Lee J Martin

Professor

1984 …2019
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Research Output 1984 2019

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Article
2019
Ischemia
Brain Injuries
Calcium
Induced Hypothermia
Brain Death
Hypothermia
Putamen
Ischemia
Pathology
Motor Cortex
Open Access
Synucleins
Neurodegenerative Diseases
Brain Injuries
Amyotrophic Lateral Sclerosis
Prosencephalon
Pyramidal Cells
Interneurons
Ischemia
Putamen
Neurons
2018

Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques

Kageyama, Y., Saito, A., Pletnikova, O., Rudow, G. L., Irie, Y., An, Y., Murakami, K., Irie, K., Resnick, S. M., Fowler, D. R., Martin, L. J. & Troncoso, J. C., Dec 1 2018, In : Scientific Reports. 8, 1, 16895.

Research output: Contribution to journalArticle

Parietal Lobe
Poisons
Amyloid Plaques
Extracellular Space
Amyloid

Delayed injury of hippocampal interneurons after neonatal hypoxia-ischemia and therapeutic hypothermia in a murine model

Chavez-Valdez, R., Emerson, P., Goffigan-Holmes, J., Kirkwood, A., Martin, L. J. & Northington, F., Aug 1 2018, In : Hippocampus. 28, 8, p. 617-630 14 p.

Research output: Contribution to journalArticle

Induced Hypothermia
Interneurons
Ischemia
Wounds and Injuries
Parvalbumins
DNA Methylation
DNA Repair
DNA Damage
Cell Death
Neurons
Diffusion Magnetic Resonance Imaging
Prosencephalon
Ischemia
Brain Hypoxia-Ischemia
Wounds and Injuries
Brain Diseases
Brain Injuries
Animal Models
Asphyxia
Ischemia

Proteasome biology is compromised in white matter after asphyxic cardiac arrest in neonatal piglets

Santos, P. T., O’brien, C. E., Chen, M. W., Hopkins, C. D., Adams, S., Kulikowicz, E., Singh, R., Koehler, R. C., Martin, L. J. & Lee, J. K., Oct 1 2018, In : Journal of the American Heart Association. 7, 20, e009415.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Heart Arrest
Ubiquitinated Proteins
Ischemia
Myelin-Oligodendrocyte Glycoprotein
2016

Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer’s mouse model

LaClair, K. D., Donde, A., Ling, J. P., Jeong, Y. H., Chhabra, R., Martin, L. J. & Wong, P. C., Dec 1 2016, In : Acta Neuropathologica. 132, 6, p. 859-873 15 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Amyloid
Alzheimer Disease
TDP-43 Proteinopathies
Prosencephalon
Spinal Muscular Atrophy
Skeletal Muscle Fibers
DNA Repair
DNA Damage
Muscle Cells
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Necrosis
Ischemia
Pathology
DNA Repair Enzymes
Axotomy
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Damage
Apoptosis

Hypothermia and Rewarming Activate a Macroglial Unfolded Protein Response Independent of Hypoxic-Ischemic Brain Injury in Neonatal Piglets

Lee-Summers, J., Wang, B., Reyes, M., Armstrong, J. S., Kulikowicz, E., Santos, P., Lee, J. H., Koehler, R. C. & Martin, L. J., Sep 14 2016, (Accepted/In press) In : Developmental Neuroscience.

Research output: Contribution to journalArticle

Unfolded Protein Response
Rewarming
Hypothermia
Brain Injuries
Ischemia
Amyotrophic Lateral Sclerosis
Motor Neurons
Calcium Channels
Transgenic Mice
Cell Membrane

White matter apoptosis is increased by delayed hypothermia and rewarming in a neonatal piglet model of hypoxic ischemic encephalopathy

Wang, B., Armstrong, J. S., Reyes, M., Kulikowicz, E., Lee, J. H., Spicer, D., Bhalala, U., Yang, Z. J., Koehler, R. C., Martin, L. J. & Lee-Summers, J., Mar 1 2016, In : Neuroscience. 316, p. 296-310 15 p.

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Rewarming
Hypothermia
Apoptosis
Oligodendroglia
2015

Additive Neuroprotection of a 20-HETE Inhibitor with Delayed Therapeutic Hypothermia after Hypoxia-Ischemia in Neonatal Piglets

Zhu, J., Wang, B., Lee, J. H., Armstrong, J. S., Kulikowicz, E., Bhalala, U. S., Martin, L. J., Koehler, R. C. & Yang, Z. J., Jul 25 2015, In : Developmental Neuroscience. 37, 4-5, p. 376-389 14 p.

