King-Wai Yau

Professor

1976 …2020

Research output per year

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Research Output

2020

Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes

Sato, M., Tsuji, T., Yang, K., Ren, X., Dreyfuss, J. M., Huang, T. L., Wang, C. H., Shamsi, F., Leiria, L. O., Lynes, M. D., Yau, K. W. & Tseng, Y. H., Jan 1 2020, In : PLoS biology. 18, 2, e3000630.

Research output: Contribution to journalArticle

Open Access
2019

Elementary response triggered by transducin in retinal rods

Yue, W. W. S., Silverman, D., Ren, X., Frederiksen, R., Sakai, K., Yamashita, T., Shichida, Y., Cornwall, M. C., Chen, J. & Yau, K-W., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 11, p. 5144-5153 10 p.

Research output: Contribution to journalArticle

Signal amplification at the rhodopsin-to-transducin·phosphodiesterase step in rod phototransduction

Yau, K-W., Yue, W. W. S. & Silverman, D., Apr 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 18, p. 8655-8656 2 p.

Research output: Contribution to journalLetter

2018

Ca2+-activated Cl current predominates in threshold response of mouse olfactory receptor neurons

Li, R. C., Lin, C. C., Ren, X., Wu, J. S., Molday, L. L., Molday, R. S. & Yau, K. W., May 22 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 21, p. 5570-5575 6 p.

Research output: Contribution to journalArticle

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells

Jiang, Z., Yue, W. W. S., Chen, L., Sheng, Y. & Yau, K-W., Oct 18 2018, In : Cell. 175, 3, p. 652-664 13 p.

Research output: Contribution to journalArticle

2017

Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket

Yue, W. W. S., Frederiksen, R., Ren, X., Luo, D. G., Yamashita, T., Shichida, Y., Carter Cornwall, M. & Yau, K-W., Feb 10 2017, In : eLife. 6, e18492.

Research output: Contribution to journalArticle

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle

Wang, Q., Yue, W. W. S., Jiang, Z., Xue, T., Kang, S. H., Bergles, D. E., Mikoshiba, K., Offermanns, S. & Yau, K-W., Jun 19 2017, In : Current Biology. 27, 12, p. 1791-1800.e5

Research output: Contribution to journalArticle

2016

Dimerization of visual pigments in vivo

Zhang, T., Cao, L. H., Kumar, S., Enemchukwu, N. O., Zhang, N., Lambert, A., Zhao, X., Jones, A., Wang, S., Dennis, E. M., Fnu, A., Ham, S., Rainier, J., Yau, K-W. & Fu, Y., Aug 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. 9093-9098 6 p.

Research output: Contribution to journalArticle

Melanopsin-expressing ganglion cells on macaque and human retinas form two morphologically distinct populations

Liao, H. W., Ren, X., Peterson, B. B., Marshak, D. W., Yau, K-W., Gamlin, P. D. & Dacey, D. M., Oct 1 2016, In : Journal of Comparative Neurology. 524, 14, p. 2845-2872 28 p.

Research output: Contribution to journalArticle

2015

Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea

Buhr, E. D., Yue, W. W. S., Ren, X., Jiang, Z., Liao, H. W. R., Mei, X., Vemaraju, S., Nguyen, M. T., Reed, R. R., Lang, R. A., Yau, K-W. & Van Gelder, R. N., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. 13093-13098 6 p.

Research output: Contribution to journalArticle

2014

Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

Zhong, X., Gutierrez, C., Xue, T., Hampton, C., Vergara, M. N., Cao, L. H., Peters, A., Park, T. S., Zambidis, E. T., Meyer, J. S., Gamm, D. M., Yau, K. W. & Canto-Soler, M. V., Jun 10 2014, In : Nature communications. 5, 4047.

Research output: Contribution to journalArticle

Light responses of primate and other mammalian cones

Cao, L. H., Luo, D. G. & Yau, K. W., Feb 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 7, p. 2752-2757 6 p.

