Koko Ishizuka

Assistant Professor

19972020

Research output per year

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Research Output

2020

A methodology for discovering novel brain-relevant peptides: Combination of ribosome profiling and peptidomics

Tharakan, R., Kreimer, S., Ubaida-Mohien, C., Lavoie, J., Olexiouk, V., Menschaert, G., Ingolia, N. T., Cole, R. N., Ishizuka, K., Sawa, A. & Nucifora, L. G., Feb 2020, In : Neuroscience Research. 151, p. 31-37 7 p.

Research output: Contribution to journalArticle

Host–parasite interaction associated with major mental illness

Kano, S. I., Hodgkinson, C. A., Jones-Brando, L., Eastwood, S., Ishizuka, K., Niwa, M., Choi, E. Y., Chang, D. J., Chen, Y., Velivela, S. D., Leister, F., Wood, J., Chowdari, K., Ducci, F., Caycedo, D. A., Heinz, E., Newman, E. R., Cascella, N., Mortensen, P. B., Zandi, P. P. & 6 others, Dickerson, F., Nimgaonkar, V., Goldman, D., Harrison, P. J., Yolken, R. H. & Sawa, A., Jan 1 2020, In : Molecular psychiatry. 25, 1, p. 194-205 12 p.

Research output: Contribution to journalArticle

2019

An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration

John, J. P., Thirunavukkarasu, P., Ishizuka, K., Parekh, P. & Sawa, A., Dec 1 2019, In : npj Systems Biology and Applications. 5, 1, 17.

Research output: Contribution to journalArticle

Open Access

The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood

Yang, K., Kondo, M. A., Jaaro-Peled, H., Cash-Padgett, T., Kano, S. I., Ishizuka, K., Pevsner, J. A., Tomoda, T., Sawa, A. & Niwa, M., Jan 1 2019, In : Schizophrenia Research.

Research output: Contribution to journalArticle

Zika virus increases mind bomb 1 levels, causing degradation of pericentriolar material 1 (PCM1) and dispersion of PCM1-containing granules from the centrosome

Wen, F., Armstrong, N., Hou, W., Cruz-Cosme, R., Obwolo, L. A., Ishizuka, K., Ullah, H., Luo, M. H., Sawa, A. & Tang, Q., Dec 6 2019, In : Journal of Biological Chemistry. 294, 49, p. 18742-18755 14 p.

Research output: Contribution to journalArticle

2018

Dynamic Changes of the Mitochondria in Psychiatric Illnesses: New Mechanistic Insights From Human Neuronal Models

Srivastava, R., Faust, T., Ramos, A., Ishizuka, K. & Sawa, A., Jan 1 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder

McLean, C. K., Narayan, S., Lin, S. Y., Rai, N., Chung, Y., Hipolito, M. M. S., Cascella, N. G., Nurnberger, J. I., Ishizuka, K., Sawa, A. & Nwulia, E. A., Dec 1 2018, In : Translational Psychiatry. 8, 1, 81.

Research output: Contribution to journalArticle

Olfactory Functioning in First-Episode Psychosis

Kamath, V., Lasutschinkow, P., Ishizuka, K. & Sawa, A., Apr 6 2018, In : Schizophrenia bulletin. 44, 3, p. 672-680 9 p.

Research output: Contribution to journalArticle

Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons

Sumitomo, A., Yukitake, H., Hirai, K., Horike, K., Ueta, K., Chung, Y., Warabi, E., Yanagawa, T., Kitaoka, S., Furuyashiki, T., Narumiya, S., Hirano, T., Niwa, M., Sibille, E., Hikida, T., Sakurai, T., Ishizuka, K., Sawa, A. & Tomoda, T., Jan 1 2018, In : Human molecular genetics. 27, 18, p. 3165-3176 12 p.

Research output: Contribution to journalArticle

2017

Aggregation of scaffolding protein DiSC1 dysregulates phosphodiesterase 4 in Huntington's disease

Tanaka, M., Ishizuka, K., Nekooki-Machida, Y., Endo, R., Takashima, N., Sasaki, H., Komi, Y., Gathercole, A., Huston, E., Ishii, K., Hui, K. K. W., Kurosawa, M., Kim, S. H., Nukina, N., Takimoto, E., Houslay, M. D. & Sawa, A., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1438-1450 13 p.

