Research Output 1981 2018

2018

Analogous detection of circulating tumor cells using the AccuCyte®-CyteFinder® system and ISET system in patients with locally advanced and metastatic prostate cancer

van der Toom, E. E., Groot, V. P., Glavaris, S. A., Gemenetzis, G., Chalfin, H. J., Wood, L. D., Wolfgang, C. L., de la Rosette, J. J. M. C. H., de Reijke, T. M. & Pienta, K. J. Jan 1 2018 (Accepted/In press) In : Prostate.

Research output: Research - peer-reviewArticle

Circulating Neoplastic Cells
Prostatic Neoplasms
Vimentin
Cell Count
Cell Size
Molecular Imaging
Prostatic Neoplasms
Radiotherapy
Recurrence
2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid
Carcinoid Tumor
Prostatic Neoplasms
human glutamate carboxypeptidase II
Positron-Emission Tomography
Prostatic Neoplasms
Tomography
human glutamate carboxypeptidase II
Lymph Nodes
2017

A Bayesian hierarchical model for prediction of latent health states from multiple data sources with application to active surveillance of prostate cancer

Coley, R. Y., Fisher, A. J., Mamawala, M., Carter, H. B., Pienta, K. J. & Zeger, S. L. Jun 1 2017 In : Biometrics. 73, 2, p. 625-634 10 p.

Research output: Research - peer-reviewArticle

Bayesian Hierarchical Model
Prostate Cancer
Surveillance
Health
Prediction
Prostatic Neoplasms
Radiotherapy
Observation
Radiation
Therapeutics

A surface tension magnetophoretic device for rare cell isolation and characterization

van der Toom, E. E., Verdone, J. E., Jun, C., Petrisor, D., Lim, S., de la Rosette, J. J. M. C. H., de Reijke, T. M., Gorin, M. A., Pienta, K. J. & Stoianovici, D. Feb 1 2017 In : Medical Oncology. 34, 2, 22

Research output: Research - peer-reviewArticle

Surface Tension
Cell Separation
Equipment and Supplies
Staining and Labeling
Neoplasms

Beyond the androgen receptor II: New approaches to understanding and treating metastatic prostate cancer; Report from the 2017 Coffey-Holden Prostate Cancer Academy Meeting

Miyahira, A. K., Cheng, H. H., Abida, W., Ellis, L., Harshman, L. C., Spratt, D. E., Simons, J. W., Pienta, K. J. & Soule, H. R. Nov 1 2017 In : Prostate. 77, 15, p. 1478-1488 11 p.

Research output: Research - peer-reviewReview article

Androgen Receptors
Prostatic Neoplasms
Therapeutics
Molecular Imaging
Epigenomics

Biomanufacturing Seamless Tubular and Hollow Collagen Scaffolds with Unique Design Features and Biomechanical Properties

Singh, A., Lee, D., Sopko, N., Matsui, H., Sabnekar, P., Liu, X., Elisseeff, J., Schoenberg, M. P., Pienta, K. & Bivalacqua, T. J. 2017 (Accepted/In press) In : Advanced Healthcare Materials.

Research output: Research - peer-reviewArticle

Cell surface Thomsen-Friedenreich proteome profiling of metastatic prostate cancer cells reveals potential link with cancer stem cell-like phenotype

Li, F., Glinskii, O. V., Mooney, B. P., Rittenhouse-Olson, K., Pienta, K. J. & Glinsky, V. V. Jan 1 2017 In : Oncotarget. 8, 58, p. 98598-98608 11 p.

Research output: Research - peer-reviewArticle

Neoplastic Stem Cells
Proteome
Prostatic Neoplasms
Phenotype
Stem Cells

Classifying the evolutionary and ecological features of neoplasms

Maley, C. C. , Aktipis, A. , Graham, T. A. , Sottoriva, A. , Boddy, A. M. , Janiszewska, M. , Silva, A. S. , Gerlinger, M. , Yuan, Y. , Pienta, K. J. , Anderson, K. S. , Gatenby, R. , Swanton, C. , Posada, D. , Wu, C. I. , Schiffman, J. D. , Hwang, E. S. , Polyak, K. , Anderson, A. R. A. , Brown, J. S. & 2 others Greaves, M. & Shibata, D. Oct 1 2017 In : Nature Reviews Cancer. 17, 10, p. 605-619 15 p.

