Laurence Carroll

2022

Functional, Aromatic, and Fluorinated Monothiosemicarbazones: Investigations into Their Structures and Activity toward the Gallium-68 Incorporation by Microwave Irradiation

Sarpaki, S., Cortezon-Tamarit, F., Exner, R. M., Song, K., De Aguiar, S. R. M. M., Ge, H., Pourzand, C., Paisey, S. J., Kociok-Köhn, G., Dilworth, J. R., Carroll, L. & Pascu, S. I., Apr 26 2022, In: ACS Omega. 7, 16, p. 13750-13777 28 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Consideration of metabolite efflux in radiolabelled choline kinetics

Li, Y., Inglese, M., Dubash, S., Barnes, C., Brickute, D., Braga, M. C., Wang, N., Beckley, A., Heinzmann, K., Allott, L., Lu, H., Chen, C., Fu, R., Carroll, L. & Aboagye, E. O., Aug 2021, In: Pharmaceutics. 13, 8, 1246.

Research output: Contribution to journal › Article › peer-review

Open Access

Detecting hypoxia: In vitro using ¹⁸F-pretargeted IEDDA "click" chemistry in live cells

Allott, L., Chen, C., Braga, M., Leung, S. F. J., Wang, N., Barnes, C., Brickute, D., Carroll, L. & Aboagye, E. O., Jun 7 2021, In: RSC Advances. 11, 33, p. 20335-20341 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Direct incorporation of [¹⁸F] into aliphatic systems: A promising Mn-catalysed labelling technique for PET imaging

Cesarec, S., Robson, J. A., Carroll, L. S., Aboagye, E. O. & Spivey, A. C., 2021, In: Current Radiopharmaceuticals. 14, 2, p. 101-106 6 p.

Research output: Contribution to journal › Article › peer-review

Investigating CXCR4 expression of tumor cells and the vascular compartment: A multimodal approach

Braga, M., Leow, C. H., Gil, J. H., Teh, J. H., Carroll, L., Long, N. J., Tang, M. X. & Aboagye, E. O., Nov 2021, In: PloS one. 16, 11 November, e0260186.

Research output: Contribution to journal › Article › peer-review

Open Access

Rapid detection of SARS-CoV-2 using a radiolabeled antibody

Pirovano, G., Ordonez, A. A., Jain, S. K., Reiner, T., Carroll, L. S. & Pillarsetty, N. V. K., Jul 1 2021, In: Nuclear Medicine and Biology. 98-99, p. 69-75 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Use of radioiodine in nuclear medicine—A brief overview

Ferris, T., Carroll, L., Jenner, S. & Aboagye, E. O., Mar 2021, In: Journal of Labelled Compounds and Radiopharmaceuticals. 64, 3, p. 92-108 17 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

2020

Caspase-Based PET for Evaluating Pro-Apoptotic Treatments in a Tuberculosis Mouse Model

Ordonez, A. A., Abhishek, S., Singh, A. K., Klunk, M. H., Azad, B. B., Aboagye, E. O., Carroll, L. & Jain, S. K., Dec 2020, In: Molecular Imaging and Biology. 22, 6, p. 1489-1494 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Radio- A nd nano-chemistry of aqueous Ga(III) ions anchored onto graphene oxide-modified complexes

Sarpaki, S., Cortezon-Tamarit, F., De Aguiar, S. R. M. M., Exner, R. M., Divall, D., Arrowsmith, R. L., Ge, H., Palomares, F. J., Carroll, L., Calatayud, D. G., Paisey, S. J., Aboagye, E. O. & Pascu, S. I., Mar 28 2020, In: Nanoscale. 12, 12, p. 6603-6608 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Tracing nutrient flux following monocarboxylate transporter-1 inhibition with AZD3965

Braga, M., Kaliszczak, M., Carroll, L., Schug, Z. T., Heinzmann, K., Baxan, N., Benito, A., Valbuena, G. N., Stribbling, S., Beckley, A., Mackay, G., Mauri, F., Latigo, J., Barnes, C., Keun, H., Gottlieb, E. & Aboagye, E. O., Jun 2020, In: Cancers. 12, 6, p. 1 1 p., 1703.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Development and Evaluation of an ¹⁸F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression

Brickute, D., Braga, M., Kaliszczak, M. A., Barnes, C., Lau, D., Carroll, L., Stevens, E., Trousil, S., Alam, I. S., Nguyen, Q. D. & Aboagye, E. O., May 6 2019, In: Molecular Pharmaceutics. 16, 5, p. 2106-2117 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Development of ⁶⁸Ga-labelled ultrasound microbubbles for whole-body PET imaging

