Kornel Schuebel

Research Associate

19962018
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Research Output 1996 2018

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Article
2018

Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling

Xin, W., Schuebel, K., Jair, K. W., Cimbro, R., De Biase, L. M., Goldman, D. & Bonci, A., Jan 1 2018, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Mesencephalon
Astrocytes
Dopaminergic Neurons
Calcium
2017

A four-gene promoter methylation marker panel consisting of GREM1, NEURL, LAD1, and NEFH predicts survival of clear cell renal cell cancer patients

Van Vlodrop, I. J. H., Joosten, S. C., De Meyer, T., Smits, K. M., Van Neste, L., Melotte, V., Baldewijns, M. M. L. L., Schouten, L. J., Van Den Brandt, P. A., Jeschke, J., Yi, J. M., Schuebel, K., Ahuja, N., Herman, J. G., Aarts, M. J., Bosman, F. T., Van Criekinge, W. & Van Engeland, M., Apr 15 2017, In : Clinical Cancer Research. 23, 8, p. 2006-2018 13 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Methylation
Cell Survival
Genes
Confidence Intervals

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia

De Biase, L. M., Schuebel, K., Fusfeld, Z. H., Jair, K., Hawes, I. A., Cimbro, R., Zhang, H., Liu, Q. R., Shen, H., Xi, Z. X., Goldman, D. & Bonci, A., Jul 19 2017, In : Neuron. 95, 2, p. 341-356.e6

Research output: Contribution to journalArticle

Microglia
Basal Ganglia
Cues
Phenotype
Lysosomes

The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder

Dubey, N., Hoffman, J. F., Schuebel, K., Yuan, Q., Martinez, P. E., Nieman, L. K., Rubinow, D. R., Schmidt, P. J. & Goldman, D., Aug 1 2017, In : Molecular Psychiatry. 22, 8, p. 1172-1184 13 p.

Research output: Contribution to journalArticle

Steroids
Genes
Hormones
Transcriptome
Messenger RNA

The influence of FKBP5 genotype on expression of FKBP5 and other glucocorticoid-regulated genes, dependent on trauma exposure

Yeo, S., Enoch, M. A., Gorodetsky, E., Akhtar, L., Schuebel, K., Roy, A. & Goldman, D., Feb 1 2017, In : Genes, Brain and Behavior. 16, 2, p. 223-232 10 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Glucocorticoids
Genotype
Wounds and Injuries
Genes
2015

Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms

Mukhopadhyay, B., Schuebel, K., Mukhopadhyay, P., Cinar, R., Godlewski, G., Xiong, K., Mackie, K., Lizak, M., Yuan, Q., Goldman, D. & Kunos, G., May 1 2015, In : Hepatology. 61, 5, p. 1615-1626 12 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Hepatocellular Carcinoma
Indoleamine-Pyrrole 2,3,-Dioxygenase
Endocannabinoids
Neoplasms

DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity

Barbier, E., Tapocik, J. D., Juergens, N., Pitcairn, C., Borich, A., Schank, J. R., Sun, H., Schuebel, K., Zhou, Z., Yuan, Q., Vendruscolo, L. F., Goldman, D. & Heilig, M., Jan 1 2015, In : Journal of Neuroscience. 35, 15, p. 6153-6164 12 p.

Research output: Contribution to journalArticle

DNA Methylation
Prefrontal Cortex
Alcoholism
Synaptotagmin II
Alcohols

Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer

Calmon, M. F., Jeschke, J., Zhang, W., Dhir, M., Siebenkäs, C., Herrera, A., Tsai, H. C., O’Hagan, H. M., Pappou, E. P., Hooker, C. M., Fu, T., Schuebel, K., Gabrielson, E., Rahal, P., Herman, J. G., Baylin, S. B. & Ahuja, N., Jan 1 2015, In : Epigenetics. 10, 7, p. 622-632 11 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Gene Silencing
Epigenomics
Breast Neoplasms
Phenotype

