Lawrence Appel

Professor

1988 …2019
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Research Output 1988 2019

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2019

A collaborative, individual-level analysis compared longitudinal outcomes across the International Network of Chronic Kidney Disease (iNETCKD) cohorts

iNET-CKD Collaborators, Nov 2019, In : Kidney International. 96, 5, p. 1217-1233 17 p.

Research output: Contribution to journalArticle

Open Access
Chronic Renal Insufficiency
Chronic Kidney Failure
Disease Progression
Comorbidity
Biomarkers

APOL1 kidney risk variants and cardiovascular disease: An individual participant data meta-analysis

Grams, M. E., Surapaneni, A., Ballew, S. H., Appel, L. J., Boerwinkle, E., Boulware, L. E., Chen, T. K., Coresh, J., Cushman, M., Divers, J., Gutiérrez, O. M., Irvin, M. R., Ix, J. H., Kopp, J. B., Kuller, L. H., Langefeld, C. D., Lipkowitz, M. S., Mukamal, K. J., Musani, S. K., Naik, R. P. & 9 others, Pajewski, N. M., Peralta, C. A., Tin, A., Wassel, C. L., Wilson, J. G., Winkler, C. A., Young, B. A., Zakai, N. A. & Freedman, B. I., Jan 1 2019, In : Journal of the American Society of Nephrology. 30, 10, p. 2027-2036 10 p.

Research output: Contribution to journalArticle

Meta-Analysis
Cardiovascular Diseases
Kidney
Genes
Heart Failure

Association between Progression of Retinopathy and Concurrent Progression of Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study

the Chronic Renal Insufficiency Cohort Study Investigators, Jul 2019, In : JAMA ophthalmology. 137, 7, p. 767-774 8 p.

Research output: Contribution to journalArticle

Kidney Diseases
Chronic Renal Insufficiency
Cohort Studies
Photography
Glomerular Filtration Rate

Burden and Outcomes of Heart Failure Hospitalizations in Adults With Chronic Kidney Disease

CRIC Study Investigators, Jun 4 2019, In : Journal of the American College of Cardiology. 73, 21, p. 2691-2700 10 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Hospitalization
Heart Failure
Glomerular Filtration Rate
Albumins

Cardiac Biomarkers and Risk of Atrial Fibrillation in Chronic Kidney Disease: The CRIC Study

on behalf of the CRIC Study Investigators, Aug 6 2019, In : Journal of the American Heart Association. 8, 15, e012200.

Research output: Contribution to journalArticle

Open Access
Chronic Renal Insufficiency
Atrial Fibrillation
Cohort Studies
Biomarkers
Troponin T
Open Access
Chronic Renal Insufficiency
Cohort Studies
Heart Failure
Biomarkers
Growth Differentiation Factor 15

Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies

Chronic Kidney Disease Prognosis Consortium and Chronic Kidney Disease Epidemiology Collaboration, Feb 1 2019, In : The Lancet Diabetes and Endocrinology. 7, 2, p. 115-127 13 p.

Research output: Contribution to journalArticle

Albuminuria
Chronic Kidney Failure
Observational Studies
Meta-Analysis
Creatinine
Chronic Renal Insufficiency
Atherosclerosis
Mediterranean Diet
Glomerular Filtration Rate
Healthy Diet

Dietary phosphorus intake and blood pressure in adults: a systematic review of randomized trials and prospective observational studies

McClure, S. T., Rebholz, C., Medabalimi, S., Hu, E. A., Xu, Z., Selvin, E. & Appel, L., May 1 2019, In : The American journal of clinical nutrition. 109, 5, p. 1264-1272 9 p.

Research output: Contribution to journalArticle

Dietary Phosphorus
Observational Studies
Prospective Studies
Blood Pressure
Phosphorus
Patient Acceptance of Health Care
Medicaid
Case Management
Medicare
Patient Readmission

Dose-dependent effects of lifestyle interventions on blood lipid levels: Results from the PREMIER trial

Dudum, R., Juraschek, S. P. & Appel, L., Jan 1 2019, In : Patient Education and Counseling.

