Lauren Jantzie

Associate Professor

20052019
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Research Output 2005 2019

2019

Chorioamnionitis in Rats Precipitates Extended Postnatal Inflammatory Lymphocyte Hyperreactivity

Yellowhair, T. R., Noor, S., Mares, B., Jose, C., Newville, J. C., Maxwell, J. R., Northington, F., Milligan, E. D., Robinson, S. & Jantzie, L., Jan 1 2019, In : Developmental Neuroscience.

Research output: Contribution to journalArticle

Chorioamnionitis
Placental Insufficiency
Lymphocytes
Laparotomy
Brain Injuries

CXCR2 blockade mitigates neural cell injury following preclinical chorioamnionitis

Yellowhair, T. R., Newville, J. C., Noor, S., Maxwell, J. R., Milligan, E. D., Robinson, S. & Jantzie, L., Jan 1 2019, In : Frontiers in Physiology. 10, APR, 324.

Research output: Contribution to journalArticle

Open Access
Chorioamnionitis
Premature Birth
Nervous System Trauma
Central Nervous System
Neutrophil Activation

Evidence for sexual dimorphism in the response to TLR3 activation in the developing neonatal mouse brain: A pilot study

Chavez-Valdez, R., Mottahedin, A., Stridh, L., Yellowhair, T. R., Jantzie, L., Northington, F. & Mallard, C., Jan 1 2019, In : Frontiers in Physiology. 10, MAR, 306.

Research output: Contribution to journalArticle

Open Access
Poly I-C
Sex Characteristics
Brain
Caspase 8
Cytokines

Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Sanchez, J. J., Sanchez, J. E., Noor, S., Ruffaner-Hanson, C. D., Davies, S., Wagner, C. R., Jantzie, L., Mellios, N., Savage, D. D. & Milligan, E. D., Apr 8 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Lymphocyte Function-Associated Antigen-1
Integrins
Alcohols
Interleukin-1
Spinal Ganglia

The association between prenatal alcohol exposure and protein expression in human placenta

Holbrook, B. D., Davies, S., Cano, S., Shrestha, S., Jantzie, L. L., Rayburn, W. F., Bakhireva, L. N. & Savage, D. D., Jan 1 2019, In : Birth Defects Research.

Research output: Contribution to journalArticle

Placenta
Ethanol
Alcohols
Association reactions
Proteins

Time to reconsider extended erythropoietin treatment for infantile traumatic brain injury?

Jantzie, L., El Demerdash, N., Newville, J. C. & Robinson, S., Aug 1 2019, In : Experimental Neurology. 318, p. 205-215 11 p.

Research output: Contribution to journalReview article

Erythropoietin
Central Nervous System
Therapeutics
Brain Injuries
Wounds and Injuries
2018

A time for cocktails and inclusion

Robinson, S., Northington, F. & Jantzie, L., Jun 1 2018, In : Neural Regeneration Research. 13, 6, p. 987-988 2 p.

Research output: Contribution to journalReview article

Effects of spinal non-viral interleukin-10 gene therapy formulated with D-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues

Vanderwall, A. G., Noor, S., Sun, M. S., Sanchez, J. E., Yang, X. O., Jantzie, L., Mellios, N. & Milligan, E. D., Mar 1 2018, In : Brain, Behavior, and Immunity. 69, p. 91-112 22 p.

Research output: Contribution to journalArticle

Open Access
Nociceptive Pain
Mannose
Genetic Therapy
Interleukin-10
Messenger RNA

Extended Combined Neonatal Treatment With Erythropoietin Plus Melatonin Prevents Posthemorrhagic Hydrocephalus of Prematurity in Rats

Robinson, S., Conteh, F. S., Oppong, A. Y., Yellowhair, T. R., Newville, J. C., Demerdash, N. E., Shrock, C. L., Maxwell, J. R., Jett, S., Northington, F. & Jantzie, L., Sep 25 2018, In : Frontiers in Cellular Neuroscience. 12, 322.

Research output: Contribution to journalArticle

Chorioamnionitis
Melatonin
Hydrocephalus
Erythropoietin
Megalencephaly

Extended erythropoietin treatment prevents chronic executive functional and microstructural deficits following early severe traumatic brain injury in rats

Robinson, S., Winer, J. L., Chan, L. A. S., Oppong, A. Y., Yellowhair, T. R., Maxwell, J. R., Andrews, N., Yang, Y., Sillerud, L. O., Meehan, W. P., Mannix, R., Brigman, J. L. & Jantzie, L., Jun 19 2018, In : Frontiers in Neurology. 9, JUN, 451.

