Kenneth Pienta

Professor

1981 …2018
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Research Output 1981 2018

2018
T-cells
prostatic neoplasms
Myeloid Cells
Infiltration
Tumors

Analogous detection of circulating tumor cells using the AccuCyte®-CyteFinder® system and ISET system in patients with locally advanced and metastatic prostate cancer

van der Toom, E. E., Groot, V. P., Glavaris, S. A., Gemenetzis, G., Chalfin, H. J., Wood, L. D., Wolfgang, C. L., de la Rosette, J. J. M. C. H., de Reijke, T. M. & Pienta, K. J. Jan 1 2018 (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Prostatic Neoplasms
Vimentin
Cell Count

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone

Roca, H., Jones, J. D., Purica, M. C., Weidner, S., Koh, A. J., Kuo, R., Wilkinson, J. E., Wang, Y., Daignault-Newton, S., Pienta, K. J., Morgan, T. M., Keller, E. T., Nör, J. E., Shea, L. D. & McCauley, L. K. Jan 2 2018 In : Journal of Clinical Investigation. 128, 1, p. 248-266 19 p.

Research output: Contribution to journalArticle

Prostate
Apoptosis
Neoplasm Metastasis
Inflammation
Bone and Bones

A Voice From the Past: Rediscovering the Virchow Node With Prostate-specific Membrane Antigen-targeted 18F-DCFPyL Positron Emission Tomography Imaging

Werner, R. A., Andree, C., Javadi, M. S., Lapa, C., Buck, A. K., Higuchi, T., Pomper, M. G., Gorin, M. A., Rowe, S. P. & Pienta, K. J. Jan 1 2018 (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Positron-Emission Tomography
human glutamate carboxypeptidase II

Characterization of Urothelial Cancer Circulating Tumor Cells with a Novel Selection-Free Method

Chalfin, H. J., Kates, M., van der Toom, E. E., Glavaris, S., Verdone, J. E., Hahn, N. M., Pienta, K. J., Bivalacqua, T. J. & Gorin, M. A. Jan 1 2018 (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Urinary Bladder Neoplasms
Neoplasms
Carcinoma
Muscles
Molecular Imaging
Prostatic Neoplasms
Radiotherapy
Recurrence
2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid

CXCL12g promotes metastatic castration-resistant prostate cancer by inducing cancer stem cell and neuroendocrine phenotypes

Jung, Y., Cackowski, F. C., Yumoto, K., Decker, A. M., Wang, J., Kim, J. K., Lee, E., Wang, Y., Chung, J. S., Gursky, A. M., Krebsbach, P. H., Pienta, K. J., Morgan, T. M. & Taichman, R. S. Apr 15 2018 In : Cancer Research. 78, 8, p. 2026-2039 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Castration
Prostatic Neoplasms
Phenotype
Circulating Neoplastic Cells
Carcinoid Tumor
Prostatic Neoplasms
human glutamate carboxypeptidase II

Epigenetic control of macrophage polarization: Implications for targeting tumor-associated macrophages

de Groot, A. E. & Pienta, K. J. Apr 17 2018 In : Oncotarget. 9, 29, p. 20908-20927 20 p.

Research output: Contribution to journalReview article

Epigenomics
Macrophages
Neoplasms
Tumor Microenvironment
Enzymes

Low-level endogenous PSMA expression in nonprostatic tumor xenografts is sufficient for in vivo tumor targeting and imaging

Nimmagadda, S., Pullambhatla, M., Chen, Y., Parsana, P., Lisok, A., Chatterjee, S., Mease, R., Rowe, S. P., Lupold, S., Pienta, K. J. & Pomper, M. G. Mar 1 2018 In : Journal of Nuclear Medicine. 59, 3, p. 486-493 8 p.