Research output: Contribution to journalArticle

LDL Cholesterol
Life Style
Lipids
Counseling
Cholesterol

Effect of a behavioral weight loss intervention in people with serious mental illness and diabetes

Tseng, E., Dalcin, A., Jerome, G. J., Gennusa, J. V., Goldsholl, S., Cook, C., Appel, L., Maruthur, N., Daumit, G. L. & Wang, N. Y., May 1 2019, In : Diabetes care. 42, 5, p. 804-809 6 p.

Research output: Contribution to journalArticle

Weight Loss
Weights and Measures
Body Weight
Weight Reduction Programs
Control Groups

Effects of a behavioural weight loss intervention in people with serious mental illness: Subgroup analyses from the ACHIEVE trial

Alexander, E., McGinty, E. B., Wang, N. Y., Dalcin, A., Jerome, G. J., Miller, E. R., Dickerson, F., Charleston, J. B., Young, D. R., Gennusa, J. V., Goldsholl, S., Cook, C., Appel, L. & Daumit, G. L., Jan 1 2019, In : Obesity Research and Clinical Practice.

Research output: Contribution to journalArticle

Weight Loss
Feeding Behavior
Bipolar Disorder
Mental Disorders
Population

Effects of sodium intake on postural lightheadedness: Results from the DASH-sodium trial

Peng, A. W., Appel, L., Mueller, N., Tang, O., Miller, E. R. & Juraschek, S. P., Jan 1 2019, In : Journal of clinical hypertension.

Research output: Contribution to journalArticle

Dizziness
Sodium
Hypertension
Diet
Blood Pressure

Electronic medical record-based cohort selection and direct-to-patient, targeted recruitment: early efficacy and lessons learned

Miller, H. N., Gleason, K. T., Juraschek, S. P., Plante, T. B., Lewis-Land, C., Woods, B., Appel, L. J., Ford, D. E. & Dennison Himmelfarb, C. R., Nov 1 2019, In : Journal of the American Medical Informatics Association : JAMIA. 26, 11, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

Electronic Health Records
Patient Selection
Phenotype
Health
Demography
Pregnancy Complications
Weight Gain
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Population
Gestational Diabetes

Healthy diet reduces markers of cardiac injury and inflammation regardless of macronutrients: Results from the OmniHeart trial

Kovell, L. C., Yeung, E. H., Miller, E. R., Appel, L., Christenson, R. H., Rebuck, H., Schulman, S. P. & Juraschek, S. P., Jan 1 2019, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journalArticle

Troponin I
C-Reactive Protein
Diet
Inflammation
Unsaturated Fats

Heart failure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

House, A. A., Wanner, C., Sarnak, M. J., Piña, I. L., McIntyre, C. W., Komenda, P., Kasiske, B. L., Deswal, A., deFilippi, C. R., Cleland, J. G. F., Anker, S. D., Herzog, C. A., Cheung, M., Wheeler, D. C., Winkelmayer, W. C., McCullough, P. A., Abu-Alfa, A. K., Amann, K., Aonuma, K., Appel, L. J. & 39 others, Baigent, C., Bakris, G. L., Banerjee, D., Boletis, J. N., Bozkurt, B., Butler, J., Chan, C. T., Costanzo, M. R., Dubin, R. F., Filippatos, G., Gikonyo, B. M., Gikonyo, D. K., Hajjar, R. J., Iseki, K., Ishii, H., Knoll, G. A., Lenihan, C. R., Lentine, K. L., Lerma, E. V., Macedo, E., Mark, P. B., Noiri, E., Palazzuoli, A., Pecoits-Filho, R., Pitt, B., Rigatto, C., Rossignol, P., Setoguchi, S., Sood, M. M., Störk, S., Suri, R. S., Szummer, K., Tang, S. C. W., Tangri, N., Thompson, A., Vijayaraghavan, K., Walsh, M., Wang, A. Y. M. & Weir, M. R., Jun 1 2019, In : Kidney International. 95, 6, p. 1304-1317 14 p.

Research output: Contribution to journalArticle

Open Access
Kidney Diseases
Chronic Renal Insufficiency
Heart Failure
Dialysis
Transplants

Lipids, Apolipoproteins, and Risk of Atherosclerotic Cardiovascular Disease in Persons With CKD

CRIC Study Investigators, Jan 1 2019, (Accepted/In press) In : American Journal of Kidney Diseases.

