Kelly Pate

Assistant Professor

20062019
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Research Output 2006 2019

2019

Atresia Ani with Imperforate Anus in a Common Marmoset (Callithrix jacchus)

Werts, A. D., Pate, N. M., Pate, K. & Garrett, C. M., Apr 1 2019, In : Comparative medicine. 69, 2, p. 151-154 4 p.

Research output: Contribution to journalArticle

Imperforate Anus
Callithrix
Callithrix jacchus
anus
abnormal development

Infectious Virus Persists in CD4+ T Cells and Macrophages in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques

Abreu, C. M., Terilli Veenhuis, R., Avalos, C. R., Graham, S., Queen, S. E., Shirk, E. N., Bullock, B. T., Li, M., Pate, K., Beck, S., Mangus, L., Mankowski, J. L., Clements, J. E. & Gama, L., Aug 1 2019, In : Journal of virology. 93, 15

Research output: Contribution to journalArticle

Open Access
Simian immunodeficiency virus
Simian Immunodeficiency Virus
Macaca
Human immunodeficiency virus
macrophages

Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques

Abreu, C. M., Terilli Veenhuis, R., Avalos, C. R., Graham, S., Parrilla, D. R., Ferreira, E. A., Queen, S. E., Shirk, E. N., Bullock, B. T., Li, M., Pate, K., Beck, S., Mangus, L., Mankowski, J. L., Mac Gabhann, F., O'Connor, S. L., Gama, L. & Clements, J. E., Aug 20 2019, In : mBio. 10, 4

Research output: Contribution to journalArticle

Open Access
Macaca
Simian Immunodeficiency Virus
Macrophages
T-Lymphocytes
HIV
2018

Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus–Infected Macaques Receiving Antiretroviral Therapy

Mangus, L., Beck, S., Queen, S. E., Brill, S. A., Shirk, E. N., Pate, K., Muth, D. C., Adams, R. J., Gama, L., Clements, J. E. & Mankowski, J. L., Jan 1 2018, In : American Journal of Pathology. 188, 1, p. 125-134 10 p.

Research output: Contribution to journalArticle

Macaca
Encephalitis
Meningitis
Central Nervous System
Lymphocytes

SIV Latency in Macrophages in the CNS

Gama, L., Abreu, C., Shirk, E. N., Queen, S. E., Beck, S., Pate, K., Bullock, B. T., Zink, M. C., Mankowski, J. L. & Clements, J. E., Jan 1 2018, Current Topics in Microbiology and Immunology. Springer Verlag, p. 111-130 20 p. (Current Topics in Microbiology and Immunology; vol. 417).

Research output: Chapter in Book/Report/Conference proceedingChapter

Myeloid Cells
Macrophages
HIV
Lentivirus
Lymphocytes
2017

Adult-onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge

Frydman, G. H., Pate, K., Marini, R. P., de Laforcade, A. M., Bosch, I., Bakthavatchalu, V., Muthupalani, S., Swennes, A. G., Lyons, C. E., Tompkins, R. G. & Fox, J. G., Jun 1 2017, In : Veterinary Clinical Pathology. 46, 2, p. 238-247 10 p.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
thrombocytopenia
Macaca mulatta
bone marrow

An SIV/macaque model targeted to study HIV-associated neurocognitive disorders

Beck, S., Queen, S. E., Pate, K., Mangus, L., Abreu, C. M., Gama, L., Witwer, K. W., Adams, R. J., Zink, M. C., Clements, J. E. & Mankowski, J. L., Oct 3 2017, (Accepted/In press) In : Journal of NeuroVirology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Macaca
HIV
Virus Diseases
Neurocognitive Disorders

HIV-1 persistence following extre277277mely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study

Henrich, T. J., Hatano, H., Bacon, O., Hogan, L. E., Rutishauser, R., Hill, A., Kearney, M. F., Anderson, E. M., Buchbinder, S. P., Cohen, S. E., Abdel-Mohsen, M., Pohlmeyer, C. W., Fromentin, R., Hoh, R., Liu, A. Y., McCune, J. M., Spindler, J., Pate, K., Hobbs, K. S., Thanh, C. & 12 others, Gibson, E. A., Kuritzkes, D. R., Siliciano, R. F., Price, R. W., Richman, D. D., Chomont, N., Siliciano, J. M., Mellors, J. W., Yukl, S. A., Blankson, J. N., Liegler, T. & Deeks, S. G., Nov 1 2017, In : PLoS Medicine. 14, 11, e1002417.

