J., Shim, H., Shimoji, M., Cookson, M. R., Huganir, R. L., Rothstein, J. D., Price, D. L., Wong, P. C., Martin, L. J., Zhu, J. J. & Cai, H., Nov 8 2006, In : Journal of Neuroscience. 26, 45, p. 11798-11806 9 p.

Research output: Contribution to journalArticle

AMPA Receptors
Amyotrophic Lateral Sclerosis
Glutamate Receptors
Receptor-Interacting Protein Serine-Threonine Kinases
Motor Neurons

Amyotrophic lateral sclerosis and Alzheimer's disease. Lessons from model systems

Price, D. L., Wong, P. C., Borchelt, D. R., Pardo-Villamizar, C. A., Thinakaran, G., Doan, A. P., Lee, M. K., Martin, L. J. & Sisodia, S. S., Sep 1997, In : Revue Neurologique. 153, 8-9, p. 484-495 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
Alzheimer Disease
Motor Neuron Disease
Amyloid beta-Protein Precursor
Gene Knockout Techniques
Motor Neurons
Interneurons
Pathology
Green Fluorescent Proteins

Animal models and degenerative disorders of the human brain

Martin, L. J., Portera-Cailliau, C., Ginsberg, S. D. & Al-Abdulla, N. A., Nov 1998, In : Lab Animal. 27, 10, p. 18-25 8 p.

Research output: Contribution to journalArticle

nervous system diseases
Brain Diseases
Nervous System Diseases
Brain
Animals
Ischemia
Brain Injuries
Calcium
Induced Hypothermia
Brain Death
Metabotropic Glutamate Receptors
Purkinje Cells
Cerebellum
Pyramidal Cells
Hippocampus

Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat

Nakajima, W., Ishida, A., Lange, M. S., Gabrielson, K. L., Wilson, M. A. A., Martin, L. J., Blue, M. E. & Johnston, M. V., Nov 1 2000, In : Journal of Neuroscience. 20, 21, p. 7994-8004 11 p.

Research output: Contribution to journalArticle

Ischemia
Apoptosis
Caspase 3
Thalamus
Neurons
Brain Injuries
Apoptosis
Ischemia
Stroke
Therapeutics
Mitochondria
Apoptosis
Neurons
Geniculate Bodies
Axotomy

Apparent diffusion coefficient scalars correlate with near-Infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-Ischemic injury

Tekes, A., Poretti, A., Scheurkogel, M. M., Huisman, T. A. G. M., Howlett, J. A., Alqahtani, E., Lee, J. H., Parkinson, C., Shapiro, K., Chung, S. E., Jennings, J., Gilmore, M., Hogue, C. W., Martin, L. J., Koehler, R. C., Northington, F. & Lee-Summers, J., Jan 1 2015, In : American Journal of Neuroradiology. 36, 1, p. 188-193 6 p.

Research output: Contribution to journalArticle

Near-Infrared Spectroscopy
Homeostasis
Internal Capsule
Blood Pressure
Wounds and Injuries

Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor

Yang, Z. J., Carter, E. L., Kibler, K. K., Kwansa, H., Crafa, D. A., Martin, L. J., Roman, R. J., Harder, D. R. & Koehler, R. C., Apr 2012, In : Journal of Neurochemistry. 121, 1, p. 168-179 12 p.

Research output: Contribution to journalArticle

Brain
Ischemia
Putamen
Brain Ischemia
Neurons

Axonal transection in adult rat brain induces transsynaptic apoptosis and persistent atrophy of target neurons

Ginsberg, S. D. & Martin, L. J., 2002, In : Journal of Neurotrauma. 19, 1, p. 99-109 11 p.

Research output: Contribution to journalArticle

Brain Fornix
Atrophy
Apoptosis
Neurons
Brain

Biochemical characterization and localization of a non-N-methyl-D-aspartate glutamate receptor in rat brain

Blackstone, C. D., Moss, S. J., Martin, L. J., Levey, A. I., Price, D. L. & Huganir, R. L., Mar 1992, In : Journal of Neurochemistry. 58, 3, p. 1118-1126 9 p.