Research output: Contribution to journalArticle

Apolipoproteins
Chronic Renal Insufficiency
Cardiovascular Diseases
Lipids
VLDL Cholesterol

Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study

CRIC Study Investigators, Jan 1 2019, (Accepted/In press) In : American Journal of Kidney Diseases.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Chronic Kidney Failure
Minerals
Cohort Studies
Parathyroid Hormone

Long-term retention in an employer-based, commercial weight-loss programme

Alexander, E., Tseng, E., Durkin, N., Jerome, G. J., Dalcin, A., Appel, L., Clark, J. & Gudzune, K. A., Feb 1 2019, In : Clinical obesity. 9, 1, p. e12284

Research output: Contribution to journalArticle

Weight Reduction Programs
Weight Loss
Odds Ratio
Weights and Measures
Cluster Analysis

Lower levels of proteinuria are associated with elevated mortality in incident dialysis patients

Hishida, M., Shafi, T., Appel, L. J., Maruyama, S., Inaguma, D. & Matsushita, K., Dec 2019, In : PloS one. 14, 12, e0226866.

Research output: Contribution to journalArticle

Open Access
Dialysis
dialysis
Proteinuria
Mortality
Medical problems

Predictors of Net Acid Excretion in the Chronic Renal Insufficiency Cohort (CRIC) Study

CRIC Study Investigators, Jan 1 2019, In : American Journal of Kidney Diseases.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Cohort Studies
Acids
Body Composition
Glomerular Filtration Rate

Recruitment of trial participants through electronic medical record patient portal messaging: A pilot study

Plante, T. B., Gleason, K. T., Miller, H. N., Charleston, J., McArthur, K., Himmelfarb, C. D., Lazo, M., Ford, D. E., Miller, E. R., Appel, L. J., Juraschek, S. P., Cronin, N., McClure, S., Miskimon, J., Mitchell, C. M., Kalyani, R. R., Roth, D. L., Schrack, J. A., Szanton, S. L., Urbanek, J. & 73 others, Walston, J., Wanigatunga, A., Baksh, S. N., Blackford, A. L., Chattopadhyay, S., Drye, L. T., Dodge, J., Ewing, C., Haider, S., Holland, S. C., Jackson, R., Lears, A., Meinert, C., Shade, D., Smith, M., Sternberg, A. L., Tonascia, J., Van Natta, M. L., Wagoner, A., Comstock, G. W., Michos, E. D., Bennett, J. D., Bowers, P., Coresh, J., Crowley, P., Crunkleton, T., Dick, B., Evans, R., Godwin, M., Hammann, L., Hawks, D., Horning, K., Hull, E., Mills, B., Minotti, M., Raley, L., Reed, A., Reeder, R., Reid, C., Shuda, M., Spikes, A., Stouffer, R., Weicht, K., Abbas, C., Carey, B., Davis, S., DeRoche-Brown, N., Gayles, D., Holland, S., Glenn-Smith, I., Johnson, D., Johnson, M., Keyes, E., Santiago, D., Sapun, C., Sneed, V., Swartz, L., Thomas, L., Christenson, R. H., Duh, S. H., Rebuck, H., Rosen, C., Cook, T., Duncan, P., Hansen, K., Kenny, A., Shapses, S., Hannah, J., Romashkan, S., Davis, C. D., Sempos, C. T., Guralnik, J. M. & Gallagher, J. C., Jan 1 2019, (Accepted/In press) In : Clinical Trials.

Research output: Contribution to journalArticle

Electronic Health Records
Vitamin D
Patient Selection
Clinical Trials
Research Ethics Committees

Serum Calcification Propensity and Coronary Artery Calcification Among Patients With CKD: The CRIC (Chronic Renal Insufficiency Cohort) Study

CRIC Study Investigators, Jun 1 2019, In : American Journal of Kidney Diseases. 73, 6, p. 806-814 9 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Coronary Vessels
Cohort Studies
Serum
Social Adjustment

Serum metabolites associated with dietary protein intake: results from the Modification of Diet in Renal Disease (MDRD) randomized clinical trial

Rebholz, C., Zheng, Z., Grams, M., Appel, L., Sarnak, M. J., Inker, L. A., Levey, A. S. & Coresh, J., Mar 1 2019, In : The American journal of clinical nutrition. 109, 3, p. 517-525 9 p.