Hernández-Gil, J., Braga, M., Harriss, B. I., Carroll, L. S., Leow, C. H., Tang, M. X., Aboagye, E. O. & Long, N. J., 2019, In: Chemical Science. 10, 21, p. 5603-5615 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

Vassileva, V., Stribbling, S. M., Barnes, C., Carroll, L., Braga, M., Abrahams, J., Heinzmann, K., Haegeman, C., MacFarlane, M., Simpson, K. L., Dive, C., Honeychurch, J., Illidge, T. M. & Aboagye, E. O., 2019, In: EJNMMI Research. 9, 18.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Iodination of terminal alkynes using KI/CuSO ₄ – A facile method with potential for radio-iodination

Ferris, T., Carroll, L., Mease, R. C., Spivey, A. C. & Aboagye, E. O., Mar 28 2019, In: Tetrahedron Letters. 60, 13, p. 936-939 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[^123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer

Glaser, M., Rajkumar, V., Diocou, S., Gendron, T., Yan, R., Sin, P. K. B., Sander, K., Carroll, L., Pedley, R. B., Aboagye, E. O., Witney, T. H. & Årstad, E., Dec 1 2019, In: Scientific reports. 9, 1, 19299.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Radiosynthesis and PET Bioimaging of ⁷⁶Br-Bedaquiline in a Murine Model of Tuberculosis

Ordonez, A. A., Carroll, L. S., Abhishek, S., Mota, F., Ruiz-Bedoya, C. A., Klunk, M. H., Singh, A. K., Freundlich, J. S., Mease, R. C. & Jain, S. K., Dec 13 2019, In: ACS Infectious Diseases. 5, 12, p. 1996-2002 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2018

Antibody Fragment and Affibody ImmunoPET Imaging Agents: Radiolabelling Strategies and Applications

Fu, R., Carroll, L., Yahioglu, G., Aboagye, E. O. & Miller, P. W., Dec 6 2018, In: ChemMedChem. 13, 23, p. 2466-2478 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Scopus citations

Synthesis, Radiolabelling and In Vitro Imaging of Multifunctional Nanoceramics

Lledos, M., Mirabello, V., Sarpaki, S., Ge, H., Smugowski, H. J., Carroll, L., Aboagye, E. O., Aigbirhio, F. I., Botchway, S. W., Dilworth, J. R., Calatayud, D. G., Plucinski, P. K., Price, G. J. & Pascu, S. I., Apr 2018, In: ChemNanoMat. 4, 4, p. 361-372 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Towards an MMP-2-activated molecular agent for cancer imaging

Cowell, S., Carroll, L., Lavdas, I., Aboagye, E. O. & Vilar, R., 2018, In: Dalton Transactions. 47, 5, p. 1530-1534 5 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2017

Molecular mechanisms of hypoxia in cancer

Challapalli, A., Carroll, L. & Aboagye, E. O., Jun 1 2017, In: Clinical and Translational Imaging. 5, 3, p. 225-253 29 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

50 Scopus citations

2016

Clinical translation of a click-labeled ¹⁸F-octreotate radioligand for imaging neuroendocrine tumors

Dubash, S. R., Nicholas Keat, K., Mapelli, P., Twyman, F., Carroll, L., Kozlowski, K., Al-Nahhas, A., Saleem, A., Huiban, M., Janisch, R., Frilling, A., Sharma, R. & Aboagye, E. O., Aug 1 2016, In: Journal of Nuclear Medicine. 57, 8, p. 1207-1213 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Erratum: Microwave gallium-68 radiochemistry for kinetically stable bis(thiosemicarbazone) complexes: Structural investigations and cellular uptake under hypoxia (Dalton Transactions (2016) 45 (144-155))

Alam, I. S., Arrowsmith, R. L., Cortezon-Tamarit, F., Twyman, F., Kociok-Köhn, G., Botchway, S. W., Dilworth, J. R., Carroll, L., Aboagye, E. O. & Pascu, S. I., 2016, In: Dalton Transactions. 45, 8, p. 3650 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

2 Scopus citations

Identification of ABC transporter interaction of a novel cyanoquinoline radiotracer and implications for tumour imaging by positron emission tomography

Slade, R. L., Pisaneschi, F., Nguyen, Q. D., Smith, G., Carroll, L., Beckley, A., Kaliszczak, M. A. & Aboagye, E. O., Aug 2016, In: PloS one. 11, 8, e0161427.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Synthesis and pre-clinical evaluation of a [¹⁸F]fluoromethyl-tanaproget derivative for imaging of progesterone receptor expression