Research output: Contribution to journalArticle

D-Aspartic Acid
Synaptic Membranes
Propionates
Glutamate Receptors
Cell membranes

Biology of mitochondria in neurodegenerative diseases

Martin, L. J., 2012, In : Progress in Molecular Biology and Translational Science. 107, p. 355-415 61 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Parkinson Disease
Alzheimer Disease
Mitochondria

Brain neuronal chromatin responses in acute soman intoxicated rats

Martin, L. J., Doebler, J. A., Wall, T. J., Shih, T. M. & Anthony, A., Aug 1986, In : Neurochemical Research. 11, 8, p. 1203-1215 13 p.

Research output: Contribution to journalArticle

Soman
Chromatin
Rats
Brain
Acetylcholinesterase

Cellular/molecular biological studies of brain abnormalities in Alzheimer's disease and animal models

Price, D. L., Koo, E. H., Sisodia, S. S., Walker, L. C., Martin, L. J. & Cork, L. C., Mar 1989, In : Journal of Neural Transmission - Parkinson's Disease and Dementia Section. 1, 1-2, p. 13 1 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Animal Models
Brain

Cellular and molecular biology of Alzheimer's disease and animal models

Sisodia, S. S., Martin, L. J., Walker, L. C., Borchelt, D. R. & Price, D. L., 1995, In : Neuroimaging Clinics of North America. 5, 1, p. 59-68 10 p.

Research output: Contribution to journalArticle

Serum Amyloid A Protein
Cell Biology
Molecular Biology
Alzheimer Disease
Animal Models

Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4

Furuta, A., Martin, L. J., Lin, C. L. G., Dykes-Hoberg, M. & Rothstein, J. D., Oct 10 1997, In : Neuroscience. 81, 4, p. 1031-1042 12 p.

Research output: Contribution to journalArticle

Excitatory Amino Acid Transporter 4
Excitatory Amino Acid Transporter 3
Amino Acid Transport System X-AG
Glutamate Plasma Membrane Transport Proteins
Purkinje Cells
Amyloid Plaques
Macaca
Amyloid
Cerebral Cortex
Primates

Cellular localization of a metabotropic glutamate receptor in rat brain

Martin, L. J., Blackstone, C. D., Huganir, R. L. & Price, D. L., 1992, In : Neuron. 9, 2, p. 259-270 12 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Brain
AMPA Receptors
Isoxazoles
Parahippocampal Gyrus

Cellular localizations of AMPA glutamate receptors within the basal forebrain magnocellular complex of rat and monkey

Martin, L. J., Blackstone, C. D., Levey, A. I., Huganir, R. L. & Price, D. L., 1993, In : Journal of Neuroscience. 13, 5, p. 2249-2263 15 p.

Research output: Contribution to journalArticle

AMPA Receptors
Glutamate Receptors
Haplorhini
Neurons
Cholinergic Neurons

Characterization of metabotropic glutamate receptor-mediated nitric oxide production in vivo

Bhardwaj, A., Northington, F., Martin, L. J., Hanley, D. F., Traystman, R. J. & Koehler, R. C., Feb 1997, In : Journal of Cerebral Blood Flow and Metabolism. 17, 2, p. 153-160 8 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Citrulline
Nitric Oxide
Acids
Dantrolene

Cognitive decline strongly correlates with cortical atrophy in Alzheimer's dementia

Mouton, P. R., Martin, L. J., Calhoun, M. E., Dal Forno, G. & Price, D. L., Sep 1998, In : Neurobiology of Aging. 19, 5, p. 371-377 7 p.

Research output: Contribution to journalArticle

Atrophy
Alzheimer Disease
Dementia
Autopsy
Cognitive Dysfunction

Comparative evaluation of synaptophysin-based methods for quantification of synapses

Calhoun, M. E., Jucker, M., Martin, L. J., Thinakaran, G., Price, D. L. & Mouton, P. R., 1996, In : Journal of Neurocytology. 25, 12, p. 821-828 8 p.

