Kenneth Pienta

Professor

1981 …2018
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Research Output 1981 2018

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2018

3D Shape Modeling for Cell Nuclear Morphological Analysis and Classification

Kalinin, A. A., Allyn-Feuer, A., Ade, A., Fon, G. V., Meixner, W., Dilworth, D., Husain, S. S., de Wett, J. R., Higgins, G. A., Zheng, G., Creekmore, A., Wiley, J. W., Verdone, J. E., Veltri, R. W., Pienta, K. J., Coffey, D. S., Athey, B. D. & Dinov, I. D., Dec 1 2018, In : Scientific Reports. 8, 1, 13658

Research output: Contribution to journalArticle

Cell Nucleus Shape
Cell Nucleus
Cell Nucleolus
Prostatic Neoplasms
Fibroblasts
T-cells
prostatic neoplasms
Myeloid Cells
Infiltration
Tumors

Analogous detection of circulating tumor cells using the AccuCyte®-CyteFinder® system and ISET system in patients with locally advanced and metastatic prostate cancer

van der Toom, E. E., Groot, V. P., Glavaris, S. A., Gemenetzis, G., Chalfin, H. J., Wood, L. D., Wolfgang, C. L., de la Rosette, J. J. M. C. H., de Reijke, T. M. & Pienta, K. J., Jan 1 2018, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Prostatic Neoplasms
Vimentin
Cell Count

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone

Roca, H., Jones, J. D., Purica, M. C., Weidner, S., Koh, A. J., Kuo, R., Wilkinson, J. E., Wang, Y., Daignault-Newton, S., Pienta, K. J., Morgan, T. M., Keller, E. T., Nör, J. E., Shea, L. D. & McCauley, L. K., Jan 2 2018, In : Journal of Clinical Investigation. 128, 1, p. 248-266 19 p.

Research output: Contribution to journalArticle

Prostate
Apoptosis
Neoplasm Metastasis
Inflammation
Bone and Bones

A Voice From the Past: Rediscovering the Virchow Node With Prostate-specific Membrane Antigen-targeted 18F-DCFPyL Positron Emission Tomography Imaging

Werner, R. A., Andree, C., Javadi, M. S., Lapa, C., Buck, A. K., Higuchi, T., Pomper, M. G., Gorin, M. A., Rowe, S. P. & Pienta, K. J., Jan 1 2018, (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Positron-Emission Tomography
human glutamate carboxypeptidase II

Characterization of Urothelial Cancer Circulating Tumor Cells with a Novel Selection-Free Method

Chalfin, H. J., Kates, M., van der Toom, E. E., Glavaris, S., Verdone, J. E., Hahn, N. M., Pienta, K. J., Bivalacqua, T. J. & Gorin, M. A., Jan 1 2018, (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Urinary Bladder Neoplasms
Neoplasms
Carcinoma
Muscles
Molecular Imaging
Prostatic Neoplasms
Radiotherapy
Recurrence
2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid

Compositional differences in gastrointestinal microbiota in prostate cancer patients treated with androgen axis-targeted therapies

Sfanos, K. S., Markowski, M. C., Peiffer, L. B., Ernst, S. E., White, J. R., Pienta, K. J., Antonarakis, E. S. & Ross, A. E., Jul 9 2018, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases. p. 1-10 10 p.

Research output: Contribution to journalArticle

Androgens
Prostatic Neoplasms
Therapeutics
Microbiota
Immunotherapy

CXCL12g promotes metastatic castration-resistant prostate cancer by inducing cancer stem cell and neuroendocrine phenotypes

Jung, Y., Cackowski, F. C., Yumoto, K., Decker, A. M., Wang, J., Kim, J. K., Lee, E., Wang, Y., Chung, J. S., Gursky, A. M., Krebsbach, P. H., Pienta, K. J., Morgan, T. M. & Taichman, R. S., Apr 15 2018, In : Cancer Research. 78, 8, p. 2026-2039 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Castration
Prostatic Neoplasms
Phenotype
Circulating Neoplastic Cells
Carcinoid Tumor
Prostatic Neoplasms
human glutamate carboxypeptidase II

Low-level endogenous PSMA expression in nonprostatic tumor xenografts is sufficient for in vivo tumor targeting and imaging

Nimmagadda, S., Pullambhatla, M., Chen, Y., Parsana, P., Lisok, A., Chatterjee, S., Mease, R., Rowe, S. P., Lupold, S., Pienta, K. J. & Pomper, M. G., Mar 1 2018, In : Journal of Nuclear Medicine. 59, 3, p. 486-493 8 p.