Research output: Contribution to journalArticle

Heterografts
Neoplasms
Small Cell Lung Carcinoma
Melanoma
Optical Imaging

Meeting report from the Prostate Cancer Foundation PSMA-directed radionuclide scientific working group

Miyahira, A. K., Pienta, K. J., Morris, M. J., Bander, N. H., Baum, R. P., Fendler, W. P., Goeckeler, W., Gorin, M. A., Hennekes, H., Pomper, M. G., Sartor, O., Tagawa, S. T., Williams, S. & Soule, H. R. Jan 1 2018 (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Radioisotopes
Prostatic Neoplasms
Clinical Trials
human glutamate carboxypeptidase II
Molecular Imaging

PBOV1 as a potential biomarker for more advanced prostate cancer based on protein and digital histomorphometric analysis

Carleton, N. M., Zhu, G., Gorbounov, M., Miller, M. C., Pienta, K. J., Resar, L. M. S. & Veltri, R. W. Jan 1 2018 (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Breast
Biomarkers
Immunohistochemistry
human glutamate carboxypeptidase II

Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms

Chalfin, H. J., Glavaris, S. A., Malihi, P. D., Sperger, J. M., Gorin, M. A., Lu, C., Goodwin, C. R., Chen, Y., Caruso, E. A., Dumpit, R., Kuhn, P., Lang, J. M., Nelson, P. S., Luo, J. & Pienta, K. J. Jan 1 2018 (Accepted/In press) In : Journal of Urology.

Research output: Contribution to journalArticle

Prostatectomy
Prostatic Neoplasms
Bone Marrow
Prostate
Neoplasms
Positron-Emission Tomography
Prostatic Neoplasms
Tomography
Surgical Pathology
Lymph Nodes

Re: Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer

Dong, L. & Pienta, K. J. Mar 1 2018 In : European Urology. 73, 3, 1 p.

Research output: Contribution to journalComment/debate

Prostatic Neoplasms
Gene Expression

Symmetry and symmetry breaking in cancer: A foundational approach to the cancer problem

Frost, J. J., Pienta, K. J. & Coffey, D. S. Feb 20 2018 In : Oncotarget. 9, 14, p. 11429-11440 12 p.

Research output: Contribution to journalArticle

Neoplasms
Fractals
Physics
Homeostasis

Targeting the tumour stroma to improve cancer therapy

Valkenburg, K. C., de Groot, A. E. & Pienta, K. J. Apr 12 2018 (Accepted/In press) In : Nature Reviews Clinical Oncology. p. 1-16 16 p.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
Tumor Microenvironment
Antineoplastic Agents
Ecosystem
2017

A Bayesian hierarchical model for prediction of latent health states from multiple data sources with application to active surveillance of prostate cancer

Coley, R. Y., Fisher, A. J., Mamawala, M., Carter, H. B., Pienta, K. J. & Zeger, S. L. Jun 1 2017 In : Biometrics. 73, 2, p. 625-634 10 p.

Research output: Contribution to journalArticle

Bayesian Hierarchical Model
Prostate Cancer
Information Storage and Retrieval
prostatic neoplasms
Surveillance

Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling

Bluemn, E. G. , Coleman, I. M. , Lucas, J. M. , Coleman, R. T. , Hernandez-Lopez, S. , Tharakan, R. , Bianchi-Frias, D. , Dumpit, R. F. , Kaipainen, A. , Corella, A. N. , Yang, Y. C. , Nyquist, M. D. , Mostaghel, E. , Hsieh, A. C. , Zhang, X. , Corey, E. , Brown, L. G. , Nguyen, H. M. , Pienta, K. , Ittmann, M. & 7 others Schweizer, M., True, L. D., Wise, D., Rennie, P. S., Vessella, R. L., Morrissey, C. & Nelson, P. S. Oct 9 2017 In : Cancer cell. 32, 4, p. 474-489.e6

Research output: Contribution to journalArticle

Inhibitor of Differentiation Protein 1
Androgen Antagonists
Fibroblast Growth Factor Receptors
Fibroblast Growth Factors
MAP Kinase Signaling System
Glutamate Carboxypeptidase II
Penile Neoplasms
Surface Antigens
Lysine
Urea
Prostatic Neoplasms
Radiotherapy
Observation
Radiation
Androgens

