Lee J Martin

Professor

1984 …2020

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Research Output

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Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets

Yang, Z. J., Torbey, M., Li, X., Bernardy, J., Golden, W. C., Martin, L. J. & Koehler, R. C., Jul 27 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 7, p. 1339-1351 13 p.

Research output: Contribution to journalArticle

Early antioxidant treatment and delayed hypothermia after hypoxia-ischemia have no additive neuroprotection in newborn pigs

Ni, X., Yang, Z. J., Wang, B., Carter, E. L., Larson, A. C., Martin, L. J. & Koehler, R. C., Sep 1 2012, In : Anesthesia and analgesia. 115, 3, p. 627-637 11 p.

Research output: Contribution to journalArticle

Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: Oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins

Martin, L. J., Price, A. C., McClendon, K. B., Al-Abdulla, N. A., Subramaniam, J. R., Wong, P. C. & Liu, Z., Apr 2003, In : Journal of Neurochemistry. 85, 1, p. 234-247 14 p.

Research output: Contribution to journalArticle

Early neurodegeneration after hypoxia-ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis

Northington, F. J., Ferriero, D. M., Graham, E. M., Traystman, R. J. & Martin, L. J., Jan 1 2001, In : Neurobiology of Disease. 8, 2, p. 207-219 13 p., 90371.

Research output: Contribution to journalArticle

Effect of AMPA receptor antagonist nbqx on neuronal survival in basal ganglia after asphymc cardiac arrest in neonatal pigs

Bramhrink, A. M., Martin, L. J., Hanley, D. F., Becker, K., Shaffher, H. D., Koehler, R. C. & Trayitman, R. J., Dec 1 1996, In : FASEB Journal. 10, 3, p. A302

Research output: Contribution to journalArticle

Effect of glutamine synthetase inhibition on astrocyte swelling and altered astroglial protein expression during hyperammonemia in rats

Tanigami, H., Rebel, A., Martin, L. J., Chen, T. Y., Brusilow, S. W., Traystman, R. J. & Koehler, R. C., Jan 1 2005, In : Neuroscience. 131, 2, p. 437-449 13 p.

Research output: Contribution to journalArticle

Effects of diazepam on soman-induced brain neuronal RNA depletion and lethality in rats

Doebler, J. A., Wall, T. J., Martin, L. J., Shih, T. M. A. & Anthony, A., Mar 18 1985, In : Life Sciences. 36, 11, p. 1107-1115 9 p.

Research output: Contribution to journalArticle

Effects of HI-6 and pralidoxime on neuronal RNA in thalamic cholinergic sites

Martin, L. J., Doebler, J. A. & Anthony, A., Nov 1985, In : Journal of the Neurological Sciences. 71, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Effects of HI-6 on brain neuronal RNA and acetylcholinesterase: Metabolic responses during acute soman intoxication

Doebler, J. A., Wall, T. J., Martin, L. J., Shih, T. M. & Anthony, A., Dec 1984, In : Toxicology. 33, 3-4, p. 311-322 12 p.

Research output: Contribution to journalArticle

Effects of oxotremorine on neuronal RNA and chromatin in thalamic cholinoceptive sites

Martin, L. J., Morse, J. D., Pritchard, G. A., Kim, Y. H. & Anthony, A., Sep 1988, In : Journal of the Neurological Sciences. 86, 2-3, p. 159-169 11 p.

Research output: Contribution to journalArticle

Effects of sodium fluoride on uptake of T-2 mycotoxin in cultured cells

Trusal, L. R. & Martin, L. J., 1987, In : Toxicon. 25, 7, p. 705-711 7 p.

Research output: Contribution to journalArticle

Effects of the AMPA receptor antagonist NBQX on outcome of newborn pigs after asphyxic cardiac arrest

Brambrink, A. M., Martin, J. L., Hanley, D. F., Becker, K. J., Koehler, R. C. & Traystman, R. J., Jan 1 1999, In : Journal of Cerebral Blood Flow and Metabolism. 19, 8, p. 927-938 12 p.