Research output: Contribution to journalArticle

Diffusion Tensor Imaging
Erythropoietin
Clinical Trials
Wounds and Injuries
Reversal Learning

Neonatal erythropoietin mitigates impaired gait, social interaction and diffusion tensor imaging abnormalities in a rat model of prenatal brain injury

Robinson, S., Corbett, C. J., Winer, J. L., Chan, L. A. S., Maxwell, J. R., Anstine, C. V., Yellowhair, T. R., Andrews, N. A., Yang, Y., Sillerud, L. O. & Jantzie, L., Apr 1 2018, In : Experimental Neurology. 302, p. 1-13 13 p.

Research output: Contribution to journalArticle

Prenatal Injuries
Diffusion Tensor Imaging
Interpersonal Relations
Erythropoietin
Gait

Repetitive neonatal erythropoietin and melatonin combinatorial treatment provides sustained repair of functional deficits in a rat model of cerebral palsy

Jantzie, L., Oppong, A. Y., Conteh, F. S., Yellowhair, T. R., Kim, J., Fink, G., Wolin, A. R., Northington, F. & Robinson, S., Apr 13 2018, In : Frontiers in Neurology. 9, APR, 233.

Research output: Contribution to journalArticle

Melatonin
Cerebral Palsy
Erythropoietin
Prenatal Injuries
Brain Injuries

Stem cells and cell-based therapies for cerebral palsy: A call for rigor

Jantzie, L., Scafidi, J. & Robinson, S., Jan 1 2018, In : Pediatric Research. 83, 1-2, p. 345-355 11 p.

Research output: Contribution to journalReview article

Cerebral Palsy
Cell- and Tissue-Based Therapy
Stem Cells
Brain Injuries
Vulnerable Populations
2017

Acute oligodendrocyte loss with persistent white matter injury in a third trimester equivalent mouse model of fetal alcohol spectrum disorder

Newville, J., Valenzuela, C. F., Li, L., Jantzie, L. & Cunningham, L. A., Aug 1 2017, In : Glia. 65, 8, p. 1317-1332 16 p.

Research output: Contribution to journalArticle

Fetal Alcohol Spectrum Disorders
Oligodendroglia
Third Pregnancy Trimester
Alcohols
Wounds and Injuries

Adolescent Mice Demonstrate a Distinct Pattern of Injury after Repetitive Mild Traumatic Brain Injury

Mannix, R., Berkner, J., Mei, Z., Alcon, S., Hashim, J., Robinson, S., Jantzie, L., Meehan, W. P. & Qiu, J., Jan 15 2017, In : Journal of Neurotrauma. 34, 2, p. 495-504 10 p.

Research output: Contribution to journalArticle

Brain Concussion
Wounds and Injuries
Unconsciousness
Impulsive Behavior
Brain

Cognitive development in preterm infants: Multifaceted deficits reflect vulnerability of rigorous neurodevelopmental pathways

Maxwell, J. R., Yellowhair, T. R., Oppong, A. Y., Camacho, J. E., Lowe, J. R., Jantzie, L. & Ohls, R. K., Aug 1 2017, In : Minerva pediatrica. 69, 4, p. 298-313 16 p.

Research output: Contribution to journalReview article

Premature Infants
Cognition
Executive Function
Premature Birth
Infant Mortality

Embracing oligodendrocyte diversity in the context of perinatal injury

Newville, J., Jantzie, L. & Cunningham, L. A., Oct 1 2017, In : Neural Regeneration Research. 12, 10, p. 1575-1585 11 p.

Research output: Contribution to journalReview article

Open Access
Oligodendroglia
Wounds and Injuries
Myelin Sheath
Brain Injuries
Population

Microstructural and microglial changes after repetitive mild traumatic brain injury in mice

Robinson, S., Berglass, J. B., Denson, J. L., Berkner, J., Anstine, C. V., Winer, J. L., Maxwell, J. R., Qiu, J., Yang, Y., Sillerud, L. O., Meehan, W. P., Mannix, R. & Jantzie, L., Apr 1 2017, In : Journal of Neuroscience Research. 95, 4, p. 1025-1035 11 p.