Research output: Research - peer-reviewReview article

Neoplasms
Ecology
Precision Medicine
Molecular Evolution
Epigenomics
Circulating Neoplastic Cells
Castration
Androgen Receptors
Prostatic Neoplasms
Messenger RNA

Correction: The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer [Oncotarget., 7, (2016) (41217-41232)] doi: 10.18632/oncotarget.9251

Shiozawa, Y., Berry, J. E., Eber, M. R., Jung, Y., Yumoto, K., Cackowski, F. C., Yoon, H. J., Parsana, P., Mehra, R., Wang, J., McGee, S., Lee, E., Nagrath, S., Pienta, K. J. & Taichman, R. S. 2017 In : Oncotarget. 8, 23, p. 38075 1 p.

Research output: Research - peer-reviewComment/debate

Neoplastic Stem Cells
Sirolimus
Prostatic Neoplasms
Bone Marrow
Phenotype

Defining the clinical utility of PSMA-targeted PET imaging of prostate cancer

Gorin, M. A., Pomper, M. G., Pienta, K. J. & Rowe, S. P. Aug 1 2017 In : BJU International. 120, 2, p. 160-161 2 p.

Research output: Research - peer-reviewEditorial

Prostatic Neoplasms

Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration

Parsana, P., Amend, S. R., Hernandez, J., Pienta, K. J. & Battle, A. Jun 26 2017 In : BMC Cancer. 17, 1, 447

Research output: Research - peer-reviewArticle

Epithelial-Mesenchymal Transition
Genes
Gene Expression
Prostatic Neoplasms
Cell Line

Oligometastatic prostate cancer: Shaping the definition with molecular imaging and an improved understanding of tumor biology

Joice, G. A., Rowe, S. P., Pienta, K. J. & Gorin, M. A. Nov 1 2017 In : Current Opinion in Urology. 27, 6, p. 533-541 9 p.

Research output: Research - peer-reviewReview article

Molecular Imaging
Prostatic Neoplasms
Neoplasms
Biomarkers
Routine Diagnostic Tests

Patterns of uptake of prostate-specific membrane antigen (PSMA)-targeted 18F-DCFPyL in peripheral ganglia

Werner, R. A., Sheikhbahaei, S., Jones, K. M., Javadi, M. S., Solnes, L. B., Ross, A. E., Allaf, M. E., Pienta, K. J., Lapa, C., Buck, A. K., Higuchi, T., Pomper, M. G., Gorin, M. A. & Rowe, S. P. Aug 22 2017 (Accepted/In press) In : Annals of Nuclear Medicine. p. 1-7 7 p.

Research output: Research - peer-reviewArticle

Ganglia
human glutamate carboxypeptidase II
Prostatic Neoplasms
Sympathetic Ganglia
Aorta

Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging

Sheikhbahaei, S., Afshar-Oromieh, A., Eiber, M., Solnes, L. B., Javadi, M. S., Ross, A. E., Pienta, K. J., Allaf, M. E., Haberkorn, U., Pomper, M. G., Gorin, M. A. & Rowe, S. P. Aug 1 2017 (Accepted/In press) In : European Journal of Nuclear Medicine and Molecular Imaging. p. 1-20 20 p.

Research output: Research - peer-reviewArticle

human glutamate carboxypeptidase II
Molecular Imaging
Normal Distribution
Prostatic Neoplasms
Patient Care

Prostate Cancer Local Recurrence Detected With Both 18F-Fluciclovine and PSMA-targeted 18F-DCFPyL PET/CT

Gorin, M. A., Pienta, K. J., Pomper, M. G. & Rowe, S. P. 2017 (Accepted/In press) In : Urology.

Research output: Research - peer-reviewArticle

Prostatic Neoplasms
Recurrence
1-amino-3-fluorocyclobutane-1-carboxylic acid
Positron Emission Tomography Computed Tomography
Prostate-Specific Antigen
Positron-Emission Tomography
human glutamate carboxypeptidase II
Prostatic Neoplasms
Information Systems

RB loss promotes prostate cancer metastasis

Thangavel, C. , Boopathi, E. , Liu, Y. , Haber, A. , Ertel, A. , Bhardwaj, A. , Addya, S. , Williams, N. , Ciment, S. J. , Cotzia, P. , Dean, J. L. , Snook, A. , McNair, C. , Price, M. , Hernandez, J. R. , Zhao, S. G. , Birbe, R. , McCarthy, J. B. , Turley, E. A. , Pienta, K. J. & 4 others Feng, F. Y., Dicker, A. P., Knudsen, K. E. & Den, R. B. Feb 15 2017 In : Cancer Research. 77, 4, p. 982-995 14 p.

