Laura Delong Wood

Associate Professor

20052019
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Research Output 2005 2019

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Article
2019

Genetics of Familial and Sporadic Pancreatic Cancer

Wood, L. D., Yurgelun, M. B. & Goggins, M. S., May 1 2019, In : Gastroenterology. 156, 7, p. 2041-2055 15 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Genes
Carcinogenesis
Adenocarcinoma
Exome

Intraductal Papillary Mucinous Neoplasms Arise From Multiple Independent Clones, Each With Distinct Mutations

Fischer, C. G., Beleva Guthrie, V., Braxton, A. M., Zheng, L., Wang, P., Song, Q., Griffin, J. F., Chianchiano, P. E., Hosoda, W., Niknafs, N., Springer, S., Dal Molin, M., Masica, D., Scharpf, R. B., Thompson, E., He, J., Wolfgang, C., Hruban, R. H., Roberts, N., O'Broin-Lennon, A. M. & 3 others, Jiao, Y., Karchin, R. & Wood, L. D., Oct 1 2019, In : Gastroenterology. 157, 4, p. 1123-1137.e22

Research output: Contribution to journalArticle

Clone Cells
Mutation
Neoplasms
Carcinogenesis
Pancreatic Neoplasms

Perineural Invasion is a Strong Prognostic Moderator in Ampulla of Vater Carcinoma: A Meta-analysis

Luchini, C., Veronese, N., Nottegar, A., Riva, G., Pilati, C., Mafficini, A., Stubbs, B., Simbolo, M., Mombello, A., Corbo, V., Cheng, L., Yachida, S., Wood, L. D., Lawlor, R. T., Salvia, R. & Scarpa, A., Jan 1 2019, In : Pancreas. 48, 1, p. 70-76 7 p.

Research output: Contribution to journalArticle

Ampulla of Vater
Meta-Analysis
Confidence Intervals
Carcinoma
Recurrence

Prevalence of Germline Mutations Associated With Cancer Risk in Patients With Intraductal Papillary Mucinous Neoplasms

Skaro, M., Nanda, N., Gauthier, C., Felsenstein, M., Jiang, Z., Qiu, M., Shindo, K., Yu, J., Hutchings, D., Javed, A. A., Beckman, R., He, J., Wolfgang, C., Thompson, E., Hruban, R. H., Klein, A., Goggins, M. S., Wood, L. D. & Roberts, N., May 1 2019, In : Gastroenterology. 156, 6, p. 1905-1913 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Neoplasms
Pancreatic Neoplasms
Mutation
Confidence Intervals

Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood

Eissa, M. A. L., Lerner, L., Abdelfatah, E., Shankar, N., Canner, J. K., Hasan, N. M., Yaghoobi, V., Huang, B., Kerner, Z., Takaesu, F., Wolfgang, C., Kwak, R., Ruiz, M., Tam, M., Pisanic, T. R., Iacobuzio-Donahue, C. A., Hruban, R. H., He, J., Wang, T. H., Wood, L. D. & 2 others, Sharma, A. & Ahuja, N., Apr 5 2019, In : Clinical Epigenetics. 11, 1, 59.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Early Detection of Cancer
Methylation
Biomarkers
Area Under Curve

Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

Kuboki, Y., Fischer, C. G., Beleva Guthrie, V., Huang, W., Yu, J., Chianchiano, P., Hosoda, W., Zhang, H., Zheng, L., Shao, X., Thompson, E., Waters, K., Poling, J., He, J., Weiss, M. J., Wolfgang, C., Goggins, M. S., Hruban, R. H., Roberts, N., Karchin, R. & 1 others, Wood, L. D., Jan 1 2019, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Pancreatic Neoplasms
Neoplasms
Mutation
Genes

Telomere alterations in neurofibromatosis type 1-associated solid tumors

Rodriguez, F. J., Graham, M. K., Brosnan-Cashman, J. A., Barber, J. R., Davis, C., Vizcaino, M. A., Palsgrove, D. N., Giannini, C., Pekmezci, M., Dahiya, S., Gokden, M., Noë, M., Wood, L. D., Pratilas, C., Morris, C. D., Belzberg, A. J., Blakeley, J. & Heaphy, C. M., Aug 28 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Telomere Homeostasis
Neurofibromatosis 1
Telomere
Glioma
Neurilemmoma

The inverted appendix – a potentially problematic diagnosis: clinicopathologic analysis of 21 cases

Birkness, J., Lam-Himlin, D., Byrnes, K., Wood, L. D. & Voltaggio, L., Jan 1 2019, In : Histopathology.

