Larissa Shimoda

Professor

19962020

Research output per year

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Research Output

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Article
2019

A nonapoptotic endothelial barrier-protective role for caspase-3

Suresh, K., Carino, K., Johnston, L., Servinsky, L., Machamer, C. E., Kolb, T. M., Lam, H., Dudek, S. M., An, S., Rane, M. J., Shimoda, L. & Damarla, M., Jun 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 6, p. L1118-L1126

Research output: Contribution to journalArticle

Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension

Suresh, K., Servinsky, L., Jiang, H., Bigham, Z., Zaldumbide, J., Huetsch, J. C., Kliment, C., Acoba, M. G., Kirsch, B. J., Claypool, S. M., Le, A., Damarla, M. & Shimoda, L. A., Jan 1 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 317, 5, p. L639-L652

Research output: Contribution to journalArticle

Open Access
2018

Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition

Barreto Ortiz, S., Hori, D., Nomura, Y., Yun, X., Jiang, H., Yong, H., Chen, J., Paek, S., Pandey, D., Sikka, G., Bhatta, A., Gillard, A., Steppan, J., Kim, J. H., Adachi, H., Barodka, V., Romer, L., An, S., Shimoda, L., Santhanam, L. & 1 others, Berkowitz, D. E., Jan 1 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 1, p. L93-L106

Research output: Contribution to journalArticle

Rho kinase and Na+/H+ exchanger mediate endothelin-1-induced pulmonary arterial smooth muscle cell proliferation and migration

Huetsch, J., Walker, J., Undem, C., Lade, J., Yun, X., Baksh, S., Jiang, H., Lai, N. & Shimoda, L., May 1 2018, In : Physiological Reports. 6, 9, e13698.

Research output: Contribution to journalArticle

2017

Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment

Lu, H., Chen, I., Shimoda, L., Park, Y., Zhang, C., Tran, L., Zhang, H. & Semenza, G. L., Feb 21 2017, In : Cell Reports. 18, 8, p. 1946-1957 12 p.

Research output: Contribution to journalArticle

2016

CD36 mediates H2O2-induced calcium influx in lung microvascular endothelial cells

Suresh, K., Servinsky, L., Reyes, J., Undem, C., Zaldumbide, J., Rentsendorj, O., Modekurty, S., Dodd-o, J. M., Scott, A. L., Pearse, D. B. & Shimoda, L., Dec 2 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 1, p. L143-L153

Research output: Contribution to journalArticle

Contribution of elevated intracellular calcium to pulmonary arterial myocyte alkalinization during chronic hypoxia

Undem, C., Luke, T. & Shimoda, L., Mar 1 2016, In : Pulmonary Circulation. 6, 1, p. 93-102 10 p.

Research output: Contribution to journalArticle

Inhibition of lipolysis ameliorates diabetic phenotype in a mouse model of obstructive sleep apnea

Weiszenstein, M., Shimoda, L., Koc, M., Seda, O. & Polak, J., Aug 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 2, p. 299-307 9 p.

Research output: Contribution to journalArticle

Lung circulation

Suresh, K. & Shimoda, L., Apr 1 2016, In : Comprehensive Physiology. 6, 2, p. 897-943 47 p.

Research output: Contribution to journalArticle

Role of Rho kinase and Na+/H+ exchange in hypoxia-induced pulmonary arterial smooth muscle cell proliferation and migration

Walker, J., Undem, C., Yun, X., Lade, J., Jiang, H. & Shimoda, L., Mar 1 2016, In : Physiological Reports. 4, 6

Research output: Contribution to journalArticle

2015

Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4

Suresh, K., Servinsky, L., Reyes, J., Baksh, S., Undem, C., Caterina, M., Pearse, D. B. & Shimoda, L. A., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 12, p. L1467-L1477

Research output: Contribution to journalArticle

System for exposing cultured cells to intermittent hypoxia utilizing gas permeable cultureware

Polak, J., Studer-Rabeler, K., McHugh, H., Hussain, M. A. & Shimoda, L. A., Jan 1 2015, In : General physiology and biophysics. 34, 3, p. 235-247 13 p.

Research output: Contribution to journalArticle

2014

Hypoxia-inducible factors regulate human and rat cystathionine â-synthase gene expression

Takano, N., Peng, Y. J., Kumar, G. K., Luo, W., Hu, H., Shimoda, L. A., Suematsu, M., Prabhakar, N. R. & Semenza, G. L., Mar 1 2014, In : Biochemical Journal. 458, 2, p. 203-211 9 p.