Research output: Contribution to journalArticle

Application of olfactory tissue and its neural progenitors to schizophrenia and psychiatric research

Lavoie, J., Sawa, A. & Ishizuka, K., 2017, In : Current Opinion in Psychiatry. 30, 3, p. 176-183 8 p.

Research output: Contribution to journalReview article

DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca2+ Transfer through the MAM

Park, S. J., Lee, S. B., Suh, Y., Kim, S. J., Lee, N., Hong, J. H., Park, C., Woo, Y., Ishizuka, K., Kim, J. H., Berggren, P. O., Sawa, A. & Park, S. K., Dec 5 2017, In : Cell Reports. 21, 10, p. 2748-2759 12 p.

Research output: Contribution to journalArticle

Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways

Shao, L., Lu, B., Wen, Z., Teng, S., Wang, L., Zhao, Y., Wang, L., Ishizuka, K., Xu, X., Sawa, A., Song, H., Ming, G. & Zhong, Y., Jul 15 2017, In : Human molecular genetics. 26, 14, p. 2634-2648 15 p.

Research output: Contribution to journalArticle

Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: A pilot study

Sagata, N., Kato, T. A., Kano, S. I., Ohgidani, M., Shimokawa, N., Sato-Kasai, M., Hayakawa, K., Kuwano, N., Wilson, A. M., Ishizuka, K., Kato, S., Nakahara, T., Nakahara-Kido, M., Setoyama, D., Sakai, Y., Ohga, S., Furue, M., Sawa, A. & Kanba, S., Dec 1 2017, In : Scientific reports. 7, 1, 13905.

Research output: Contribution to journalArticle

The Olfactory Neural Epithelium As a Tool in Neuroscience

Lavoie, J., Gassó Astorga, P., Segal-Gavish, H., Wu, Y. W. C., Chung, Y., Cascella, N. G., Sawa, A. & Ishizuka, K., Feb 1 2017, In : Trends in Molecular Medicine. 23, 2, p. 100-103 4 p.

Research output: Contribution to journalShort survey

2016

Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1

Jaaro-Peled, H., Altimus, C., LeGates, T., Cash-Padgett, T., Zoubovsky, S., Hikida, T., Ishizuka, K., Hattar, S., Mongrain, V. & Sawa, A., Nov 1 2016, In : Neuroscience Research. 112, p. 63-69 7 p.

Research output: Contribution to journalArticle

DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1

Niwa, M., Cash-Padgett, T., Kubo, K. I., Saito, A., Ishii, K., Sumitomo, A., Taniguchi, Y., Ishizuka, K., Jaaro-Peled, H., Tomoda, T., Nakajima, K., Sawa, A. & Kamiya, A., Nov 1 2016, In : Molecular Psychiatry. 21, 11, p. 1488-1489 2 p.

Research output: Contribution to journalComment/debate

Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controls

Passeri, E., Jones-Brando, L., Bordón, C., Sengupta, S., Wilson, A. M., Primerano, A., Rapoport, J. L., Ishizuka, K., Kano, S. I., Yolken, R. H. & Sawa, A., Feb 1 2016, In : Microbes and Infection. 18, 2, p. 153-158 6 p.

Research output: Contribution to journalArticle

Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium

Horiuchi, Y., Kondo, M. A., Okada, K., Takayanagi, Y., Tanaka, T., Ho, T., Varvaris, M., Tajinda, K., Hiyama, H., Ni, K., Colantuoni, C., Schretlen, D., Cascella, N. G., Pevsner, J., Ishizuka, K. & Sawa, A., Oct 11 2016, In : Translational psychiatry. 6, 10, p. e915

Research output: Contribution to journalArticle

The potential of DISC1 protein as a therapeutic target for mental illness

Sawa, A., Ishizuka, K. & Katsanis, N., Jun 2 2016, In : Expert opinion on therapeutic targets. 20, 6, p. 641-643 3 p.