Research output: Contribution to journalArticle

Polyps
Ganglia
Appendiceal Neoplasms
Mucous Membrane
Mucocele

Well-differentiated Pancreatic Neuroendocrine Tumor in a Patient with Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM)

Noë, M., Hackeng, W. M., De Leng, W. W. J., Vergeer, M., Vleggaar, F. P., Morsink, F. H. M., Wood, L. D., Hruban, R. H., Offerhaus, G. J. A. & Brosens, L. A. A., Jan 1 2019, In : American Journal of Surgical Pathology.

Research output: Contribution to journalArticle

Dysplastic Nevus Syndrome
Neuroendocrine Tumors
Germ-Line Mutation
Neurofibromatosis 2
p16 Genes

Why is pancreatic cancer so deadly? The pathologist's view

Hruban, R. H., Gaida, M. M., Thompson, E., Hong, S. M., Noë, M., Brosens, L. A. A., Jongepier, M., Offerhaus, G. J. A. & Wood, L. D., Jan 1 2019, In : Journal of Pathology.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
Pathologists
2018

A "clearer" View of Pancreatic Pathology: A Review of Tissue Clearing and Advanced Microscopy Techniques

Hong, S. M., Noë, M., Hruban, C. A., Thompson, E., Wood, L. D. & Hruban, R. H., Jan 1 2018, (Accepted/In press) In : Advances in Anatomic Pathology.

Research output: Contribution to journalArticle

Microscopy
Pathology
Anatomy
Light
Exocrine Pancreas

Analogous detection of circulating tumor cells using the AccuCyte®-CyteFinder® system and ISET system in patients with locally advanced and metastatic prostate cancer

van der Toom, E. E., Groot, V. P., Glavaris, S. A., Gemenetzis, G., Chalfin, H. J., Wood, L. D., Wolfgang, C., de la Rosette, J. J. M. C. H., de Reijke, T. M. & Pienta, K., Jan 1 2018, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Prostatic Neoplasms
Vimentin
Cell Count
Blood Group Antigens
Neoplasms
Adenocarcinoma
Logistic Models
Pancreatic Neoplasms
Pancreatic Ducts
Adenocarcinoma
Hematoxylin
Eosine Yellowish-(YS)
Smad4 Protein

Circulating Tumor Cells Dynamics in Pancreatic Adenocarcinoma Correlate With Disease Status: Results of the Prospective CLUSTER Study

Gemenetzis, G., Groot, V. P., Yu, J., Ding, D., Teinor, J. A., Javed, A. A., Wood, L. D., Burkhart, R., Cameron, J. L., Makary, M. A., Weiss, M. J., He, J. & Wolfgang, C., Sep 1 2018, In : Annals of surgery. 268, 3, p. 408-420 13 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Adenocarcinoma
Prospective Studies
Recurrence
Tumor Biomarkers

Clinical and Radiographic Gastrointestinal Abnormalities in McCune-Albright Syndrome

Robinson, C., Estrada, A., Zaheer, A., Singh, V., Wolfgang, C., Goggins, M. S., Hruban, R. H., Wood, L. D., Noë, M., Montgomery, E. A., Guthrie, L. C., O'Broin-Lennon, A. M., Boyce, A. M. & Collins, M. T., Nov 1 2018, In : The Journal of clinical endocrinology and metabolism. 103, 11, p. 4293-4303 11 p.

Research output: Contribution to journalArticle

Polyostotic Fibrous Dysplasia
Pathology
Magnetic resonance
Medical problems
Magnetic Resonance Cholangiopancreatography

Distinction of intrahepatic metastasis from multicentric carcinogenesis in multifocal hepatocellular carcinoma using molecular alterations

Chianchiano, P., Pezhouh, M. K., Kim, A., Luchini, C., Cameron, A. M., Weiss, M. J., He, J., Voltaggio, L., Oshima, K., Anders, R. A. & Wood, L. D., Feb 1 2018, In : Human Pathology. 72, p. 127-134 8 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Carcinogenesis
Neoplasm Metastasis
Mutation
Neoplasms

GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling

Ideno, N., Yamaguchi, H., Ghosh, B., Gupta, S., Okumura, T., Steffen, D. J., Fisher, C. G., Wood, L. D., Singhi, A. D., Nakamura, M., Gutkind, J. S. & Maitra, A., Nov 1 2018, In : Gastroenterology. 155, 5, p. 1593-1607.e12

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Doxycycline
Neoplasms
Pancreas

Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology

Noë, M., Rezaee, N., Asrani, K., Skaro, M., Groot, V. P., Wu, P. H., Olson, M. T., Hong, S. M., Kim, S. J., Weiss, M. J., Wolfgang, C., Makary, M. A., He, J., Cameron, J. L., Wirtz, D., Roberts, N., Offerhaus, G. J. A., Brosens, L. A. A., Wood, L. D. & Hruban, R. H., Jul 1 2018, In : American Journal of Pathology. 188, 7, p. 1530-1535 6 p.

Research output: Contribution to journalArticle

Pancreas
Anatomy
Pathology
Pancreatic Neoplasms
Paraffin

IPMNs with co-occurring invasive cancers: Neighbours but not always relatives

Felsenstein, M., Noë, M., Masica, D. L., Hosoda, W., Chianchiano, P., Fischer, C. G., Lionheart, G., Brosens, L. A. A., Pea, A., Yu, J., Gemenetzis, G., Groot, V. P., Makary, M. A., He, J., Weiss, M. J., Cameron, J. L., Wolfgang, C., Hruban, R. H., Roberts, N., Karchin, R. & 2 others, Goggins, M. S. & Wood, L. D., Mar 2 2018, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Neoplasms
Adenocarcinoma
Mucinous Adenocarcinoma
Carcinoma
Carcinoma, Intraductal, Noninfiltrating

Molecular alterations associated with metastases of solid pseudopapillary neoplasms of the pancreas

Amato, E., Mafficini, A., Hirabayashi, K., Lawlor, R. T., Fassan, M., Vicentini, C., Barbi, S., Delfino, P., Sikora, K., Rusev, B., Simbolo, M., Esposito, I., Antonello, D., Pea, A., Sereni, E., Ballotta, M., Maggino, L., Marchegiani, G., Ohike, N., Wood, L. D. & 5 others, Salvia, R., Klöppel, G., Zamboni, G., Scarpa, A. & Corbo, V., Jan 1 2018, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasm Metastasis
Mutation
Glucose Transporter Type 1
Exome

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschênes, A., Somerville, T. D. D., Froeling, F. E. M., Burkhart, R., Denroche, R. E., Jang, G. H., Miyabayashi, K., Young, C. M., Patel, H., Ma, M., Lacomb, J. F., Palmaira, R. L. D., Javed, A. A., Huynh, J. C., Johnson, M., Arora, K. & 50 others, Robine, N., Shah, M., Sanghvi, R., Goetz, A. B., Lowder, C. Y., Martello, L., Driehuis, E., Lecomte, N., Askan, G., Iacobuzio-Donahue, C. A., Clevers, H., Wood, L. D., Hruban, R. H., Thompson, E., Aguirre, A. J., Wolpin, B. M., Sasson, A., Kim, J., Wu, M., Bucobo, J. C., Allen, P., Sejpal, D. V., Nealon, W., Sullivan, J. D., Winter, J. M., Gimotty, P. A., Grem, J. L., Dimaio, D. J., Buscaglia, J. M., Grandgenett, P. M., Brody, J. R., Hollingsworth, M. A., O’kane, G. M., Notta, F., Kim, E., Crawford, J. M., Devoe, C., Ocean, A., Wolfgang, C., Yu, K. H., Li, E., Vakoc, C. R., Hubert, B., Fischer, S. E., Wilson, J. M., Moffitt, R., Knox, J., Krasnitz, A., Gallinger, S. & Tuveson, D. A., Sep 1 2018, In : Cancer Discovery. 8, 9, p. 1112-1129 18 p.