Research output: Contribution to journalArticle

Brain Concussion
Closed Head Injuries
Wounds and Injuries
Magnetic Resonance Imaging
Biological Phenomena

Preclinical chorioamnionitis dysregulates CXCL1/CXCR2 signaling throughout the placental-fetal-brain axis

Yellowhair, T. R., Noor, S., Maxwell, J. R., Anstine, C. V., Oppong, A. Y., Robinson, S., Milligan, E. D. & Jantzie, L., Jan 1 2017, (Accepted/In press) In : Experimental Neurology.

Research output: Contribution to journalArticle

Chorioamnionitis
Brain Injuries
Ligands
Brain
Nervous System Trauma

Prenatal alcohol exposure potentiates chronic neuropathic pain, spinal glial and immune cell activation and alters sciatic nerve and DRG cytokine levels

Noor, S., Sanchez, J. J., Vanderwall, A. G., Sun, M. S., Maxwell, J. R., Davies, S., Jantzie, L., Petersen, T. R., Savage, D. D. & Milligan, E. D., Mar 1 2017, In : Brain, Behavior, and Immunity. 61, p. 80-95 16 p.

Research output: Contribution to journalArticle

Open Access
Spinal Ganglia
Neuralgia
Sciatic Nerve
Neuroglia
Chronic Pain
2016

Dysregulation of FMRP/mTOR Signaling Cascade in Hypoxic-Ischemic Injury of Premature Human Brain

Lechpammer, M., Wintermark, P., Merry, K. M., Jackson, M. C., Jantzie, L. & Jensen, F. E., Mar 1 2016, In : Journal of child neurology. 31, 4, p. 426-432 7 p.

Research output: Contribution to journalArticle

Fragile X Mental Retardation Protein
Wounds and Injuries
Brain
Brain Diseases
70-kDa Ribosomal Protein S6 Kinases

Erythropoietin Modulates Cerebral and Serum Degradation Products from Excess Calpain Activation following Prenatal Hypoxia-Ischemia

Jantzie, L., Winer, J. L., Corbett, C. J. & Robinson, S., Feb 1 2016, In : Developmental Neuroscience. 38, 1, p. 15-26 12 p.

Research output: Contribution to journalArticle

Calpain
Erythropoietin
Ischemia
Spectrin
Central Nervous System

Imaging and serum biomarkers reflecting the functional efficacy of extended erythropoietin treatment in rats following infantile traumatic brain injury

Robinson, S., Winer, J. L., Berkner, J., Chan, L. A. S., Denson, J. L., Maxwell, J. R., Yang, Y., Sillerud, L. O., Tasker, R. C., Meehan, W. P., Mannix, R. & Jantzie, L., Jun 1 2016, In : Journal of Neurosurgery: Pediatrics. 17, 6, p. 739-755 17 p.

Research output: Contribution to journalArticle

Erythropoietin
Biomarkers
Serum
Therapeutics
Gait
2015

Chloride cotransporter NKCC1 inhibitor bumetanide protects against white matter injury in a rodent model of periventricular leukomalacia

Jantzie, L., Hu, M. Y., Park, H. K., Jackson, M. C., Yu, J., Maxwell, J. R. & Jensen, F. E., Apr 19 2015, In : Pediatric research. 77, 4, p. 554-562 9 p.

Research output: Contribution to journalArticle

Open Access
Member 2 Solute Carrier Family 12
Periventricular Leukomalacia
Bumetanide
Chlorides
Rodentia

Combined in utero hypoxia-ischemia and lipopolysaccharide administration in rats induces chorioamnionitis and a fetal inflammatory response syndrome

Maxwell, J. R., Denson, J. L., Joste, N. E., Robinson, S. & Jantzie, L., Dec 1 2015, In : Placenta. 36, 12, p. 1378-1384 7 p.

Research output: Contribution to journalArticle

Chorioamnionitis
Lipopolysaccharides
Ischemia
Central Nervous System
Inflammation

Developmental expression of N-methyl-d-aspartate (NMDA) receptor subunits in human white and gray matter: Potential mechanism of increased vulnerability in the immature brain

Jantzie, L., Talos, D. M., Jackson, M. C., Park, H. K., Graham, D. A., Lechpammer, M., Folkerth, R. D., Volpe, J. J. & Jensen, F. E., Jan 1 2015, In : Cerebral Cortex. 25, 2, p. 482-495 14 p.