Research output: Contribution to journalArticle

2013

Adaptation to steady light by intrinsically photosensitive retinal ganglion cells

Do, M. T. H. & Yau, K. W., Apr 30 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 18, p. 7470-7475 6 p.

Research output: Contribution to journalArticle

Determining consequences of retinal membrane guanylyl cyclase (RetGC1) deficiency in human leber congenital amaurosis en route to therapy: Residual cone-photoreceptor vision correlates with biochemical properties of the mutants

Jacobson, S. G., Cideciyan, A. V., Peshenko, I. V., Sumaroka, A., Olshevskaya, E. V., Cao, L., Schwartz, S. B., Roman, A. J., Olivares, M. B., Sadigh, S., Yau, K. W., Heon, E., Stone, E. M. & Dizhoor, A. M., Jan 1 2013, In : Human molecular genetics. 22, 1, p. 168-183 16 p., dds421.

Research output: Contribution to journalArticle

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

Welsbie, D. S., Yang, Z., Ge, Y., Mitchell, K. L., Zhou, X., Martin, S. E., Berlinicke, C. A., Hackler, L., Fuller, J., Fu, J., Cao, L. H., Han, B., Auld, D., Xue, T., Hirai, S. I., Germain, L., Simard-Bisson, C., Blouin, R., Nguyen, J. V., Davis, C. H. O. & 12 others, Enke, R. A., Boye, S. L., Merbs, S. L., Marsh-Armstrong, N., Hauswirth, W. W., Diantonio, A., Nickells, R. W., Inglese, J., Hanes, J., Yau, K. W., Quigley, H. A. & Zack, D. J., Mar 5 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 10, p. 4045-4050 6 p.

Research output: Contribution to journalArticle

On and off retinal circuit assembly by divergent molecular mechanisms

Sun, L. O., Jiang, Z., Rivlin-Etzion, M., Hand, R., Brady, C. M., Matsuoka, R. L., Yau, K. W., Feller, M. B. & Kolodkin, A. L., Jan 1 2013, In : Science. 342, 6158, 1241974.

Research output: Contribution to journalArticle

Photoreceptors

Yau, K-W., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 488-491 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Guidance-cue control of horizontal cell morphology, lamination, and synapse formation in the mammalian outer retina

Matsuoka, R. L., Jiang, Z., Samuels, I. S., Nguyen-Ba-Charvet, K. T., Sun, L. O., Peachey, N. S., Chédotal, A., Yau, K. W. & Kolodkin, A. L., May 16 2012, In : Journal of Neuroscience. 32, 20, p. 6859-6868 10 p.

Research output: Contribution to journalArticle

Photochemical nature of parietopsin

Sakai, K., Imamoto, Y., Su, C. Y., Tsukamoto, H., Yamashita, T., Terakita, A., Yau, K. W. & Shichida, Y., Mar 6 2012, In : Biochemistry. 51, 9, p. 1933-1941 9 p.

Research output: Contribution to journalArticle

Restoration of vision after transplantation of photoreceptors

Pearson, R. A., Barber, A. C., Rizzi, M., Hippert, C., Xue, T., West, E. L., Duran, Y., Smith, A. J., Chuang, J. Z., Azam, S. A., Luhmann, U. F. O., Benucci, A., Sung, C. H., Bainbridge, J. W., Carandini, M., Yau, K. W., Sowden, J. C. & Ali, R. R., May 3 2012, In : Nature. 485, 7396, p. 99-103 5 p.

Research output: Contribution to journalArticle

2011

Activation of visual pigments by light and heat

Luo, D. G., Yue, W. W. S., Ala-Laurila, P. & Yau, K. W., Jun 10 2011, In : Science. 332, 6035, p. 1307-1312 6 p.