Research output: Contribution to journalEditorial

2015

Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: Studies of lysosomal storage diseases and channelopathy

Kano, S., Yuan, M., Cardarelli, R. A., Maegawa, G., Higurashi, N., Gaval-Cruz, M., Wilson, A. M., Tristan, C., Kondo, M. A., Chen, Y., Koga, M., Obie, C., Ishizuka, K., Seshadri, S., Srivastava, R., Kato, T. A., Horiuchi, Y., Sedlak, T. W., Lee, Y., Rapoport, J. L. & 6 others, Hirose, S., Okano, H., Valle, D., O’Donnell, P., Sawa, A. & Kai, M., Jan 1 2015, In : Current Molecular Medicine. 15, 2, p. 138-145 8 p.

Research output: Contribution to journalArticle

DISC1 regulates trafficking and processing of APP and Aβ generation

Shahani, N., Seshadri, S., Jaaro-Peled, H., Ishizuka, K., Hirota-Tsuyada, Y., Wang, Q., Koga, M., Sedlak, T. W., Korth, C., Brandon, N. J., Kamiya, A., Subramaniam, S., Tomoda, T. & Sawa, A., Jul 24 2015, In : Molecular psychiatry. 20, 7, p. 874-879 6 p.

Research output: Contribution to journalArticle

Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities

Passeri, E., Wilson, A. M., Primerano, A., Kondo, M. A., Sengupta, S., Srivastava, R., Koga, M., Obie, C., Zandi, P. P., Goes, F. S., Valle, D., Rapoport, J. L., Sawa, A., Kano, S. I. & Ishizuka, K., Dec 2015, In : Neuroscience Research. 101, p. 57-61 5 p.

Research output: Contribution to journalArticle

Half-life of DISC1 protein and its pathological significance under hypoxia stress

Barodia, S. K., Park, S. K., Ishizuka, K., Sawa, A. & Kamiya, A., Aug 1 2015, In : Neuroscience Research. 97, p. 1-6 6 p.

Research output: Contribution to journalArticle

Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex

Seshadri, S., Faust, T., Ishizuka, K., Delevich, K., Chung, Y., Kim, S. H., Cowles, M., Niwa, M., Jaaro-Peled, H., Tomoda, T., Lai, C., Anton, E. S., Li, B. & Sawa, A., Dec 11 2015, In : Nature communications. 6, 10118.

Research output: Contribution to journalArticle

Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade

Tristan, C. A., Ramos, A., Shahani, N., Emiliani, F. E., Nakajima, H., Noeh, C. C., Kato, Y., Takeuchi, T., Noguchi, T., Kadowaki, H., Sedlak, T. W., Ishizuka, K., Ichijo, H. & Sawa, A., Jan 2 2015, In : Journal of Biological Chemistry. 290, 1, p. 56-64 9 p.

Research output: Contribution to journalArticle

2014

Olfactory neurons obtained through nasal biopsy combined with laser-capture microdissection: A potential approach to study treatment response in mental disorders

Narayan, S., McLean, C., Sawa, A., Lin, S. Y., Rai, N., Hipolito, M. M. S., Cascella, N., Nurnberger, J. J. I., Ishizuka, K. & Nwulia, E. A., Dec 4 2014, In : Journal of Visualized Experiments. 94, e51853.

Research output: Contribution to journalArticle

2013

DISC1-ATF4 transcriptional repression complex: Dual regulation of the cAMP-PDE4 cascade by DISC1

Soda, T., Frank, C., Ishizuka, K., Baccarella, A., Park, Y. U., Flood, Z., Park, S. K., Sawa, A. & Tsai, L. H., Aug 1 2013, In : Molecular psychiatry. 18, 8, p. 898-908 11 p.

Research output: Contribution to journalArticle

Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia

Coughlin, J. M., Ishizuka, K., Kano, S. I., Edwards, J. A., Seifuddin, F. T., Shimano, M. A., Daley, E. L., Zandi, P. P., Leweke, F. M., Cascella, N. G., Pomper, M. G., Yolken, R. H. & Sawa, A., Jan 1 2013, In : Molecular psychiatry. 18, 1, p. 10-11 2 p.

Research output: Contribution to journalLetter

Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders

Horiuchi, Y., Kano, S. I., Ishizuka, K., Cascella, N. G., Ishii, S., Talbot, C. C., Jaffe, A. E., Okano, H., Pevsner, J., Colantuoni, C. & Sawa, A., Dec 1 2013, In : Neuroscience Research. 77, 4, p. 247-250 4 p.

