Laura Ensign-Hodges

Associate Professor

20092019

Research output per year

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Research Output

  • 32 Article
  • 4 Review article
  • 2 Editorial
  • 1 Conference contribution
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Article
2019

Conceptual design of a universal donor screening approach for vaginal microbiota transplant

Delong, K., Bensouda, S., Zulfiqar, F., Zierden, H. C., Hoang, T. M., Abraham, A. G., Coleman, J. S., Cone, R. A., Gravitt, P. E., Hendrix, C. W., Fuchs, E. J., Gaydos, C. A., Weld, E. D. & Ensign, L. M., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, AUG, 306.

Research output: Contribution to journalArticle

Open Access

Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis

Luo, L., Yang, J., Oh, Y., Hartsock, M. J., Xia, S., Kim, Y. C., Ding, Z., Meng, T., Eberhart, C. G., Ensign-Hodges, L., Thorne, J., Stark, W. J., Duh, E. J., Xu, Q. & Hanes, J. S., Feb 28 2019, In : Journal of Controlled Release. 296, p. 68-80 13 p.

Research output: Contribution to journalArticle

Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization

Wang, B., Tang, Y., Oh, Y., Lamb, N. W., Xia, S., Ding, Z., Chen, B., Suarez, M. J., Meng, T., Kulkarni, V., Eberhart, C. G., Ensign-Hodges, L., Stark, W. J., Hanes, J. S. & Xu, Q., Apr 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 17, p. 119-123 5 p.

Research output: Contribution to journalArticle

Development of a mucoinert progesterone nanosuspension for safer and more effective prevention of preterm birth

Hoang, T., Zierden, H., Date, A., Ortiz, J., Gumber, S., Anders, N., He, P., Segars, J., Hanes, J. S., Mahendroo, M. & Ensign-Hodges, L., Feb 10 2019, In : Journal of Controlled Release. 295, p. 74-86 13 p.

Research output: Contribution to journalArticle

2018

Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema

Hoang, T., Date, A. A., Ortiz, J. O., Young, T. W., Bensouda, S., Xiao, P., Marzinke, M. A., Rohan, L., Fuchs, E., Hendrix, C., Gumber, S., Villinger, F., Cone, R. A., Hanes, J. S. & Ensign-Hodges, L., Jan 1 2018, (Accepted/In press) In : European Journal of Pharmaceutics and Biopharmaceutics.

Research output: Contribution to journalArticle

Hypo-osmolar formulation of tenofovir (TFV) enema promotes uptake and metabolism of TFV in tissues, leading to prevention of SHIV/SIV infection

Xiao, P., Gumber, S., Marzinke, M. A., Date, A. A., Hoang, T., Hanes, J. S., Ensign-Hodges, L., Wang, L., Rohan, L., Fuchs, E., Hendrix, C. & Villinger, F., Jan 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, e01644-17.

Research output: Contribution to journalArticle

Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease

Date, A. A., Halpert, G., Babu, T., Ortiz, J., Kanvinde, P., Dimitrion, P., Narayan, J., Zierden, H., Betageri, K., Musmanno, O., Wiegand, H., Huang, X., Gumber, S., Hanes, J. S. & Ensign-Hodges, L., Dec 1 2018, In : Biomaterials. 185, p. 97-105 9 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa pyocyanin production reduced by quorum-sensing inhibiting nanocarriers

Lu, H. D., Pearson, E., Ristroph, K. D., Duncan, G. A., Ensign-Hodges, L., Suk, J. S., Hanes, J. S. & Prud'homme, R. K., Jun 10 2018, In : International Journal of Pharmaceutics. 544, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

2017

Development of absorbable, antibiotic-eluting sutures for ophthalmic surgery

Kashiwabuchi, F., Parikh, K., Omiadze, R., Zhang, S., Luo, L., Patel, H. V., Xu, Q., Ensign-Hodges, L., Mao, H. Q., Hanes, J. S. & McDonnell, P. J., Jan 1 2017, In : Translational Vision Science and Technology. 6, 1, 1.

