Kelly Elise Dooley

Associate Professor

20022019
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Research Output 2002 2019

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Article
2019

Advancing the development of new tuberculosis treatment regimens: The essential role of translational and clinical pharmacology and microbiology

Dooley, K. E., Hanna, D., Mave, V., Eisenach, K. & Savic, R. M., Jul 1 2019, In : PLoS medicine. 16, 7, p. e1002842

Research output: Contribution to journalArticle

Open Access
Clinical Pharmacology
Microbiology
Tuberculosis

Adverse outcome pathway for aminoglycoside ototoxicity in drug-resistant tuberculosis treatment

Hong, H., Dooley, K. E., Starbird, L. E., Francis, H. W. & Farley, J., Jan 1 2019, In : Archives of Toxicology.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Aminoglycosides
Audition
Hearing Loss
Oxidative stress

Alternative dosing guidelines to improve outcomes in childhood tuberculosis: a mathematical modelling study

Radtke, K. K., Dooley, K. E., Dodd, P. J., Garcia-Prats, A. J., McKenna, L., Hesseling, A. C. & Savic, R. M., Sep 1 2019, In : The Lancet. Child & adolescent health. 3, 9, p. 636-645 10 p.

Research output: Contribution to journalArticle

Tuberculosis
Guidelines
Rifampin
Weights and Measures
Nutritional Status
2018

A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women

Schalkwijk, S., Ter Heine, R., Colbers, A. C., Huitema, A. D. R., Denti, P., Dooley, K. E., Capparelli, E., Best, B. M., Cressey, T. R., Greupink, R., Russel, F. G. M., Mirochnick, M. & Burger, D. M., Mar 8 2018, (Accepted/In press) In : Clinical Pharmacokinetics. p. 1-13 13 p.

Research output: Contribution to journalArticle

efavirenz
Pregnant Women
Pharmacokinetics
Pregnancy
Population

Challenges of TB and HIV co-treatment: updates and insights

Tornheim, J. & Dooley, K. E., Nov 1 2018, In : Current Opinion in HIV and AIDS. 13, 6, p. 486-491 6 p.

Research output: Contribution to journalArticle

Tuberculosis
HIV
Multidrug-Resistant Tuberculosis
Therapeutics
Routine Diagnostic Tests

Effect of Diabetes Mellitus on the Pharmacokinetics and Pharmacodynamics of Tuberculosis Treatment

Alfarisi, O., Mave, V., Gaikwad, S., Sahasrabudhe, T., Ramachandran, G., Kumar, H., Gupte, N., Kulkarni, V., Deshmukh, S., Atre, S., Raskar, S., Lokhande, R., Barthwal, M., Kakrani, A., Chon, S., Gupta, A., Golub, J. E. & Dooley, K. E., Nov 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 11

Research output: Contribution to journalArticle

Pyrazinamide
Diabetes Mellitus
Tuberculosis
Pharmacokinetics
Isoniazid

Levofloxacin population pharmacokinetics in south african children treated for multidrug-resistant tuberculosis

Denti, P., Garcia-Prats, A. J., Draper, H. R., Wiesner, L., Winckler, J., Thee, S., Dooley, K. E., Savic, R. M., McIlleron, H. M., Simon Schaaf, H. & Hesseling, A. C., Feb 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 2, e01521-17.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Levofloxacin
Pharmacokinetics
Weights and Measures
Population

Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data

Rifat, D., Prideaux, B., Savic, R. M., Urbanowski, M. E., Parsons, T. L., Luna, B., Marzinke, M. A., Ordonez Suarez, A., DeMarco, V. P., Jain, S., Dartois, V., Bishai, W. R. & Dooley, K. E., Apr 4 2018, In : Science Translational Medicine. 10, 435, eaai7786.

