Kristin Bigos

Assistant Professor

20022016
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Research Output 2002 2016

2016

Differential response to risperidone in schizophrenia patients by KCNH2Genotype and drug metabolizer status

Heide, J., Zhang, F., Bigos, K., Mann, S. A., Carr, V. J., Weickert, C. S., Green, M. J., Weinberger, D. & Vandenberg, J. I., Jan 1 2016, In : American Journal of Psychiatry. 173, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

Risperidone
Schizophrenia
Antipsychotic Agents
Protein Isoforms
Genotype
2014

Differential effects of common variants in SCN2A on general cognitive ability, brain physiology, and messenger RNA expression in schizophrenia cases and control individuals

Dickinson, D., Straub, R. E., Trampush, J. W., Gao, Y., Feng, N., Xie, B., Shin, J. H., Lim, H. K., Ursini, G., Bigos, K., Kolachana, B., Hashimoto, R., Takeda, M., Baum, G. L., Rujescu, D., Callicott, J. H., Hyde, T., Berman, K. F., Kleinman, J. & Weinberger, D., 2014, In : JAMA Psychiatry. 71, 6, p. 647-656 10 p.

Research output: Contribution to journalArticle

Aptitude
Schizophrenia
Messenger RNA
Brain
Genotype
2012
Antipsychotic Agents
Schizophrenia
Protein Isoforms
olanzapine
Brain

Response to Warner letter

Zhang, F., Apud, J. A., Bigos, K. & Weinberger, D., Dec 1 2012, In : American Journal of Psychiatry. 169, 12, p. 1318-1319 2 p.

Research output: Contribution to journalArticle

2011

Genetic variation in CYP3A43 explains racial difference in olanzapine clearance

Bigos, K., Bies, R. R., Pollock, B. G., Lowy, J. J., Zhang, F. & Weinberger, D., Jun 2011, In : Molecular Psychiatry. 16, 6, p. 620-625 6 p.

Research output: Contribution to journalArticle

olanzapine
Antipsychotic Agents
Genotype
Clinical Medicine
Gene Frequency
2010

Genetic variation in CACNA1C affects brain circuitries related to mental illness

Bigos, K., Mattay, V., Callicott, J. H., Straub, R. E., Vakkalanka, R., Kolachana, B., Hyde, T., Lipska, B. K., Kleinman, J. & Weinberger, D., Sep 2010, In : Archives of General Psychiatry. 67, 9, p. 939-945 7 p.

Research output: Contribution to journalArticle

Schizophrenia
Brain
Single Nucleotide Polymorphism
Genotype
Magnetic Resonance Imaging

Imaging genetics-days of future past

Bigos, K. & Weinberger, D., Nov 2010, In : NeuroImage. 53, 3, p. 804-809 6 p.

Research output: Contribution to journalArticle

Brain
Genes
Genetic Polymorphisms
Individuality
Neuroimaging

Population pharmacokinetics of antipsychotics

Bigos, K., Bies, R. R., Marder, S. R. & Pollock, B. G., Jan 1 2010, Antipsychotic Trials in Schizophrenia: The CATIE Project. Cambridge University Press, p. 267-280 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Antipsychotic Agents
olanzapine
Pharmacokinetics
Risperidone
Pharmaceutical Preparations
2009

Dysregulation of neurosteroids in obsessive compulsive disorder

Bigos, K., Folan, M. M., Jones, M. R., Haas, G. L., Kroboth, F. J. & Kroboth, P. D., Jan 2009, In : Journal of Psychiatric Research. 43, 4, p. 442-445 4 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Obsessive-Compulsive Disorder
Neurotransmitter Agents
Hydrocortisone
Corticotropin-Releasing Hormone

Sex differences in the pharmacokinetics and pharmacodynamics of antidepressants: An updated review

Bigos, K., Pollock, B. G., Stankevich, B. A. & Bies, R. R., Dec 2009, In : Gender Medicine. 6, 4, p. 522-543 22 p.

Research output: Contribution to journalArticle

Sex Characteristics
Antidepressive Agents
Pharmacokinetics
mental illness
edition
2008

Acute 5-HT reuptake blockade potentiates human amygdala reactivity

Bigos, K., Pollock, B. G., Aizenstein, H. J., Fisher, P. M., Bies, R. R. & Hariri, A. R., Dec 2008, In : Neuropsychopharmacology. 33, 13, p. 3221-3225 5 p.