Research output: Contribution to journalArticle

Melanopsin signalling in mammalian iris and retina

Xue, T., Do, M. T. H., Riccio, A., Jiang, Z., Hsieh, J., Wang, H. C., Merbs, S. L., Welsbie, D. S., Yoshioka, T., Weissgerber, P., Stolz, S., Flockerzi, V., Freichel, M., Simon, M. I., Clapham, D. E. & Yau, K. W., Nov 3 2011, In : Nature. 479, 7371, p. 67-72 6 p.

Research output: Contribution to journalArticle

Unitary response of mouse olfactory receptor neurons

Ben-Chaim, Y., Cheng, M. M. & Yau, K. W., Jan 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 2, p. 822-827 6 p.

Research output: Contribution to journalArticle

2010

Deletion of GRK1 causes retina degeneration through a transducin- independent mechanism

Fan, J., Sakurai, K., Chen, C. K., Rohrer, B., Wu, B. X., Yau, K. W., Kefalov, V. & Crouch, R. K., Feb 17 2010, In : Journal of Neuroscience. 30, 7, p. 2496-2503 8 p.

Research output: Contribution to journalArticle

Erratum: Deletion of GRK1 Causes Retina Degeneration through a Transducin-Independent Mechanism (J. Neurosci. (2010) 30:14 (2496-2503))

Fan, J., Sakurai, K., Chen, C. K., Rohrer, B., Wu, B. X., Yau, K. W., Kefalov, V. & Crouch, R. K., Apr 7 2010, In : Journal of Neuroscience. 30, 14

Research output: Contribution to journalComment/debate

Intrinsically photosensitive retinal ganglion cells

Do, M. T. H. & Yau, K-W., Oct 2010, In : Physiological Reviews. 90, 4, p. 1547-1581 35 p.

Research output: Contribution to journalArticle

Introducing Marie E. Burns, the 2009 recipient of the Cogan Award

Yau, K. W., Mar 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 3, 1 p.

Research output: Contribution to journalComment/debate

Photoreceptors: Physiology

Luo, D. G., Su, C. Y. & Yau, K-W., 2010, Encyclopedia of Neuroscience. Elsevier Ltd, p. 677-686 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Signaling by olfactory receptor neurons near threshold

Bhandawat, V., Reisert, J. & Yau, K. W., Oct 26 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 43, p. 18682-18687 6 p.

Research output: Contribution to journalArticle

Tracer coupling of intrinsically photosensitive retinal ganglion cells to amacrine cells in the mouse retina

Pérez De Sevilla Müller, L., Do, M. T. H., Yau, K. W., He, S. & Baldridge, W. H., Dec 1 2010, In : Journal of Comparative Neurology. 518, 23, p. 4813-4824 12 p.

Research output: Contribution to journalArticle

2009

Intrinsic light response of retinal horizontal cells of teleosts

Cheng, N., Tsunenari, T. & Yau, K. W., Aug 13 2009, In : Nature. 460, 7257, p. 899-903 5 p.

Research output: Contribution to journalArticle

Photon capture and signalling by melanopsin retinal ganglion cells

Do, M. T. H., Kang, S. H., Xue, T., Zhong, H., Liao, H. W., Bergles, D. E. & Yau, K. W., Jan 15 2009, In : Nature. 457, 7227, p. 281-287 7 p.

Research output: Contribution to journalArticle

Phototransduction Motifs and Variations

Yau, K-W. & Hardie, R. C., Oct 16 2009, In : Cell. 139, 2, p. 246-264 19 p.

Research output: Contribution to journalArticle

2008

How vision begins: An odyssey

Luo, D. G., Xue, T. & Yau, K-W., Jul 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 29, p. 9855-9862 8 p.

Research output: Contribution to journalArticle

Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision

Güler, A. D., Ecker, J. L., Lall, G. S., Haq, S., Altimus, C. M., Liao, H. W., Barnard, A. R., Cahill, H., Badea, T. C., Zhao, H., Hankins, M. W., Berson, D. M., Lucas, R. J., Yau, K. W. & Hattar, S., May 1 2008, In : Nature. 453, 7191, p. 102-105 4 p.