Merchant, S., Allott, L., Carroll, L., Tittrea, V., Kealey, S., Witney, T. H., Miller, P. W., Smith, G. & Aboagye, E. O., 2016, In: RSC Advances. 6, 62, p. 57569-57579 11 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth

Trousil, S., Kaliszczak, M., Schug, Z., Nguyen, Q. D., Tomasi, G., Favicchio, R., Brickute, D., Fortt, R., Twyman, F. J., Carroll, L., Kalusa, A., Navaratnam, N., Adejumo, T., Carling, D., Gottlieb, E. & Aboagye, E. O., 2016, In: Oncotarget. 7, 24, p. 37103-37120 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2015

Design, synthesis and initial characterisation of a radiolabelled [¹⁸F]pyrimidoindolone probe for detecting activated caspase-3/7

Udemba, A., Smith, G., Nguyen, Q. D., Kaliszczak, M., Carroll, L., Fortt, R., Fuchter, M. J. & Aboagye, E. O., May 21 2015, In: Organic and Biomolecular Chemistry. 13, 19, p. 5418-5423 6 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Microwave gallium-68 radiochemistry for kinetically stable bis(thiosemicarbazone) complexes: structural investigations and cellular uptake under hypoxia

Alam, I. S., Arrowsmith, R. L., Cortezon-Tamarit, F., Twyman, F., Kociok-Köhn, G., Botchway, S. W., Dilworth, J. R., Carroll, L., Aboagye, E. O. & Pascu, S. I., Oct 27 2015, In: Dalton Transactions. 45, 1, p. 144-155 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Mn-salen catalysed benzylic C-H activation for the synthesis of aryl [¹⁸F]CF₃-containing PET probes

Carroll, L., Evans, H. L., Spivey, A. C. & Aboagye, E. O., May 18 2015, In: Chemical Communications. 51, 40, p. 8439-8441 3 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

PET imaging of steroid hormone receptor expression

Allott, L., Smith, G., Aboagye, E. O. & Carroll, L., Oct 2015, In: Molecular imaging. 14, 9, p. 534-550 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2014

A bioorthogonal ⁶⁸Ga-labelling strategy for rapid in vivo imaging

Evans, H. L., Nguyen, Q. D., Carroll, L. S., Kaliszczak, M., Twyman, F. J., Spivey, A. C. & Aboagye, E. O., Jul 24 2014, In: Chemical Communications. 50, 67, p. 9557-9560 4 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography

Witney, T. H., Carroll, L., Alam, I. S., Chandrashekran, A., De Nguyen, Q., Sala, R., Harris, R., De Berardinis, R. J., Agarwal, R. & Aboagye, E. O., Mar 1 2014, In: Cancer Research. 74, 5, p. 1319-1328 10 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Biodistribution and radiation dosimetry of deuterium-substituted ¹⁸F-fluoromethyl-[1, 2-²H₄]choline in healthy volunteers

Challapalli, A., Sharma, R., Hallett, W. A., Kozlowski, K., Carroll, L., Brickute, D., Twyman, F., Al-Nahhas, A. & Aboagye, E. O., Feb 1 2014, In: Journal of Nuclear Medicine. 55, 2, p. 256-263 8 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Bioorthogonal chemistry for ⁶⁸Ga radiolabelling of DOTA-containing compounds

Evans, H. L., Carroll, L., Aboagye, E. O. & Spivey, A. C., Apr 2014, In: Journal of Labelled Compounds and Radiopharmaceuticals. 57, 4, p. 291-297 7 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Radiolabeled RGD tracer kinetics annotates differential α_vβ₃ integrin expression linked to cell intrinsic and vessel expression

Alam, I. S., Witney, T. H., Tomasi, G., Carroll, L., Twyman, F. J., Nguyen, Q. D. & Aboagye, E. O., Aug 2014, In: Molecular Imaging and Biology. 16, 4, p. 558-566 9 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2013

Bioorthogonal chemistry for pre-targeted molecular imaging-progress and prospects

Carroll, L., Evans, H. L., Aboagye, E. O. & Spivey, A. C., Sep 21 2013, In: Organic and Biomolecular Chemistry. 11, 35, p. 5772-5781 10 p.