Spectrin repeat containing nuclear envelope 1 and forkhead box protein E1 are promising markers for the detection of colorectal cancer in blood

Melotte, V., Yi, J. M., Lentjes, M. H. F. M., Smits, K. M., Van Neste, L., Niessen, H. E. C., Wouters, K. A. D., Louwagie, J., Schuebel, K., Herman, J. G., Baylin, S. B., Van Criekinge, W., Meijer, G. A., Ahuja, N. & Van Engeland, M., Feb 1 2015, In : Cancer Prevention Research. 8, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Spectrin
Nuclear Envelope
Colorectal Neoplasms
Confidence Intervals
2014

Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer

Wrangle, J., Machida, E. O., Danilova, L. V., Hulbert, A., Franco, N., Zhang, W., Glöckner, S. C., Tessema, M., Van Neste, L., Easwaran, H., Schuebel, K., Licchesi, J., Hooker, C. M., Ahuja, N., Amano, J., Belinsky, S. A., Baylin, S. B., Herman, J. G. & Brock, M. V., Apr 1 2014, In : Clinical Cancer Research. 20, 7, p. 1856-1864 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Methylation
Lung Neoplasms
Neoplasms
Atlases
2013

Frequent inactivation of Cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines

Jeschke, J., O'Hagan, H. M., Zhang, W., Vatapalli, R., Calmon, M. F., Danilova, L. V., Nelkenbrecher, C., Van Neste, L., Bijsmans, I. T. G. W., Van Engeland, M., Gabrielson, E., Schuebel, K., Winterpacht, A., Baylin, S. B., Herman, J. G. & Ahuja, N., Jun 15 2013, In : Clinical Cancer Research. 19, 12, p. 3201-3211 11 p.

Research output: Contribution to journalArticle

Cysteine Dioxygenase
Anthracyclines
Breast Neoplasms
DNA Methylation
Reactive Oxygen Species
2012

Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen

Jeschke, J., Van Neste, L., Glöckner, S. C., Dhir, M., Calmon, M. F., Deregowski, V., Van Criekinge, W., Vlassenbroeck, I., Koch, A., Chan, T. A., Cope, L., Hooker, C. M., Schuebel, K., Gabrielson, E., Winterpacht, A., Baylin, S. B., Herman, J. G. & Ahuja, N., Jul 2012, In : Epigenetics. 7, 7, p. 701-709 9 p.

Research output: Contribution to journalArticle

Biomarkers
Breast Neoplasms
Methylation
Genes
Neoplasm Genes
2011

Genomic and epigenomic integration identifies a prognostic signature in colon cancer

Yi, J. M., Dhir, M., Van Neste, L., Downing, S. R., Jeschke, J., Glockner, S. C., Calmon, M. D. F., Hooker, C. M., Funes, J. M., Boshoff, C., Smits, K. M., Van Engeland, M., Weijenberg, M. P., Iacobuzio-Donahue, C. A., Herman, J. G., Schuebel, K., Baylin, S. B. & Ahuja, N., Mar 15 2011, In : Clinical Cancer Research. 17, 6, p. 1535-1545 11 p.

Research output: Contribution to journalArticle

Epigenomics
Colonic Neoplasms
Colorectal Neoplasms
DNA Methylation
Extracellular Matrix

Hyperactivation of anandamide synthesis and regulation of cell-Cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver

Mukhopadhyay, B., Cinar, R., Yin, S., Liu, J., Tam, J., Godlewski, G., Harvey-White, J., Mordi, I., Cravatt, B. F., Lotersztajn, S., Gao, B., Yuan, Q., Schuebel, K., Goldman, D. & Kunos, G., Apr 12 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 6323-6328 6 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Cell Cycle
Liver
Endocannabinoids
Liver Regeneration
2010

Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus

Easwaran, H., Van Neste, L., Cope, L., Sen, S., Mohammad, H. P., Pageau, G. J., Lawrence, J. B., Herman, J. G., Schuebel, K. & Baylin, S. B., Oct 15 2010, In : Cancer Research. 70, 20, p. 8015-8024 10 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Chromatin
Gene Silencing
CpG Islands
Neoplasms

A bioinformatics pipeline for cancer epigenetics

van Neste, L., Herman, J. G., Schuebel, K., Cope, L., Baylin, S. B., van Criekinge, W. & Ahuja, N., 2010, In : Current Bioinformatics. 5, 3, p. 153-163 11 p.