Research output: Contribution to journalArticle

Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation

Schneider, C. S., Xu, Q., Boylan, N. J., Chisholm, J., Tang, B. C., Schuster, B. S., Henning, A., Ensign-Hodges, L., Lee, E., Adstamongkonkul, P., Simons, B. W., Wang, S. Y. S., Gong, X., Yu, T., Boyle, M. P., Suk, J. S. & Hanes, J. S., Apr 1 2017, In : Science advances. 3, 4, e1601556.

Research output: Contribution to journalArticle

Preclinical evaluation of intravesical cisplatin nanoparticles for non–muscle-invasive bladder cancer

Kates, M., Date, A., Yoshida, T., Afzal, U., Kanvinde, P., Babu, T., Sopko, N. A., Matsui, H., Hahn, N., McConkey, D., Baras, A., Hanes, J. S., Ensign-Hodges, L. & Bivalacqua, T., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6592-6601 10 p.

Research output: Contribution to journalArticle

2016

Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus

Henry, C. E., Wang, Y. Y., Yang, Q., Hoang, T., Chattopadhyay, S., Hoen, T., Ensign-Hodges, L., Nunn, K. L., Schroeder, H., McCallen, J., Moench, T., Cone, R., Roffler, S. R. & Lai, S. K., Oct 1 2016, In : Acta Biomaterialia. 43, p. 61-70 10 p.

Research output: Contribution to journalArticle

Local enema treatment to inhibit FOLH1/GCPII as a novel therapy for inflammatory bowel disease

Date, A. A., Rais, R., Babu, T., Ortiz, J., Kanvinde, P., Thomas, A. G., Zimmermann, S. C., Gadiano, A. J., Halpert, G., Slusher, B. & Ensign-Hodges, L., Nov 24 2016, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces

Yu, T., Chisholm, J., Choi, W. J., Anonuevo, A., Pulicare, S., Zhong, W., Chen, M., Fridley, C., Lai, S. K., Ensign-Hodges, L., Suk, J. S. & Hanes, J. S., 2016, (Accepted/In press) In : Advanced healthcare materials.

Research output: Contribution to journalArticle

Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo

Maisel, K., Reddy, M., Xu, Q., Chattopadhyay, S., Cone, R., Ensign-Hodges, L. & Hanes, J. S., Jun 1 2016, In : Nanomedicine. 11, 11, p. 1337-1343 7 p.

Research output: Contribution to journalArticle

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

Date, A. A., Hanes, J. S. & Ensign-Hodges, L., Feb 26 2016, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

2015

Enema ion compositions for enhancing colorectal drug delivery

Maisel, K., Chattopadhyay, S., Moench, T., Hendrix, C., Cone, R., Ensign, L. M. & Hanes, J., May 17 2015, In : Journal of Controlled Release. 209, p. 280-287 8 p.

Research output: Contribution to journalArticle

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

Xu, Q., Ensign, L. M., Boylan, N. J., Schön, A., Gong, X., Yang, J. C., Lamb, N. W., Cai, S., Yu, T., Freire, E. & Hanes, J., Sep 22 2015, In : ACS Nano. 9, 9, p. 9217-9227 11 p.

Research output: Contribution to journalArticle

Liposome-based mucus-penetrating particles (MPP) for mucosal theranostics: Demonstration of diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI)

Yu, T., Chan, K. W. Y., Anonuevo, A., Song, X., Schuster, B. S., Chattopadhyay, S., Xu, Q., Oskolkov, N., Patel, H., Ensign, L. M., van Zjil, P. C. M., McMahon, M. T. & Hanes, J., Feb 1 2015, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 2, p. 401-405 5 p.