A surface tension magnetophoretic device for rare cell isolation and characterization

van der Toom, E. E., Verdone, J. E., Jun, C., Petrisor, D., Lim, S., de la Rosette, J. J. M. C. H., de Reijke, T. M., Gorin, M. A., Pienta, K. J. & Stoianovici, D. Feb 1 2017 In : Medical Oncology. 34, 2, 22

Research output: Contribution to journalArticle

Surface Tension
Cell Separation
Equipment and Supplies
Staining and Labeling
Fluorescent Antibody Technique

Beyond the androgen receptor II: New approaches to understanding and treating metastatic prostate cancer; Report from the 2017 Coffey-Holden Prostate Cancer Academy Meeting

Miyahira, A. K., Cheng, H. H., Abida, W., Ellis, L., Harshman, L. C., Spratt, D. E., Simons, J. W., Pienta, K. J. & Soule, H. R. Nov 1 2017 In : Prostate. 77, 15, p. 1478-1488 11 p.

Research output: Contribution to journalReview article

Androgen Receptors
Prostatic Neoplasms
Therapeutics
Molecular Imaging
Epigenomics

Biomanufacturing Seamless Tubular and Hollow Collagen Scaffolds with Unique Design Features and Biomechanical Properties

Singh, A., Lee, D., Sopko, N., Matsui, H., Sabnekar, P., Liu, X., Elisseeff, J., Schoenberg, M. P., Pienta, K. & Bivalacqua, T. J. 2017 (Accepted/In press) In : Advanced Healthcare Materials.

Research output: Contribution to journalArticle

Cell surface Thomsen-Friedenreich proteome profiling of metastatic prostate cancer cells reveals potential link with cancer stem cell-like phenotype

Li, F., Glinskii, O. V., Mooney, B. P., Rittenhouse-Olson, K., Pienta, K. J. & Glinsky, V. V. Jan 1 2017 In : Oncotarget. 8, 58, p. 98598-98608 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Proteome
Prostatic Neoplasms
Phenotype
Stem Cells

Classifying the evolutionary and ecological features of neoplasms

Maley, C. C. , Aktipis, A. , Graham, T. A. , Sottoriva, A. , Boddy, A. M. , Janiszewska, M. , Silva, A. S. , Gerlinger, M. , Yuan, Y. , Pienta, K. J. , Anderson, K. S. , Gatenby, R. , Swanton, C. , Posada, D. , Wu, C. I. , Schiffman, J. D. , Hwang, E. S. , Polyak, K. , Anderson, A. R. A. , Brown, J. S. & 2 others Greaves, M. & Shibata, D. Oct 1 2017 In : Nature Reviews Cancer. 17, 10, p. 605-619 15 p.

Research output: Contribution to journalReview article

Neoplasms
Ecology
Precision Medicine
Molecular Evolution
Epigenomics
Circulating Neoplastic Cells
Castration
Androgen Receptors
Prostatic Neoplasms
Messenger RNA

Correction: The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer [Oncotarget., 7, (2016) (41217-41232)] doi: 10.18632/oncotarget.9251

Shiozawa, Y., Berry, J. E., Eber, M. R., Jung, Y., Yumoto, K., Cackowski, F. C., Yoon, H. J., Parsana, P., Mehra, R., Wang, J., McGee, S., Lee, E., Nagrath, S., Pienta, K. J. & Taichman, R. S. 2017 In : Oncotarget. 8, 23, p. 38075 1 p.

Research output: Contribution to journalComment/debate

Neoplastic Stem Cells
Sirolimus
Prostatic Neoplasms
Bone Marrow
Phenotype

Defining the clinical utility of PSMA-targeted PET imaging of prostate cancer

Gorin, M. A., Pomper, M. G., Pienta, K. J. & Rowe, S. P. Aug 1 2017 In : BJU International. 120, 2, p. 160-161 2 p.