Research output: Contribution to journalArticle

Bioinformatics
Computational Biology
Epigenomics
Biology
Cancer

Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells

Ohm, J. E., Mali, P., Van Neste, L., Berman, D. M., Liang, L., Pandiyan, K., Briggs, K. J., Zhang, W., Argani, P., Simons, B., Yu, W., Matsui, W., Van Criekinge, W., Rassool, F. V., Zambidis, E., Schuebel, K., Cope, L., Yen, J., Mohammad, H. P., Cheng, L. & 1 others, Baylin, S. B., Oct 1 2010, In : Cancer Research. 70, 19, p. 7662-7673 12 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Epigenomics
Gene Silencing
Carcinogenesis
Neoplasms

Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma

Van Vlodrop, I. J. H., Baldewijns, M. M. L., Smits, K. M., Schouten, L. J., Van Neste, L., Van Criekinge, W., Van Poppel, H., Lerut, E., Schuebel, K., Ahuja, N., Herman, J. G., De Bruïne, A. P. & Van Engeland, M., Feb 2010, In : American Journal of Pathology. 176, 2, p. 575-584 10 p.

Research output: Contribution to journalArticle

CpG Islands
Renal Cell Carcinoma
Methylation
Confidence Intervals
Neoplasms
2009

Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers

Tessema, M., Yu, Y. Y., Stidley, C. A., Machida, E. O., Schuebel, K., Baylin, S. B. & Belinsky, S. A., 2009, In : Carcinogenesis. 30, 7, p. 1132-1138 7 p.

Research output: Contribution to journalArticle

Methylation
Genes
Neoplasms
Adenocarcinoma of lung
Bronchoscopy

Methylation of TFPI2 in stool DNA: A potential novel biomarker for the detection of colorectal cancer

Glöckner, S. C., Dhir, M., Joo, M. Y., McGarvey, K. E., Van Neste, L., Louwagie, J., Chan, T. A., Kleeberger, W., De Bruïne, A. P., Smits, K. M., Khalid-de Bakker, C. A. J., Jonkers, D. M. A. E., Stockbrügger, R. W., Meijer, G. A., Oort, F. A., Iacobuzio-Donahue, C., Bierau, K., Herman, J. G., Baylin, S. B., Van Engeland, M. & 2 others, Schuebel, K. & Ahuja, N., Jun 1 2009, In : Cancer Research. 69, 11, p. 4691-4699 9 p.

Research output: Contribution to journalArticle

Methylation
Colorectal Neoplasms
Biomarkers
DNA
Choristoma
2008

Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors

Joo, M. Y., Tsai, H. C., Glöckner, S. C., Lin, S., Ohm, J. E., Easwaran, H., James, C. D., Costello, J. F., Riggins, G. J., Eberhart, C. G., Laterra, J. J., Vescovi, A. L., Ahuja, N., Herman, J. G., Schuebel, K. & Baylin, S. B., Oct 1 2008, In : Cancer Research. 68, 19, p. 8094-8103 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Glioblastoma
Colorectal Neoplasms
Histone Code
Neoplasms

A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells

Ting, A. H., Suzuki, H., Cope, L., Schuebel, K., Lee, B. H., Toyota, M., Imai, K., Shinomura, Y., Tokino, T. & Baylin, S. B., Apr 15 2008, In : Cancer Research. 68, 8, p. 2570-2575 6 p.