Research output: Contribution to journalArticle

Melanopsin mediates light-dependent relaxation in blood vessels

Sikka, G., Hussmann, G. P., Pandey, D., Cao, S., Hori, D., Park, J. T., Steppan, J., Kim, J. H., Barodka, V., Myers, A. C., Santhanam, L., Nyhan, D., Halushka, M. K., Koehler, R. C., Snyder, S. H., Shimoda, L. A. & Berkowitz, D. E., Dec 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 50, p. 17977-17982 6 p.

Research output: Contribution to journalArticle

Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3

Damarla, M., Parniani, A. R., Johnston, L., Maredia, H., Serebreni, L., Hamdan, O., Sidhaye, V. K., Shimoda, L. A., Myers, A. C., Crow, M. T., Schmidt, E. P., Machamer, C. E., Gaestel, M., Rane, M. J., Kolb, T. M., Kim, B. S., Damico, R. L. & Hassoun, P. M., May 2014, In : American journal of respiratory cell and molecular biology. 50, 5, p. 932-941 10 p.

Research output: Contribution to journalArticle

The aquaporin 1 C-terminal tail is required for migration and growth of pulmonary arterial myocytes

Lai, N., Lade, J., Leggett, K., Yun, X., Baksh, S., Chau, E., Crow, M. T., Sidhaye, V., Wang, J. & Shimoda, L. A., Jun 2014, In : American journal of respiratory cell and molecular biology. 50, 6, p. 1010-1020 11 p.

Research output: Contribution to journalArticle

2013

Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1

Pisarcik, S., Maylor, J., Lu, W., Yun, X., Undem, C., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Jun 11 2013, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 304, 8, p. L549-L561

Research output: Contribution to journalArticle

Intermittent hypoxia impairs glucose homeostasis in C57BL6/J mice: Partial improvement with Cessation of the exposure

Polak, J., Shimoda, L. A., Drager, L. F., Undem, C., McHugh, H., Polotsky, V. Y. & Punjabi, N. M., Oct 1 2013, In : Sleep. 36, 10, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

2012

Digoxin inhibits development of hypoxic pulmonary hypertension in mice

Abud, E. M., Maylor, J., Undem, C., Punjabi, A., Zaiman, A. L., Myers, A. C., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Jan 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 4, p. 1239-1244 6 p.

Research output: Contribution to journalArticle

Endothelin-1 Augments Na+/H+ Exchange Activity in Murine Pulmonary Arterial Smooth Muscle Cells via Rho Kinase

Undem, C., Rios, E. J., Maylor, J. & Shimoda, L. A., Sep 28 2012, In : PloS one. 7, 9, e46303.

Research output: Contribution to journalArticle

Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1

Leggett, K., Maylor, J., Undem, C., Lai, N., Lu, W., Schweitzer, K., King, L. S., Myers, A. C., Sylvester, J. T., Sidhaye, V. & Shimoda, L. A., Aug 15 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 303, 4, p. L343-L353

Research output: Contribution to journalArticle

Hypoxic pulmonary vasoconstriction

Sylvester, J. T., Shimoda, L. A., Aaronson, P. I. & Ward, J. P. T., Jan 2012, In : Physiological reviews. 92, 1, p. 367-520 154 p.

Research output: Contribution to journalArticle

Initial characterization of exstrophy bladder smooth muscle cells in culture

Suson, K. D., Stec, A. A., Shimoda, L. A. & Gearhart, J. P., Oct 1 2012, In : Journal of Urology. 188, 4 SUPPL., p. 1521-1527 7 p.

Research output: Contribution to journalArticle

Kinase-dependent activation of voltage-gated Ca 2+ channels by ET-1 in pulmonary arterial myocytes during chronic hypoxia

Luke, T., Maylor, J., Undem, C., Sylvester, J. T. & Shimoda, L. A., May 15 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 302, 10, p. L1128-L1139

Research output: Contribution to journalArticle

Transforming growth factor-β1 mediates migration in cultured human control and exstrophy bladder smooth muscle cells

Suson, K. D., Stec, A. A., Gearhart, J. P. & Shimoda, L. A., Jan 1 2012, In : Journal of Urology. 188, 4 SUPPL., p. 1528-1534 7 p.