Research output: Contribution to journalArticle

Open Access

Epigenetic regulation of motor neuron cell death through DNA methylation

Chestnut, B. A., Chang, Q., Price, A., Lesuisse, C., Wong, M. & Martin, L. J., Nov 16 2011, In : Journal of Neuroscience. 31, 46, p. 16619-16636 18 p.

Research output: Contribution to journalArticle

Excitotoxic neuronal death in the immature brain is an apoptosis- necrosis morphological continuum

Portera-Cailliau, C., Price, D. L. & Martin, L. J., Feb 3 1997, In : Journal of Comparative Neurology. 378, 1, p. 10-87 78 p.

Research output: Contribution to journalArticle

Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

Lee, M. K., Slunt, H. H., Martin, L. J., Thinakaran, G., Kim, G., Gandy, S. E., Seeger, M., Koo, E., Price, D. L. & Sisodia, S. S., Dec 1 1996, In : Journal of Neuroscience. 16, 23, p. 7513-7525 13 p.

Research output: Contribution to journalArticle

Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as "continuum" phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain

Northington, F. J., Zelaya, M. E., O'Riordan, D. P., Blomgren, K., Flock, D. L., Hagberg, H., Ferriero, D. M. & Martin, L. J., Nov 23 2007, In : Neuroscience. 149, 4, p. 822-833 12 p.

Research output: Contribution to journalArticle

Failure to sustain recovery of Na,K-ATPase function is a possible mechanism for striatal neurodegeneration in hypoxic-ischemic newborn piglets

Golden, W. C., Brambrink, A. M., Traystman, R. J. & Martin, L. J., Mar 31 2001, In : Molecular Brain Research. 88, 1-2, p. 94-102 9 p.

Research output: Contribution to journalArticle

Familial amyotrophic lateral sclerosis and Alzheimer's disease: Transgenic models

Wong, P. C., Borchelt, D. R., Lee, M. K., Pardo, C. A., Thinakaran, G., Martin, L. J., Sisodia, S. S. & Price, D. L., Dec 1 1998, In : Advances in experimental medicine and biology. 446, p. 145-159 15 p.

Research output: Contribution to journalArticle

Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in the septum

Ginsberg, S. D., Portera-Cailliau, C. & Martin, L. J., Feb 1 1999, In : Neuroscience. 88, 4, p. 1059-1071 13 p.

Research output: Contribution to journalArticle

Global incomplete cerebral ischemia produces predominantly cortical neuronal injury

Sieber, F. E., Palmon, S. C., Traystman, R. J. & Martin, L. J., Nov 1995, In : Stroke. 26, 11, p. 2091-2095 5 p.

Research output: Contribution to journalArticle

Glutamate transporter protein subtypes are expressed differentially during rat cns development

Furuta, A., Rothstein, J. D. & Martin, J. L., Nov 6 1997, In : Journal of Neuroscience. 17, 21, p. 8363-8375 13 p.

Research output: Contribution to journalArticle

Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis

Chang, Q. & Martin, L. J., Feb 23 2011, In : Journal of Neuroscience. 31, 8, p. 2815-2827 13 p.

Research output: Contribution to journalArticle

GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis

Martin, L. J., Fancelli, D., Wong, M., Niedzwiecki, M., Ballarini, M., Plyte, S. & Chang, Q., Dec 19 2014, In : Frontiers in Cellular Neuroscience. 8, DEC, 433.

Research output: Contribution to journalArticle

Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice

Kofler, J., Hattori, K., Sawada, M., DeVries, A. C., Martin, L. J., Hurn, P. D. & Traystman, R. J., Jun 15 2004, In : Journal of Neuroscience Methods. 136, 1, p. 33-44 12 p.

Research output: Contribution to journalArticle

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

Lee, M. K., Borchelt, D. R., Kim, G., Thinakaran, G., Slunt, H. H., Ratovitski, T., Martin, L. J., Kittur, A., Gandy, S., Levey, A. I., Jenkins, N., Copeland, N., Price, D. L. & Sisodia, S. S., Jul 1 1997, In : Nature medicine. 3, 7, p. 756-760 5 p.