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Design and synthesis of novel ¹⁸F-radiolabelled glucosamine derivatives for cancer imaging

Carroll, L., Witney, T. H. & Aboagye, E. O., Apr 2013, In: MedChemComm. 4, 4, p. 653-656 4 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

Trousil, S., Carroll, L., Kalusa, A., Aberg, O., Kaliszczak, M. & Aboagye, E. O., Apr 2013, In: MedChemComm. 4, 4, p. 693-696 4 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance

Kaliszczak, M., Patel, H., Kroll, S. H. B., Carroll, L., Smith, G., Delaney, S., Heathcote, D. A., Bondke, A., Fuchter, M. J., Coombes, R. C., Barrett, A. G. M., Ali, S. & Aboagye, E. O., Oct 29 2013, In: British journal of cancer. 109, 9, p. 2356-2367 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Temporal and spatial evolution of therapy-induced tumor apoptosis detected by caspase-3-selective molecular imaging

Nguyen, Q. D., Lavdas, I., Gubbins, J., Smith, G., Fortt, R., Carroll, L. S., Graham, M. A. & Aboagye, E. O., Jul 15 2013, In: Clinical Cancer Research. 19, 14, p. 3914-3924 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

2012

A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers

Bejot, R., Carroll, L., Bhakoo, K., Declerck, J. & Gouverneur, V., Jan 1 2012, In: Bioorganic and Medicinal Chemistry. 20, 1, p. 324-329 6 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Copper-free click—a promising tool for pre-targeted PET imaging

Evans, H. L., Slade, R. L., Carroll, L., Smith, G., Nguyen, Q. D., Iddon, L., Kamaly, N., Stöckmann, H., Leeper, F. J., Aboagye, E. O. & Spivey, A. C., Jan 3 2012, In: Chemical Communications. 48, 7, p. 991-993 3 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Evaluation of deuterated ¹⁸F- and ¹¹C-labeled choline analogs for cancer detection by positron emission tomography

Witney, T. H., Alam, I. S., Turton, D. R., Smith, G., Carroll, L., Brickute, D., Twyman, F. J., Nguyen, Q. D., Tomasi, G., Awais, R. O. & Aboagye, E. O., Feb 15 2012, In: Clinical Cancer Research. 18, 4, p. 1063-1072 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

New frontiers in the design and synthesis of imaging probes for PET Oncology: Current challenges and future directions

Smith, G., Carroll, L. & Aboagye, E. O., Dec 1 2012, In: Molecular Imaging and Biology. 14, 6, p. 653-666 14 p.

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Radiosynthesis and in vivo tumor uptake of 2-deoxy-2-[¹⁸F] fluoro-myo-inositol

Carroll, L., Perumal, M., Vasdev, N., Robins, E. & Aboagye, E. O., Oct 1 2012, In: Bioorganic and Medicinal Chemistry Letters. 22, 19, p. 6148-6150 3 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Synthesis and evaluation of nucleoside radiotracers for imaging proliferation

Smith, G., Sala, R., Carroll, L., Behan, K., Glaser, M., Robins, E., Nguyen, Q. D. & Aboagye, E. O., Jul 2012, In: Nuclear Medicine and Biology. 39, 5, p. 652-665 14 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

2011

The traceless Staudinger ligation for indirect ¹⁸F- radiolabelling

Carroll, L., Boldon, S., Bejot, R., Moore, J. E., Declerck, J. & Gouverneur, V., Jan 1 2011, In: Organic and Biomolecular Chemistry. 9, 1, p. 136-140 5 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

2010

Erratum to "Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [¹⁸F]FMISO as hypoxia-selective tracer for PET" [Nucl. Med. Biol. 2010;37:565-575]

Bejot, R., Kersemans, V., Kelly, C., Carroll, L., King, R. C. & Gouverneur, V., Nov 2010, In: Nuclear Medicine and Biology. 37, 8, p. 1013 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Orthogonal ¹⁸F and ⁶⁴Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Carroll, L., Bejot, R., Hueting, R., King, R., Bonnitcha, P., Bayly, S., Christlieb, M., Dilworth, J. R., Gee, A. D., Declerck, J. & Gouverneur, V., Jun 21 2010, In: Chemical Communications. 46, 23, p. 4052-4054 3 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [¹⁸F]FMISO as hypoxia-selective tracer for PET

Bejot, R., Kersemans, V., Kelly, C., Carroll, L., King, R. C. & Gouverneur, V., Jul 2010, In: Nuclear Medicine and Biology. 37, 5, p. 565-575 11 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2009

Fluorous synthesis of ¹⁸F radiotracers with the [ ¹⁸F]fluoride ion: Nucleophilic fluorination as the detagging process

Bejot, R., Fowler, T., Carroll, L., Boldon, S., Moore, J. E., Declerck, J. & Gouverneur, V., Jan 5 2009, In: Angewandte Chemie - International Edition. 48, 3, p. 586-589 4 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Laurence Carroll

Research output

Search results