Research output: Contribution to journalArticle

2011

A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension

Zaiman, A. L., Damico, R., Thoms-Chesley, A., Clark Files, D., Kesari, P., Johnston, L., Swaim, M., Mozammel, S., Myers, A. C., Halushka, M., El-Haddad, H., Shimoda, L. A., Peng, C. F., Hassoun, P. M., Champion, H. C., Kitsis, R. N. & Crow, M. T., Dec 6 2011, In : Circulation. 124, 23, p. 2533-2542 10 p.

Research output: Contribution to journalArticle

Control of TH17/Treg balance by hypoxia-inducible factor 1

Dang, E. V., Barbi, J., Yang, H. Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H. R., Luo, W., Zeller, K., Shimoda, L., Topalian, S. L., Semenza, G. L., Dang, C. V., Pardoll, D. M. & Pan, F., Sep 2 2011, In : Cell. 146, 5, p. 772-784 13 p.

Research output: Contribution to journalArticle

Enhancement of myofilament calcium sensitivity by acute hypoxia in rat distal pulmonary arteries

Weigand, L., Shimoda, L. A. & Sylvester, J. T., Sep 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 3, p. L380-L387

Research output: Contribution to journalArticle

Hypoxia. 4. Hypoxia and ion channel function

Shimoda, L. A. & Polak, J., May 1 2011, In : American Journal of Physiology - Cell Physiology. 300, 5, p. C951-C967

Research output: Contribution to journalArticle

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue

Rey, S., Luo, W., Shimoda, L. A. & Semenza, G. L., May 5 2011, In : Blood. 117, 18, p. 4988-4998 11 p.

Research output: Contribution to journalArticle

2010

Intermittent and sustained hypoxia induce a similar gene expression profile in human aortic endothelial cells

Polotsky, V. Y., Savransky, V., Bevans-Fonti, S., Reinke, C., Li, J., Grigoryev, D. N. & Shimoda, L. A., May 2010, In : Physiological Genomics. 41, 3, p. 306-314 9 p.

Research output: Contribution to journalArticle

T-cell activation under hypoxic conditions enhances IFN-γ secretion

Roman, J., Rangasamy, T., Guo, J., Sugunan, S., Meednu, N., Packirisamy, G., Shimoda, L. A., Golding, A., Semenza, G. & Georas, S. N., Jan 1 2010, In : American journal of respiratory cell and molecular biology. 42, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

2009
2008

Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K + channel expression in pulmonary arterial myocytes

Whitman, E. M., Pisarcik, S., Luke, T., Fallon, M., Wang, J., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Feb 1 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 2, p. L309-L318

Research output: Contribution to journalArticle

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

Zhang, H., Bosch-Marce, M., Shimoda, L. A., Yee, S. T., Jin, H. B., Wesley, J. B., Gonzalez, F. J. & Semenza, G. L., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 10892-10903 12 p.

Research output: Contribution to journalArticle

Role of the TGF-β/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension

Zaiman, A. L., Podowski, M., Medicherla, S., Gordy, K., Xu, F., Zhen, L., Shimoda, L. A., Neptune, E., Higgins, L., Murphy, A., Chakravarty, S., Protter, A., Sehgal, P. B., Champion, H. C. & Tuder, R. M., Apr 15 2008, In : American journal of respiratory and critical care medicine. 177, 8, p. 896-905 10 p.

Research output: Contribution to journalArticle

2007

Ca2+ signaling in hypoxic pulmonary vasoconstriction: Effects of myosin light chain and Rho kinase antagonists

Wang, J., Weigand, L., Foxson, J., Shimoda, L. A. & Sylvester, J. T., Sep 1 2007, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 293, 3, p. L674-L685

Research output: Contribution to journalArticle

Exon-based mapping of microarray probes: Recovering differential gene expression signal in underpowered hypoxia experiment

Grigoryev, D. N., Ma, S. F., Shimoda, L. A., Johns, R. A., Lee, B. & Garcia, J. G. N., Apr 1 2007, In : Molecular and Cellular Probes. 21, 2, p. 134-139 6 p.

Research output: Contribution to journalArticle

HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

Fukuda, R., Zhang, H., Kim, J. W., Shimoda, L., Dang, C. V. & Semenza, GL. L., Apr 6 2007, In : Cell. 129, 1, p. 111-122 12 p.

Research output: Contribution to journalArticle

Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition

Shimoda, L. A., Luke, T., Sylvester, J. T., Shih, H. W., Jain, A. & Swenson, E. R., Apr 1 2007, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, 4, p. L1002-L1012

Research output: Contribution to journalArticle