Research output: Contribution to journalArticle

Induced Hypothermia
Hypothermia
Ischemia
Putamen
Thalamus

Apparent diffusion coefficient scalars correlate with near-Infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-Ischemic injury

Tekes, A., Poretti, A., Scheurkogel, M. M., Huisman, T. A. G. M., Howlett, J. A., Alqahtani, E., Lee, J. H., Parkinson, C., Shapiro, K., Chung, S. E., Jennings, J., Gilmore, M., Hogue, C. W., Martin, L. J., Koehler, R. C., Northington, F. & Lee-Summers, J., Jan 1 2015, In : American Journal of Neuroradiology. 36, 1, p. 188-193 6 p.

Research output: Contribution to journalArticle

Near-Infrared Spectroscopy
Homeostasis
Internal Capsule
Blood Pressure
Wounds and Injuries

Correction: Hypoxia-ischemia and therapeutic hypothermia in the neonatal mouse brain - A longitudinal study

Burnsed, J. C., Chavez-Valdez, R., Hossain, M. S., Kesavan, K., Martin, L. J. & Zhang, J., May 26 2015, In : PLoS One. 10, 5, e0129406.

Research output: Contribution to journalArticle

Hypothermia
Brain

Hypoxia-ischemia and therapeutic hypothermia in the neonatal mouse brain - A longitudinal study

Burnsed, J. C., Chavez-Valdez, R., Hossain, M. S., Kesavan, K., Martin, L. J., Zhang, J. & Northington, F., Mar 16 2015, In : PLoS One. 10, 3, e0118889.

Research output: Contribution to journalArticle

Hypothermia
Induced Hypothermia
hypothermia
longitudinal studies
ischemia

Rewarming from therapeutic hypothermia induces cortical neuron apoptosis in a swine model of neonatal hypoxic-ischemic encephalopathy

Wang, B., Armstrong, J. S., Lee, J. H., Bhalala, U., Kulikowicz, E., Zhang, H., Reyes, M., Moy, N., Spicer, D., Zhu, J., Yang, Z. J., Koehler, R. C., Martin, L. J. & Lee-Summers, J., May 5 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 5, p. 781-793 13 p.

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Induced Hypothermia
Rewarming
Swine
Apoptosis
2014
Labeling
DNA Damage
Muscle
Skeletal Muscle
DNA

GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis

Martin, L. J., Fancelli, D., Wong, M., Niedzwiecki, M., Ballarini, M., Plyte, S. & Chang, Q., Dec 19 2014, In : Frontiers in Cellular Neuroscience. 8, DEC, 433.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Permeability
Pharmaceutical Preparations
Therapeutics
Motor Neurons
Diffusion Magnetic Resonance Imaging
Hippocampus
Ischemia
Hypoxia
Staining and Labeling

Induced pluripotent stem cells from familial alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties

Machairaki, V., Ryu, J., Peters, A., Chang, Q., Li, T., Park, T. S., Burridge, P. W., Talbot, C. C., Asnaghi, L., Martin, L. J., Zambidis, E. & Koliatsos, V. E., Dec 15 2014, In : Stem Cells and Development. 23, 24, p. 2996-3010 15 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Alzheimer Disease
Presenilin-1
Neurons
Mutation
Diffusion Magnetic Resonance Imaging
Ischemia
Brain
Edema
Formaldehyde
Brain-Derived Neurotrophic Factor
Sex Characteristics
Ischemia
Prosencephalon
Diencephalon

Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA)

Fayzullina, S. & Martin, L. J., Mar 25 2014, In : PLoS One. 9, 3, e93329.

Research output: Contribution to journalArticle

Spinal Muscular Atrophy
muscular atrophy
Motor Neurons
motor neurons
DNA damage

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

Martin, L. J., Semenkow, S., Hanaford, A. & Wong, M., May 2014, In : Neurobiology of Aging. 35, 5, p. 1132-1152 21 p.

Research output: Contribution to journalArticle

Synucleins
Transgenic Mice
Parkinson Disease
Movement Disorders
Substantia Nigra
Leucine Enkephalin
Substance P
Corpus Striatum
Primates
Calbindins
2013

Aberrant Regulation of DNA Methylation in Amyotrophic Lateral Sclerosis: A New Target of Disease Mechanisms

Martin, L. J. & Wong, M., Oct 2013, In : Neurotherapeutics. 10, 4, p. 722-733 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
DNA Methylation
Motor Neurons
Nerve Degeneration
Epigenomics

Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet

Yang, Z. J., Wang, B., Kwansa, H., Heitmiller, K. D., Hong, G., Carter, E. L., Jamrogowicz, J. L., Larson, A. C., Martin, L. J. & Koehler, R. C., Oct 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 10, p. 1612-1620 9 p.

