Laurence Carroll

Assistant Professor

20062020

Research output per year

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Research Output

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Article

Towards an MMP-2-activated molecular agent for cancer imaging

Cowell, S., Carroll, L., Lavdas, I., Aboagye, E. O. & Vilar, R., Jan 1 2018, In : Dalton Transactions. 47, 5, p. 1530-1534 5 p.

Research output: Contribution to journalArticle

The traceless Staudinger ligation for indirect 18F- radiolabelling

Carroll, L., Boldon, S., Bejot, R., Moore, J. E., Declerck, J. & Gouverneur, V., Jan 1 2011, In : Organic and Biomolecular Chemistry. 9, 1, p. 136-140 5 p.

Research output: Contribution to journalArticle

The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth

Trousil, S., Kaliszczak, M., Schug, Z., Nguyen, Q. D., Tomasi, G., Favicchio, R., Brickute, D., Fortt, R., Twyman, F. J., Carroll, L., Kalusa, A., Navaratnam, N., Adejumo, T., Carling, D., Gottlieb, E. & Aboagye, E. O., Jan 1 2016, In : Oncotarget. 7, 24, p. 37103-37120 18 p.

Research output: Contribution to journalArticle

Temporal and spatial evolution of therapy-induced tumor apoptosis detected by caspase-3-selective molecular imaging

Nguyen, Q. D., Lavdas, I., Gubbins, J., Smith, G., Fortt, R., Carroll, L. S., Graham, M. A. & Aboagye, E. O., Jul 15 2013, In : Clinical Cancer Research. 19, 14, p. 3914-3924 11 p.

Research output: Contribution to journalArticle

Synthesis of propargylic fluorides from allenylsilanes

Carroll, L., Pacheco, M. C., Garcia, L. & Gouverneur, V., Jan 1 2006, In : Chemical Communications. 39, p. 4113-4115 3 p.

Research output: Contribution to journalArticle

Synthesis and pre-clinical evaluation of a [18F]fluoromethyl-tanaproget derivative for imaging of progesterone receptor expression

Merchant, S., Allott, L., Carroll, L., Tittrea, V., Kealey, S., Witney, T. H., Miller, P. W., Smith, G. & Aboagye, E. O., Jan 1 2016, In : RSC Advances. 6, 62, p. 57569-57579 11 p.

Research output: Contribution to journalArticle

Synthesis and evaluation of nucleoside radiotracers for imaging proliferation

Smith, G., Sala, R., Carroll, L., Behan, K., Glaser, M., Robins, E., Nguyen, Q. D. & Aboagye, E. O., Jul 1 2012, In : Nuclear Medicine and Biology. 39, 5, p. 652-665 14 p.

Research output: Contribution to journalArticle

Synthesis, Radiolabelling and In Vitro Imaging of Multifunctional Nanoceramics

Lledos, M., Mirabello, V., Sarpaki, S., Ge, H., Smugowski, H. J., Carroll, L., Aboagye, E. O., Aigbirhio, F. I., Botchway, S. W., Dilworth, J. R., Calatayud, D. G., Plucinski, P. K., Price, G. J. & Pascu, S. I., Apr 2018, In : ChemNanoMat. 4, 4, p. 361-372 12 p.

Research output: Contribution to journalArticle

Stereospecific anti SE2′ fluorination of allenylsilanes: Synthesis of enantioenriched propargylic fluorides

Carroll, L., McCullough, S., Rees, T., Claridge, T. D. W. & Gouverneur, V., May 12 2008, In : Organic and Biomolecular Chemistry. 6, 10, p. 1731-1733 3 p.

Research output: Contribution to journalArticle

Radiosynthesis and PET Bioimaging of 76Br-Bedaquiline in a Murine Model of Tuberculosis

Ordonez, A. A., Carroll, L. S., Abhishek, S., Mota, F., Ruiz-Bedoya, C. A., Klunk, M. H., Singh, A. K., Freundlich, J. S., Mease, R. C. & Jain, S. K., Jan 1 2019, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

Radiosynthesis and in vivo tumor uptake of 2-deoxy-2-[18F] fluoro-myo-inositol

Carroll, L., Perumal, M., Vasdev, N., Robins, E. & Aboagye, E. O., Oct 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 19, p. 6148-6150 3 p.

Research output: Contribution to journalArticle

Radiolabeled RGD tracer kinetics annotates differential αvβ3 integrin expression linked to cell intrinsic and vessel expression

Alam, I. S., Witney, T. H., Tomasi, G., Carroll, L., Twyman, F. J., Nguyen, Q. D. & Aboagye, E. O., Aug 2014, In : Molecular Imaging and Biology. 16, 4, p. 558-566 9 p.