Research output: Contribution to journalArticle

Open Access
Periventricular Leukomalacia
Brain
Brain Injuries
Rodentia
Ischemia

Modeling encephalopathy of prematurity using prenatal hypoxia-ischemia with intra-amniotic lipopolysaccharide in rats

Jantzie, L., Winer, J. L., Maxwell, J. R., Chan, L. A. S. & Robinson, S., Nov 20 2015, In : Journal of Visualized Experiments. 2015, 105, e53196.

Research output: Contribution to journalArticle

Brain Diseases
Lipopolysaccharides
Rats
Premature Birth
Ischemia

Postnatal erythropoietin mitigates impaired cerebral cortical development following subplate loss from prenatal hypoxia-ischemia

Jantzie, L., Corbett, C. J., Firl, D. J. & Robinson, S., Sep 1 2015, In : Cerebral Cortex. 25, 9, p. 2683-2695 13 p.

Research output: Contribution to journalArticle

Erythropoietin
Ischemia
Up-Regulation
Extremely Premature Infants
Symporters

Preclinical Models of Encephalopathy of Prematurity

Jantzie, L. & Robinson, S., Jul 25 2015, In : Developmental Neuroscience. 37, 4-5, p. 277-288 12 p.

Research output: Contribution to journalReview article

Brain Diseases
Central Nervous System
Wounds and Injuries
Nervous System Trauma
Mammals

Prenatal hypoxia–ischemia induces abnormalities in CA3 microstructure, potassium chloride co-transporter 2 expression and inhibitory tone

Jantzie, L., Getsy, P. M., Denson, J. L., Firl, D. J., Maxwell, J. R., Rogers, D. A., Wilson, C. G. & Robinson, S., Sep 3 2015, In : Frontiers in Cellular Neuroscience. 9, september, 347.

Research output: Contribution to journalArticle

Symporters
Potassium Chloride
Brain Injuries
gamma-Aminobutyric Acid
Up-Regulation
2014

Chronic gliosis and behavioral deficits in mice following repetitive mild traumatic brain injury

Mannix, R., Berglass, J., Berkner, J., Moleus, P., Qiu, J., Andrews, N., Gunner, G., Berglass, L., Jantzie, L., Robinson, S. & Meehan, W. P., Dec 1 2014, In : Journal of Neurosurgery. 121, 6, p. 1342-1350 9 p.

Research output: Contribution to journalArticle

Brain Concussion
Gliosis
Exploratory Behavior
Brain
Rotarod Performance Test

Complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupts brain development and motor function

Jantzie, L., Corbett, C. J., Berglass, J., Firl, D. J., Flores, J., Mannix, R. & Robinson, S., Aug 1 2014, In : Journal of Neuroinflammation. 11, 1, 131.

Research output: Contribution to journalArticle

Encephalitis
Lipopolysaccharides
Ischemia
Gait
Wounds and Injuries

Erythropoietin attenuates loss of potassium chloride co-transporters following prenatal brain injury

Jantzie, L., Getsy, P. M., Firl, D. J., Wilson, C. G., Miller, R. H. & Robinson, S., 2014, In : Molecular and Cellular Neuroscience. 61, p. 152-162 11 p.

Research output: Contribution to journalArticle

Prenatal Injuries
Symporters
Potassium Chloride
Erythropoietin
Brain Injuries

Sex differences in the effect of progesterone after controlled cortical impact in adolescent mice: A preliminary study Laboratory investigation

Mannix, R., Berglass, J., Berkner, J., Moleus, P., Qiu, J., Jantzie, L., Meehan, W. P., Stanley, R. M. & Robinson, S., Dec 1 2014, In : Journal of Neurosurgery. 121, 6, p. 1337-1341 5 p.

Research output: Contribution to journalArticle

Sex Characteristics
Progesterone
Pediatrics
Wounds and Injuries
Theoretical Models
2013

Erythropoietin signaling promotes oligodendrocyte development following prenatal systemic hypoxic-ischemic brain injury

Jantzie, L., Miller, R. H. & Robinson, S., Dec 2013, In : Pediatric Research. 74, 6, p. 658-667 10 p.