Research output: Contribution to journalArticle

rifapentine
Rifampin
Tuberculosis
Pharmacokinetics
Clinical Trials

Poor Obstetric and Infant Outcomes in Human Immunodeficiency Virus-Infected Pregnant Women with Tuberculosis in South Africa: The Tshepiso Study

Salazar-Austin, N., Hoffmann, J., Cohn, S., Mashabela, F., Waja, Z., Lala, S., Hoffmann, C., Dooley, K. E., Chaisson, R. E. & Martinson, N., Mar 5 2018, In : Clinical Infectious Diseases. 66, 6, p. 921-929 9 p.

Research output: Contribution to journalArticle

South Africa
Obstetrics
Pregnant Women
Tuberculosis
HIV
Meningeal Tuberculosis
Tuberculosis
Pediatrics
Therapeutics
Rabbits

Suboptimal Antituberculosis Drug Concentrations and Outcomes in Small and HIV-Coinfected Children in India: Recommendations for Dose Modifications

Guiastrennec, B., Ramachandran, G., Karlsson, M. O., Kumar, A. K. H., Bhavani, P. K., Gangadevi, N. P., Swaminathan, S., Gupta, A., Dooley, K. E. & Savic, R. M., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Rifampin
India
HIV
Guidelines
Pediatrics

The Global Neurological Burden of Tuberculosis

Thakur, K., Das, M., Dooley, K. E. & Gupta, A., Apr 1 2018, In : Seminars in Neurology. 38, 2, p. 226-237 12 p., 180017.

Research output: Contribution to journalArticle

Central Nervous System Tuberculosis
Meningeal Tuberculosis
Tuberculosis
Intracranial Tuberculoma
Internal Capsule
2017

Defining the optimal dose of rifapentine for pulmonary tuberculosis: Exposure-response relations from two phase II clinical trials

Savic, R. M., Weiner, M., Mackenzie, W. R., Engle, M., Whitworth, W. C., Johnson, J. L., Nsubuga, P., Nahid, P., Nguyen, N. V., Peloquin, C. A., Dooley, K. E. & Dorman, S. E., 2017, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

rifapentine
Phase II Clinical Trials
Pulmonary Tuberculosis
Pharmacokinetics
Therapeutics

In vitro and in vivo activity of biapenem against drug-susceptible and rifampicin-resistant Mycobacterium tuberculosis

Kaushik, A., Ammerman, N., Tasneen, R., Story-Roller, E., Dooley, K. E., Dorman, S. E., Nuermberger, E. & Lamichhane, G., Aug 1 2017, In : Journal of Antimicrobial Chemotherapy. 72, 8, p. 2320-2325 6 p., dkx152.

Research output: Contribution to journalArticle

biapenem
Rifampin
Mycobacterium tuberculosis
Pharmaceutical Preparations
In Vitro Techniques

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

Mave, V., Kinikar, A., Kagal, A., Nimkar, S., Koli, H., Khwaja, S., Bharadwaj, R., Gerona, R., Wen, A., Ramachandran, G., Kumar, H., Bacchetti, P., Dooley, K. E., Gupte, N., Gupta, A. & Gandhi, M., Dec 1 2017, In : PLoS One. 12, 12, e0189101.

Research output: Contribution to journalArticle

isoniazid
Isoniazid
tuberculosis
Hair
Area Under Curve

New Paradigm for Translational Modeling to Predict Long-term Tuberculosis Treatment Response

Bartelink, I. H., Zhang, N., Keizer, R. J., Strydom, N., Converse, P. J., Dooley, K. E., Nuermberger, E. & Savic, R. M., 2017, (Accepted/In press) In : Clinical and Translational Science.

Research output: Contribution to journalArticle

Tuberculosis
rifapentine
Pharmacokinetics
Confidence Intervals
Rifampin

Population pharmacokinetics of pyrazinamide in patients with tuberculosis

Alsultan, A., Savic, R., Dooley, K. E., Weiner, M., Whitworth, W., MacKenzie, W. R. & Peloquin, C. A., Jun 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 6, e02625-16.

