Karen Ehrenman

Research Associate

1985 …2017
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1985 2017

2017

The parasite Toxoplasma sequesters diverse Rab host vesicles within an intravacuolar network

Romano, J. D., Nolan, S. J., Porter, C., Ehrenman, K., Hartman, E. J., Hsia, R. C. & Coppens, I., Jan 1 2017, In : Journal of Cell Biology. 216, 12, p. 4235-4254 20 p.

Research output: Contribution to journalArticle

Toxoplasma
Vacuoles
Parasites
Membranes
Sphingolipids
2016

A lipolytic lecithin: Cholesterol acyltransferase secreted by toxoplasma facilitates parasite replication and egress

Pszenny, V., Ehrenman, K., Romano, J. D., Kennard, A., Schultz, A., Roos, D. S., Grigg, M. E., Carruthers, V. B. & Coppens, I., Feb 19 2016, In : Journal of Biological Chemistry. 291, 8, p. 3725-3746 22 p.

Research output: Contribution to journalArticle

Phosphatidylcholine-Sterol O-Acyltransferase
Toxoplasma
Parasites
Cholesterol
Vacuoles

Overexpression of Plasmodium berghei ATG8 by liver forms leads to cumulative defects in organelle dynamics and to generation of noninfectious merozoites

Voss, C., Ehrenman, K., Mlambo, G., Mishra, S., Kumar, K. A., Sacci, J. B., Sinnis, P. & Coppens, I., 2016, In : mBio. 7, 3, e00682-16.

Research output: Contribution to journalArticle

Merozoites
Plasmodium berghei
Organelles
Apicoplasts
Parasites
2014

Characterization of the ATG8-conjugation system in 2 Plasmodium species with special focus on the liver stage: Possible linkage between the apicoplastic and autophagic systems?

Jayabalasingham, B., Voss, C., Ehrenman, K., Romano, J. D., Smith, M. E., Fidock, D. A., Bosch, J. & Coppens, I., Feb 2014, In : Autophagy. 10, 2, p. 269-284 16 p.

Research output: Contribution to journalArticle

Plasmodium
Parasites
Apicoplasts
Organelles
Plasmodium berghei
2013

A novel co-infection model with Toxoplasma and Chlamydia trachomatis highlights the importance of host cell manipulation for nutrient scavenging

Romano, J. D., de Beaumont, C., Carrasco, J. A., Ehrenman, K., Bavoil, P. M. & Coppens, I., Apr 2013, In : Cellular Microbiology. 15, 4, p. 619-646 28 p.

Research output: Contribution to journalArticle

Chlamydia trachomatis
Toxoplasma
Coinfection
Chlamydia
Food

Cryptosporidium parvum scavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes

Ehrenman, K., Wanyiri, J. W., Bhat, N., Ward, H. D. & Coppens, I., Jul 2013, In : Cellular Microbiology. 15, 7, p. 1182-1197 16 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Enterocytes
LDL Cholesterol
Cholesterol
Cryptosporidium

Fierce competition between Toxoplasma and Chlamydia for host cell structures in dually infected cells

Romano, J. D., de Beaumont, C., Carrasco, J. A., Ehrenman, K., Bavoil, P. M. & Coppens, I., Feb 2013, In : Eukaryotic Cell. 12, 2, p. 265-277 13 p.

Research output: Contribution to journalArticle

Chlamydia
Toxoplasma
Vacuoles
Organelles
Chlamydia trachomatis
2011

Deficiency of a Niemann-Pick, type C1-related protein in Toxoplasma is associated with multiple lipidoses and increased pathogenicity

Lige, B., Romano, J. D., Bandaru, V. V. R., Ehrenman, K., Levitskaya, J., Sampels, V., Haughey, N. & Coppens, I., Dec 2011, In : PLoS Pathogens. 7, 12, e1002410.