Research output: Contribution to journalArticle

Open Access
Diet Therapy
Dietary Proteins
Protein-Restricted Diet
Randomized Controlled Trials
Kidney

Serum Metabolomic Alterations Associated with Proteinuria in CKD

Chronic Kidney Disease Biomarkers Consortium Investigators, Mar 7 2019, In : Clinical journal of the American Society of Nephrology : CJASN. 14, 3, p. 342-353 12 p.

Research output: Contribution to journalArticle

Metabolomics
Proteinuria
Diet Therapy
Serum
Webcasts

Sex-related disparities in CKD progression

CRIC Investigators, Jan 1 2019, In : Journal of the American Society of Nephrology. 30, 1, p. 137-146 10 p.

Research output: Contribution to journalArticle

Chronic Kidney Failure
Sex Characteristics
Social Adjustment
Biological Factors
Chronic Renal Insufficiency

Single Measurements of Carboxy-Terminal Fibroblast Growth Factor 23 and Clinical Risk Prediction of Adverse Outcomes in CKD

CRIC Study Investigators, Dec 2019, In : American Journal of Kidney Diseases. 74, 6, p. 771-781 11 p.

Research output: Contribution to journalArticle

Mortality
Chronic Kidney Failure
Area Under Curve
Heart Failure
Chronic Renal Insufficiency

Subclinical Cardiovascular Disease and Fall Risk in Older Adults: Results From the Atherosclerosis Risk in Communities Study

Juraschek, S. P., Daya, N., Appel, L. J., Miller, E. R., Matsushita, K., Michos, E. D., Windham, B. G., Ballantyne, C. M. & Selvin, E., Sep 1 2019, In : Journal of the American Geriatrics Society. 67, 9, p. 1795-1802 8 p.

Research output: Contribution to journalArticle

Troponin T
Brain Natriuretic Peptide
Atherosclerosis
Cardiovascular Diseases
International Classification of Diseases

The association of dietary phosphorus with blood pressure: results from a secondary analysis of the PREMIER trial

McClure, S. T., Rebholz, C., Mitchell, D. C., Selvin, E. & Appel, L., Jan 1 2019, (Accepted/In press) In : Journal of Human Hypertension.

Research output: Contribution to journalArticle

Dietary Phosphorus
Phosphorus
Blood Pressure
Urine Specimen Collection
Sex Education

The Percentage of Dietary Phosphorus Excreted in the Urine Varies by Dietary Pattern in a Randomized Feeding Study in Adults

McClure, S. T., Rebholz, C., Phillips, K. M., Champagne, C. M., Selvin, E. & Appel, L., May 1 2019, In : The Journal of nutrition. 149, 5, p. 816-823 8 p.

Research output: Contribution to journalArticle

Dietary Phosphorus
Phosphorus
Urine
Diet
Hypertension

The Serum Metabolome Identifies Biomarkers of Dietary Acid Load in 2 Studies of Adults with Chronic Kidney Disease

Rebholz, C., Surapaneni, A., Levey, A. S., Sarnak, M. J., Inker, L. A., Appel, L., Coresh, J. & Grams, M., Apr 1 2019, In : The Journal of nutrition. 149, 4, p. 578-585 8 p.

Research output: Contribution to journalArticle

Metabolome
Chronic Renal Insufficiency
Biomarkers
Acids
Serum

Vitamin D Metabolic Ratio and Risks of Death and CKD Progression

CRIC Study Investigators, Nov 2019, In : Kidney International Reports. 4, 11, p. 1598-1607 10 p.

Research output: Contribution to journalArticle

Open Access
Chronic Renal Insufficiency
Vitamin D
Disease Progression
Odds Ratio
Chronic Kidney Failure
2018

Association of Age with Blood Pressure Across the Lifespan in Isolated Yanomami and Yekwana Villages

Mueller, N., Noya-Alarcon, O., Contreras, M., Appel, L. & Dominguez-Bello, M. G., Jan 1 2018, (Accepted/In press) In : JAMA Cardiology.

