Laurence Carroll

Assistant Professor

20062019
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Research Output 2006 2019

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2019

Development and Evaluation of an 18 F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression

Brickute, D., Braga, M., Kaliszczak, M. A., Barnes, C., Lau, D., Carroll, L., Stevens, E., Trousil, S., Alam, I. S., Nguyen, Q. D. & Aboagye, E. O., May 6 2019, In : Molecular Pharmaceutics. 16, 5, p. 2106-2117 12 p.

Research output: Contribution to journalArticle

CXC Chemokines
Chemokine Receptors
Cations
Neoplasms
Metformin

Development of 68Ga-labelled ultrasound microbubbles for whole-body PET imaging

Hernández-Gil, J., Braga, M., Harriss, B. I., Carroll, L., Leow, C. H., Tang, M. X., Aboagye, E. O. & Long, N. J., Jan 1 2019, In : Chemical Science. 10, 21, p. 5603-5615 13 p.

Research output: Contribution to journalArticle

Open Access
Positron emission tomography
Phospholipids
Bearings (structural)
Ultrasonics
Imaging techniques

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

Vassileva, V., Stribbling, S. M., Barnes, C., Carroll, L., Braga, M., Abrahams, J., Heinzmann, K., Haegeman, C., MacFarlane, M., Simpson, K. L., Dive, C., Honeychurch, J., Illidge, T. M. & Aboagye, E. O., Jan 1 2019, In : EJNMMI Research. 9, 18.

Research output: Contribution to journalArticle

Genetic Models
Cell Death
Biomarkers
Apoptosis
Caspase 3

Iodination of terminal alkynes using KI/CuSO 4 – A facile method with potential for radio-iodination

Ferris, T., Carroll, L., Mease, R., Spivey, A. C. & Aboagye, E. O., Mar 28 2019, In : Tetrahedron Letters. 60, 13, p. 936-939 4 p.

Research output: Contribution to journalArticle

Alkynes
Halogenation
Radio
Buffers
Acetates

One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer

Glaser, M., Rajkumar, V., Diocou, S., Gendron, T., Yan, R., Sin, P. K. B., Sander, K., Carroll, L., Pedley, R. B., Aboagye, E. O., Witney, T. H. & Årstad, E., Dec 1 2019, In : Scientific reports. 9, 1, 19299.

Research output: Contribution to journalArticle

Open Access
Isatin
Triazoles
Single-Photon Emission-Computed Tomography
Caspase 3
Apoptosis
2018

Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications

Fu, R., Carroll, L., Yahioglu, G., Aboagye, E. O. & Miller, P. W., Jan 1 2018, (Accepted/In press) In : ChemMedChem.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Positron emission tomography
Positron-Emission Tomography
Imaging techniques
Antibodies

Synthesis, Radiolabelling and In Vitro Imaging of Multifunctional Nanoceramics

Lledos, M., Mirabello, V., Sarpaki, S., Ge, H., Smugowski, H. J., Carroll, L., Aboagye, E. O., Aigbirhio, F. I., Botchway, S. W., Dilworth, J. R., Calatayud, D. G., Plucinski, P. K., Price, G. J. & Pascu, S. I., Apr 1 2018, In : ChemNanoMat. 4, 4, p. 361-372 12 p.

Research output: Contribution to journalArticle

Imaging techniques
Radioisotopes
Silicon Dioxide
Silica
Molecular imaging

Towards an MMP-2-activated molecular agent for cancer imaging

Cowell, S., Carroll, L., Lavdas, I., Aboagye, E. O. & Vilar, R., Jan 1 2018, In : Dalton Transactions. 47, 5, p. 1530-1534 5 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Matrix Metalloproteinases
Imaging techniques
Peptides
Gadolinium
2016

Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors

Dubash, S. R., Nicholas Keat, K., Mapelli, P., Twyman, F., Carroll, L., Kozlowski, K., Al-Nahhas, A., Saleem, A., Huiban, M., Janisch, R., Frilling, A., Sharma, R. & Aboagye, E. O., Aug 1 2016, In : Journal of Nuclear Medicine. 57, 8, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Safety
Spleen
Multiple Endocrine Neoplasia
Neoplasm Metastasis

Identification of ABC transporter interaction of a novel cyanoquinoline radiotracer and implications for tumour imaging by positron emission tomography

Slade, R. L., Pisaneschi, F., Nguyen, Q. D., Smith, G., Carroll, L., Beckley, A., Kaliszczak, M. A. & Aboagye, E. O., Aug 1 2016, In : PLoS One. 11, 8, e0161427.