Research output: Contribution to journalArticle

Pyrazinamide
Tuberculosis
Pharmacokinetics
Population
Area Under Curve

Prevention of TB using rifampicin plus isoniazid reduces nevirapine concentrations in HIV-exposed infants

on behalf of the Tshepiso Study Team, Jul 1 2017, In : Journal of Antimicrobial Chemotherapy. 72, 7, p. 2028-2034 7 p., dkx112.

Research output: Contribution to journalArticle

Nevirapine
Isoniazid
Rifampin
HIV
Therapeutics

Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model

Kendall, E., Shrestha, S., Cohen, T., Nuermberger, E., Dooley, K. E., Gonzalez-Angulo, L., Churchyard, G. J., Nahid, P., Rich, M. L., Bansbach, C., Forissier, T., Lienhardt, C. & Dowdy, D. W., Jan 1 2017, In : PLoS Medicine. 14, 1, e1002202.

Research output: Contribution to journalArticle

Rifampin
Tuberculosis
Uncertainty
Pharmaceutical Preparations
Mortality

Rifampin vs. rifapentine: what is the preferred rifamycin for tuberculosis?

Alfarisi, O., Alghamdi, W. A., Al-Shaer, M. H., Dooley, K. E. & Peloquin, C. A., Aug 19 2017, (Accepted/In press) In : Expert Review of Clinical Pharmacology. p. 1-10 10 p.

Research output: Contribution to journalArticle

rifapentine
Rifampin
Latent Tuberculosis
Tuberculosis
Drug Interactions
2016

A new trial design to accelerate tuberculosis drug development: The Phase IIC Selection Trial with Extended Posttreatment follow-up (STEP)

Phillips, P. P. J., Dooley, K. E., Gillespie, S. H., Heinrich, N., Stout, J. E., Nahid, P., Diacon, A. H., Aarnoutse, R. E., Kibiki, G. S., Boeree, M. J. & Hoelscher, M., 2016, In : BMC Medicine. 14, 1, 51.

Research output: Contribution to journalArticle

Tuberculosis
Pharmaceutical Preparations
Random Allocation
Treatment Failure
Communicable Diseases

A phase 2 randomized trial of a rifapentine plus moxifloxacin-based regimen for treatment of pulmonary tuberculosis

Conde, M. B., Mello, F. C. Q., Duarte, R. S., Cavalcante, S. C., Rolla, V., Dalcolmo, M., Loredo, C., Durovni, B., Armstrong, D. T., Efron, A., Link Barnes, G., Marzinke, M. A., Savic, R. M., Dooley, K. E., Cohn, S., Moulton, L. H., Chaisson, R. E. & Dorman, S. E., May 1 2016, In : PLoS One. 11, 5, e0154778.

Research output: Contribution to journalArticle

rifapentine
Pulmonary Tuberculosis
tuberculosis
lungs
isoniazid

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (CTRIUMPH): Protocol for a multicentric prospective observational study