Research output: Contribution to journalArticle

HIV Infections
Observational Studies
HIV-1
HIV
RNA

Immune activation of platelets in response to serial phlebotomy in pigtailed macaques (Macaca nemestrina)

Vermillion, M. S., Lyons, C. E., Najarro, K. M., Adams, R. J. & Pate, K., Jul 1 2017, In : Comparative Medicine. 67, 4, p. 360-367 8 p.

Research output: Contribution to journalArticle

Macaca nemestrina
platelet activation
Phlebotomy
blood platelet count
Platelet Activation

Platelets and Hemostasis

Frydman, G. H., Pate, K. & Vitsky, A., Dec 15 2017, Hematopoietic System Toxicology. Elsevier Inc., Vol. 12-15. p. 60-113 54 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hemostasis
Blood Platelets
Megakaryocytes
Hematopoietic Stem Cells
Allergy and Immunology

The mouse viral outgrowth assay: Avatars for the detection of HIV-1 reservoirs

Pate, K. & Blankson, J. N., Nov 21 2017, In : Retrovirology. 14, 1, 52.

Research output: Contribution to journalReview article

HIV-1
Therapeutics
In Vitro Techniques
2016

Discovery of 6-Diazo-5-oxo- l -norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

Rais, R., Jančařík, A., Tenora, L., Nedelcovych, M., Alt, J., Englert, J., Rojas, C., Le Thi, Q. H., Elgogary, A., Tan, J., Monincová, L., Pate, K., Adams, R. J., Ferraris, D., Powell, J., Majer, P. & Slusher, B., Sep 22 2016, In : Journal of Medicinal Chemistry. 59, 18, p. 8621-8633 13 p.

Research output: Contribution to journalArticle

Diazooxonorleucine
Prodrugs
Glioblastoma
Haplorhini
Glutamine

Reactivation of SIV reservoirs in the brain of virally suppressed macaques

The LRA-SIV Study Group, Sep 20 2016, (Accepted/In press) In : AIDS.

Research output: Contribution to journalArticle

Macaca
Brain
Viral Load
In Situ Hybridization
Acquired Immunodeficiency Syndrome
Macaca nemestrina
Macaca
vitamin B12
Vitamin B 12
Macaca mulatta
2015

A murine viral outgrowth assay to detect residual HIV type 1 in patients with undetectable viral loads

Pate, K., Pohlmeyer, C. W., Walker-Sperling, V. E., Foote, J. B., Najarro, K. M., Cryer, C. G., Salgado, M., Gama, L., Engle, E. L., Shirk, E. N., Queen, S. E., Chioma, S., Vermillion, M. S., Bullock, B., Li, M., Lyons, C. E., Adams, R. J., Zink, M. C., Clements, J. E., Mankowski, J. L. & 1 others, Blankson, J. N., Nov 1 2015, In : Journal of Infectious Diseases. 212, 9, p. 1387-1396 10 p.

Research output: Contribution to journalArticle

Viral Load
HIV-1
HIV
Simian Immunodeficiency Virus
T-Lymphocytes

Bone Disease in the Common Marmoset: Radiographic and Histological Findings

Olson, E. J., Shaw, G. C., Hutchinson, E., Schultz-Darken, N., Bolton, I. D., Parker, J. B., Morrison, J. M., Baxter, V. K., Pate, K., Mankowski, J. L. & Carlson, C. S., Sep 24 2015, In : Veterinary Pathology. 52, 5, p. 883-893 11 p.

Research output: Contribution to journalArticle

bone diseases
Callithrix
Callithrix jacchus
Bone Diseases
lesions (animal)

Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior

Freeman, Z. T., Rice, K. A., Soto, P. L., Pate, K., Weed, M. R., Ator, N. A., DeLeon, I. G., Wong, D. F., Zhou, Y., Mankowski, J. L., Zink, M. C., Adams, R. J. & Hutchinson, E., May 26 2015, In : Translational Psychiatry. 5, 5, e567.

Research output: Contribution to journalArticle

Guanfacine
Self-Injurious Behavior
Macaca mulatta
Pharmacology
Macaca

Paving the path to HIV neurotherapy: Predicting SIV CNS disease

Beck, S., Queen, S. E., Witwer, K. W., Pate, K., Mangus, L., Gama, L., Adams, R. J., Clements, J. E., Zink, M. C. & Mankowski, J. L., Jul 15 2015, In : European Journal of Pharmacology. 759, p. 303-312 10 p., 69819.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Macaca
HIV
Biomarkers
MHC Class I Genes

Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis

Muth, D. C., McAlexander, M. A., Ostrenga, L. J., Pate, N. M., Izzi, J., Adams, R. J., Pate, K., Beck, S., Karim, B. O. & Witwer, K. W., Aug 8 2015, In : BMC Veterinary Research. 11, 1, 187.