Research output: Contribution to journalArticle

2012

Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits

Bader, V., Tomppo, L., Trossbach, S. V., Bradshaw, N. J., Prikulis, I., Rutger Leliveld, S., Lin, C. Y., Ishizuka, K., Sawa, A., Ramos, A., Rosa, I., García, Å., Requena, J. R., Hipolito, M., Rai, N., Nwulia, E., Henning, U., Ferrea, S., Luckhaus, C., Ekelund, J. & 4 others, Veijola, J., Järvelin, M. R., Hennah, W. & Korth, C., Oct 1 2012, In : Human molecular genetics. 21, 20, p. 4406-4418 13 p., dds273.

Research output: Contribution to journalArticle

2011

DISC1-dependent switch from progenitor proliferation to migration in the developing cortex

Ishizuka, K., Kamiya, A., Oh, E. C., Kanki, H., Seshadri, S., Robinson, J. F., Murdoch, H., Dunlop, A. J., Kubo, K. I., Furukori, K., Huang, B., Zeledon, M., Hayashi-Takagi, A., Okano, H., Nakajima, K., Houslay, M. D., Katsanis, N. & Sawa, A., May 5 2011, In : Nature. 473, 7345, p. 92-96 5 p.

Research output: Contribution to journalArticle

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function

Wang, Q., Charych, E. I., Pulito, V. L., Lee, J. B., Graziane, N. M., Crozier, R. A., Revilla-Sanchez, R., Kelly, M. P., Dunlop, A. J., Murdoch, H., Taylor, N., Xie, Y., Pausch, M., Hayashi-Takagi, A., Ishizuka, K., Seshadri, S., Bates, B., Kariya, K., Sawa, A., Weinberg, R. J. & 4 others, Moss, S. J., Houslay, M. D., Yan, Z. & Brandon, N. J., Oct 1 2011, In : Molecular psychiatry. 16, 10, p. 1006-1023 18 p.

Research output: Contribution to journalArticle

2010

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A. J., Makino, Y., Seshadri, A. J., Ishizuka, K., Srivastava, D. P., Xie, Z., Baraban, J. M., Houslay, M. D., Tomoda, T., Brandon, N. J., Kamiya, A., Yan, Z., Penzes, P. & Sawa, A., Mar 1 2010, In : Nature neuroscience. 13, 3, p. 327-332 6 p.

Research output: Contribution to journalArticle

Disrupted-in-Schizophrenia-1 expression is regulated by β-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade

Seshadri, S., Kamiya, A., Yokota, Y., Prikulis, I., Kano, S. I., Hayashi-Takagi, A., Stanco, A., Eom, T. Y., Rao, S., Ishizuka, K., Wong, P., Korth, C., Anton, E. S. & Sawa, A., Mar 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 12, p. 5622-5627 6 p.

Research output: Contribution to journalArticle

Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania Smell Identification Test

Ishizuka, K., Tajinda, K., Colantuoni, C., Morita, M., Winicki, J., Le, C., Lin, S., Schretlen, D., Sawa, A. & Cascella, N. G., Jan 1 2010, In : Neuroscience Research. 66, 1, p. 106-110 5 p.

Research output: Contribution to journalArticle

Neuronal biomarkers from patients with mental illnesses: A novel method through nasal biopsy combined with laser-captured microdissection

Tajinda, K., Ishizuka, K., Colantuoni, C., Morita, M., Winicki, J., Le, C., Lin, S., Schretlen, D., Sawa, A. & Cascella, N., Mar 1 2010, In : Molecular psychiatry. 15, 3, p. 231-232 2 p.

Research output: Contribution to journalLetter

Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology

Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., Cadet, J. L., Pardo, C., Mori, S., Kamiya, A., Vogel, M. W., Sawa, A., Ross, C. A. & Pletnikov, M. V., Dec 15 2010, In : Biological psychiatry. 68, 12, p. 1172-1181 10 p.

Research output: Contribution to journalArticle

2008

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: Evidence of epistasis and competitive binding

Burdick, K. E., Kamiya, A., Hodgkinson, C. A., Lencz, T., Derosse, P., Ishizuka, K., Elashvili, S., Arai, H., Goldman, D., Sawa, A. & Malhotra, A. K., Aug 1 2008, In : Human molecular genetics. 17, 16, p. 2462-2473 12 p.