Research output: Contribution to journalArticle

Phototransduction in Rods and Cones

Luo, D. G., Kefalov, V. & Yau, K. W., Jan 1 2008, Vision I. Elsevier Inc., Vol. 1. p. 269-301 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Quantal noise from human red cone pigment

Fu, Y., Kefalov, V., Luo, D. G., Xue, T. & Yau, K. W., May 29 2008, In : Nature neuroscience. 11, 5, p. 565-571 7 p.

Research output: Contribution to journalArticle

2007

Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells

Gamlin, P. D. R., McDougal, D. H., Pokorny, J., Smith, V. C., Yau, K. W. & Dacey, D. M., Mar 1 2007, In : Vision Research. 47, 7, p. 946-954 9 p.

Research output: Contribution to journalArticle

In vivo gene delivery in the retina using polyethylenimine

Liao, H. W. & Yau, K-W., Mar 2007, In : BioTechniques. 42, 3, p. 285-288 4 p.

Research output: Contribution to journalArticle

Molecular properties of rhodopsin and rod function

Imai, H., Kefalov, V., Sakurai, K., Chisaka, O., Ueda, Y., Onishi, A., Morizumi, T., Fu, Y., Ichikawa, K., Nakatani, K., Honda, Y., Chen, J., Yau, K-W. & Shichida, Y., Mar 2 2007, In : Journal of Biological Chemistry. 282, 9, p. 6677-6684 8 p.

Research output: Contribution to journalArticle

Olfactory marker protein modulates the cAMP kinetics of the odour-induced response in cilia of mouse olfactory receptor neurons

Reisert, J., Yau, K-W. & Margolis, F. L., Dec 15 2007, In : Journal of Physiology. 585, 3, p. 731-740 10 p.

Research output: Contribution to journalArticle

Phototransduction in mouse rods and cones

Fu, Y. & Yau, K. W., Aug 1 2007, In : Pflugers Archiv European Journal of Physiology. 454, 5, p. 805-819 15 p.

Research output: Contribution to journalReview article

Signaling properties of a short-wave cone visual pigment and its role in phototransduction

Shi, G., Yau, K-W., Chen, J. & Kefalov, V. J., Sep 19 2007, In : Journal of Neuroscience. 27, 38, p. 10084-10093 10 p.

Research output: Contribution to journalArticle

The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors

Baehr, W., Karan, S., Maeda, T., Luo, D. G., Li, S., Bronson, J. D., Watt, C. B., Yau, K. W., Frederick, J. M. & Palczewski, K., Mar 23 2007, In : Journal of Biological Chemistry. 282, 12, p. 8837-8847 11 p.

Research output: Contribution to journalArticle

2006

Ca2+-activated Cl- current from human bestrophin-4 in excised membrane patches

Tsunenari, T., Nathans, J. & Yau, K-W., Jun 2006, In : Journal of General Physiology. 127, 6, p. 749-754 6 p.

Research output: Contribution to journalArticle

Central projections of melanopsin-expressing retinal ganglion cells in the mouse

Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K. W. & Berson, D. M., Jul 20 2006, In : Journal of Comparative Neurology. 497, 3, p. 326-349 24 p.

Research output: Contribution to journalArticle

Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping

Michalakis, S., Reisert, J., Geiger, H., Wetzel, C., Zong, X., Bradley, J., Spehr, M., Hüttl, S., Gerstner, A., Pfeifer, A., Hatt, H., Yau, K. W. & Biel, M., Nov 17 2006, In : Journal of Biological Chemistry. 281, 46, p. 35156-35166 11 p.

Research output: Contribution to journalArticle

Parietal-eye phototransduction components and their potential evolutionary implications

Su, C. Y., Luo, D. G., Terakita, A., Shichida, Y., Liao, H. W., Kazmi, M. A., Sakmar, T. P. & Yau, K-W., Mar 17 2006, In : Science. 311, 5767, p. 1617-1621 5 p.

Research output: Contribution to journalArticle