Research output: Contribution to journalArticle

exosomes
Exosomes
Endometriosis
Macaca
Primate Diseases
Macaca mulatta
animal injuries
incidence
animal well-being
abnormal behavior
2014

CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.

Kelly, K. M., Tocchetti, C. G., Lyashkov, A., Tarwater, P. M., Bedja, D., Graham, D. R., Beck, S. E., Metcalf Pate, K. A., Queen, S. E., Adams, R. J., Paolocci, N. & Mankowski, J. L., 2014, In : Journal of the American Heart Association. 3, 2

Research output: Contribution to journalArticle

Macaca
HIV
Cardiac Myocytes
Viral Load
Chemokines

Loss of corneal sensory nerve fibers in SIV-infected macaques: An alternate approach to investigate HIV-induced PNS damage

Dorsey, J. L., Mangus, L., Oakley, J. D., Beck, S., Kelly, K. M., Queen, S. E., Pate, K., Adams, R. J., Marfurt, C. F. & Mankowski, J. L., 2014, In : American Journal of Pathology. 184, 6, p. 1652-1659 8 p.

Research output: Contribution to journalArticle

Macaca
Nerve Fibers
HIV
Peripheral Nervous System Diseases
Trigeminal Ganglion

TGFβ-mediated downregulation of thrombopoietin is associated with platelet decline in asymptomatic SIV infection

Pate, K., Lyons, C. E., Dorsey, J. L., Queen, S. E., Adams, R. J., Morrell, C. N. & Mankowski, J. L., Apr 15 2014, In : Journal of Acquired Immune Deficiency Syndromes. 65, 5, p. 510-516 7 p.

Research output: Contribution to journalArticle

Thrombopoietin
Simian Immunodeficiency Virus
Transforming Growth Factors
Virus Diseases
Blood Platelets
2013
Macaca nemestrina
Enterocolitis
enterocolitis
amyloidosis
Biopsy

Evaluation of diagnostic methods for myocoptes musculinus according to age and treatment status of mice (mus musculus)

Rice, K. A., Albacarys, L. K., Pate, K., Perkins, C., Henderson, K. S. & Watson, J., Nov 2013, In : Journal of the American Association for Laboratory Animal Science. 52, 6, p. 773-781 9 p.

Research output: Contribution to journalArticle

Mus musculus
fur
diagnostic techniques
mice
mites

Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: Reduced replicating and latent SIV in the brain

Kelly, K. M., Beck, S., Pate, K., Queen, S. E., Dorsey, J. L., Adams, R. J., Avery, L. B., Hubbard, W., Tarwater, P. & Mankowski, J. L., Nov 28 2013, In : AIDS. 27, 18

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Macaca
Central Nervous System
Brain
Central Nervous System Diseases

Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques

Pate, K., Lyons, C. E., Dorsey, J. L., Shirk, E. N., Queen, S. E., Adams, R. J., Gama, L., Morrell, C. N. & Mankowski, J. L., Sep 15 2013, In : Journal of Infectious Diseases. 208, 6, p. 874-883 10 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Platelet Activation
Macaca
Virus Diseases
Platelet Count

Serum albumin and body weight as biomarkers for the antemortem identification of bone and gastrointestinal disease in the common marmoset

Baxter, V. K., Shaw, G. C., Sotuyo, N. P., Carlson, C. S., Olson, E. J., Zink, M. C., Mankowski, J. L., Adams, R. J., Hutchinson, E. & Pate, K., Dec 6 2013, In : PLoS One. 8, 12, e82747.

Research output: Contribution to journalArticle

bone diseases
Callithrix
Callithrix jacchus
Gastrointestinal Diseases
Callitrichidae
2011
Mus musculus
fur
mites
mice
sampling
Thrombocytopenia
Blood Platelets
HIV
HIV Infections
Endothelium
2009

Comparison of side effects between buprenorphine and meloxicam used postoperatively in Dutch belted rabbits (Oryctolagus cuniculus)

Cooper, C. S., Pate, K., Barat, C. E., Cook, J. A. & Scorpio, D. G., May 2009, In : Journal of the American Association for Laboratory Animal Science. 48, 3, p. 279-285 7 p.

Research output: Contribution to journalArticle

Dutch Belted (rabbit breed)
buprenorphine
meloxicam
Oryctolagus cuniculus
rabbits
2006

Development of red-eyed treefrog eggs affects efficiency and choices of egg-foraging wasps

Warkentin, K. M., Buckley, C. R. & Pate, K., Feb 2006, In : Animal Behaviour. 71, 2, p. 417-425 9 p.

Research output: Contribution to journalArticle

Agalychnis callidryas
wasp
embryo (animal)
foraging
egg