Research output: Contribution to journalArticle

Organoids
Pancreatic Neoplasms
Drug Therapy
Therapeutics
Precision Medicine

Pancreatic cancer arising in the remnant pancreas is not always a relapse of the preceding primary

Luchini, C., Pea, A., Yu, J., He, J., Salvia, R., Riva, G., Weiss, M. J., Bassi, C., Cameron, J. L., Hruban, R. H., Goggins, M. S., Wolfgang, C., Scarpa, A., Wood, L. D. & Lawlor, R. T., Jan 1 2018, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreas
Adenocarcinoma
Recurrence
Neoplasms

PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications

Luchini, C., Cros, J., Pea, A., Pilati, C., Veronese, N., Rusev, B., Capelli, P., Mafficini, A., Nottegar, A., Brosens, L. A. A., Noë, M., Offerhaus, G. J. A., Chianchiano, P., Riva, G., Piccoli, P., Parolini, C., Malleo, G., Lawlor, R. T., Corbo, V., Sperandio, N. & 5 others, Barbareschi, M., Fassan, M., Cheng, L., Wood, L. D. & Scarpa, A., Nov 1 2018, In : Human Pathology. 81, p. 157-165 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Giant Cells
Adenocarcinoma
Carcinoma
Neoplasms

Whole-exome sequencing of duodenal neuroendocrine tumors in patients with neurofibromatosis type 1

Noë, M., Pea, A., Luchini, C., Felsenstein, M., Barbi, S., Bhaijee, F., Yonescu, R., Ning, Y., Adsay, N. V., Zamboni, G., Lawlor, R. T., Scarpa, A., Offerhaus, G. J. A., Brosens, L. A. A., Hruban, R. H., Roberts, N. & Wood, L. D., May 30 2018, (Accepted/In press) In : Modern Pathology. p. 1-7 7 p.

Research output: Contribution to journalArticle

Exome
Neurofibromatosis 1
Neuroendocrine Tumors
Chromosomes, Human, Pair 22
Neoplasms
2017

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

Mello, S. S., Valente, L. J., Raj, N., Seoane, J. A., Flowers, B. M., McClendon, J., Bieging-Rolett, K. T., Lee, J., Ivanochko, D., Kozak, M. M., Chang, D. T., Longacre, T. A., Koong, A. C., Arrowsmith, C. H., Kim, S. K., Vogel, H., Wood, L. D., Hruban, R. H., Curtis, C. & Attardi, L. D., Oct 9 2017, In : Cancer Cell. 32, 4, p. 460-473.e6

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
p53 Genes
Transcriptional Activation
Mutation

Cancer-associated mutations in endometriosis without cancer

Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., Ho, J., Wu, R. C., Lac, V., Ogawa, H., Tessier-Cloutier, B., Alhassan, R., Wang, A., Wang, Y., Cohen, J. D., Wong, F. & 20 others, Hasanovic, A., Orr, N., Zhang, M., Popoli, M., McMahon, K. W., Wood, L. D., Mattox, A., Allaire, C., Segars, J., Williams, C., Tomasetti, C., Boyd, N., Kinzler, K. W., Gilks, C. B., Diaz, L., Wang, T-L., Vogelstein, B., Yong, P. J., Huntsman, D. G. & Shih, I. M., May 11 2017, In : New England Journal of Medicine. 376, 19, p. 1835-1848 14 p.

Research output: Contribution to journalArticle

Endometriosis
Mutation
Neoplasms
Epithelium
Exome

Circulating Epithelial Cells in Intraductal Papillary Mucinous Neoplasms and Cystic Pancreatic Lesions

Poruk, K. E., Valero, V., He, J., Ahuja, N., Cameron, J. L., Weiss, M. J., O'Broin-Lennon, A. M., Goggins, M. S., Wood, L. D. & Wolfgang, C., Aug 1 2017, In : Pancreas. 46, 7, p. 943-947 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Epithelial Cells
Keratins
Neoplasms
Pancreas

Circulating tumor cells expressing markers of tumor-initiating cells predict poor survival and cancer recurrence in patients with pancreatic ductal adenocarcinoma

Poruk, K. E., Blackford, A. L., Weiss, M. J., Cameron, J. L., He, J., Goggins, M. S., Rasheed, Z. A., Wolfgang, C. & Wood, L. D., Jun 1 2017, In : Clinical Cancer Research. 23, 11, p. 2681-2690 10 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Neoplastic Stem Cells
Adenocarcinoma
Recurrence
Survival

Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

Hosoda, W., Chianchiano, P., Griffin, J. F., Pittman, M. E., Brosens, L. A. A., Noë, M., Yu, J., Shindo, K., Suenaga, M., Rezaee, N., Yonescu, R., Ning, Y., Albores-Saavedra, J., Yoshizawa, N., Harada, K., Yoshizawa, A., Hanada, K., Yonehara, S., Shimizu, M., Uehara, T. & 6 others, Samra, J. S., Gill, A. J., Wolfgang, C., Goggins, M. S., Hruban, R. H. & Wood, L. D., May 1 2017, In : Journal of Pathology. 242, 1, p. 16-23 8 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Adenocarcinoma
Exome
Genes

Haplotype Counting for Sensitive Chimerism Testing: Potential for Early Leukemia Relapse Detection

Debeljak, M., Mocci, E., Morrison, M. C., Pallavajjalla, A., Beierl, K., Amiel, M., Noë, M., Wood, L. D., Lin, M-T., Gocke, C., Klein, A., Fuchs, E. J., Jones, R. J. & Eshleman, J., May 1 2017, In : Journal of Molecular Diagnostics. 19, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

Chimerism
Haplotypes
Leukemia
Recurrence
Bone Marrow Transplantation

High grade serous ovarian carcinomas originate in the fallopian tube

Labidi-Galy, S. I., Papp, E., Hallberg, D., Niknafs, N., Adleff, V., Noe, M., Bhattacharya, R., Novak, M., Jones, S., Phallen, J., Hruban, C. A., Hirsch, M. S., Lin, D. I., Schwartz, L., Maire, C. L., Tille, J. C., Bowden, M., Ayhan, A., Wood, L. D., Scharpf, R. B. & 6 others, Kurman, R. J., Wang, T-L., Shih, I. M., Karchin, R., Drapkin, R. & Velculescu, V. E., Dec 1 2017, In : Nature Communications. 8, 1, 1093.

Research output: Contribution to journalArticle

Fallopian Tubes
Carcinoma in Situ
Tumors
grade
cancer

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

Makohon-Moore, A. P., Zhang, M., Reiter, J. G., Bozic, I., Allen, B., Kundu, D., Chatterjee, K., Wong, F., Jiao, Y., Kohutek, Z. A., Hong, J., Attiyeh, M., Javier, B., Wood, L. D., Hruban, R. H., Nowak, M. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Iacobuzio-Donahue, C. A., Jan 16 2017, (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasm Metastasis
Mutation
Genes
Genome

Neat1 is a p53-inducible lincRNA essential for transformation suppression

Mello, S. S., Sinow, C., Raj, N., Mazur, P. K., Bieging-Rolett, K., Broz, D. K., Imam, J. F. C., Vogel, H., Wood, L. D., Sage, J., Hirose, T., Nakagawa, S., Rinn, J. & Attardi, L. D., 2017, In : Genes and Development. 31, 11, p. 1095-1108 14 p.

Research output: Contribution to journalArticle

p53 Genes
Neoplasms
Untranslated RNA
Chromatin Immunoprecipitation
Fibroblasts

Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma

Luchini, C., Pea, A., Lionheart, G., Mafficini, A., Nottegar, A., Veronese, N., Chianchiano, P., Brosens, L. A. A., Noë, M., Offerhaus, G. J. A., Yonescu, R., Ning, Y., Malleo, G., Riva, G., Piccoli, P., Cataldo, I., Capelli, P., Zamboni, G., Scarpa, A. & Wood, L. D., Oct 1 2017, In : Journal of Pathology. 243, 2, p. 148-154 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Giant Cells
Pancreas
Adenocarcinoma
Carcinoma

Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas

Wood, L. D., Noë, M., Hackeng, W., Brosens, L. A. A., Bhaijee, F., Debeljak, M., Yu, J., Suenaga, M., Singhi, A. D., Zaheer, A., Boyce, A., Robinson, C., Eshleman, J., Goggins, M. S., Hruban, R. H., Collins, M. T., O'Broin-Lennon, A. M. & Montgomery, E. A., Feb 10 2017, (Accepted/In press) In : Virchows Archiv. p. 1-10 10 p.