Research output: Contribution to journalArticle

Adenosine A2A Receptors
Neurons
Ischemia
Cyclic AMP-Dependent Protein Kinases
Brain

Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS

Wong, M., Gertz, B., Chestnut, B. A. & Martin, L. J., Dec 25 2013, In : Frontiers in Cellular Neuroscience. 7, DEC, 279.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
DNA Methylation
Mitochondrial DNA
Transgenic Mice
5-Methylcytosine

Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain

Creeley, C., Dikranian, K., Dissen, G., Martin, L. J., Olney, J. & Brambrink, A., Jun 2013, In : British Journal of Anaesthesia. 110, SUPPL.1

Research output: Contribution to journalArticle

Oligodendroglia
Propofol
Macaca mulatta
Apoptosis
Neurons

The olfactory bulb in newborn piglet is a reservoir of neural stem and progenitor cells

Martin, L. J., Katzenelson, A., Koehler, R. C. & Chang, Q., Nov 21 2013, In : PLoS One. 8, 11, e81105.

Research output: Contribution to journalArticle

olfactory bulb
Neural Stem Cells
Lateral Ventricles
Olfactory Bulb
Stem cells
2012

Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor

Yang, Z. J., Carter, E. L., Kibler, K. K., Kwansa, H., Crafa, D. A., Martin, L. J., Roman, R. J., Harder, D. R. & Koehler, R. C., Apr 2012, In : Journal of Neurochemistry. 121, 1, p. 168-179 12 p.

Research output: Contribution to journalArticle

Brain
Ischemia
Putamen
Brain Ischemia
Neurons

Biology of mitochondria in neurodegenerative diseases

Martin, L. J., 2012, In : Progress in Molecular Biology and Translational Science. 107, p. 355-415 61 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Parkinson Disease
Alzheimer Disease
Mitochondria

Early antioxidant treatment and delayed hypothermia after hypoxia-ischemia have no additive neuroprotection in newborn pigs

Ni, X., Yang, Z. J., Wang, B., Carter, E. L., Larson, A. C., Martin, L. J. & Koehler, R. C., Sep 2012, In : Anesthesia and Analgesia. 115, 3, p. 627-637 11 p.

Research output: Contribution to journalArticle

Hypothermia
Swine
Ischemia
Antioxidants
Putamen

Inhibitory synaptic regulation of motoneurons: A new target of disease mechanisms in amyotrophic lateral sclerosis

Martin, L. J. & Chang, Q., Feb 2012, In : Molecular Neurobiology. 45, 1, p. 30-42 13 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
Glycine Receptors
Glutamic Acid
Interneurons
Astrocytes
Ischemia
Neurons
Receptor-Interacting Protein Serine-Threonine Kinases
Protein Kinases
SMN Complex Proteins
Amyotrophic Lateral Sclerosis
Motor Neurons
Transgenic Mice
Cell Nucleus
Brain Injuries
Receptor-Interacting Protein Serine-Threonine Kinases
Cell Death
Necrosis
Protein Kinases
2011
Gene Knockout Techniques
Motor Neurons
Interneurons
Pathology
Green Fluorescent Proteins

Epigenetic regulation of motor neuron cell death through DNA methylation

Chestnut, B. A., Chang, Q., Price, A., Lesuisse, C., Wong, M. & Martin, L. J., Nov 16 2011, In : Journal of Neuroscience. 31, 46, p. 16619-16636 18 p.

Research output: Contribution to journalArticle

Motor Neurons
DNA Methylation
Epigenomics
Cell Death
Methyltransferases
Amyotrophic Lateral Sclerosis
Transgenic Mice
Mitochondria
Neurons
Motor Neurons

Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis

Chang, Q. & Martin, L. J., Feb 23 2011, In : Journal of Neuroscience. 31, 8, p. 2815-2827 13 p.

Research output: Contribution to journalArticle

Glycine Receptors
Amyotrophic Lateral Sclerosis
Motor Neurons
Transgenic Mice
Glycine

Mitochondrial pathobiology in ALS

Martin, L. J., Dec 2011, In : Journal of Bioenergetics and Biomembranes. 43, 6, p. 569-579 11 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Mitochondria
Apoptosis Regulatory Proteins
Cell Aging
Mitochondrial Proteins
Neurodegenerative diseases
Glycine Receptors
Induced currents
Amyotrophic Lateral Sclerosis
Motor Neurons
Neurodegenerative diseases
Glycine Receptors
Induced currents
Amyotrophic Lateral Sclerosis
Motor Neurons