Research output: Contribution to journalArticle

positron-emission tomography
ABC transporters
Positron emission tomography
ATP-Binding Cassette Transporters
Epidermal Growth Factor Receptor

Synthesis and pre-clinical evaluation of a [18F]fluoromethyl-tanaproget derivative for imaging of progesterone receptor expression

Merchant, S., Allott, L., Carroll, L., Tittrea, V., Kealey, S., Witney, T. H., Miller, P. W., Smith, G. & Aboagye, E. O., Jan 1 2016, In : RSC Advances. 6, 62, p. 57569-57579 11 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Derivatives
Imaging techniques
Ligands
Positron emission tomography

The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth

Trousil, S., Kaliszczak, M., Schug, Z., Nguyen, Q. D., Tomasi, G., Favicchio, R., Brickute, D., Fortt, R., Twyman, F. J., Carroll, L., Kalusa, A., Navaratnam, N., Adejumo, T., Carling, D., Gottlieb, E. & Aboagye, E. O., Jan 1 2016, In : Oncotarget. 7, 24, p. 37103-37120 18 p.

Research output: Contribution to journalArticle

Choline Kinase
Choline
Phosphatidylcholines
Mitochondria
Phosphorylcholine
2015

Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

Udemba, A., Smith, G., Nguyen, Q. D., Kaliszczak, M., Carroll, L., Fortt, R., Fuchter, M. J. & Aboagye, E. O., May 21 2015, In : Organic and Biomolecular Chemistry. 13, 19, p. 5418-5423 6 p.

Research output: Contribution to journalArticle

Caspase 7
apoptosis
Caspase 3
Apoptosis
probes

Microwave gallium-68 radiochemistry for kinetically stable bis(thiosemicarbazone) complexes: structural investigations and cellular uptake under hypoxia

Alam, I. S., Arrowsmith, R. L., Cortezon-Tamarit, F., Twyman, F., Kociok-Köhn, G., Botchway, S. W., Dilworth, J. R., Carroll, L., Aboagye, E. O. & Pascu, S. I., Oct 27 2015, In : Dalton Transactions. 45, 1, p. 144-155 12 p.

Research output: Contribution to journalArticle

Thiosemicarbazones
Gallium
Microwaves
Cells
Flow cytometry

Mn-salen catalysed benzylic C-H activation for the synthesis of aryl [18F]CF3-containing PET probes

Carroll, L., Evans, H. L., Spivey, A. C. & Aboagye, E. O., May 18 2015, In : Chemical Communications. 51, 40, p. 8439-8441 3 p.

Research output: Contribution to journalArticle

Fluorination
Fluorides
Functional groups
Chemical activation
Mn-salen

PET imaging of steroid hormone receptor expression

Allott, L., Smith, G., Aboagye, E. O. & Carroll, L., Nov 1 2015, In : Molecular Imaging. 14, 10, p. 534-550 17 p.

Research output: Contribution to journalArticle

Steroid hormones
steroids
Positron emission tomography
hormones
Steroid Receptors
2014

A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging

Evans, H. L., Nguyen, Q. D., Carroll, L., Kaliszczak, M., Twyman, F. J., Spivey, A. C. & Aboagye, E. O., Aug 28 2014, In : Chemical Communications. 50, 67, p. 9557-9560 4 p.

Research output: Contribution to journalArticle

Monoclonal antibodies
Labeling
Monoclonal Antibodies
Imaging techniques
Electrons

A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography

Witney, T. H., Carroll, L., Alam, I. S., Chandrashekran, A., De Nguyen, Q., Sala, R., Harris, R., De Berardinis, R. J., Agarwal, R. & Aboagye, E. O., Mar 1 2014, In : Cancer Research. 74, 5, p. 1319-1328 10 p.