Research output: Contribution to journalArticle

Polyostotic Fibrous Dysplasia
Gastrointestinal Tract
Pancreas
Polyps
Esophagogastric Junction

PBRM1 loss is a late event during the development of cholangiocarcinoma

Luchini, C., Robertson, S. A., Hong, S. M., Felsenstein, M., Anders, R. A., Pea, A., Nottegar, A., Veronese, N., He, J., Weiss, M. J., Capelli, P., Scarpa, A., Argani, P., Kapur, P. & Wood, L. D., Sep 1 2017, In : Histopathology. 71, 3, p. 375-382 8 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Bile Pigments
Carcinogenesis
Mutation
Chromatin

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Genovese, G., Carugo, A., Tepper, J., Robinson, F. S., Li, L., Svelto, M., Nezi, L., Corti, D., Minelli, R., Pettazzoni, P., Gutschner, T., Wu, C. C., Seth, S., Akdemir, K. C., Leo, E., Amin, S., Molin, M. D., Ying, H., Kwong, L. N., Colla, S. & 23 others, Takahashi, K., Ghosh, P., Giuliani, V., Muller, F., Dey, P., Jiang, S., Garvey, J., Liu, C. G., Zhang, J., Heffernan, T. P., Toniatti, C., Fleming, J. B., Goggins, M. S., Wood, L. D., Sgambato, A., Agaimy, A., Maitra, A., Roberts, C. W. M., Wang, H., Viale, A., DePinho, R. A., Draetta, G. F. & Chin, L., Feb 16 2017, In : Nature. 542, 7641, p. 362-366 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Endoplasmic Reticulum Stress
Neoplasms
Unfolded Protein Response

The Almost-normal Liver Biopsy: Presentation, Clinical Associations, and Outcome

Czeczok, T. W., van Arnam, J. S., Wood, L. D., Torbenson, M. S. & Mounajjed, T., Jun 13 2017, (Accepted/In press) In : American Journal of Surgical Pathology.

Research output: Contribution to journalArticle

Biopsy
Liver
Differential Diagnosis
Biochemistry
Liver Diseases

The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

Begum, A., Ewachiw, T., Jung, C., Huang, A., Norberg, K. J., Marchionni, L., McMillan, R., Penchev, V., Rajeshkumar, N. V., Maitra, A., Wood, L. D., Wang, C., Wolfgang, C., De Jesus-Acosta, A., Laheru, D., Shapiro, I. M., Padval, M., Pachter, J. A., Weaver, D. T., Rasheed, Z. A. & 1 others, Matsui, W., Jul 1 2017, In : PLoS One. 12, 7, e0180181.

Research output: Contribution to journalArticle

non-specific protein-tyrosine kinase
Focal Adhesion Protein-Tyrosine Kinases
Neoplastic Stem Cells
adenocarcinoma
Stem cells
2016

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis

Hackeng, W. M., Brosens, L. A. A., Poruk, K. E., Noë, M., Hosoda, W., Poling, J. S., Rizzo, A., Campbell-Thompson, M., Atkinson, M. A., Konukiewitz, B., Klöppel, G., Heaphy, C. M., Meeker, A. K. & Wood, L. D., Oct 1 2016, In : Human Pathology. 56, p. 93-100 8 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Neuroendocrine Tumors
Telomere
Carcinogenesis
Fluorescence In Situ Hybridization

A robust nonlinear tissue-component discrimination method for computational pathology

Sarnecki, J. S., Burns, K., Wood, L. D., Waters, K. M., Hruban, R. H., Wirtz, D. & Wu, P. H., Apr 1 2016, In : Laboratory Investigation. 96, 4, p. 450-458 9 p.

Research output: Contribution to journalArticle

Pathology
Color
Tissue Fixation
Biomedical Research
Immunohistochemistry

Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma

Poruk, K. E., Valero, V., Saunders, T., Blackford, A. L., Griffin, J. F., Poling, J., Hruban, R. H., Anders, R. A., Herman, J., Zheng, L., Rasheed, Z. A., Laheru, D., Ahuja, N., Weiss, M. J., Cameron, J. L., Goggins, M. S., Iacobuzio-Donahue, C. A., Wood, L. D. & Wolfgang, C., Jan 7 2016, (Accepted/In press) In : Annals of Surgery.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Adenocarcinoma
Phenotype
Recurrence
Survival

Extranodal extension is an important prognostic parameter for both colonic and rectal cancer

Luchini, C., Nottegar, A., Pea, A., Solmi, M., Stubbs, B., Capelli, P., Sergi, G., Manzato, E., Fassan, M., Wood, L. D., Scarpa, A. & Veronese, N., May 1 2016, In : Annals of Oncology. 27, 5, p. 955-956 2 p., mdw051.