Research output: Contribution to journalArticle

Hypothermia and Rewarming Activate a Macroglial Unfolded Protein Response Independent of Hypoxic-Ischemic Brain Injury in Neonatal Piglets

Lee-Summers, J., Wang, B., Reyes, M., Armstrong, J. S., Kulikowicz, E., Santos, P., Lee, J. H., Koehler, R. C. & Martin, L. J., Sep 14 2016, (Accepted/In press) In : Developmental Neuroscience.

Research output: Contribution to journalArticle

Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming

Agnew, D. M., Koehler, R. C., Guerguerian, A. M., Shaffner, D. H., Traystman, R. J., Martin, L. J. & Ichord, R. N., Aug 1 2003, In : Pediatric research. 54, 2, p. 253-262 10 p.

Research output: Contribution to journalArticle

Hypoxia-ischemia and therapeutic hypothermia in the neonatal mouse brain - A longitudinal study

Burnsed, J. C., Chavez-Valdez, R., Hossain, M. S., Kesavan, K., Martin, L. J., Zhang, J. & Northington, F. J., Mar 16 2015, In : PloS one. 10, 3, e0118889.

Research output: Contribution to journalArticle

Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum

Lee Martin, J., Brambrink, A. M., Lehmann, C., Portera-Cailliau, C., Koehler, R., Rothstein, J. & Traystman, R. J., Sep 1 1997, In : Annals of neurology. 42, 3, p. 335-348 14 p.

Research output: Contribution to journalArticle

Open Access

Immunological detection of glutamate receptor subtypes in human central nervous system

Blackstone, C. D., Levey, A. I., Martin, L. J., Price, D. L. & Huganir, R. L., Jun 1992, In : Annals of neurology. 31, 6, p. 680-683 4 p.

Research output: Contribution to journalArticle

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

Chandrasekaran, K., Giordano, T., Brady, D. R., Stoll, J., Martin, L. J. & Rapoport, S. I., Jul 1994, In : Molecular Brain Research. 24, 1-4, p. 336-340 5 p.

Research output: Contribution to journalArticle

Induced pluripotent stem cells from familial alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties

Mahairaki, V., Ryu, J., Peters, A., Chang, Q., Li, T., Park, T. S., Burridge, P. W., Talbot, C. C., Asnaghi, L., Martin, L. J., Zambidis, E. T. & Koliatsos, V. E., Dec 15 2014, In : Stem Cells and Development. 23, 24, p. 2996-3010 15 p.

Research output: Contribution to journalArticle

Inhibitory synaptic regulation of motoneurons: A new target of disease mechanisms in amyotrophic lateral sclerosis

Martin, L. J. & Chang, Q., Feb 2012, In : Molecular Neurobiology. 45, 1, p. 30-42 13 p.

Research output: Contribution to journalArticle

Injury-induced apoptosis of neurons in adult brain is mediated by p53-dependent and p53-independent pathways and requires Bax

Martin, L. J., Kaiser, A., Yu, J. W., Natale, J. E. & Al-Abdulla, N. A., May 7 2001, In : Journal of Comparative Neurology. 433, 3, p. 299-311 13 p.

Research output: Contribution to journalArticle

Injury-induced spinal motor neuron apoptosis is preceded by DNA single-strand breaks and is p53- and Bax-dependent

Martin, L. J. & Liu, Z., Feb 15 2002, In : Journal of Neurobiology. 50, 3, p. 181-197 17 p.

Research output: Contribution to journalArticle

Involvement of apolipoprotein E in herpes simplex encephalitis

Nicoll, J. A. R., Martin, L., Stewart, J., Murray, L. S., Love, S. & Kennedy, P. G. E., Mar 26 2001, In : Neuroreport. 12, 4, p. 695-698 4 p.

Research output: Contribution to journalArticle

Open Access

Laminar segregation of the cortical plate during corticogenesis is accompanied by changes in glutamate receptor expression

Furuta, A. & Martin, L. J., Apr 13 1999, In : Journal of Neurobiology. 39, 1, p. 67-80 14 p.

Research output: Contribution to journalArticle