Kellie Smith

Assistant Professor

20132019

Research output per year

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Research Output

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Article

An unexpected journey: How cancer immunotherapy has paved the way for an HIV-1 cure

Smith, K. & Housseau, F., 2015, In : Discovery medicine. 19, 104, p. 229-238 10 p.

Research output: Contribution to journalArticle

Dendritic cells restore CD8+ T cell reactivity to autologous HIV-1

Smith, K., Mailliard, R. B., Larsen, B. B., Wong, K., Gupta, P., Mullins, J. I. & Rinaldo, C. R., 2014, In : Journal of Virology. 88, 17, p. 9976-9990 15 p.

Research output: Contribution to journalArticle

Dynamics of tumor and immune responses during immune checkpoint blockade in non–small cell lung cancer

Anagnostou, V., Forde, P. M., White, J. R., Niknafs, N., Hruban, C., Naidoo, J., Marrone, K., Ashok Sivakumar, I. K., Bruhm, D. C., Rosner, S., Phallen, J., Leal, A., Adleff, V., Smith, K. N., Cottrell, T. R., Rhymee, L., Palsgrove, D. N., Hann, C. L., Levy, B., Feliciano, J. & 16 others, Georgiades, C., Verde, F., Illei, P., Li, Q. K., Gabrielson, E., Brock, M. V., Isbell, J. M., Sauter, J. L., Taube, J., Scharpf, R. B., Karchin, R., Pardoll, D. M., Chaft, J. E., Hellmann, M. D., Brahmer, J. R. & Velculescu, V. E., Jan 1 2019, In : Cancer Research. 79, 6, p. 1214-1225 12 p.

Research output: Contribution to journalArticle

Open Access

Effective cytotoxic T lymphocyte targeting of persistent HIV-1 during antiretroviral therapy requires priming of naive CD8+ T cells

Smith, K., Mailliard, R. B., Piazza, P. A., Fischer, W., Korber, B. T., Fecek, R. J., Ratner, D., Gupta, P., Mullins, J. I. & Rinaldob, C. R., 2016, In : mBio. 7, 3, e00473-16.

Research output: Contribution to journalArticle

Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

Anagnostou, V., Smith, K., Forde, P., Niknafs, N., Bhattacharya, R., White, J., Zhang, T., Adleff, V., Phallen, J., Wali, N., Hruban, C., Guthrie, V. B., Rodgers, K., Naidoo, J., Kang, H., Sharfman, W., Georgiades, C. S., Verde, F., Illei, P. B., Li, Q. K. & 9 others, Gabrielson, E., Brock, M. V., Zahnow, C., Baylin, S. B., Scharpf, R. B., Brahmer, J., Karchin, R., Pardoll, A. M. & Velculescu, V. E., Mar 1 2017, In : Cancer Discovery. 7, 3, p. 264-276 13 p.

Research output: Contribution to journalArticle

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D., Uram, J., Smith, K., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., Wong, F., Azad, N., Rucki, A. A., Laheru, D., Donehower, R. C., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., Greten, T. F. & 26 others, Duffy, A. G., Ciombor, K. K., Eyring, A. D., Lam, B. H., Joe, A., Kang, S. P., Holdhoff, M., Danilova, L. V., Cope, L., Meyer, C., Zhou, S., Goldberg, R. M., Armstrong, D. K., Bever, K., Nickles Fader, A. N., Taube, J. M., Housseau, F., Spetzler, D., Xiao, N., Pardoll, A. M., Papadopoulos, N., Kinzler, K. W., Eshleman, J., Vogelstein, B., Anders, R. A. & Diaz, L. A., Jul 28 2017, In : Science. 357, 6349, p. 409-413 5 p.

Research output: Contribution to journalArticle

Neoadjuvant PD-1 blockade in resectable lung cancer

Forde, P., Chaft, J. E., Smith, K., Anagnostou, V., Cottrell, T. R., Hellmann, M. D., Zahurak, M., Broderick, S., Yang, S. C., Jones, D. R., Battafarano, R. J., Velez, M. J., Rekhtman, N., Olah, Z., Verde, F., Naidoo, J., Marrone, K., Guo, H., Sidhom, J. W., Zhang, J. & 15 others, Caushi, J. X., Chan, H. Y., Scharpf, R. B., White, J., Gabrielson, E., Wang, H., Rosner, G., Rusch, V., Wolchok, J. D., Merghoub, T., Taube, J. M., Velculescu, V. E., Topalian, S., Brahmer, J. & Pardoll, A. M., May 24 2018, In : New England Journal of Medicine. 378, 21, p. 1976-1986 11 p.