Research output: Contribution to journalArticle

Synaptophysin
Synapses
Dentate Gyrus
Densitometry
Western Blotting

Correction: Hypoxia-ischemia and therapeutic hypothermia in the neonatal mouse brain - A longitudinal study

Burnsed, J. C., Chavez-Valdez, R., Hossain, M. S., Kesavan, K., Martin, L. J. & Zhang, J., May 26 2015, In : PLoS One. 10, 5, e0129406.

Research output: Contribution to journalArticle

Hypothermia
Brain

Cytophotometric analyses of brain neuronal RNA in soman intoxicated rabbits

Doebler, J. A., Wall, T. J., Moore, R. A., Martin, L. J., Shih, T. M. & Anthony, A., 1984, In : Toxicology. 32, 2, p. 153-163 11 p.

Research output: Contribution to journalArticle

Soman
Brain
RNA
Rabbits
Cytophotometry

Cytophotometric analyses of mesencephalic reticular formation neuronal RNA in soman intoxicated rats

Doebler, J. A., Martin, L. J., Shih, T. M. & Anthony, A., 1985, In : Neurochemistry International. 7, 3, p. 415-420 6 p.

Research output: Contribution to journalArticle

Soman
Lethal Dose 50
RNA
Cholinergic Agents
Cytophotometry

Cytophotometric analyses of thalamic neuronal RNA in soman intoxicated rats

Martin, L. J., Doebler, J. A., Shih, T. M. & Anthony, A., Oct 8 1984, In : Life Sciences. 35, 15, p. 1593-1600 8 p.

Research output: Contribution to journalArticle

Soman
Rats
RNA
Cholinergic Agents
Ventral Thalamic Nuclei

Cytophotometric analysis of neuronal chromatin and RNA changes in oxotremorine-treated rats

Martin, L. J., Doebler, J. A. & Anthony, A., 1986, In : Experimental Biology and Medicine. 181, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

Oxotremorine
Chromatin
Rats
RNA
DNA

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

Rothstein, J. D., Martin, L. J. & Kuncl, R. W., May 28 1992, In : New England Journal of Medicine. 326, 22, p. 1464-1468 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Glutamic Acid
Spinal Cord
Brain
Synaptosomes

Delayed injury of hippocampal interneurons after neonatal hypoxia-ischemia and therapeutic hypothermia in a murine model

Chavez-Valdez, R., Emerson, P., Goffigan-Holmes, J., Kirkwood, A., Martin, L. J. & Northington, F., Aug 1 2018, In : Hippocampus. 28, 8, p. 617-630 14 p.

Research output: Contribution to journalArticle

Induced Hypothermia
Interneurons
Ischemia
Wounds and Injuries
Parvalbumins

Delayed neural network degeneration after neonatal hypoxia-ischemia

Stone, B. S., Zhang, J., Mack, D. W., Mori, S., Martin, L. J. & Northington, F., Nov 2008, In : Annals of Neurology. 64, 5, p. 535-546 12 p.

Research output: Contribution to journalArticle

Diffusion Tensor Imaging
Ischemia
Wounds and Injuries
Brain
Axons

Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis

Northington, F., Ferriero, D. M., Flock, D. L. & Martin, L. J., Mar 15 2001, In : Journal of Neuroscience. 21, 6, p. 1931-1938 8 p.

Research output: Contribution to journalArticle

Thalamus
Death Domain Receptors
Ischemia
Brain Injuries
Apoptosis
Type C Phospholipases
Ischemia
Dogs
Proteins
Hippocampus

Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer’s mouse model

LaClair, K. D., Donde, A., Ling, J. P., Jeong, Y. H., Chhabra, R., Martin, L. J. & Wong, P. C., Dec 1 2016, In : Acta Neuropathologica. 132, 6, p. 859-873 15 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Amyloid
Alzheimer Disease
TDP-43 Proteinopathies
Prosencephalon