Gupte, A., Padmapriyadarsini, C., Mave, V., Kadam, D., Suryavanshi, N., Shivakumar, S. V. B. Y., Kohli, R., Gupte, N., Thiruvengadam, K., Kagal, A., Meshram, S., Bharadwaj, R., Khadse, S., Ramachandran, G., Hanna, L. E., Pradhan, N., Gomathy, N. S., Deluca, A., Gupta, A., Swaminathan, S. & 73 others, Kinikar, A., Raja, A., Nagraj, A., Anand Kumar, B., More, A., Gaikwad, A., Nangude, A., Balaji, S., Thomas, B., Joseph, B., Bharath, T. K., Brindha, B., Dowdy, D. W., Pole, D., Devanathan, A., Devi Sangamithrai, M., Jain, D., Dolla, C. K., Smit, G., Gangadarsharma, R., Chaugule, H., Koli, H., Hemanthkumar, Jeeva, J., Elf, J., Golub, J. E., Chandane, J., Savita, K., Kannan, M., Karthikesh, M., Karunakaran, S., Dooley, K. E., Murali, L., Lavanya, M., Madasamy, S., Mageshkumar, M., Mangaiyarkarasi, S., Gujare, M., Manoharan, S., Michel Premkumar, M., Munivardhan, P., Murugesan, S., Gomathy, N. S., Nagaraj, Ponnuraja, C., Premkumar, N., Lokhande, R., Rajkumar, S., Ranganathan, K., Rani, S., Madewar, R., Bollinger, R. C., Warlick, R., Shivakoti, R., Javanjal, S., Sathyamurthi, P., Pawar, S., Hande, S., Muley, S., Sali, S., Shubhapriya, K., Biswal, S., Silambu Chelvi, K., Nimkar, S., Selvaraj, S., Salvi, S., Raskar, S., Devi, U., Kulkarni, V., Hulyalkar, V., Tayawade, V., Bansode, V. & Daware, Y., 2016, In : BMJ Open. 6, 2, e010542.

Research output: Contribution to journalArticle

Observational Studies
Tuberculosis
Prospective Studies
Research
Biomarkers

Drug-resistant tuberculosis clinical trials: Proposed core research definitions in adults

Furin, J., Alirol, E., Allen, E., Fielding, K., Merle, C., Abubakar, I., Andersen, J., Davies, G., Dheda, K., Diacon, A., Dooley, K. E., Dravnice, G., Eisenach, K., Everitt, D., Ferstenberg, D., Goolam-Mahomed, A., Grobusch, M. P., Gupta, R., Harausz, E., Harrington, M. & 13 others, Horsburgh, C. R., Lienhardt, C., McNeeley, D., Mitnick, C. D., Nachman, S., Nahid, P., Nunn, A. J., Phillips, P., Rodriguez, C., Shah, S., Wells, C., Thomas-Nyang'wa, B. & Du Cros, P., Mar 1 2016, In : International Journal of Tuberculosis and Lung Disease. 20, 3, p. 290-294 5 p.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Clinical Trials
Research
Manuscripts
Pharmaceutical Preparations

Isoniazid hair concentrations in children with tuberculosis: A proof of concept study

Mave, V., Chandanwale, A., Kinikar, A., Khadse, S., Kagal, A., NGupte, N., Suryavanshi, N., Nimkar, S., Koli, H., Khwaja, S., Bharadwaj, R., Joshi, S., Horng, H., Benet, L. Z., Ramachandran, G., Dooley, K. E., Gupta, A. & Gandhi, M., Jun 1 2016, In : International Journal of Tuberculosis and Lung Disease. 20, 6, p. 844-847 4 p.

Research output: Contribution to journalArticle

Isoniazid
Hair
Tuberculosis
Drug Monitoring
Liquid Chromatography

Pharmacokinetic Interactions for Drugs with a Long Half-Life—Evidence for the Need of Model-Based Analysis

Svensson, E. M., Acharya, C., Clauson, B., Dooley, K. E. & Karlsson, M. O., Jan 1 2016, In : AAPS Journal. 18, 1, p. 171-179 9 p.

Research output: Contribution to journalArticle

Drug Interactions
Pharmacokinetics
bedaquiline
Pharmaceutical Preparations
Half-Life

Population Pharmacokinetics of Rifampin in Pregnant Women with Tuberculosis and HIV Coinfection in Soweto, South Africa

on behalf of the Tshepiso Study Team & Martinson, N., Mar 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 3, p. 1234-1241 8 p.

