Kellie Smith

Assistant Professor

20132019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 2013 2019

Filter
Article
2019

Dynamics of tumor and immune responses during immune checkpoint blockade in non–small cell lung cancer

Anagnostou, V., Forde, P. M., White, J. R., Niknafs, N., Hruban, C., Naidoo, J., Marrone, K., Ashok Sivakumar, I. K., Bruhm, D. C., Rosner, S., Phallen, J., Leal, A., Adleff, V., Smith, K. N., Cottrell, T. R., Rhymee, L., Palsgrove, D. N., Hann, C. L., Levy, B., Feliciano, J. & 16 others, Georgiades, C., Verde, F., Illei, P., Li, Q. K., Gabrielson, E., Brock, M. V., Isbell, J. M., Sauter, J. L., Taube, J., Scharpf, R. B., Karchin, R., Pardoll, D. M., Chaft, J. E., Hellmann, M. D., Brahmer, J. R. & Velculescu, V. E., Jan 1 2019, In : Cancer Research. 79, 6, p. 1214-1225 12 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
DNA
Neoplasms
Therapeutics
Confidence Intervals

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Smith, K. N., Llosa, N. J., Cottrell, T. R., Siegel, N., Fan, H., Suri, P., Chan, H. Y., Guo, H., Oke, T., Awan, A. H., Verde, F., Danilova, L., Anagnostou, V., Tam, A. J., Luber, B. S., Bartlett, B. R., Aulakh, L. K., Sidhom, J. W., Zhu, Q., Sears, C. L. & 21 others, Cope, L., Sharfman, W. H., Thompson, E. D., Riemer, J., Marrone, K. A., Naidoo, J., Velculescu, V. E., Forde, P. M., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Durham, J. N., Wang, H., Le, D. T., Justesen, S., Taube, J. M., Diaz, L. A., Brahmer, J. R., Pardoll, D. M., Anders, R. A. & Housseau, F., Feb 11 2019, In : Journal for immunotherapy of cancer. 7, 1, 40.

Research output: Contribution to journalArticle

Open Access
Oncogenes
T-Lymphocytes
Biomarkers
DNA Mismatch Repair
Neoplasms
2018

Neoadjuvant PD-1 blockade in resectable lung cancer

Forde, P., Chaft, J. E., Smith, K., Anagnostou, V., Cottrell, T. R., Hellmann, M. D., Zahurak, M., Broderick, S., Yang, S. C., Jones, D. R., Battafarano, R. J., Velez, M. J., Rekhtman, N., Olah, Z., Verde, F., Naidoo, J., Marrone, K., Guo, H., Sidhom, J. W., Zhang, J. & 15 others, Caushi, J. X., Chan, H. Y., Scharpf, R. B., White, J., Gabrielson, E., Wang, H., Rosner, G., Rusch, V., Wolchok, J. D., Merghoub, T., Taube, J. M., Velculescu, V. E., Topalian, S., Brahmer, J. & Pardoll, A. M., May 24 2018, In : New England Journal of Medicine. 378, 21, p. 1976-1986 11 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Clone Cells
Neoplasms
Non-Small Cell Lung Carcinoma
T-Lymphocytes

Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: A proposal for quantitative immune-related pathologic response criteria (irPRC)

Cottrell, T. R., Thompson, E., Forde, P., Stein, J. E., Duffield, A. S., Anagnostou, V., Rekhtman, N., Anders, R. A., Cuda, J. D., Illei, P. B., Gabrielson, E., Askin, F. B., Niknafs, N., Smith, K., Velez, M. J., Sauter, J. L., Isbell, J. M., Jones, D. R., Battafarano, R. J., Yang, S. C. & 10 others, Danilova, L. V., Wolchok, J. D., Topalian, S., Velculescu, V. E., Pardoll, A. M., Brahmer, J., Hellmann, M. D., Chaft, J. E., Cimino-Mathews, A. M. & Taube, J. M., Jan 1 2018, In : Annals of Oncology. 29, 8, p. 1853-1860 8 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Non-Small Cell Lung Carcinoma
Neoplasms
Tumor-Infiltrating Lymphocytes
Neoadjuvant Therapy

The mutation-associated neoantigen functional expansion of specific T cells (MANAFEST) assay: A sensitive platform for monitoring antitumor immunity

Danilova, L. V., Anagnostou, V., Caushi, J. X., Sidhom, J. W., Guo, H., Chan, H. Y., Suri, P., Tam, A., Zhang, J., Asmar, M. E., Marrone, K., Naidoo, J., Brahmer, J., Forde, P., Baras, A., Cope, L., Velculescu, V. E., Pardoll, A. M., Housseau, F. & Smith, K., Aug 1 2018, In : Cancer immunology research. 6, 8, p. 888-899 12 p.