Research output: Contribution to journalArticle

Rectal Neoplasms
Colonic Neoplasms

Extranodal extension of lymph node metastasis is a marker of poor prognosis in oesophageal cancer: A systematic review with meta-analysis

Luchini, C., Wood, L. D., Cheng, L., Nottegar, A., Stubbs, B., Solmi, M., Capelli, P., Pea, A., Sergi, G., Manzato, E., Fassan, M., Bagante, F., Bollschweiler, E., Giacopuzzi, S., Kaneko, T., de Manzoni, G., Barbareschi, M., Scarpa, A. & Veronese, N., Jul 7 2016, (Accepted/In press) In : Journal of Clinical Pathology.

Research output: Contribution to journalArticle

Esophageal Neoplasms
Meta-Analysis
Lymph Nodes
Odds Ratio
Neoplasm Metastasis

Extranodal Extension of Nodal Metastases Is a Poor Prognostic Indicator in Gastric Cancer: a Systematic Review and Meta-analysis

Veronese, N., Fassan, M., Wood, L. D., Stubbs, B., Solmi, M., Capelli, P., Pea, A., Nottegar, A., Sergi, G., Manzato, E., Carraro, S., Maruzzo, M., Cataldo, I., Bagante, F., Barbareschi, M., Cheng, L., Bencivenga, M., de Manzoni, G. & Luchini, C., Jul 13 2016, (Accepted/In press) In : Journal of Gastrointestinal Surgery. p. 1-7 7 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Meta-Analysis
Confidence Intervals
Neoplasm Metastasis
Odds Ratio

Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma

Yachida, S., Wood, L. D., Suzuki, M., Takai, E., Totoki, Y., Kato, M., Luchini, C., Arai, Y., Nakamura, H., Hama, N., Elzawahry, A., Hosoda, F., Shirota, T., Morimoto, N., Hori, K., Funazaki, J., Tanaka, H., Morizane, C., Okusaka, T., Nara, S. & 20 others, Shimada, K., Hiraoka, N., Taniguchi, H., Higuchi, R., Oshima, M., Okano, K., Hirono, S., Mizuma, M., Arihiro, K., Yamamoto, M., Unno, M., Yamaue, H., Weiss, M. J., Wolfgang, C., Furukawa, T., Nakagama, H., Vogelstein, B., Kiyono, T., Hruban, R. H. & Shibata, T., Feb 8 2016, In : Cancer Cell. 29, 2, p. 229-240 12 p.

Research output: Contribution to journalArticle

Carcinoma
Asian Americans
Genes
Exome
Phenotype

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

Laklai, H., Miroshnikova, Y. A., Pickup, M. W., Collisson, E. A., Kim, G. E., Barrett, A. S., Hill, R. C., Lakins, J. N., Schlaepfer, D. D., Mouw, J. K., LeBleu, V. S., Roy, N., Novitskiy, S. V., Johansen, J. S., Poli, V., Kalluri, R., Iacobuzio-Donahue, C. A., Wood, L. D., Hebrok, M., Hansen, K. & 2 others, Moses, H. L. & Weaver, V. M., May 1 2016, In : Nature Medicine. 22, 5, p. 497-505 9 p.

Research output: Contribution to journalArticle

Tumors
Adenocarcinoma
Transforming Growth Factors
Fibrosis
Pancreatic Ductal Carcinoma

Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma

Rezaee, N., Barbon, C., Zaki, A., He, J., Salman, B., Hruban, R. H., Cameron, J. L., Herman, J. M., Ahuja, N., O'Broin-Lennon, A. M., Weiss, M. J., Wood, L. D. & Wolfgang, C., 2016, In : HPB. 18, 3, p. 236-246 11 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Survival
Pancreatic Neoplasms

Metastatic pancreatic adenocarcinoma associated with chronic calcific pancreatitis and a heterozygous SPINK1 N34S mutation

Moran, R. A., Klapheke, R., Jalaly, N. Y., Makary, M. A., Hirose, K., Goggins, M. S., Wood, L. D., Laheru, D., O'Broin-Lennon, A. M., Khashab, M. & Singh, V., Sep 1 2016, In : Pancreatology. 16, 5, p. 869-872 4 p.

Research output: Contribution to journalArticle

Serine Proteinase Inhibitors
Chronic Pancreatitis
Adenocarcinoma
Mutation
Pancreatic Neoplasms