Research output: Research - peer-reviewArticle

Prostatic Neoplasms
Neoplasm Metastasis
Neoplasms
Phenotype
Critical Pathways

Revisiting seed and soil: Examining the primary tumor and cancer cell foraging in metastasis

De Groot, A. E., Roy, S., Brown, J. S., Pienta, K. J. & Amend, S. R. Apr 1 2017 In : Molecular Cancer Research. 15, 4, p. 361-370 10 p.

Research output: Research - peer-reviewReview article

Seeds
Soil
Neoplasm Metastasis
Neoplasms
Reward

Selection-free method reveals phenotypic diversity among prostate cancer circulating tumour cells

Chalfin, H. J., Pienta, K. J. & Gorin, M. A. Nov 1 2017 In : BJU International. 120, 5, p. E4

Research output: Research - peer-reviewEditorial

Circulating Neoplastic Cells
Prostatic Neoplasms
Liver
Lacrimal Apparatus
Kidney
Submandibular Gland
Parotid Gland

Tenascin-C and integrin α9 mediate interactions of prostate cancer with the bone microenvironment

Martin, R. S., Pathak, R., Jain, A., Jung, S. Y., Hilsenbeck, S. G., Piña-Barba, M. C., Sikora, A. G., Pienta, K. J. & Rowley, D. R. Nov 1 2017 In : Cancer Research. 77, 21, p. 5977-5988 12 p.

Research output: Research - peer-reviewArticle

Tenascin
Bone Neoplasms
Integrins
Prostatic Neoplasms
Neoplasm Metastasis

The identification of macrophage-enriched glycoproteins using glycoproteomics

Zarif, J. C., Yang, W., Hernandez, J. R., Zhang, H. & Pienta, K. J. Jun 1 2017 In : Molecular and Cellular Proteomics. 16, 6, p. 1029-1037 9 p.

Research output: Research - peer-reviewArticle

Glycoproteins
Macrophages
Prostatic Neoplasms
Neoplasms
Membrane Glycoproteins

The prostate metastasis suppressor gene NDRG1 differentially regulates cell motility and invasion

Sharma, A., Mendonca, J., Ying, J., Kim, H. S., Verdone, J. E., Zarif, J. C., Carducci, M., Hammers, H., Pienta, K. J. & Kachhap, S. 2017 In : Molecular Oncology. 11, 6, p. 655-669 15 p.

Research output: Research - peer-reviewArticle

myc Genes
Tumor Suppressor Genes
Cell Movement
Prostate
Down-Regulation

The tumor microenvironment at a turning point knowledge gained over the last decade, and challenges and opportunities ahead: A white paper from the NCI TME network

DeClerck, Y. A., Pienta, K. J., Woodhouse, E. C., Singer, D. S. & Mohla, S. Mar 1 2017 In : Cancer Research. 77, 5, p. 1051-1059 9 p.

Research output: Research - peer-reviewReview article

Tumor Microenvironment
Foster Home Care
Theoretical Models
Research
Neoplasms

TWIST1-WDR5-hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis

Malek, R., Gajula, R. P., Williams, R. D., Nghiem, B., Simons, B. W., Nugent, K., Wang, H., Taparra, K., Lemtiri-Chlieh, G., Yoon, A. R., True, L., An, S. S., DeWeese, T. L., Ross, A. E., Schaeffer, E. M., Pienta, K. J., Hurley, P. J., Morrissey, C. & Tran, P. T. Jun 15 2017 In : Cancer Research. 77, 12, p. 3181-3193 13 p.

Research output: Research - peer-reviewArticle

Chromatin
Prostatic Neoplasms
Neoplasm Metastasis
Prostate
Phenotype

Uptake of the prostate-specific membrane antigen-targeted PET radiotracer 18F-DCFPyL in elastofibroma dorsi

Gorin, M. A., Mareshdeh, W., Ross, A. E., Allaf, M. E., Pienta, K. J., Pomper, M. G. & Rowe, S. P. Jul 12 2017 (Accepted/In press) In : Nuclear Medicine Communications.