Research output: Contribution to journalArticle

Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET

Bejot, R., Kersemans, V., Kelly, C., Carroll, L., King, R. C. & Gouverneur, V., Jul 1 2010, In : Nuclear Medicine and Biology. 37, 5, p. 565-575 11 p.

Research output: Contribution to journalArticle

PET imaging of steroid hormone receptor expression

Allott, L., Smith, G., Aboagye, E. O. & Carroll, L., Oct 2015, In : Molecular imaging. 14, 9, p. 534-550 17 p.

Research output: Contribution to journalArticle

Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Carroll, L., Bejot, R., Hueting, R., King, R., Bonnitcha, P., Bayly, S., Christlieb, M., Dilworth, J. R., Gee, A. D., Declerck, J. & Gouverneur, V., Jun 21 2010, In : Chemical Communications. 46, 23, p. 4052-4054 3 p.

Research output: Contribution to journalArticle

One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer

Glaser, M., Rajkumar, V., Diocou, S., Gendron, T., Yan, R., Sin, P. K. B., Sander, K., Carroll, L., Pedley, R. B., Aboagye, E. O., Witney, T. H. & Årstad, E., Dec 1 2019, In : Scientific reports. 9, 1, 19299.

Research output: Contribution to journalArticle

Open Access

Mn-salen catalysed benzylic C-H activation for the synthesis of aryl [18F]CF3-containing PET probes

Carroll, L., Evans, H. L., Spivey, A. C. & Aboagye, E. O., May 18 2015, In : Chemical Communications. 51, 40, p. 8439-8441 3 p.

Research output: Contribution to journalArticle

Microwave gallium-68 radiochemistry for kinetically stable bis(thiosemicarbazone) complexes: structural investigations and cellular uptake under hypoxia

Alam, I. S., Arrowsmith, R. L., Cortezon-Tamarit, F., Twyman, F., Kociok-Köhn, G., Botchway, S. W., Dilworth, J. R., Carroll, L., Aboagye, E. O. & Pascu, S. I., Oct 27 2015, In : Dalton Transactions. 45, 1, p. 144-155 12 p.

Research output: Contribution to journalArticle

Iodination of terminal alkynes using KI/CuSO 4 – A facile method with potential for radio-iodination

Ferris, T., Carroll, L., Mease, R., Spivey, A. C. & Aboagye, E. O., Mar 28 2019, In : Tetrahedron Letters. 60, 13, p. 936-939 4 p.

Research output: Contribution to journalArticle

Identification of ABC transporter interaction of a novel cyanoquinoline radiotracer and implications for tumour imaging by positron emission tomography

Slade, R. L., Pisaneschi, F., Nguyen, Q. D., Smith, G., Carroll, L., Beckley, A., Kaliszczak, M. A. & Aboagye, E. O., Aug 1 2016, In : PLoS One. 11, 8, e0161427.

Research output: Contribution to journalArticle

Fluorous synthesis of 18F radiotracers with the [ 18F]fluoride ion: Nucleophilic fluorination as the detagging process

Bejot, R., Fowler, T., Carroll, L., Boldon, S., Moore, J. E., Declerck, J. & Gouverneur, V., Jan 5 2009, In : Angewandte Chemie - International Edition. 48, 3, p. 586-589 4 p.

Research output: Contribution to journalArticle

Evaluation of deuterated 18F- and 11C-labeled choline analogs for cancer detection by positron emission tomography

Witney, T. H., Alam, I. S., Turton, D. R., Smith, G., Carroll, L., Brickute, D., Twyman, F. J., Nguyen, Q. D., Tomasi, G., Awais, R. O. & Aboagye, E. O., Feb 15 2012, In : Clinical Cancer Research. 18, 4, p. 1063-1072 10 p.

Research output: Contribution to journalArticle

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

Vassileva, V., Stribbling, S. M., Barnes, C., Carroll, L., Braga, M., Abrahams, J., Heinzmann, K., Haegeman, C., MacFarlane, M., Simpson, K. L., Dive, C., Honeychurch, J., Illidge, T. M. & Aboagye, E. O., Jan 1 2019, In : EJNMMI Research. 9, 18.

Research output: Contribution to journalArticle

Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance

Kaliszczak, M., Patel, H., Kroll, S. H. B., Carroll, L., Smith, G., Delaney, S., Heathcote, D. A., Bondke, A., Fuchter, M. J., Coombes, R. C., Barrett, A. G. M., Ali, S. & Aboagye, E. O., Oct 29 2013, In : British journal of cancer. 109, 9, p. 2356-2367 12 p.