Research output: Contribution to journalArticle

Glycogen
Positron-Emission Tomography
Neoplasms
Fluorodeoxyglucose F18
Glucose

Biodistribution and radiation dosimetry of deuterium-substituted 18F-fluoromethyl-[1, 2-2H4]choline in healthy volunteers

Challapalli, A., Sharma, R., Hallett, W. A., Kozlowski, K., Carroll, L., Brickute, D., Twyman, F., Al-Nahhas, A. & Aboagye, E. O., Feb 1 2014, In : Journal of Nuclear Medicine. 55, 2, p. 256-263 8 p.

Research output: Contribution to journalArticle

Radiometry
Deuterium
Choline
Healthy Volunteers
Injections

Bioorthogonal chemistry for 68Ga radiolabelling of DOTA-containing compounds

Evans, H. L., Carroll, L., Aboagye, E. O. & Spivey, A. C., Jan 1 2014, In : Journal of Labelled Compounds and Radiopharmaceuticals. 57, 4, p. 291-297 7 p.

Research output: Contribution to journalArticle

Metals
Catalysis
Radiochemistry
Click Chemistry
Copper

Radiolabeled RGD tracer kinetics annotates differential αvβ3 integrin expression linked to cell intrinsic and vessel expression

Alam, I. S., Witney, T. H., Tomasi, G., Carroll, L., Twyman, F. J., Nguyen, Q. D. & Aboagye, E. O., Jan 1 2014, In : Molecular Imaging and Biology. 16, 4, p. 558-566 9 p.

Research output: Contribution to journalArticle

Integrins
Positron-Emission Tomography
Microvessels
Neoplasms
Tumor Burden
2013

Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging

Carroll, L., Witney, T. H. & Aboagye, E. O., Jan 1 2013, In : MedChemComm. 4, 4, p. 653-656 4 p.

Research output: Contribution to journalArticle

Glucosamine
Derivatives
Molecular imaging
Imaging techniques
Biochemistry

Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

Trousil, S., Carroll, L., Kalusa, A., Aberg, O., Kaliszczak, M. & Aboagye, E. O., Jan 1 2013, In : MedChemComm. 4, 4, p. 693-696 4 p.

Research output: Contribution to journalArticle

Choline Kinase
Tumors
Derivatives
Pharmaceutical Preparations
Neoplasms

Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance

Kaliszczak, M., Patel, H., Kroll, S. H. B., Carroll, L., Smith, G., Delaney, S., Heathcote, D. A., Bondke, A., Fuchter, M. J., Coombes, R. C., Barrett, A. G. M., Ali, S. & Aboagye, E. O., Oct 29 2013, In : British Journal of Cancer. 109, 9, p. 2356-2367 12 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Cyclin-Dependent Kinases
Drug Resistance
Apoptosis
Cyclin D1

Temporal and spatial evolution of therapy-induced tumor apoptosis detected by caspase-3-selective molecular imaging

Nguyen, Q. D., Lavdas, I., Gubbins, J., Smith, G., Fortt, R., Carroll, L., Graham, M. A. & Aboagye, E. O., Jul 15 2013, In : Clinical Cancer Research. 19, 14, p. 3914-3924 11 p.

Research output: Contribution to journalArticle

Molecular Imaging
Caspase 3
Positron-Emission Tomography
Apoptosis
Neoplasms
2012

A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers

Bejot, R., Carroll, L., Bhakoo, K., Declerck, J. & Gouverneur, V., Jan 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 1, p. 324-329 6 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Biomarkers
Screening
Libraries
Molecules

Copper-free click - A promising tool for pre-targeted PET imaging

Evans, H. L., Slade, R. L., Carroll, L., Smith, G., Nguyen, Q. D., Iddon, L., Kamaly, N., Stöckmann, H., Leeper, F. J., Aboagye, E. O. & Spivey, A. C., Jan 25 2012, In : Chemical Communications. 48, 7, p. 991-993 3 p.