Research output: Contribution to journalArticle

CpG Islands
Gene Silencing
HCT116 Cells
Neoplasms
DNA

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

McLendon, R., Friedman, A., Bigner, D., Van Meir, E. G., Brat, D. J., Mastrogianakis, G. M., Olson, J. J., Mikkelsen, T., Lehman, N., Aldape, K., Yung, W. K. A., Bogler, O., Weinstein, J. N., VandenBerg, S., Berger, M., Prados, M., Muzny, D., Morgan, M., Scherer, S., Sabo, A. & 211 others, Nazareth, L., Lewis, L., Hall, O., Zhu, Y., Ren, Y., Alvi, O., Yao, J., Hawes, A., Jhangiani, S., Fowler, G., San Lucas, A., Kovar, C., Cree, A., Dinh, H., Santibanez, J., Joshi, V., Gonzalez-Garay, M. L., Miller, C. A., Milosavljevic, A., Donehower, L., Wheeler, D. A., Gibbs, R. A., Cibulskis, K., Sougnez, C., Fennell, T., Mahan, S., Wilkinson, J., Ziaugra, L., Onofrio, R., Bloom, T., Nicol, R., Ardlie, K., Baldwin, J., Gabriel, S., Lander, E. S., Ding, L., Fulton, R. S., McLellan, M. D., Wallis, J., Larson, D. E., Shi, X., Abbott, R., Fulton, L., Chen, K., Koboldt, D. C., Wendl, M. C., Meyer, R., Tang, Y., Lin, L., Osborne, J. R., Dunford-Shore, B. H., Miner, T. L., Delehaunty, K., Markovic, C., Swift, G., Courtney, W., Pohl, C., Abbott, S., Hawkins, A., Leong, S., Haipek, C., Schmidt, H., Wiechert, M., Vickery, T., Scott, S., Dooling, D. J., Chinwalla, A., Weinstock, G. M., Mardis, E. R., Wilson, R. K., Getz, G., Winckler, W., Verhaak, R. G. W., Lawrence, M. S., O'Kelly, M., Robinson, J., Alexe, G., Beroukhim, R., Carter, S., Chiang, D., Gould, J., Gupta, S., Korn, J., Mermel, C., Mesirov, J., Monti, S., Nguyen, H., Parkin, M., Reich, M., Stransky, N., Weir, B. A., Garraway, L., Golub, T., Meyerson, M., Chin, L., Protopopov, A., Zhang, J., Perna, I., Aronson, S., Sathiamoorthy, N., Ren, G., Yao, J., Wiedemeyer, W. R., Kim, H., Sek, W. K., Xiao, Y., Kohane, I. S., Seidman, J., Park, P. J., Kucherlapati, R., Laird, P. W., Cope, L., Herman, J. G., Weisenberger, D. J., Pan, F., Van Den Berg, D., Van Neste, L., Joo, M. Y., Schuebel, K., Baylin, S. B., Absher, D. M., Li, J. Z., Southwick, A., Brady, S., Aggarwal, A., Chung, T., Sherlock, G., Brooks, J. D., Myers, R. M., Spellman, P. T., Purdom, E., Jakkula, L. R., Lapuk, A. V., Marr, H., Dorton, S., Yoon, G. C., Han, J., Ray, A., Wang, V., Durinck, S., Robinson, M., Wang, N. J., Vranizan, K., Peng, V., Van Name, E., Fontenay, G. V., Ngai, J., Conboy, J. G., Parvin, B., Feiler, H. S., Speed, T. P., Gray, J. W., Brennan, C., Socci, N. D., Olshen, A., Taylor, B. S., Lash, A., Schultz, N., Reva, B., Antipin, Y., Stukalov, A., Gross, B., Cerami, E., Wei, Q. W., Qin, L. X., Seshan, V. E., Villafania, L., Cavatore, M., Borsu, L., Viale, A., Gerald, W., Sander, C., Ladanyi, M., Perou, C. M., Hayes, D. N., Topal, M. D., Hoadley, K. A., Qi, Y., Balu, S., Shi, Y., Wu, J., Penny, R., Bittner, M., Shelton, T., Lenkiewicz, E., Morris, S., Beasley, D., Sanders, S., Kahn, A., Sfeir, R., Chen, J., Nassau, D., Feng, L., Hickey, E., Barker, A., Gerhard, D. S., Vockley, J., Compton, C., Vaught, J., Fielding, P., Ferguson, M. L., Schaefer, C., Zhang, J., Madhavan, S., Buetow, K. H., Collins, F., Good, P., Guyer, M., Ozenberger, B., Peterson, J. & Thomson, E., Oct 23 2008, In : Nature. 455, 7216, p. 1061-1068 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Atlases
Genes
DNA Methylation
Neoplasms

Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis

Chan, T. A., Glockner, S., Joo, M. Y., Chen, W., Van Neste, L., Cope, L., Herman, J. G., Velculescu, V. E., Schuebel, K., Ahuja, N. & Baylin, S. B., May 2008, In : PLoS Medicine. 5, 5, p. 823-837 15 p., e114.

Research output: Contribution to journalArticle

Neoplasm Genes
Epigenomics
Mutation
Neoplasms
Genes

Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells

McGarvey, K. M., Van Neste, L., Cope, L., Ohm, J. E., Herman, J. G., Van Criekinge, W., Schuebel, K. & Baylin, S. B., Jul 15 2008, In : Cancer Research. 68, 14, p. 5753-5759 7 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Chromatin
DNA
Genes
Gene Expression

Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer

Zhang, W., Glöckner, S. C., Guo, M., Machida, E. O., Wang, D. H., Easwaran, H., Van Neste, L., Herman, J. G., Schuebel, K., Watkins, D. N., Ahuja, N. & Baylin, S. B., Apr 15 2008, In : Cancer Research. 68, 8, p. 2764-2772 9 p.

Research output: Contribution to journalArticle

Epigenomics
Colorectal Neoplasms
CpG Islands
Genes
Cell Line

Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia

Dhir, M., Montgomery, E. A., Glöckner, S. C., Schuebel, K., Hooker, C. M., Herman, J. G., Baylin, S. B., Gearhart, S. L. & Ahuja, N., Oct 2008, In : Journal of Gastrointestinal Surgery. 12, 10, p. 1745-1753 9 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Epigenomics
Genes
Neoplasms
Methylation
2007

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

Ohm, J. E., McGarvey, K. M., Yu, X., Cheng, L., Schuebel, K., Cope, L., Mohammad, H. P., Chen, W., Daniel, V. C., Yu, W., Berman, D. M., Jenuwein, T., Pruitt, K., Sharkis, S. J., Watkins, D. N., Herman, J. G. & Baylin, S. B., Feb 2007, In : Nature Genetics. 39, 2, p. 237-242 6 p.

Research output: Contribution to journalArticle

Tumor Suppressor Genes
Chromatin
Stem Cells
DNA
Neoplasms

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer

Schuebel, K., Chen, W., Cope, L., Glöckner, S. C., Suzuki, H., Yi, J. M., Chan, T. A., Van Neste, L., Van Criekinge, W., Van Den Bosch, S., Van Engeland, M., Ting, A. H., Jair, K., Yu, W., Toyota, M., Imai, K., Ahuja, N., Herman, J. G. & Baylin, S. B., Sep 2007, In : PLoS Genetics. 3, 9, p. 1709-1723 15 p.

Research output: Contribution to journalArticle

colorectal neoplasms
Colorectal Neoplasms
mutation
cancer
DNA

Genomic biology: The epigenomic era opens

Baylin, S. B. & Schuebel, K., Aug 2 2007, In : Nature. 448, 7153, p. 548-549 2 p.