Research output: Contribution to journalArticle

Lipidoses
Toxoplasma
Virulence
Parasites
Sterols
2010

Novel roles for ATP-binding cassette G transporters in lipid redistribution in Toxoplasma

Ehrenman, K., Sehgal, A., Lige, B., Stedman, T. T., Joiner, K. A. & Coppens, I., Jun 2010, In : Molecular Microbiology. 76, 5, p. 1232-1249 18 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Toxoplasma
Vacuoles
Lipids
Parasites
2004

Disruption of Aldehyde Reductase Increases Group Size in Dictyostelium

Ehrenman, K., Yang, G., Hong, W. P., Gao, T., Jang, W., Brock, D. A., Hatton, R. D., Shoemaker, J. D. & Gomer, R. H., Jan 9 2004, In : Journal of Biological Chemistry. 279, 2, p. 837-847 11 p.

Research output: Contribution to journalArticle

Open Access
Aldehyde Reductase
Dictyostelium
Glucose
Sorbitol
Metabolites
2003

Two Components of a Secreted Cell Number-counting Factor Bind to Cells and Have Opposing Effects on cAMP Signal Transduction in Dictyostelium

Brock, D. A., Ehrenman, K., Ammann, R., Tang, Y. & Gomer, R. H., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52262-52272 11 p.

Research output: Contribution to journalArticle

Open Access
Signal transduction
Dictyostelium
Signal Transduction
Cell Count
Chemical activation
2002

Cells respond to and bind countin, a component of a multisubunit cell number counting factor

Gao, T., Ehrenman, K., Tang, L., Leippe, M., Brock, D. A. & Gomer, R. H., Sep 6 2002, In : Journal of Biological Chemistry. 277, 36, p. 32596-32605 10 p.

Research output: Contribution to journalArticle

Open Access
Signal transduction
Myosins
Cell Count
Polymerization
Phosphorylation
2001

Hepatocyte growth factor is secreted by osteoblasts and cooperatively permits the survival of haematopoietic progenitors

Taichman, R. S., Reilly, M. J., Verma, R. S., Ehrenman, K. & Emerson, S. G., Mar 12 2001, In : British journal of haematology. 112, 2, p. 438-448 11 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Osteoblasts
Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cells
Stem Cells

Numerous growth factors, cytokines, and chemokines are secreted by human CD34 + cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner

Majka, M., Janowska-Wieczorek, A., Ratajczak, J., Ehrenman, K., Pietrzkowski, Z., Anna Kowalska, M., Gewirtz, A. M., Emerson, S. G. & Ratajczak, M. Z., May 15 2001, In : Blood. 97, 10, p. 3075-3085 11 p.

Research output: Contribution to journalArticle

Open Access
Megakaryocyte Progenitor Cells
Granulocyte Precursor Cells
Erythroblasts
Hematopoiesis
Macrophage Inflammatory Proteins
1998

Evidence for complex nuclear inheritance in a pedigree with nonsyndromic deafness due to a homoplasmic mitochondrial mutation

Bykhovskaya, Y., Shohat, M., Ehrenman, K., Johnson, D., Hamon, M., Cantor, R. M., Aouizerat, B., Bu, X., Rotter, J. I., Jaber, L. & Fischel-Ghodsian, N., Jun 5 1998, In : American journal of medical genetics. 77, 5, p. 421-426 6 p.

Research output: Contribution to journalArticle

Pedigree
Mutation
Viverridae
Hearing Loss
Hearing

Novel human malignancy-associated gene (MAG) expressed in various tumors and in some tumor preexisting conditions

Ljubimova, J. Y., Wilson, S. E., Petrovic, L. M., Ehrenman, K., Ljubimov, A. V., Demetriou, A. A., Geller, S. A. & Black, K. L., Oct 1 1998, In : Cancer Research. 58, 19, p. 4475-4479 5 p.

Research output: Contribution to journalArticle

Preexisting Condition Coverage
Genes
Neoplasms
Liver
Hepatocellular Carcinoma
1997

Temporal bone analysis of patients with presbycusis reveals high frequency on mitochondrial mutations

Fischel-Ghodsian, N., Bykhovskaya, Y., Taylor, K., Kahen, T., Cantor, R., Ehrenman, K., Smith, R. & Keithley, E., Aug 1 1997, In : Hearing Research. 110, 1-2, p. 147-154 8 p.