Research output: Contribution to journalArticle

Copper
Imaging techniques
Tuning
2-fluoroethylazide

Evaluation of deuterated 18F- and 11C-labeled choline analogs for cancer detection by positron emission tomography

Witney, T. H., Alam, I. S., Turton, D. R., Smith, G., Carroll, L., Brickute, D., Twyman, F. J., Nguyen, Q. D., Tomasi, G., Awais, R. O. & Aboagye, E. O., Feb 15 2012, In : Clinical Cancer Research. 18, 4, p. 1063-1072 10 p.

Research output: Contribution to journalArticle

Choline
Positron-Emission Tomography
Neoplasms
Betaine
Halogenation

Radiosynthesis and in vivo tumor uptake of 2-deoxy-2-[18F] fluoro-myo-inositol

Carroll, L., Perumal, M., Vasdev, N., Robins, E. & Aboagye, E. O., Oct 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 19, p. 6148-6150 3 p.

Research output: Contribution to journalArticle

Inositol
Tumors
Neoplasms
Halogenation
Membrane Lipids

Synthesis and evaluation of nucleoside radiotracers for imaging proliferation

Smith, G., Sala, R., Carroll, L., Behan, K., Glaser, M., Robins, E., Nguyen, Q. D. & Aboagye, E. O., Jul 1 2012, In : Nuclear Medicine and Biology. 39, 5, p. 652-665 14 p.

Research output: Contribution to journalArticle

Nucleosides
Phosphorylation
Positron-Emission Tomography
Thymidine
Radiochemistry
2011

The traceless Staudinger ligation for indirect 18F- radiolabelling

Carroll, L., Boldon, S., Bejot, R., Moore, J. E., Declerck, J. & Gouverneur, V., Jan 1 2011, In : Organic and Biomolecular Chemistry. 9, 1, p. 136-140 5 p.

Research output: Contribution to journalArticle

phosphine
phosphines
Ligation
Molecules
Radio
2010

Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Carroll, L., Bejot, R., Hueting, R., King, R., Bonnitcha, P., Bayly, S., Christlieb, M., Dilworth, J. R., Gee, A. D., Declerck, J. & Gouverneur, V., Jun 21 2010, In : Chemical Communications. 46, 23, p. 4052-4054 3 p.

Research output: Contribution to journalArticle

Amides
Labeling

Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET

Bejot, R., Kersemans, V., Kelly, C., Carroll, L., King, R. C. & Gouverneur, V., Jul 1 2010, In : Nuclear Medicine and Biology. 37, 5, p. 565-575 11 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Neoplasms
Biomarkers
Nitroreductases
Inbred CBA Mouse
2009

Fluorous synthesis of 18F radiotracers with the [ 18F]fluoride ion: Nucleophilic fluorination as the detagging process

Bejot, R., Fowler, T., Carroll, L., Boldon, S., Moore, J. E., Declerck, J. & Gouverneur, V., Jan 5 2009, In : Angewandte Chemie - International Edition. 48, 3, p. 586-589 4 p.

Research output: Contribution to journalArticle

Fluorination
Prosthetics
Fluorides
Distillation
Purification
2008

Stereospecific anti SE2′ fluorination of allenylsilanes: Synthesis of enantioenriched propargylic fluorides

Carroll, L., McCullough, S., Rees, T., Claridge, T. D. W. & Gouverneur, V., May 12 2008, In : Organic and Biomolecular Chemistry. 6, 10, p. 1731-1733 3 p.

Research output: Contribution to journalArticle

Fluorination
fluorination
Halogenation
Fluorides
fluorides
2006

Synthesis of propargylic fluorides from allenylsilanes

Carroll, L., Pacheco, M. C., Garcia, L. & Gouverneur, V., Oct 13 2006, In : Chemical Communications. 39, p. 4113-4115 3 p.

Research output: Contribution to journalArticle

Acetonitrile
Fluorides
Temperature
acetonitrile
selectfluor