Research output: Contribution to journalArticle

Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: A proposal for quantitative immune-related pathologic response criteria (irPRC)

Cottrell, T. R., Thompson, E., Forde, P., Stein, J. E., Duffield, A. S., Anagnostou, V., Rekhtman, N., Anders, R. A., Cuda, J. D., Illei, P. B., Gabrielson, E., Askin, F. B., Niknafs, N., Smith, K., Velez, M. J., Sauter, J. L., Isbell, J. M., Jones, D. R., Battafarano, R. J., Yang, S. C. & 10 others, Danilova, L. V., Wolchok, J. D., Topalian, S., Velculescu, V. E., Pardoll, A. M., Brahmer, J., Hellmann, M. D., Chaft, J. E., Cimino-Mathews, A. M. & Taube, J. M., Jan 1 2018, In : Annals of Oncology. 29, 8, p. 1853-1860 8 p.

Research output: Contribution to journalArticle

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Smith, K. N., Llosa, N. J., Cottrell, T. R., Siegel, N., Fan, H., Suri, P., Chan, H. Y., Guo, H., Oke, T., Awan, A. H., Verde, F., Danilova, L., Anagnostou, V., Tam, A. J., Luber, B. S., Bartlett, B. R., Aulakh, L. K., Sidhom, J. W., Zhu, Q., Sears, C. L. & 21 others, Cope, L., Sharfman, W. H., Thompson, E. D., Riemer, J., Marrone, K. A., Naidoo, J., Velculescu, V. E., Forde, P. M., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Durham, J. N., Wang, H., Le, D. T., Justesen, S., Taube, J. M., Diaz, L. A., Brahmer, J. R., Pardoll, D. M., Anders, R. A. & Housseau, F., Feb 11 2019, In : Journal for immunotherapy of cancer. 7, 1, 40.

Research output: Contribution to journalArticle

Open Access

Programming T cell killers for an HIV cure: Teach the new dogs new tricks and let the sleeping dogs lie

Smith, K., Mailliar, R. B. & Rinaldo, C. R., 2015, In : Forum on Immunopathological Diseases and Therapeutics. 6, 1-2, p. 67-77 11 p.

Research output: Contribution to journalArticle

Quantifying the anti-tumor immune response in patients receiving immunotherapy

Caushi, J. X. & Smith, K., 2017, In : Discovery medicine. 24, 130, p. 59-68 10 p.

Research output: Contribution to journalArticle

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis

Housseau, F., Wu, S., Wick, E. C., Fan, H., Wu, X., Llosa, N., Smith, K., Tam, A., Ganguly, S., Wanyiri, J. W., Iyadorai, T., Malik, A. A., Roslani, A. C., Vadivelu, J. S., Van Meerbeke, S., Huso, D. L., Pardoll, A. M. & Sears, C. L., Apr 15 2016, In : Cancer Research. 76, 8, p. 2115-2124 10 p.

Research output: Contribution to journalArticle

Selective induction of CTL helper rather than killer activity by natural epitope variants promotes dendritic cell-mediated HIV-1 dissemination

Mailliard, R. B., Smith, K., Fecek, R. J., Rappocciolo, G., Nascimento, E. J. M., Marques, E. T., Watkins, S. C., Mullins, J. I. & Rinaldo, C. R., Sep 1 2013, In : Journal of Immunology. 191, 5, p. 2570-2580 11 p.

Research output: Contribution to journalArticle

The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8+ T cell responses

Melhem, N. M., Smith, K., Huang, X. L., Colleton, B. A., Jiang, W., Mailliard, R. B., Mullins, J. I. & Rinaldo, C. R., Feb 2014, In : Virology. 450-451, p. 34-48 15 p.

Research output: Contribution to journalArticle

The mutation-associated neoantigen functional expansion of specific T cells (MANAFEST) assay: A sensitive platform for monitoring antitumor immunity

Danilova, L. V., Anagnostou, V., Caushi, J. X., Sidhom, J. W., Guo, H., Chan, H. Y., Suri, P., Tam, A., Zhang, J., Asmar, M. E., Marrone, K., Naidoo, J., Brahmer, J., Forde, P., Baras, A., Cope, L., Velculescu, V. E., Pardoll, A. M., Housseau, F. & Smith, K., Aug 1 2018, In : Cancer immunology research. 6, 8, p. 888-899 12 p.

Research output: Contribution to journalArticle