Research output: Contribution to journalArticle

Rifampin
South Africa
Coinfection
Pregnant Women
Tuberculosis

Treatment Failure, Drug Resistance, and CD4 T-Cell Count Decline among Postpartum Women on Antiretroviral Therapy in South Africa

Hoffmann, C., Cohn, S., Mashabela, F., Hoffmann, J. D., McIlleron, H., Denti, P., Haas, D. W., Dooley, K. E., Martinson, N. A. & Chaisson, R. E., Jan 1 2016, In : Journal of Acquired Immune Deficiency Syndromes. 71, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

CD4 Lymphocyte Count
South Africa
Treatment Failure
Drug Resistance
Postpartum Period
2015

Challenges in the clinical assessment of novel tuberculosis drugs

Dooley, K. E., Phillips, P. P. J., Nahid, P. & Hoelscher, M., Sep 24 2015, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Contribution to journalArticle

Tuberculosis
Pharmaceutical Preparations
Imagination
Biomarkers
Clinical Trials

Daily rifapentine for treatment of pulmonary tuberculosis: A randomized, dose-ranging trial

Dorman, S. E., Feb 1 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 3, p. 333-343 11 p.

Research output: Contribution to journalArticle

rifapentine
Pulmonary Tuberculosis
Rifampin
Sputum
Therapeutics

Determination of [11C]rifampin pharmacokinetics within Mycobacterium tuberculosis-infected mice by using dynamic positron emission tomography bioimaging

DeMarco, V. P., Ordonez Suarez, A., Klunk, M., Prideaux, B., Wang, H., Zhuo, Z., Tonge, P. J., Dannals, R. F., Holt, D., Lee, C. K., Weinstein, E. A., Dartois, V., Dooley, K. E. & Jain, S., Sep 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 9, p. 5768-5774 7 p.

Research output: Contribution to journalArticle

Rifampin
Mycobacterium tuberculosis
Positron-Emission Tomography
Pharmacokinetics
Pharmaceutical Preparations

Novel dosing strategies increase exposures of the potent antituberculosis drug rifapentine but are poorly tolerated in healthy volunteers

ACTG A5311 Study Team & Dorman, S. E., Jun 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 6, p. 3399-3405 7 p.

Research output: Contribution to journalArticle

rifapentine
Healthy Volunteers
Fats
Breakfast
Pharmaceutical Preparations

Pediatric Tuberculous Meningitis: Model-Based Approach to Determining Optimal Doses of the Anti-Tuberculosis Drugs Rifampin and Levofloxacin for Children

Savic, R. M., Ruslami, R., Hibma, J. E., Hesseling, A., Ramachandran, G., Ganiem, A. R., Swaminathan, S., McIlleron, H., Gupta, A., Thakur, K., Van Crevel, R., Aarnoutse, R. & Dooley, K. E., Dec 1 2015, In : Clinical Pharmacology and Therapeutics. 98, 6, p. 622-629 8 p.

Research output: Contribution to journalArticle

Meningeal Tuberculosis
Levofloxacin
Rifampin
Tuberculosis
Pediatrics

Pharmacokinetics and safety of ofloxacin in children with drug-resistant tuberculosis

Garcia-Prats, A. J., Draper, H. R., Thee, S., Dooley, K. E., McIlleron, H. M., Seddon, J. A., Wiesner, L., Castel, S., Schaaf, H. S. & Hesseling, A. C., Oct 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 10, p. 6073-6079 7 p.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Ofloxacin
Pharmacokinetics
Safety
Body Weight

Pharmacokinetics of efavirenz and treatment of HIV-1 among pregnant women with and without tuberculosis coinfection

Dooley, K. E., Denti, P., Martinson, N., Cohn, S., Mashabela, F., Hoffmann, J., Haas, D. W., Hull, J., Msandiwa, R., Castel, S., Wiesner, L. & Chaisson, R. E., Jan 15 2015, In : Journal of Infectious Diseases. 211, 2, p. 197-205 9 p.