Research output: Contribution to journalArticle

Immunity
T-Lymphocytes
Mutation
Antigens
Cytokines
2017

Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

Anagnostou, V., Smith, K., Forde, P., Niknafs, N., Bhattacharya, R., White, J., Zhang, T., Adleff, V., Phallen, J., Wali, N., Hruban, C., Guthrie, V. B., Rodgers, K., Naidoo, J., Kang, H., Sharfman, W., Georgiades, C. S., Verde, F., Illei, P. B., Li, Q. K. & 9 others, Gabrielson, E., Brock, M. V., Zahnow, C., Baylin, S. B., Scharpf, R. B., Brahmer, J., Karchin, R., Pardoll, A. M. & Velculescu, V. E., Mar 1 2017, In : Cancer Discovery. 7, 3, p. 264-276 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasms
T-Lymphocytes
Mutation
T-Cell Antigen Receptor

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D., Uram, J., Smith, K., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., Wong, F., Azad, N., Rucki, A. A., Laheru, D., Donehower, R. C., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., Greten, T. F. & 26 others, Duffy, A. G., Ciombor, K. K., Eyring, A. D., Lam, B. H., Joe, A., Kang, S. P., Holdhoff, M., Danilova, L. V., Cope, L., Meyer, C., Zhou, S., Goldberg, R. M., Armstrong, D. K., Bever, K., Nickles Fader, A. N., Taube, J. M., Housseau, F., Spetzler, D., Xiao, N., Pardoll, A. M., Papadopoulos, N., Kinzler, K. W., Eshleman, J., Vogelstein, B., Anders, R. A. & Diaz, L. A., Jul 28 2017, In : Science. 357, 6349, p. 409-413 5 p.

Research output: Contribution to journalArticle

Neoplasms
DNA Mismatch Repair
Disease-Free Survival
Turcot syndrome
Colorectal Neoplasms

Quantifying the anti-tumor immune response in patients receiving immunotherapy

Caushi, J. X. & Smith, K., 2017, In : Discovery medicine. 24, 130, p. 59-68 10 p.

Research output: Contribution to journalArticle

Immunotherapy
Neoplasms
Therapeutics
Biomarkers
Population
2016

Effective cytotoxic T lymphocyte targeting of persistent HIV-1 during antiretroviral therapy requires priming of naive CD8+ T cells

Smith, K., Mailliard, R. B., Piazza, P. A., Fischer, W., Korber, B. T., Fecek, R. J., Ratner, D., Gupta, P., Mullins, J. I. & Rinaldob, C. R., 2016, In : mBio. 7, 3, e00473-16.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
HIV-1
T-Lymphocytes
Dendritic Cells
Therapeutics

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis

Housseau, F., Wu, S., Wick, E. C., Fan, H., Wu, X., Llosa, N., Smith, K., Tam, A., Ganguly, S., Wanyiri, J. W., Iyadorai, T., Malik, A. A., Roslani, A. C., Vadivelu, J. S., Van Meerbeke, S., Huso, D. L., Pardoll, A. M. & Sears, C. L., Apr 15 2016, In : Cancer Research. 76, 8, p. 2115-2124 10 p.

Research output: Contribution to journalArticle

Th17 Cells
Colon
Carcinogenesis
Bacteroides fragilis
T-Lymphocytes
2015

An unexpected journey: How cancer immunotherapy has paved the way for an HIV-1 cure

Smith, K. & Housseau, F., 2015, In : Discovery medicine. 19, 104, p. 229-238 10 p.

Research output: Contribution to journalArticle

Immunotherapy
HIV-1
Neoplasms
Viremia
Cytotoxic T-Lymphocytes

Programming T cell killers for an HIV cure: Teach the new dogs new tricks and let the sleeping dogs lie

Smith, K., Mailliar, R. B. & Rinaldo, C. R., 2015, In : Forum on Immunopathological Diseases and Therapeutics. 6, 1-2, p. 67-77 11 p.

Research output: Contribution to journalArticle

T-cells
Cytotoxic T-Lymphocytes
HIV
Dogs
T-Lymphocytes
2014

Dendritic cells restore CD8+ T cell reactivity to autologous HIV-1

Smith, K., Mailliard, R. B., Larsen, B. B., Wong, K., Gupta, P., Mullins, J. I. & Rinaldo, C. R., 2014, In : Journal of Virology. 88, 17, p. 9976-9990 15 p.

Research output: Contribution to journalArticle

dendritic cells
Human immunodeficiency virus 1
Dendritic Cells
HIV-1
T-lymphocytes

The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8+ T cell responses

Melhem, N. M., Smith, K., Huang, X. L., Colleton, B. A., Jiang, W., Mailliard, R. B., Mullins, J. I. & Rinaldo, C. R., Feb 2014, In : Virology. 450-451, p. 34-48 15 p.

Research output: Contribution to journalArticle

HIV-1
Epitopes
T-Lymphocytes
Cytotoxic T-Lymphocytes
Aptitude
2013

Selective induction of CTL helper rather than killer activity by natural epitope variants promotes dendritic cell-mediated HIV-1 dissemination

Mailliard, R. B., Smith, K., Fecek, R. J., Rappocciolo, G., Nascimento, E. J. M., Marques, E. T., Watkins, S. C., Mullins, J. I. & Rinaldo, C. R., Sep 1 2013, In : Journal of Immunology. 191, 5, p. 2570-2580 11 p.

Research output: Contribution to journalArticle

Dendritic Cells
HIV-1
Epitopes
Viruses
Immunotherapy