Research output: Contribution to journalArticle

Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles

Lu, H. D., Spiegel, A. C., Hurley, A., Perez, L. J., Maisel, K., Ensign, L. M., Hanes, J., Bassler, B. L., Semmelhack, M. F. & Prud'Homme, R. K., Apr 8 2015, In : Nano Letters. 15, 4, p. 2235-2241 7 p.

Research output: Contribution to journalArticle

2014

Hyaluronan in cervical epithelia protects against infection-mediated preterm birth

Akgul, Y., Word, R. A., Ensign, L. M., Yamaguchi, Y., Lydon, J., Hanes, J. & Mahendroo, M., Dec 1 2014, In : Journal of Clinical Investigation. 124, 12, p. 5481-5489 9 p.

Research output: Contribution to journalArticle

Pretreatment of human cervicovaginal mucus with pluronic F127 enhances nanoparticle penetration without compromising mucus barrier properties to herpes simplex virus

Ensign, L. M., Lai, S. K., Wang, Y. Y., Yang, M., Mert, O., Hanes, J. & Cone, R., Dec 8 2014, In : Biomacromolecules. 15, 12, p. 4403-4409 7 p.

Research output: Contribution to journalArticle

Vaginal Delivery of Paclitaxel via Nanoparticles with Non-Mucoadhesive Surfaces Suppresses Cervical Tumor Growth

Yang, M., Yu, T., Wang, Y. Y., Lai, S. K., Zeng, Q., Miao, B., Tang, B. C., Simons, B. W., Ensign, L. M., Liu, G., Chan, K. W. Y., Juang, C. Y., Mert, O., Wood, J., Fu, J., Mcmahon, M. T., Wu, T. C., Hung, C. F. & Hanes, J., Jul 2014, In : Advanced Healthcare Materials. 3, 7, p. 1044-1052 9 p.

Research output: Contribution to journalArticle

2013

Enhanced vaginal drug delivery through the use of hypotonic formulations that induce fluid uptake

Ensign, L. M., Hoen, T. E., Maisel, K., Cone, R. A. & Hanes, J. S., Sep 1 2013, In : Biomaterials. 34, 28, p. 6922-6929 8 p.

Research output: Contribution to journalArticle

Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues

Ensign, L. M., Henning, A., Schneider, C. S., Maisel, K., Wang, Y. Y., Porosoff, M. D., Cone, R. & Hanes, J., Jun 3 2013, In : Molecular Pharmaceutics. 10, 6, p. 2176-2182 7 p.

Research output: Contribution to journalArticle

The microstructure and bulk rheology of human cervicovaginal mucus are remarkably resistant to changes in pH

Wang, Y. Y., Lai, S. K., Ensign, L. M., Zhong, W., Cone, R. & Hanes, J., Dec 9 2013, In : Biomacromolecules. 14, 12, p. 4429-4435 7 p.

Research output: Contribution to journalArticle

2012

A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles

Mert, O., Lai, S. K., Ensign, L., Yang, M., Wang, Y. Y., Wood, J. & Hanes, J., Feb 10 2012, In : Journal of Controlled Release. 157, 3, p. 455-460 6 p.

Research output: Contribution to journalArticle

Mucus penetrating nanoparticles: Biophysical tool and method of drug and gene delivery

Ensign, L. M., Schneider, C., Suk, J. S., Cone, R. & Hanes, J., Jul 24 2012, In : Advanced Materials. 24, 28, p. 3887-3894 8 p.

Research output: Contribution to journalArticle

Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus

Ensign, L. M., Tang, B. C., Wang, Y. Y., Tse, T. A., Hoen, T., Cone, R. & Hanes, J., Jun 13 2012, In : Science translational medicine. 4, 138, 138ra79.

Research output: Contribution to journalArticle

2009

The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles

Suk, J. S., Lai, S. K., Wang, Y. Y., Ensign, L. M., Zeitlin, P. L., Boyle, M. P. & Hanes, J., May 1 2009, In : Biomaterials. 30, 13, p. 2591-2597 7 p.

Research output: Contribution to journalArticle