Research output: Contribution to journalArticle

Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly

Sawamura, N., Ando, T., Maruyama, Y., Fujimuro, M., Mochizuki, H., Honjo, K., Shimoda, M., Toda, H., Sawamura-Yamamoto, T., Makuch, L. A., Hayashi, A., Ishizuka, K., Cascella, N. G., Kamiya, A., Ishida, N., Tomoda, T., Hai, T., Furukubo-Tokunaga, K. & Sawa, A., Dec 1 2008, In : Molecular psychiatry. 13, 12, p. 1138-1148 11 p.

Research output: Contribution to journalArticle

Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: A candidate for psychiatric illnesses

Kamiya, A., Tan, P. L., Kubo, K. I., Engelhard, C., Ishizuka, K., Kubo, A., Tsukita, S., Pulver, A. E., Nakajima, K., Cascella, N. G., Katsanis, N. & Sawa, A., Sep 1 2008, In : Archives of general psychiatry. 65, 9, p. 996-1006 11 p.

Research output: Contribution to journalArticle

2007

Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans

Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andradé, M., Tankou, S., Mori, S., Gallagher, M., Ishizuka, K., Pletnikov, M., Kida, S. & Sawa, A., Sep 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 36, p. 14501-14506 6 p.

Research output: Contribution to journalArticle

Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice [4]

Ishizuka, K., Chen, J., Taya, S., Li, W., Millar, J. K., Xu, Y., Clapcote, S. J., Hookway, C., Morita, M., Kamiya, A., Tomoda, T., Lipska, B. K., Roder, J. C., Pletnikov, M., Porteous, D., Silva, A. J., Cannon, T. D., Kaibuchi, K., Brandon, N. J., Weinberger, D. R. & 1 others, Sawa, A., Oct 1 2007, In : Molecular psychiatry. 12, 10, p. 897-899 3 p.

Research output: Contribution to journalLetter

2006

A Review of Disrupted-in-Schizophrenia-1 (disc1): Neurodevelopment, Cognition, and Mental Conditions

Ishizuka, K., Paek, M., Kamiyaand, A. & Sawa, A., Jun 15 2006, In : Biological psychiatry. 59, 12, p. 1189-1197 9 p.

Research output: Contribution to journalReview article

Differential Expression of Disrupted-in-Schizophrenia (DISC1) in Bipolar Disorder

Maeda, K., Nwulia, E., Chang, J., Balkissoon, R., Ishizuka, K., Chen, H., Zandi, P., McInnis, M. G. & Sawa, A., Nov 1 2006, In : Biological psychiatry. 60, 9, p. 929-935 7 p.

Research output: Contribution to journalArticle

Usefulness of measurement of the temporal stem on magnetic resonance imaging in the diagnosis of frontotemporal dementia

Hayashida, Y., Hirai, T., Korogi, Y., Kimura, T., Ishizuka, K., Kawanaka, K., Yamura, M., Kitajima, M., Ikushima, I. & Yamashita, Y., Jun 1 2006, In : Acta Radiologica. 47, 6, p. 603-608 6 p.

Research output: Contribution to journalArticle

2005

Phosphorylation of tau at serine 416 by Ca2+/calmodulin- dependent protein kinase II in neuronal soma in brain

Yamamoto, H., Hiragami, Y., Murayama, M., Ishizuka, K., Kawahara, M. & Takashima, A., Aug 1 2005, In : Journal of Neurochemistry. 94, 5, p. 1438-1447 10 p.

Research output: Contribution to journalArticle

2002

Possible assessment for antioxidant capacity in Alzheimer's disease by measuring lymphocyte heme oxygenase-1 expression with real-time RT-PCR

Ishizuka, K., Kimura, T., Yoshitake, J., Akaike, T., Shono, M., Takamatsu, J., Katsuragi, S., Kitamura, T. & Miyakawa, T., Jan 1 2002, In : Annals of the New York Academy of Sciences. 977, p. 173-178 6 p.

Research output: Contribution to journalArticle

2000

Apolipoprotein E ε4 and tardive dyskinesia in a Japanese population

Kimura, T., Shono, M., Yokota, S., Ishizuka, K., Watanabe, M., Takamatsu, J. & Miyakawa, T., Dec 2 2000, In : Journal of Psychiatric Research. 34, 4-5, p. 329-332 4 p.

Research output: Contribution to journalArticle