Research output: Contribution to journalArticle

Amygdala
Serotonin
Citalopram
Psychiatry
Psychomotor Agitation

Pharmacokinetics in geriatric psychiatry

Bigos, K., Chew, M. L. & Bies, R. R., Feb 2008, In : Current Psychiatry Reports. 10, 1, p. 30-36 7 p.

Research output: Contribution to journalArticle

Geriatric Psychiatry
Pharmacokinetics
Psychiatry
Pharmaceutical Preparations
Aptitude

Sex, race, and smoking impact olanzapine exposure

Bigos, K., Pollock, B. G., Coley, K. C., Miller, D. D., Marder, S. R., Aravagiri, M., Kirshner, M. A., Schneider, L. S. & Bies, R. R., Feb 2008, In : Journal of Clinical Pharmacology. 48, 2, p. 157-165 9 p.

Research output: Contribution to journalArticle

olanzapine
Smoking
Antipsychotic Agents
Pharmaceutical Preparations
Population

Suboptimal aminoglycoside dosing in critically ill patients

Rea, R. S., Capitano, B., Bies, R., Bigos, K., Smith, R. & Lee, H., Dec 2008, In : Therapeutic Drug Monitoring. 30, 6, p. 674-681 8 p.

Research output: Contribution to journalArticle

Aminoglycosides
Critical Illness
Microbial Sensitivity Tests
Tobramycin
Intensive Care Units
2007

Neuroimaging: Technologies at the Interface of Genes, Brain, and Behavior

Bigos, K. & Hariri, A. R., Nov 2007, In : Neuroimaging Clinics of North America. 17, 4, p. 459-467 9 p.

Research output: Contribution to journalArticle

Neuroimaging
Technology
Neurobiology
Brain
Genetic Polymorphisms
2006

Decreasing pain and anxiety associated with patient-activated atrial shock: A placebo-controlled study of adjunctive sedation with oral triazolam

Fabian, T. J., Schwartzman, D. S., Ujhelyi, M. R., Corey, S. E., Bigos, K., Pollock, B. G. & Kroboth, P. D., Apr 2006, In : Journal of Cardiovascular Electrophysiology. 17, 4, p. 391-395 5 p.

Research output: Contribution to journalArticle

Triazolam
Shock
Anxiety
Placebos
Pain

Population pharmacokinetics in geriatric psychiatry

Bigos, K., Bies, R. R. & Pollock, B. G., Dec 2006, In : American Journal of Geriatric Psychiatry. 14, 12, p. 993-1003 11 p.

Research output: Contribution to journalArticle

Geriatric Psychiatry
Pharmacokinetics
Population
Pharmaceutical Preparations
Aptitude
2004

Gender and Antidepressants

Bies, R. R., Bigos, K. & Pollock, B. G., 2004, Principles of Gender-Specific Medicine. Elsevier Inc., Vol. 2. p. 860-868 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Antidepressive Agents
Hormones
Epidemiology
Pharmacokinetics
Depression
2003

Gender differences in the pharmacokinetics and pharmacodynamics of antidepressants

Bies, R. R., Bigos, K. & Pollock, B. G., 2003, In : Journal of Gender-Specific Medicine. 6, 3, p. 12-20 9 p.

Research output: Contribution to journalArticle

Women's Health
Menopause
Antidepressive Agents
Pharmacokinetics

Influence of DHEA administration on 24-hour cortisol concentrations

Kroboth, P. D., Amico, J. A., Stone, R. A., Folan, M., Frye, R. F., Kroboth, F. J., Bigos, K., Fabian, T. J., Linares, A. M., Pollock, B. G. & Hakala, C., Feb 2003, In : Journal of Clinical Psychopharmacology. 23, 1, p. 96-99 4 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Hydrocortisone
Placebos
Cross-Over Studies
Area Under Curve
2002

The influence of hormones and pharmaceutical agents on DHEA and DHEA-S concentrations: A review of clinical studies

Salek, F. S., Bigos, K. & Kroboth, P. D., 2002, In : Journal of Clinical Pharmacology. 42, 3, p. 247-266 20 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Hormones
Pharmaceutical Preparations
Androgens
Clinical Studies