Research output: Contribution to journalArticle

efavirenz
Coinfection
HIV-1
Pregnant Women
Tuberculosis

Toward Earlier Inclusion of Pregnant and Postpartum Women in Tuberculosis Drug Trials: Consensus Statements from an International Expert Panel

Gupta, A., Mathad, J. S., Abdel-Rahman, S. M., Albano, J. D., Botgros, R., Brown, V., Browning, R. S., Dawson, L., Dooley, K. E., Gnanashanmugam, D., Grinsztejn, B., Hernandez-DIaz, S., Jean-Philippe, P., Kim, P., Lyerly, A. D., Mirochnick, M., Mofenson, L. M., Montepiedra, G., Piper, J., Sahin, L. & 6 others, Savic, R., Smith, B., Spiegel, H., Swaminathan, S., Watts, D. H. & White, A., Jul 10 2015, In : Clinical Infectious Diseases. 62, 6, p. 761-769 9 p.

Research output: Contribution to journalArticle

Postpartum Period
Pregnant Women
Tuberculosis
Pharmaceutical Preparations
Pregnancy
2014

Designing drug trials: considerations for pregnant women

Sheffield, J., Siegel, D., Mirochnick, M., Heine, R. P., Nguyen, C., Bergman, K. L., Savic, R. M., Long, J., Dooley, K. E. & Nesin, M., Dec 15 2014, In : Clinical Infectious Diseases. 59, p. S437-S444

Research output: Contribution to journalArticle

Pregnant Women
Pharmaceutical Preparations
National Institute of Allergy and Infectious Diseases (U.S.)
Clinical Pharmacology
National Institutes of Health (U.S.)

Impact of lopinavir-ritonavir or nevirapine on bedaquiline exposures and potential implications for patients with tuberculosis-HIV coinfection

Svensson, E. M., Dooley, K. E. & Karlsson, M. O., Nov 1 2014, In : Antimicrobial Agents and Chemotherapy. 58, 11, p. 6406-6412 7 p.

Research output: Contribution to journalArticle

bedaquiline
Lopinavir
Nevirapine
Ritonavir
Coinfection

Phase I safety, pharmacokinetics, and pharmacogenetics study of the antituberculosis drug PA-824 with concomitant lopinavir-ritonavir, efavirenz, or rifampin

Dooley, K. E., Luetkemeyer, A. F., Park, J. G., Allen, R., Cramer, Y., Murray, S., Sutherland, D., Aweeka, F., Koletar, S. L., Marzan, F., Bao, J., Savic, R., Haas, D. W., Barr, L., Egizi, E., Hovind, L., Janik, J., Lizak, P., Mendel, C. & Size, T., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 9, p. 5245-5252 8 p.

Research output: Contribution to journalArticle

efavirenz
Lopinavir
Ritonavir
Rifampin
Pharmacokinetics

Population pharmacokinetics of rifapentine and desacetyl rifapentine in healthy volunteers: Nonlinearities in clearance and bioavailability

Savic, R. M., Lu, Y., Bliven-Sizemore, E., Weiner, M., Nuermberger, E., Burman, W., Dorman, S. E. & Dooley, K. E., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 6, p. 3035-3042 8 p.

Research output: Contribution to journalArticle

rifapentine
Biological Availability
Healthy Volunteers
Pharmacokinetics
Population

Quantification of rifapentine, a potent antituberculosis drug, from dried blood spot samples using liquid chromatographic-tandem mass spectrometric analysis

Parsons, T. L., Marzinke, M. A., Hoang, T., Bliven-Sizemore, E., Weiner, M., Mac Kenzie, W. R., Dorman, S. E. & Dooley, K. E., Nov 1 2014, In : Antimicrobial Agents and Chemotherapy. 58, 11, p. 6747-6757 11 p.

Research output: Contribution to journalArticle

rifapentine
Pharmaceutical Preparations
Phlebotomy
Blood Volume
Hematocrit

Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti-TB drug

Svensson, E. M., Murray, S., Karlsson, M. O. & Dooley, K. E., Sep 16 2014, In : The Journal of antimicrobial chemotherapy. 70, 4, p. 1106-1114 9 p.