Research output: Research - peer-reviewArticle

Prostatic Neoplasms
human glutamate carboxypeptidase II
2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid
Thoracic Wall
2016

Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer

Stoyanova, T. , Riedinger, M. , Lin, S. , Faltermeier, C. M. , Smith, B. A. , Zhang, K. X. , Going, C. C. , Goldstein, A. S. , Lee, J. K. , Drake, J. M. , Rice, M. A. , Hsu, E. C. , Nowroozizadeh, B. , Castor, B. , Orellana, S. Y. , Blum, S. M. , Cheng, D. , Pienta, K. J. , Reiter, R. E. , Pitteri, S. J. & 2 others Huang, J. & Witte, O. N. Oct 18 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. E6457-E6466

Research output: Research - peer-reviewArticle

Castration
Prostatic Neoplasms
Neoplasms
Prostate
Epithelial-Mesenchymal Transition

A Novel Approach for Performing Bone Marrow Aspiration at the Time of Radical Prostatectomy

Tosoian, J. J., Reyes, D. K., Gorin, M. A., Hortopan, S., Partin, A. W., Pienta, K. J., Ross, A. E. & Schaeffer, E. M. May 1 2016 In : Urology Case Reports. 6, p. 45-46 2 p.

Research output: Research - peer-reviewArticle

Prostatectomy
Prostatic Neoplasms
Bone Marrow
Pubic Bone
Therapeutics

A phase 2 trial of salvage radiation and concurrent weekly docetaxel after a rising prostate-specific antigen level after radical prostatectomy

Jackson, W. C., Feng, F. Y., Daignault, S., Hussain, M., Smith, D., Cooney, K., Pienta, K., Jolly, S., Hollenbeck, B., Olson, K. B., Sandler, H. M., Ray, M. E. & Hamstra, D. A. Jan 1 2016 In : Advances in Radiation Oncology. 1, 1, p. 59-66 8 p.

Research output: Research - peer-reviewArticle

docetaxel
Salvage Therapy
Prostate-Specific Antigen
Prostatectomy
Radiotherapy

A phased strategy to differentiate human CD14+ monocytes into classically and alternatively activated macrophages and dendritic cells

Zarif, J. C., Hernandez, J. R., Verdone, J. E., Campbell, S. P., Drake, C. G. & Pienta, K. J. Jul 1 2016 In : BioTechniques. 61, 1, p. 33-41 9 p.

Research output: Research - peer-reviewArticle

Dendritic Cells
Monocytes
Macrophages
Cytokines
In Vitro Techniques

A simple selection-free method for detecting disseminated tumor cells (DTCs) in murine bone marrow

Valkenburg, K. C., Amend, S. R., Verdone, J. E., van der Toom, E. E., Hernandez, J. R., Gorin, M. A. & Pienta, K. J. 2016 In : Oncotarget. 7, 43, p. 69794-69803 10 p.

Research output: Research - peer-reviewArticle

Bone Marrow
Neoplasms
Neoplasm Metastasis
Biological Phenomena
Bone Neoplasms

Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer; Report From the 2016 Coffey-Holden Prostate Cancer Academy Meeting

Miyahira, A. K., Roychowdhury, S., Goswami, S., Ippolito, J. E., Priceman, S. J., Pritchard, C. C., Sfanos, K. S., Subudhi, S. K., Simons, J. W., Pienta, K. J. & Soule, H. R. 2016 (Accepted/In press) In : Prostate.

Research output: Research - peer-reviewArticle

Prostatic Neoplasms
Seeds
Soil
Therapeutics
DNA Repair-Deficiency Disorders

Circulating tumour cells as biomarkers of prostate, bladder, and kidney cancer

Gorin, M. A., Verdone, J. E., van der Toom, E., Bivalacqua, T. J., Allaf, M. E. & Pienta, K. J. Nov 22 2016 (Accepted/In press) In : Nature Reviews Urology.

Research output: Research - peer-reviewArticle

Circulating Neoplastic Cells
Kidney Neoplasms
Urinary Bladder Neoplasms
Prostatic Neoplasms
Biomarkers
Prostatic Neoplasms
Immunohistochemistry
human glutamate carboxypeptidase II

Development of an Automated and Sensitive Microfluidic Device for Capturing and Characterizing Circulating Tumor Cells (CTCs) from Clinical Blood Samples

Gogoi, P., Sepehri, S., Zhou, Y., Gorin, M. A., Paolillo, C., Capoluongo, E., Gleason, K., Payne, A., Boniface, B., Cristofanilli, M., Morgan, T. M., Fortina, P., Pienta, K. J., Handique, K. & Wang, Y. 2016 In : PloS one. 11, 1, p. e0147400

Research output: Research - peer-reviewArticle

Microfluidics
Tumors
Blood
Cells
Lab-On-A-Chip Devices

Disseminated tumor cells and dormancy in prostate cancer metastasis

Van der Toom, E. E., Verdone, J. E. & Pienta, K. J. Aug 1 2016 In : Current Opinion in Biotechnology. 40, p. 9-15 7 p.