Research output: Contribution to journalArticle

Heterografts
Neoplasms
Small Cell Lung Carcinoma
Melanoma
Optical Imaging

Meeting report from the Prostate Cancer Foundation PSMA-directed radionuclide scientific working group

Miyahira, A. K., Pienta, K. J., Morris, M. J., Bander, N. H., Baum, R. P., Fendler, W. P., Goeckeler, W., Gorin, M. A., Hennekes, H., Pomper, M. G., Sartor, O., Tagawa, S. T., Williams, S. & Soule, H. R., Jan 1 2018, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Radioisotopes
Prostatic Neoplasms
Clinical Trials
human glutamate carboxypeptidase II
Molecular Imaging

Molecular imaging reporting and data systems (MI-RADS): a generalizable framework for targeted radiotracers with theranostic implications

Werner, R. A., Bundschuh, R. A., Bundschuh, L., Javadi, M. S., Higuchi, T., Weich, A., Sheikhbahaei, S., Pienta, K. J., Buck, A. K., Pomper, M. G., Gorin, M. A., Lapa, C. & Rowe, S. P., Jan 1 2018, (Accepted/In press) In : Annals of Nuclear Medicine.

Research output: Contribution to journalArticle

Somatostatin Receptors
Antigen Receptors
Molecular Imaging
Information Systems
Positron-Emission Tomography

Optimization of Immunofluorescent Detection of Bone Marrow Disseminated Tumor Cells

Axelrod, H. D., Pienta, K. J. & Valkenburg, K. C., Jul 1 2018, In : Biological Procedures Online. 20, 1, 13

Research output: Contribution to journalArticle

Bone Marrow
Staining and Labeling
Neoplasms
Circulating Neoplastic Cells
Bone Matrix

PBOV1 as a potential biomarker for more advanced prostate cancer based on protein and digital histomorphometric analysis

Carleton, N. M., Zhu, G., Gorbounov, M., Miller, M. C., Pienta, K. J., Resar, L. M. S. & Veltri, R. W., Jan 1 2018, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Breast
Biomarkers
Immunohistochemistry
human glutamate carboxypeptidase II

Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms

Chalfin, H. J., Glavaris, S. A., Malihi, P. D., Sperger, J. M., Gorin, M. A., Lu, C., Goodwin, C. R., Chen, Y., Caruso, E. A., Dumpit, R., Kuhn, P., Lang, J. M., Nelson, P. S., Luo, J. & Pienta, K. J., Jan 1 2018, (Accepted/In press) In : Journal of Urology.

Research output: Contribution to journalArticle

Prostatectomy
Prostatic Neoplasms
Bone Marrow
Prostate
Neoplasms
Positron-Emission Tomography
Prostatic Neoplasms
Tomography
Surgical Pathology
Lymph Nodes

SSTR-RADS version 1.0 as a reporting system for SSTR PET imaging and selection of potential PRRT candidates: A proposed standardization framework

Werner, R. A., Solnes, L. B., Javadi, M. S., Weich, A., Gorin, M. A., Pienta, K. J., Higuchi, T., Buck, A. K., Pomper, M. G., Rowe, S. P. & Lapa, C., Jul 1 2018, In : Journal of Nuclear Medicine. 59, 7, p. 1085-1091 7 p.