Research output: Contribution to journalEditorial

Prostatic Neoplasms

Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration

Parsana, P., Amend, S. R., Hernandez, J., Pienta, K. J. & Battle, A. Jun 26 2017 In : BMC Cancer. 17, 1, 447

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Gene Expression
Genes
Cell Line
Molecular Imaging
Prostatic Neoplasms
Neoplasms
Biomarkers
Routine Diagnostic Tests

Patterns of uptake of prostate-specific membrane antigen (PSMA)-targeted 18F-DCFPyL in peripheral ganglia

Werner, R. A., Sheikhbahaei, S., Jones, K. M., Javadi, M. S., Solnes, L. B., Ross, A. E., Allaf, M. E., Pienta, K. J., Lapa, C., Buck, A. K., Higuchi, T., Pomper, M. G., Gorin, M. A. & Rowe, S. P. Aug 22 2017 (Accepted/In press) In : Annals of Nuclear Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticle

Ganglia
Prostatic Neoplasms
Sympathetic Ganglia
Aorta
human glutamate carboxypeptidase II

Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging

Sheikhbahaei, S., Afshar-Oromieh, A., Eiber, M., Solnes, L. B., Javadi, M. S., Ross, A. E., Pienta, K. J., Allaf, M. E., Haberkorn, U., Pomper, M. G., Gorin, M. A. & Rowe, S. P. Aug 1 2017 (Accepted/In press) In : European Journal of Nuclear Medicine and Molecular Imaging. p. 1-20 20 p.

Research output: Contribution to journalArticle

Molecular Imaging
Normal Distribution
Prostatic Neoplasms
Patient Care
Pathology
Prostatic Neoplasms
Recurrence
Prostate-Specific Antigen
1-amino-3-fluorocyclobutane-1-carboxylic acid
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Prostatic Neoplasms
Information Systems
human glutamate carboxypeptidase II

RB loss promotes prostate cancer metastasis

Thangavel, C. , Boopathi, E. , Liu, Y. , Haber, A. , Ertel, A. , Bhardwaj, A. , Addya, S. , Williams, N. , Ciment, S. J. , Cotzia, P. , Dean, J. L. , Snook, A. , McNair, C. , Price, M. , Hernandez, J. R. , Zhao, S. G. , Birbe, R. , McCarthy, J. B. , Turley, E. A. , Pienta, K. J. & 4 others Feng, F. Y., Dicker, A. P., Knudsen, K. E. & Den, R. B. Feb 15 2017 In : Cancer Research. 77, 4, p. 982-995 14 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasm Metastasis
Neoplasms
Phenotype
Critical Pathways

Revisiting seed and soil: Examining the primary tumor and cancer cell foraging in metastasis

De Groot, A. E., Roy, S., Brown, J. S., Pienta, K. J. & Amend, S. R. Apr 1 2017 In : Molecular Cancer Research. 15, 4, p. 361-370 10 p.

Research output: Contribution to journalReview article

Seeds
Soil
Neoplasm Metastasis
Neoplasms
Reward

Selection-free method reveals phenotypic diversity among prostate cancer circulating tumour cells

Chalfin, H. J., Pienta, K. J. & Gorin, M. A. Nov 1 2017 In : BJU International. 120, 5, p. E4

Research output: Contribution to journalEditorial

Circulating Neoplastic Cells
Prostatic Neoplasms
Liver
Lacrimal Apparatus
Submandibular Gland
Parotid Gland
Kidney

Tenascin-C and integrin α9 mediate interactions of prostate cancer with the bone microenvironment

Martin, R. S., Pathak, R., Jain, A., Jung, S. Y., Hilsenbeck, S. G., Piña-Barba, M. C., Sikora, A. G., Pienta, K. J. & Rowley, D. R. Nov 1 2017 In : Cancer Research. 77, 21, p. 5977-5988 12 p.

Research output: Contribution to journalArticle

Tenascin
Bone Neoplasms
Integrins
Prostatic Neoplasms
Neoplasm Metastasis

The identification of macrophage-enriched glycoproteins using glycoproteomics

Zarif, J. C., Yang, W., Hernandez, J. R., Zhang, H. & Pienta, K. J. Jun 1 2017 In : Molecular and Cellular Proteomics. 16, 6, p. 1029-1037 9 p.