Research output: Contribution to journalArticle

Oligodendroglia
Erythropoietin
Brain Injuries
Wounds and Injuries
Ischemia
2012

Regional differences in susceptibility to hypoxic-ischemic injury in the preterm brain: Exploring the spectrum from white matter loss to selective grey matter injury in a rat model

Selip, D. B., Jantzie, L., Chang, M., Jackson, M. C., Fitzgerald, E. C., Boll, G., Murphy, A. & Jensen, F. E., Sep 18 2012, In : Neurology Research International. 2012, 725184.

Research output: Contribution to journalArticle

Open Access
Wounds and Injuries
Brain
Brain Injuries
Periventricular Leukomalacia
Gliosis
2010

Cerebral amino acid profiles after hypoxia-reoxygenation and N-acetylcysteine treatment in the newborn piglet

Jantzie, L., Cheung, P. Y., Johnson, S. T., Bigam, D. L. & Todd, K. G., Mar 1 2010, In : Neonatology. 97, 3, p. 195-203 9 p.

Research output: Contribution to journalArticle

Acetylcysteine
Amino Acids
Free Radicals
Ischemia
Brain Injuries

Developmental regulation of group i metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia

Jantzie, L., Talos, D. M., Selip, D. B., An, L., Jackson, M. C., Folkerth, R. D., Deng, W. & Jensen, F. E., Nov 1 2010, In : Neuron Glia Biology. 6, 4, p. 277-288 12 p.

Research output: Contribution to journalArticle

Periventricular Leukomalacia
Metabotropic Glutamate Receptors
Oligodendroglia
Rodentia
Brain
Open Access
Doxycycline
Ischemia
Cytokines
Lateral Ventricles
Brain-Derived Neurotrophic Factor
2008

Neonatal ischemic stroke: A hypoxic-ischemic injury to the developing brain

Jantzie, L., Todd, K. G. & Cheung, P. Y., Mar 1 2008, In : Future Neurology. 3, 2, p. 99-102 4 p.

Research output: Contribution to journalEditorial

Open Access
Stroke
Wounds and Injuries
Brain

Persistent neurochemical changes in neonatal piglets after hypoxia-ischemia and resuscitation with 100%, 21% or 18% oxygen

Jantzie, L., Cheung, P. Y., Obaid, L., Emara, M., Johnson, S. T., Bigam, D. L. & Todd, K. G., Apr 1 2008, In : Resuscitation. 77, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

Resuscitation
Ischemia
Oxygen
Amino Acids
Common Carotid Artery

Postresuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain

Lee, T. F., Jantzie, L., Todd, K. G. & Cheung, P. Y., Jan 1 2008, In : Intensive Care Medicine. 34, 1, p. 190-197 8 p.

Research output: Contribution to journalArticle

Acetylcysteine
Hydrogen Peroxide
Brain
Lipid Peroxides
Taurine
2007

Methods in immunochemistry

Jantzie, L., Tanay, V. A. M. I. & Todd, K. G., Dec 1 2007, Handbook of Neurochemistry and Molecular Neurobiology: Practical Neurochemistry Methods. Springer US, p. 193-218 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunochemistry
Antigens
Immunosorbents
Antibodies
Assays
2006

The effects of doxycycline administration on amino acid neurotransmitters in an animal model of neonatal hypoxia-ischemia

Jantzie, L., Rauw, G. A. & Todd, K. G., Dec 1 2006, In : Neurochemistry International. 49, 8, p. 717-728 12 p.

Research output: Contribution to journalArticle

Doxycycline
Neurotransmitter Agents
Ischemia
Animal Models
Amino Acids
2005

Doxycycline reduces cleaved caspase-3 and microglial activation in an animal model of neonatal hypoxia-ischemia

Jantzie, L., Cheung, P. Y. & Todd, K. G., Mar 1 2005, In : Journal of Cerebral Blood Flow and Metabolism. 25, 3, p. 314-324 11 p.

Research output: Contribution to journalArticle

Doxycycline
Caspase 3
Ischemia
Animal Models
Brain

Inferior olivary neurons innervate multiple zones of the flocculus in pigeons (Columba livia)

Pakan, J. M. P., Todd, K. G., Nguyen, A. P., Winship, I. R., Hurd, P. L., Jantzie, L. & Wylie, D. R. W., May 30 2005, In : Journal of Comparative Neurology. 486, 2, p. 159-168 10 p.

Research output: Contribution to journalArticle

Columbidae
Neurons
Optic Flow
Injections
Purkinje Cells