Research output: Contribution to journalArticle

Product Packaging
Epigenomics
Genome
DNA
Proteins

Molecular genetic analyses of human endogenous retroviral elements belonging to the HERV-P family in primates, human tissues, and cancer cells

Yi, J. M., Schuebel, K. & Kim, H. S., Jan 1 2007, In : Genomics. 89, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Primates
Molecular Biology
Neoplasms
Genes
Gene Duplication
2006

CIMPle origin for promoter hypermethylation in colorectal cancer?

Schuebel, K., Chen, W. & Baylin, S. B., Jul 2006, In : Nature Genetics. 38, 7, p. 738-740 3 p.

Research output: Contribution to journalArticle

CpG Islands
Colorectal Neoplasms
Gene Silencing
DNA Methylation
Phenotype

De novo CpG island methylation in human cancer cells

Jair, K. W., Bachman, K. E., Suzuki, H., Ting, A. H., Rhee, I., Yen, R-W., Baylin, S. B. & Schuebel, K., Jan 15 2006, In : Cancer Research. 66, 2, p. 682-692 11 p.

Research output: Contribution to journalArticle

CpG Islands
Methylation
Methyltransferases
DNA Methylation
Neoplasms

Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation

Ting, A. H., Jair, K. W., Schuebel, K. & Baylin, S. B., Jan 15 2006, In : Cancer Research. 66, 2, p. 729-735 7 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Methyltransferases
DNA
Small Interfering RNA
Gene Silencing
2005

In living color: DNA methyltransferase caught in the act

Schuebel, K. & Baylin, S. B., Oct 2005, In : Nature Methods. 2, 10, p. 736-738 3 p.

Research output: Contribution to journalArticle

Fluorescence Recovery After Photobleaching
Methyltransferases
Epigenomics
Color
Cell Membrane

Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling

Nakakura, E. K., Sriuranpong, V. R., Kunnimalaiyaan, M., Hsiao, E. C., Schuebel, K., Borges, M. W., Jin, N., Collins, B., Nelkin, B. D., Chen, H. & Ball, D. W., Jul 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4350-4356 7 p.

Research output: Contribution to journalArticle

Carcinoid Tumor
Tumors
Cells
Serotonin
Tissue

Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation

Ting, A. H., Schuebel, K., Herman, J. G. & Baylin, S. B., Aug 2005, In : Nature Genetics. 37, 8, p. 906-910 5 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Gene Silencing
DNA Methylation
Neoplasms
Plant RNA
2004

CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1

Ting, A. H., Jair, K. W., Suzuki, H., Yen, R-W., Baylin, S. B. & Schuebel, K., Jun 2004, In : Nature Genetics. 36, 6, p. 582-584 3 p.

Research output: Contribution to journalArticle

CpG Islands
RNA Interference
Colorectal Neoplasms
Methyltransferases
Colonic Neoplasms

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

Suzuki, H., Watkins, D. N., Jair, K. W., Schuebel, K., Markowitz, S. D., Chen, W. D., Pretlow, T. P., Yang, B., Akiyama, Y., Van Engeland, M., Toyota, M., Tokino, T., Hinoda, Y., Imai, K., Herman, J. G. & Baylin, S. B., Apr 2004, In : Nature Genetics. 36, 4, p. 417-422 6 p.

Research output: Contribution to journalArticle

Epigenomics
Colorectal Neoplasms
Catenins
Mutation
Genes

Mammalian DNA methyltransferase 1: Inspiration for new directions

Ting, A. H., Jair, K. W., Suzuki, H., Yen, R-W., Baylin, S. B. & Schuebel, K., Aug 2004, In : Cell cycle (Georgetown, Tex.). 3, 8, p. 1024-1026 3 p.

Research output: Contribution to journalArticle

Methyltransferases
Gene Targeting
DNA
Ablation
Bioactivity
2003

Epigenetic inactivation of CHFR in human tumors

Toyota, M., Sasaki, Y., Satoh, A., Ogi, K., Kikuchi, T., Suzuki, H., Mita, H., Tanaka, N., Itoh, F., Issa, J. P. J., Jair, K. W., Schuebel, K., Imai, K. & Tokino, T., Jun 24 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 13, p. 7818-7823 6 p.