Research output: Contribution to journalArticle

rifapentine
bedaquiline
Rifampin
Pharmaceutical Preparations
Pharmacokinetics

Treatment default amongst patients with tuberculosis in urban Morocco: Predicting and explaining default and post-default sputum smear and drug susceptibility results

Cherkaoui, I., Sabouni, R., Ghali, I., Kizub, D., Billioux, A., Bennani, K., Bourkadi, J. E., Benmamoun, A., Lahlou, O., El Aouad, R. & Dooley, K. E., Apr 3 2014, In : PLoS One. 9, 4, e93574.

Research output: Contribution to journalArticle

Morocco
Sputum
tuberculosis
Tuberculosis
drugs
2013

Induction of influx and efflux transporters and cytochrome P450 3A4 in primary human hepatocytes by rifampin, rifabutin, and rifapentine

Williamson, B., Dooley, K. E., Zhang, Y., Back, D. J. & Owen, A., Dec 2013, In : Antimicrobial Agents and Chemotherapy. 57, 12, p. 6366-6369 4 p.

Research output: Contribution to journalArticle

rifapentine
Rifabutin
Cytochrome P-450 CYP3A
Rifampin
Cytochrome P-450 Enzyme System

Model-based estimates of the effects of efavirenz on bedaquiline pharmacokinetics and suggested dose adjustments for patients coinfected with HIV and tuberculosis

Svensson, E. M., Aweeka, F., Park, J. G., Marzan, F., Dooley, K. E. & Karlsson, M. O., Jun 2013, In : Antimicrobial Agents and Chemotherapy. 57, 6, p. 2780-2787 8 p.

Research output: Contribution to journalArticle

efavirenz
bedaquiline
Tuberculosis
Pharmacokinetics
HIV

Pipeline of drugs for related diseases: Tuberculosis

Dooley, K. E., Nuermberger, E. & Diacon, A. H., Nov 2013, In : Current Opinion in HIV and AIDS. 8, 6, p. 579-585 7 p.

Research output: Contribution to journalArticle

Tuberculosis
rifapentine
Pharmaceutical Preparations
Multidrug-Resistant Tuberculosis
Nitroimidazoles

Reply to Seddon, Schaaf, and Hesseling

Dooley, K. E., Mitnick, C., Degroote, M. A., Obuku, E., Hamilton, C. D., Makhene, M., Shah, S., Brust, J. C. M., Durakovic, N. & Nuermberger, E., 2013, In : Clinical Infectious Diseases. 56, 1, p. 168-169 2 p.

Research output: Contribution to journalArticle

Antitubercular Agents
Multidrug-Resistant Tuberculosis

Safety, tolerability, and pharmacokinetics of the HIV integrase inhibitor dolutegravir given twice daily with rifampin or once daily with rifabutin: Results of a phase 1 study among healthy subjects

Dooley, K. E., Sayre, P., Borland, J., Purdy, E., Chen, S., Song, I., Peppercorn, A., Everts, S., Piscitelli, S. & Flexner, C. W., Jan 1 2013, In : Journal of Acquired Immune Deficiency Syndromes. 62, 1, p. 21-27 7 p.

Research output: Contribution to journalArticle

HIV Integrase Inhibitors
Rifabutin
Rifampin
Healthy Volunteers
Pharmacokinetics

World health organization group 5 drugs for the treatment of drug-resistant tuberculosis: Unclear efficacy or untapped potential?

Dooley, K. E., Obuku, E. A., Durakovic, N., Belitsky, V., Mitnick, C. & Nuermberger, E., May 1 2013, In : Journal of Infectious Diseases. 207, 9, p. 1352-1358 7 p.

Research output: Contribution to journalArticle

Multidrug-Resistant Tuberculosis
Clofazimine
Linezolid
Poisons
beta-Lactams