Research output: Contribution to journalArticle

Blood Pressure

Cardiovascular events after new-onset atrial fibrillation in adults with CKD: Results from the Chronic Renal Insufficiency Cohort (CRIC) study

Bansal, N., Xie, D., Sha, D., Appel, L., Deo, R., Feldman, H. I., He, J., Jamerson, K., Kusek, J. W., Messe, S., Navaneethan, S. D., Rahman, M., Ricardo, A. C., Soliman, E. Z., Townsend, R. & Go, A. S., Dec 1 2018, In : Journal of the American Society of Nephrology. 29, 12, p. 2859-2869 11 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Atrial Fibrillation
Cohort Studies
Confidence Intervals
Heart Failure

Central blood pressure and cardiovascular outcomes in chronic kidney disease

CRIC Study Investigators, Apr 6 2018, In : Clinical Journal of the American Society of Nephrology. 13, 4, p. 585-595 11 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Arm
Blood Pressure
Confidence Intervals
Mortality

Characteristics and trends of clinical trials funded by the National Institutes of Health between 2005 and 2015

Gresham, G. K., Ehrhardt, S., Meinert, J. L., Appel, L. & Meinert, C. L., Feb 1 2018, In : Clinical Trials. 15, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

National Institutes of Health (U.S.)
Clinical Trials
Budgets
Sample Size
Biomedical Research
Diet
Blood Pressure
Health
Cardiovascular Diseases
Prehypertension

CKD Self-management: Phenotypes and Associations With Clinical Outcomes

on behalf of the & CRIC Study Investigators, Jan 1 2018, (Accepted/In press) In : American Journal of Kidney Diseases.

Research output: Contribution to journalArticle

Self Care
Disease Management
Chronic Renal Insufficiency
Phenotype
Disease Progression
Chronic Renal Insufficiency
Dialysis
Cohort Studies
Peritoneal Dialysis
Catheters
Clinical Trials
Blood Pressure
Research
Hypertension
Ambulatory Care
Primary Prevention
Blood Pressure
Safety
Cardiovascular Diseases
Safety Management

Dietary cholesterol intake and sources among U.S adults: Results from national health and nutrition examination surveys (NHANES), 2001–2014

Xu, Z., McClure, S. T. & Appel, L., Jun 14 2018, In : Nutrients. 10, 6, 771.

Research output: Contribution to journalArticle

Dietary Cholesterol
National Health and Nutrition Examination Survey
Nutrition Surveys
cholesterol
Cholesterol

Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis

Fitzgerald, K., Vizthum, D., Henry-Barron, B., Schweitzer, A., Cassard, S., Kossoff, E. H., Hartman, A. L., Kapogiannis, D., Sullivan, P., Baer, D. J., Mattson, M. P., Appel, L. & Mowry, E. M., Jul 1 2018, In : Multiple Sclerosis and Related Disorders. 23, p. 33-39 7 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Diet
Weights and Measures
Weight Loss
Patient Reported Outcome Measures
Dietary Phosphorus
calcitriol
parathyroid hormone
Calcitriol
Parathyroid Hormone

Effects of the DASH diet and sodium intake on bloating: Results from the DASH-Sodium trial

Peng, A. W., Juraschek, S. P., Appel, L., Miller, E. R. & Mueller, N., Jan 1 2018, In : American Journal of Gastroenterology. 114, 7, p. 1109-1115 7 p.

Research output: Contribution to journalArticle

Sodium
Diet
Dietary Sodium
Odds Ratio
Confidence Intervals

Estimated 24-hour urinary sodium and potassium excretion in US Adults

Cogswell, M. E., Loria, C. M., Terry, A. L., Zhao, L., Wang, C. Y., Chen, T. C., Wright, J. D., Pfeiffer, C. M., Merritt, R., Moy, C. S. & Appel, L., Mar 27 2018, In : JAMA - Journal of the American Medical Association. 319, 12, p. 1209-1220 12 p.

Research output: Contribution to journalArticle

Potassium
Sodium
Urine
Urine Specimen Collection
Population

Evolution of Echocardiographic Measures of Cardiac Disease From CKD to ESRD and Risk of All-Cause Mortality: Findings From the CRIC Study

CRIC Study Investigators, Sep 1 2018, In : American Journal of Kidney Diseases. 72, 3, p. 390-399 10 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Chronic Kidney Failure
Heart Diseases
Cohort Studies
Stroke Volume

Health Behaviors in Younger and Older Adults With CKD: Results From the CRIC Study

CRIC Study Investigators, Jan 1 2018, (Accepted/In press) In : Kidney International Reports.

Research output: Contribution to journalArticle

Health Behavior
Chronic Renal Insufficiency
Young Adult
Confidence Intervals
Disease Progression