Research output: Contribution to journalArticle

Development of 68Ga-labelled ultrasound microbubbles for whole-body PET imaging

Hernández-Gil, J., Braga, M., Harriss, B. I., Carroll, L. S., Leow, C. H., Tang, M. X., Aboagye, E. O. & Long, N. J., Jan 1 2019, In : Chemical Science. 10, 21, p. 5603-5615 13 p.

Research output: Contribution to journalArticle

Open Access

Development and Evaluation of an 18F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression

Brickute, D., Braga, M., Kaliszczak, M. A., Barnes, C., Lau, D., Carroll, L., Stevens, E., Trousil, S., Alam, I. S., Nguyen, Q. D. & Aboagye, E. O., May 6 2019, In : Molecular Pharmaceutics. 16, 5, p. 2106-2117 12 p.

Research output: Contribution to journalArticle

Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

Trousil, S., Carroll, L., Kalusa, A., Aberg, O., Kaliszczak, M. & Aboagye, E. O., Apr 2013, In : MedChemComm. 4, 4, p. 693-696 4 p.

Research output: Contribution to journalArticle

Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging

Carroll, L., Witney, T. H. & Aboagye, E. O., Apr 2013, In : MedChemComm. 4, 4, p. 653-656 4 p.

Research output: Contribution to journalArticle

Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

Udemba, A., Smith, G., Nguyen, Q. D., Kaliszczak, M., Carroll, L., Fortt, R., Fuchter, M. J. & Aboagye, E. O., May 21 2015, In : Organic and Biomolecular Chemistry. 13, 19, p. 5418-5423 6 p.

Research output: Contribution to journalArticle

Copper-free click—a promising tool for pre-targeted PET imaging

Evans, H. L., Slade, R. L., Carroll, L., Smith, G., Nguyen, Q. D., Iddon, L., Kamaly, N., Stöckmann, H., Leeper, F. J., Aboagye, E. O. & Spivey, A. C., Jan 3 2012, In : Chemical Communications. 48, 7, p. 991-993 3 p.

Research output: Contribution to journalArticle

Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors

Dubash, S. R., Nicholas Keat, K., Mapelli, P., Twyman, F., Carroll, L., Kozlowski, K., Al-Nahhas, A., Saleem, A., Huiban, M., Janisch, R., Frilling, A., Sharma, R. & Aboagye, E. O., Aug 1 2016, In : Journal of Nuclear Medicine. 57, 8, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

Caspase-Based PET for Evaluating Pro-Apoptotic Treatments in a Tuberculosis Mouse Model

Ordonez, A. A., Abhishek, S., Singh, A. K., Klunk, M. H., Azad, B. B., Aboagye, E. O., Carroll, L. & Jain, S. K., Jan 1 2020, (Accepted/In press) In : Molecular Imaging and Biology.

Research output: Contribution to journalArticle

Bioorthogonal chemistry for 68Ga radiolabelling of DOTA-containing compounds

Evans, H. L., Carroll, L., Aboagye, E. O. & Spivey, A. C., Apr 2014, In : Journal of Labelled Compounds and Radiopharmaceuticals. 57, 4, p. 291-297 7 p.

Research output: Contribution to journalArticle

Biodistribution and radiation dosimetry of deuterium-substituted 18F-fluoromethyl-[1, 2-2H4]choline in healthy volunteers

Challapalli, A., Sharma, R., Hallett, W. A., Kozlowski, K., Carroll, L., Brickute, D., Twyman, F., Al-Nahhas, A. & Aboagye, E. O., Feb 1 2014, In : Journal of Nuclear Medicine. 55, 2, p. 256-263 8 p.

Research output: Contribution to journalArticle

Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications

Fu, R., Carroll, L., Yahioglu, G., Aboagye, E. O. & Miller, P. W., Jan 1 2018, (Accepted/In press) In : ChemMedChem.

Research output: Contribution to journalArticle

A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography

Witney, T. H., Carroll, L., Alam, I. S., Chandrashekran, A., De Nguyen, Q., Sala, R., Harris, R., De Berardinis, R. J., Agarwal, R. & Aboagye, E. O., Mar 1 2014, In : Cancer Research. 74, 5, p. 1319-1328 10 p.

Research output: Contribution to journalArticle

A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers

Bejot, R., Carroll, L., Bhakoo, K., Declerck, J. & Gouverneur, V., Jan 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 1, p. 324-329 6 p.

Research output: Contribution to journalArticle

A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging

Evans, H. L., Nguyen, Q. D., Carroll, L. S., Kaliszczak, M., Twyman, F. J., Spivey, A. C. & Aboagye, E. O., Aug 28 2014, In : Chemical Communications. 50, 67, p. 9557-9560 4 p.

Research output: Contribution to journalArticle