Research output: Contribution to journalArticle

Macrophages
Glycoproteins
Prostatic Neoplasms
Membrane Glycoproteins
Tumors

The prostate metastasis suppressor gene NDRG1 differentially regulates cell motility and invasion

Sharma, A., Mendonca, J., Ying, J., Kim, H. S., Verdone, J. E., Zarif, J. C., Carducci, M., Hammers, H., Pienta, K. J. & Kachhap, S. 2017 In : Molecular Oncology. 11, 6, p. 655-669 15 p.

Research output: Contribution to journalArticle

myc Genes
Tumor Suppressor Genes
Cell Movement
Prostate
Down-Regulation

The tumor microenvironment at a turning point knowledge gained over the last decade, and challenges and opportunities ahead: A white paper from the NCI TME network

DeClerck, Y. A., Pienta, K. J., Woodhouse, E. C., Singer, D. S. & Mohla, S. Mar 1 2017 In : Cancer Research. 77, 5, p. 1051-1059 9 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Foster Home Care
Theoretical Models
Research
Neoplasms

TWIST1-WDR5-hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis

Malek, R., Gajula, R. P., Williams, R. D., Nghiem, B., Simons, B. W., Nugent, K., Wang, H., Taparra, K., Lemtiri-Chlieh, G., Yoon, A. R., True, L., An, S. S., DeWeese, T. L., Ross, A. E., Schaeffer, E. M., Pienta, K. J., Hurley, P. J., Morrissey, C. & Tran, P. T. Jun 15 2017 In : Cancer Research. 77, 12, p. 3181-3193 13 p.

Research output: Contribution to journalArticle

Chromatin
Prostatic Neoplasms
Neoplasm Metastasis
Prostate
Long Noncoding RNA
Prostatic Neoplasms
Thoracic Wall
human glutamate carboxypeptidase II
2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid
2016

Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer

Stoyanova, T. , Riedinger, M. , Lin, S. , Faltermeier, C. M. , Smith, B. A. , Zhang, K. X. , Going, C. C. , Goldstein, A. S. , Lee, J. K. , Drake, J. M. , Rice, M. A. , Hsu, E. C. , Nowroozizadeh, B. , Castor, B. , Orellana, S. Y. , Blum, S. M. , Cheng, D. , Pienta, K. J. , Reiter, R. E. , Pitteri, S. J. & 2 others Huang, J. & Witte, O. N. Oct 18 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. E6457-E6466

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Prostate
Neoplasms
Epithelial-Mesenchymal Transition

A Novel Approach for Performing Bone Marrow Aspiration at the Time of Radical Prostatectomy

Tosoian, J. J., Reyes, D. K., Gorin, M. A., Hortopan, S., Partin, A. W., Pienta, K. J., Ross, A. E. & Schaeffer, E. M. May 1 2016 In : Urology Case Reports. 6, p. 45-46 2 p.

Research output: Contribution to journalArticle

Prostatectomy
Prostatic Neoplasms
Pubic Bone
Bone Marrow
Therapeutics

A phase 2 trial of salvage radiation and concurrent weekly docetaxel after a rising prostate-specific antigen level after radical prostatectomy

Jackson, W. C., Feng, F. Y., Daignault, S., Hussain, M., Smith, D., Cooney, K., Pienta, K., Jolly, S., Hollenbeck, B., Olson, K. B., Sandler, H. M., Ray, M. E. & Hamstra, D. A. Jan 1 2016 In : Advances in Radiation Oncology. 1, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

docetaxel
Salvage Therapy
Prostate-Specific Antigen
Prostatectomy
Radiotherapy

A phased strategy to differentiate human CD14+ monocytes into classically and alternatively activated macrophages and dendritic cells

Zarif, J. C., Hernandez, J. R., Verdone, J. E., Campbell, S. P., Drake, C. G. & Pienta, K. J. Jul 1 2016 In : BioTechniques. 61, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Macrophages
Dendritic Cells
Monocytes
Cytokines
Network protocols