Research output: Contribution to journalArticle

Somatostatin Receptors
Molecular Imaging
Peptide Receptors
Neuroendocrine Tumors
Radioisotopes

Stereotactic ablative radiation therapy for oligometastatic prostate cancer delays time-to-next systemic treatment

Moyer, C. L., Phillips, R., Deek, M. P., Radwan, N., Ross, A. E., Antonarakis, E. S., Reyes, D., Wright, J., Terezakis, S. A., Song, D. Y., DeVille, C., Walsh, P. C., DeWeese, T. L., Carducci, M., Schaeffer, E. M., Pienta, K. J., Eisenberger, M. & Tran, P. T., Jan 1 2018, (Accepted/In press) In : World journal of urology.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Radiotherapy
Disease-Free Survival
Radiation
Hormones

Symmetry and symmetry breaking in cancer: A foundational approach to the cancer problem

Frost, J. J., Pienta, K. J. & Coffey, D. S., Feb 20 2018, In : Oncotarget. 9, 14, p. 11429-11440 12 p.

Research output: Contribution to journalArticle

Neoplasms
Fractals
Physics
Homeostasis

Targeting the tumour stroma to improve cancer therapy

Valkenburg, K. C., de Groot, A. E. & Pienta, K. J., Apr 12 2018, (Accepted/In press) In : Nature Reviews Clinical Oncology. p. 1-16 16 p.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
Tumor Microenvironment
Antineoplastic Agents
Ecosystem
2017

A Bayesian hierarchical model for prediction of latent health states from multiple data sources with application to active surveillance of prostate cancer

Coley, R. Y., Fisher, A. J., Mamawala, M., Carter, H. B., Pienta, K. J. & Zeger, S. L., Jun 1 2017, In : Biometrics. 73, 2, p. 625-634 10 p.

Research output: Contribution to journalArticle

Bayesian Hierarchical Model
Prostate Cancer
Information Storage and Retrieval
prostatic neoplasms
Surveillance

Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling

Bluemn, E. G. , Coleman, I. M. , Lucas, J. M. , Coleman, R. T. , Hernandez-Lopez, S. , Tharakan, R. , Bianchi-Frias, D. , Dumpit, R. F. , Kaipainen, A. , Corella, A. N. , Yang, Y. C. , Nyquist, M. D. , Mostaghel, E. , Hsieh, A. C. , Zhang, X. , Corey, E. , Brown, L. G. , Nguyen, H. M. , Pienta, K. , Ittmann, M. & 7 others Schweizer, M., True, L. D., Wise, D., Rennie, P. S., Vessella, R. L., Morrissey, C. & Nelson, P. S., Oct 9 2017, In : Cancer Cell. 32, 4, p. 474-489.e6

Research output: Contribution to journalArticle

Inhibitor of Differentiation Protein 1
Androgen Antagonists
Fibroblast Growth Factor Receptors
Fibroblast Growth Factors
MAP Kinase Signaling System
Glutamate Carboxypeptidase II
Penile Neoplasms
Surface Antigens
Lysine
Urea
Prostatic Neoplasms
Radiotherapy
Observation
Radiation
Androgens

A surface tension magnetophoretic device for rare cell isolation and characterization

van der Toom, E. E., Verdone, J. E., Jun, C., Petrisor, D., Lim, S., de la Rosette, J. J. M. C. H., de Reijke, T. M., Gorin, M. A., Pienta, K. J. & Stoianovici, D., Feb 1 2017, In : Medical Oncology. 34, 2, 22

Research output: Contribution to journalArticle

Surface Tension
Cell Separation
Equipment and Supplies
Staining and Labeling
Fluorescent Antibody Technique

Biomanufacturing Seamless Tubular and Hollow Collagen Scaffolds with Unique Design Features and Biomechanical Properties

Singh, A., Lee, D., Sopko, N., Matsui, H., Sabnekar, P., Liu, X., Elisseeff, J., Schoenberg, M. P., Pienta, K. & Bivalacqua, T. J., 2017, (Accepted/In press) In : Advanced healthcare materials.

Research output: Contribution to journalArticle

Cell surface Thomsen-Friedenreich proteome profiling of metastatic prostate cancer cells reveals potential link with cancer stem cell-like phenotype

Li, F., Glinskii, O. V., Mooney, B. P., Rittenhouse-Olson, K., Pienta, K. J. & Glinsky, V. V., Jan 1 2017, In : Oncotarget. 8, 58, p. 98598-98608 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Proteome
Prostatic Neoplasms
Phenotype
Stem Cells
Circulating Neoplastic Cells
Castration
Androgen Receptors
Prostatic Neoplasms
Messenger RNA

Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration

Parsana, P., Amend, S. R., Hernandez, J., Pienta, K. J. & Battle, A., Jun 26 2017, In : BMC Cancer. 17, 1, 447

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Gene Expression
Genes
Cell Line

Patterns of uptake of prostate-specific membrane antigen (PSMA)-targeted 18F-DCFPyL in peripheral ganglia

Werner, R. A., Sheikhbahaei, S., Jones, K. M., Javadi, M. S., Solnes, L. B., Ross, A. E., Allaf, M. E., Pienta, K. J., Lapa, C., Buck, A. K., Higuchi, T., Pomper, M. G., Gorin, M. A. & Rowe, S. P., Aug 22 2017, (Accepted/In press) In : Annals of Nuclear Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticle

Ganglia
Prostatic Neoplasms
Sympathetic Ganglia
Aorta
human glutamate carboxypeptidase II

Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging

Sheikhbahaei, S., Afshar-Oromieh, A., Eiber, M., Solnes, L. B., Javadi, M. S., Ross, A. E., Pienta, K. J., Allaf, M. E., Haberkorn, U., Pomper, M. G., Gorin, M. A. & Rowe, S. P., Aug 1 2017, (Accepted/In press) In : European Journal of Nuclear Medicine and Molecular Imaging. p. 1-20 20 p.

Research output: Contribution to journalArticle

Molecular Imaging
Normal Distribution
Prostatic Neoplasms
Patient Care
Pathology
Prostatic Neoplasms
Recurrence
Prostate-Specific Antigen
1-amino-3-fluorocyclobutane-1-carboxylic acid
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Prostatic Neoplasms
Information Systems
human glutamate carboxypeptidase II

RB loss promotes prostate cancer metastasis

Thangavel, C. , Boopathi, E. , Liu, Y. , Haber, A. , Ertel, A. , Bhardwaj, A. , Addya, S. , Williams, N. , Ciment, S. J. , Cotzia, P. , Dean, J. L. , Snook, A. , McNair, C. , Price, M. , Hernandez, J. R. , Zhao, S. G. , Birbe, R. , McCarthy, J. B. , Turley, E. A. , Pienta, K. J. & 4 others Feng, F. Y., Dicker, A. P., Knudsen, K. E. & Den, R. B., Feb 15 2017, In : Cancer Research. 77, 4, p. 982-995 14 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasm Metastasis
Neoplasms
Phenotype
Critical Pathways
Liver
Lacrimal Apparatus
Submandibular Gland
Parotid Gland
Kidney

Tenascin-C and integrin α9 mediate interactions of prostate cancer with the bone microenvironment

Martin, R. S., Pathak, R., Jain, A., Jung, S. Y., Hilsenbeck, S. G., Piña-Barba, M. C., Sikora, A. G., Pienta, K. J. & Rowley, D. R., Nov 1 2017, In : Cancer Research. 77, 21, p. 5977-5988 12 p.

Research output: Contribution to journalArticle

Tenascin
Bone Neoplasms
Integrins
Prostatic Neoplasms
Neoplasm Metastasis

The identification of macrophage-enriched glycoproteins using glycoproteomics

Zarif, J. C., Yang, W., Hernandez, J. R., Zhang, H. & Pienta, K. J., Jun 1 2017, In : Molecular and Cellular Proteomics. 16, 6, p. 1029-1037 9 p.

Research output: Contribution to journalArticle

Macrophages
Glycoproteins
Prostatic Neoplasms
Membrane Glycoproteins
Tumors

The prostate metastasis suppressor gene NDRG1 differentially regulates cell motility and invasion

Sharma, A., Mendonca, J., Ying, J., Kim, H. S., Verdone, J. E., Zarif, J. C., Carducci, M., Hammers, H., Pienta, K. J. & Kachhap, S., 2017, In : Molecular Oncology. 11, 6, p. 655-669 15 p.