Research output: Contribution to journalArticle

Presbycusis
Temporal Bone
Mutation
Hearing Loss
Spiral Ganglion
1994

Characterization of cDNAs encoding the murine A + U-rich RNA-binding protein AUF1

Ehrenman, K., Long, L., Wagner, B. J. & Brewer, G., Nov 18 1994, In : Gene. 149, 2, p. 315-319 5 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Complementary DNA
Clone Cells
Messenger RNA
Peptides
1993

Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1

Zhang, W., Wagner, B. J., Ehrenman, K., Schaefer, A. W., DeMaria, C. T., Crater, D., DeHaven, K., Long, L. & Brewer, G., Jan 1 1993, In : Molecular and cellular biology. 13, 12, p. 7652-7665 14 p.

Research output: Contribution to journalArticle

Open Access
AU Rich Elements
RNA-Binding Proteins
Organism Cloning
Complementary DNA
Peptides
1991

The erythropoietin receptor gene: Cloning and identification of multiple transcripts in an erythroid cell line OCIM1

Ehrenman, K. & St. John, T., Sep 30 1991, In : Experimental Hematology. 19, 9, p. 973-977 5 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
Erythroid Cells
Organism Cloning
Amino Acids
Cell Line
1990

Genetic and Molecular Analysis of RNA Splicing in Escherichia coli

Belfort, M., Ehrenman, K. & Chandry, P. S., Jan 1 1990, In : Methods in Enzymology. 181, C, p. 521-539 19 p.

Research output: Contribution to journalArticle

RNA Splicing
Escherichia coli
Molecular Biology
RNA
Assays
1989

Sequence specificity of the P6 pairing for splicing of the group I td intron of phage T4

Ehrenman, K., Schroeder, R., Chandry, P. S., Hall, D. H. & Belfort, M., Nov 25 1989, In : Nucleic acids research. 17, 22, p. 9147-9163 17 p.

Research output: Contribution to journalArticle

Bacteriophage T4
Introns
RNA Splice Sites
Mutation
Base Pairing
1988

Genes within genes: independent expression of phage T4 intron open reading frames and the genes in which they reside.

Gott, J. M., Zeeh, A., Bell-Pedersen, D., Ehrenman, K., Belfort, M. & Shub, D. A., Jan 1 1988, In : Genes & development. 2, 12 B, p. 1791-1799 9 p.

Research output: Contribution to journalArticle

Open Access
Bacteriophage T4
Introns
Open Reading Frames
Gene Expression
Genes
1987

Two domains for splicing in the intron of the phage T4 thymidylate synthase (td) gene established by nondirected mutagenesis

Hall, D. H., Povinelli, C. M., Ehrenman, K., Pedersen-Lane, J., Chu, F. & Belfort, M., Jan 16 1987, In : Cell. 48, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Bacteriophage T4
Mutagenesis
RNA Splice Sites
Bacteriophages
1986

Processing of phage T4 td-encoded RNA is analogous to the eukaryotic group I splicing pathway

Ehrenman, K., Pedersen-Lane, J., West, D., Herman, R., Maley, F. & Belfort, M., Dec 19 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 16, p. 5875-5879 5 p.

Research output: Contribution to journalArticle

Open Access
Bacteriophage T4
Introns
RNA
Cyclization
Guanosine

RNA splicing and in vivo expression of the intron-containing td gene of bacteriophage T4

Belfort, M., Pedersen-Lane, J., Ehrenman, K., Chu, F. K., Maley, G. F., Maley, F., McPheeters, D. S. & Gold, L., Jan 1 1986, In : Gene. 41, 1, p. 93-102 10 p.

Research output: Contribution to journalArticle

RNA Splicing
Thymidylate Synthase
Bacteriophage T4
Introns
Genes
1985

Processing of the intron-containing thymidylate synthase (td) gene of phage T4 is at the RNA level

Belfort, M., Pedersen-Lane, J., West, D., Ehrenman, K., Maley, G., Chu, F. & Maley, F., Jan 1 1985, In : Cell. 41, 2, p. 375-382 8 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Bacteriophage T4
Bacteriophages
Introns
Genes