Research output: Research - peer-reviewArticle

Prostatic Neoplasms
Neoplasm Metastasis
Neoplasms
Tumors
Cells

DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis

Lee, E., Wang, J., Yumoto, K., Jung, Y., Cackowski, F. C., Decker, A. M., Li, Y., Franceschi, R. T., Pienta, K. J. & Taichman, R. S. Sep 1 2016 In : Neoplasia. 18, 9, p. 553-566 14 p.

Research output: Research - peer-reviewArticle

Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
Methyltransferases
Mesenchymal Stromal Cells
Prostatic Neoplasms

Multidisciplinary intervention of early, lethal metastatic prostate cancer: Report from the 2015 Coffey-Holden Prostate Cancer Academy Meeting

Miyahira, A. K., Lang, J. M., Den, R. B., Garraway, I. P., Lotan, T. L., Ross, A. E., Stoyanova, T., Cho, S. Y., Simons, J. W., Pienta, K. J. & Soule, H. R. Feb 1 2016 In : Prostate. 76, 2, p. 125-139 15 p.

Research output: Research - peer-reviewArticle

Prostatic Neoplasms
Clinical Trials
Molecular Imaging
Tumor Biomarkers
Early Diagnosis

Murine hind limb long bone dissection and bone marrow isolation

Amend, S. R., Valkenburg, K. C. & Pienta, K. J. Apr 1 2016 In : Journal of Visualized Experiments. 2016, 110, e53936

Research output: Research - peer-reviewArticle

Dissection
Extremities
Bone Marrow
Bone and Bones
Bone

Murine prostate micro-dissection and surgical castration

Valkenburg, K. C., Amend, S. R. & Pienta, K. J. May 11 2016 In : Journal of Visualized Experiments. 2016, 111, e53984

Research output: Research - peer-reviewArticle

Castration
Dissection
Prostate
Microdissection
Testosterone

Nucleolin Staining May Aid in the Identification of Circulating Prostate Cancer Cells

Chalfin, H. J., Verdone, J. E., van der Toom, E. E., Glavaris, S., Gorin, M. A. & Pienta, K. J. Sep 16 2016 (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Research - peer-reviewArticle

Circulating Neoplastic Cells
Prostatic Neoplasms
Staining and Labeling
nucleolin
Leukocytes

Oligometastatic prostate cancer: definitions, clinical outcomes, and treatment considerations

Tosoian, J. J., Gorin, M. A., Ross, A. E., Pienta, K. J., Tran, P. T. & Schaeffer, E. M. Oct 11 2016 (Accepted/In press) In : Nature Reviews Urology.

Research output: Research - peer-reviewArticle

Prostatic Neoplasms
Neoplasm Metastasis
Therapeutics
Literature
Poisons
Positron-Emission Tomography
Prostatic Neoplasms
human glutamate carboxypeptidase II
Molecular Imaging
Therapeutics

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

Cheung, K. J., Padmanaban, V., Silvestri, V., Schipper, K., Cohen, J. D., Fairchild, A. N., Gorin, M. A., Verdone, J. E., Pienta, K. J., Bader, J. S. & Ewald, A. J. Feb 16 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E854-E863

Research output: Research - peer-reviewArticle

Keratin-14
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Circulating Neoplastic Cells

Positive feedback loops between inflammatory, bone and cancer cells during metastatic niche construction

Kianercy, A. & Pienta, K. J. Oct 1 2016 Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 936, p. 137-148 12 p. (Advances in Experimental Medicine and Biology; vol. 936)

Research output: ResearchChapter

Bone Neoplasms
Neoplasm Metastasis
Bone and Bones
Neoplasms
Bone

Prediction of the Pathologic Gleason Score to Inform a Personalized Management Program for Prostate Cancer

Coley, R. Y., Zeger, S. L., Mamawala, M., Pienta, K. J. & Carter, H. B. 2016 (Accepted/In press) In : European Urology.

Research output: Research - peer-reviewArticle

Neoplasm Grading
Prostatic Neoplasms
Prostatectomy
Biopsy
Area Under Curve