Research output: Contribution to journalArticle

Epigenomics
Methylation
M Phase Cell Cycle Checkpoints
Neoplasms
Histones
2002

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

Rhee, I., Bachman, K. E., Park, B. H., Jair, K. W., Yen, R-W., Schuebel, K., Cui, H., Feinberg, A. P., Lengauer, C., Kinzler, K. W., Baylin, S. B. & Vogelstein, B., Apr 8 2002, In : Nature. 416, 6880, p. 552-556 5 p.

Research output: Contribution to journalArticle

Methylation
DNA Methylation
Genes
Methyltransferases
Gene Silencing
2001

Abberant patterns of DNA methylation, chromatin formation and gene expression in cancer

Baylin, S. B., Esteller, M., Rountree, M. R., Bachman, K. E., Schuebel, K. & Herman, J. G., 2001, In : Human Molecular Genetics. 10, 7, p. 687-692 6 p.

Research output: Contribution to journalArticle

DNA Methylation
Chromatin
Gene Expression
Methylation
Genes

Mammalian scratch: A neural-specific Snail family transcriptional repressor

Nakakura, E. K., Watkins, D. N., Schuebel, K., Sriuranpong, V., Borges, M. W., Nelkin, B. D. & Ball, D. W., Mar 27 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 7, p. 4010-4015 6 p.

Research output: Contribution to journalArticle

Snails
E-Box Elements
Basic Helix-Loop-Helix Transcription Factors
Zinc Fingers
Neurons
2000

CpG methylation is maintained in human cancer cells lacking DNMT1

Rhee, I., Jalr, K. W., Yen, R-W., Lengauer, C., Herman, J. G., Kinzler, K. W., Vogelstein, B., Baylin, S. B. & Schuebel, K., Apr 27 2000, In : Nature. 404, 6781, p. 1003-1007 5 p.

Research output: Contribution to journalArticle

Methylation
Methyltransferases
Neoplasms
Homologous Recombination
DNA
1999

Identification of four variants in the tryptophan hydroxylase promoter and association to behavior

Rotondo, A., Schuebel, K., Bergen, A. W., Aragon, R., Virkkunen, M., Linnoila, M., Goldman, D. & Nielsen, D. A., Jan 1 1999, In : Molecular Psychiatry. 4, 4, p. 360-368 9 p.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Linkage Disequilibrium
North American Indians
Gene Frequency
Population
1998

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

Schuebel, K., Movilla, N., Rosa, J. L. & Bustelo, X. R., Nov 16 1998, In : EMBO Journal. 17, 22, p. 6608-6621 14 p.

Research output: Contribution to journalArticle

Phosphorylation
Oncogene Proteins
Chemical activation
Guanosine
GTP Phosphohydrolases

S. typhimurium Encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells

Hardt, W. D., Chen, L. M., Schuebel, K., Bustelo, X. R. & Galán, J. E., May 29 1998, In : Cell. 93, 5, p. 815-826 12 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Nuclear Envelope
Membranes
Bacterial Proteins
Guanosine Triphosphate
1997

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Crespo, P., Schuebel, K., Ostrom, A. A., Gutkind, J. S. & Bustelo, X. R., Jan 9 1997, In : Nature. 385, 6612, p. 169-172 4 p.

Research output: Contribution to journalArticle

Phosphotyrosine
Proto-Oncogenes
Oncogene Proteins
Guanosine Triphosphate
Tyrosine
1996

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes

Schuebel, K., Bustelo, X. R., Nielsen, D. A., Song, B. J., Barbacid, M., Goldman, D. & Lee, I. J., Oct 17 1996, In : Oncogene. 13, 2, p. 363-371 9 p.

Research output: Contribution to journalArticle

Proto-Oncogenes
Cell Nucleus Division
Messenger RNA
Cytokinesis
Oncogene Proteins