Research output: Contribution to journalArticle

myc Genes
Tumor Suppressor Genes
Cell Movement
Prostate
Down-Regulation

TWIST1-WDR5-hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis

Malek, R., Gajula, R. P., Williams, R. D., Nghiem, B., Simons, B. W., Nugent, K., Wang, H., Taparra, K., Lemtiri-Chlieh, G., Yoon, A. R., True, L., An, S. S., DeWeese, T. L., Ross, A. E., Schaeffer, E. M., Pienta, K. J., Hurley, P. J., Morrissey, C. & Tran, P. T., Jun 15 2017, In : Cancer Research. 77, 12, p. 3181-3193 13 p.

Research output: Contribution to journalArticle

Chromatin
Prostatic Neoplasms
Neoplasm Metastasis
Prostate
Long Noncoding RNA
Prostatic Neoplasms
Thoracic Wall
human glutamate carboxypeptidase II
2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid
2016

Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer

Stoyanova, T. , Riedinger, M. , Lin, S. , Faltermeier, C. M. , Smith, B. A. , Zhang, K. X. , Going, C. C. , Goldstein, A. S. , Lee, J. K. , Drake, J. M. , Rice, M. A. , Hsu, E. C. , Nowroozizadeh, B. , Castor, B. , Orellana, S. Y. , Blum, S. M. , Cheng, D. , Pienta, K. J. , Reiter, R. E. , Pitteri, S. J. & 2 others Huang, J. & Witte, O. N., Oct 18 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. E6457-E6466

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Prostate
Neoplasms
Epithelial-Mesenchymal Transition

A Novel Approach for Performing Bone Marrow Aspiration at the Time of Radical Prostatectomy

Tosoian, J. J., Reyes, D. K., Gorin, M. A., Hortopan, S., Partin, A. W., Pienta, K. J., Ross, A. E. & Schaeffer, E. M., May 1 2016, In : Urology Case Reports. 6, p. 45-46 2 p.

Research output: Contribution to journalArticle

Prostatectomy
Prostatic Neoplasms
Pubic Bone
Bone Marrow
Therapeutics

A phase 2 trial of salvage radiation and concurrent weekly docetaxel after a rising prostate-specific antigen level after radical prostatectomy

Jackson, W. C., Feng, F. Y., Daignault, S., Hussain, M., Smith, D., Cooney, K., Pienta, K., Jolly, S., Hollenbeck, B., Olson, K. B., Sandler, H. M., Ray, M. E. & Hamstra, D. A., Jan 1 2016, In : Advances in Radiation Oncology. 1, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

docetaxel
Salvage Therapy
Prostate-Specific Antigen
Prostatectomy
Radiotherapy

A phased strategy to differentiate human CD14+ monocytes into classically and alternatively activated macrophages and dendritic cells

Zarif, J. C., Hernandez, J. R., Verdone, J. E., Campbell, S. P., Drake, C. G. & Pienta, K. J., Jul 1 2016, In : BioTechniques. 61, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Macrophages
Dendritic Cells
Monocytes
Cytokines
Network protocols

A simple selection-free method for detecting disseminated tumor cells (DTCs) in murine bone marrow

Valkenburg, K. C., Amend, S. R., Verdone, J. E., van der Toom, E. E., Hernandez, J. R., Gorin, M. A. & Pienta, K. J., 2016, In : Oncotarget. 7, 43, p. 69794-69803 10 p.

Research output: Contribution to journalArticle

Bone Marrow
Neoplasms
Neoplasm Metastasis
Biological Phenomena
Bone Neoplasms

Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer; Report From the 2016 Coffey-Holden Prostate Cancer Academy Meeting

Miyahira, A. K., Roychowdhury, S., Goswami, S., Ippolito, J. E., Priceman, S. J., Pritchard, C. C., Sfanos, K. S., Subudhi, S. K., Simons, J. W., Pienta, K. J. & Soule, H. R., 2016, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Seeds
Soil
DNA Repair-Deficiency Disorders
Microbiota

Circulating tumour cells as biomarkers of prostate, bladder, and kidney cancer

Gorin, M. A., Verdone, J. E., van der Toom, E., Bivalacqua, T. J., Allaf, M. E. & Pienta, K. J., Nov 22 2016, (Accepted/In press) In : Nature Reviews Urology.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Kidney Neoplasms
Urinary Bladder Neoplasms
Prostatic Neoplasms
Biomarkers
Prostatic Neoplasms
Immunohistochemistry
human glutamate carboxypeptidase II