1990 …2020

Research output per year

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2020

Revisiting a controversy: The effect of EGF on EGFR dimer stability

Singh, D. R., King, C., Salotto, M. & Hristova, K., Jan 1 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 1, 183015.

Research output: Contribution to journalArticle

2019

Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling

Gomez-Soler, M., Gehring, M. P., Lechtenberg, B. C., Zapata-Mercado, E., Hristova, K. & Pasquale, E. B., May 31 2019, In : Journal of Biological Chemistry. 294, 22, p. 8791-8805 15 p.

Research output: Contribution to journalArticle

Mechanism of Action of Peptides That Cause the pH-Triggered Macromolecular Poration of Lipid Bilayers

Kim, S. Y., Pittman, A. E., Zapata-Mercado, E., King, G. M., Wimley, W. C. & Hristova, K. A., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6706-6718 13 p.

Research output: Contribution to journalArticle

2018

Dimerization of the Trk receptors in the plasma membrane: Effects of their cognate ligands

Ahmed, F. & Hristova, K. A., Nov 30 2018, In : Biochemical Journal. 475, 22, p. 3669-3685 17 p.

Research output: Contribution to journalArticle

Interactions between NRP1 and VEGFR2 molecules in the plasma membrane

King, C., Wirth, D., Workman, S. & Hristova, K. A., Jan 1 2018, (Accepted/In press) In : Biochimica et Biophysica Acta - Biomembranes.

Research output: Contribution to journalArticle

Potent macromolecule-sized poration of lipid bilayers by the macrolittins, a synthetically evolved family of pore-forming peptides

Li, S., Kim, S. Y., Pittman, A. E., King, G. M., Wimley, W. C. & Hristova, K. A., Mar 19 2018, (Accepted/In press) In : Unknown Journal.

Research output: Contribution to journalArticle

Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs

Walsh, S. M., Mathiasen, S., Christensen, S. M., Fay, J. F., King, C., Provasi, D., Borrero, E., Rasmussen, S. G. F., Fung, J. J., Filizola, M., Hristova, K., Kobilka, B., Farrens, D. L. & Stamou, D., Jul 17 2018, In : Biophysical journal. 115, 2, p. 300-312 13 p.

Research output: Contribution to journalArticle

The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures

Singh, D. R., Kanvinde, P., King, C., Pasquale, E. B. & Hristova, K., Dec 1 2018, In : Communications biology. 1, 1, 15.

Research output: Contribution to journalArticle

Open Access
2017

A new method to study heterodimerization of membrane proteins and its application to fibroblast growth factor receptors

Del Piccolo, N., Sarabipour, S. & Hristova, K. A., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1188-1301 114 p.

Research output: Contribution to journalArticle

Cooperative interactions between VEGFR2 extracellular Ig-like subdomains ensure VEGFR2 dimerization

King, C., Wirth, D., Workman, S. & Hristova, K. A., Nov 1 2017, In : Biochimica et Biophysica Acta - General Subjects. 1861, 11, p. 2559-2567 9 p.

Research output: Contribution to journalArticle

Ebola virus delta peptide is a viroporin

He, J., Melnik, L. I., Komin, A., Wiedman, G., Fuselier, T., Morris, C. F., Starr, C. G., Searson, P. C., Gallaher, W. R., Hristova, K. A., Garry, R. F. & Wimley, W. C., Aug 1 2017, In : Journal of Virology. 91, 16, e00438-17.

Research output: Contribution to journalArticle

Intracellular Domain Contacts Contribute to Ecadherin Constitutive Dimerization in the Plasma Membrane

Singh, D. R., Ahmed, F., Sarabipour, S. & Hristova, K. A., Jul 7 2017, In : Journal of Molecular Biology. 429, 14, p. 2231-2245 15 p.

Research output: Contribution to journalArticle

pH-triggered, macromolecule-sized poration of lipid bilayers by synthetically evolved peptides

Wiedman, G., Kim, S. Y., Zapata-Mercado, E., Wimley, W. C. & Hristova, K. A., Jan 18 2017, In : Journal of the American Chemical Society. 139, 2, p. 937-945 9 p.

Research output: Contribution to journalArticle

Quantifying the Interaction between EGFR Dimers and Grb2 in Live Cells

Del Piccolo, N. & Hristova, K. A., 2017, (Accepted/In press) In : Biophysical Journal.

Research output: Contribution to journalArticle

The SAM domain inhibits EphA2 interactions in the plasma membrane

Singh, D. R., Ahmed, F., Paul, M. D., Gedam, M., Pasquale, E. B. & Hristova, K. A., Jan 1 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Understanding the FRET signatures of interacting membrane proteins

King, C., Raicu, V. & Hristova, K. A., Mar 31 2017, In : Journal of Biological Chemistry. 292, 13, p. 5291-5310 20 p.

Research output: Contribution to journalArticle

2016

A small peptide promotes EphA2 kinase-dependent signaling by stabilizing EphA2 dimers

Singh, D. R., Pasquale, E. B. & Hristova, K. A., Sep 1 2016, In : Biochimica et Biophysica Acta - General Subjects. 1860, 9, p. 1922-1928 7 p.

Research output: Contribution to journalArticle

Fully quantified spectral imaging reveals in vivo membrane protein interactions

King, C., Stoneman, M., Raicu, V. & Hristova, K., Feb 2016, In : Integrative Biology (United Kingdom). 8, 2, p. 216-229 14 p.

Research output: Contribution to journalArticle

Mechanism of FGF receptor dimerization and activation

Sarabipour, S. & Hristova, K., Jan 4 2016, In : Nature communications. 7, 10262.

Research output: Contribution to journalArticle

Pathogenic Cysteine Removal Mutations in FGFR Extracellular Domains Stabilize Receptor Dimers and Perturb the TM Dimer Structure

Sarabipour, S. & Hristova, K. A., Oct 9 2016, In : Journal of Molecular Biology. 428, 20, p. 3903-3910 8 p.

Research output: Contribution to journalArticle

Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: Mechanisms and challenges

Komin, A., Russell, L. M., Hristova, K. A. & Searson, P. C., Apr 5 2016, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Contribution to journalArticle

VEGFR-2 conformational switch in response to ligand binding

Sarabipour, S., Ballmer-Hofer, K. & Hristova, K. A., Apr 7 2016, In : eLife. 5, APRIL2016, e13876.

Research output: Contribution to journalArticle

2015

A high-capacitance salt-free dielectric for self-healable, printable, and flexible organic field effect transistors and chemical sensor

Huang, W., Besar, K., Zhang, Y., Yang, S., Wiedman, G., Liu, Y., Guo, W., Song, J., Hemker, K., Hristova, K. A., Kymissis, I. J. & Katz, H. E., Jun 1 2015, In : Advanced Functional Materials. 25, 24, p. 3745-3755 11 p.

Research output: Contribution to journalArticle

Analytical characterization of plasma membrane-derived vesicles produced via osmotic and chemical vesiculation

Sarabipour, S., Chan, R. B., Zhou, B., Di Paolo, G. & Hristova, K., Jul 1 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 7, p. 1591-1598 8 p.

Research output: Contribution to journalArticle

Characterization of Membrane Protein Interactions in Plasma Membrane Derived Vesicles with Quantitative Imaging Förster Resonance Energy Transfer

Sarabipour, S., Del Piccolo, N. & Hristova, K., Aug 5 2015, In : Accounts of chemical research. 48, 8, p. 2262-2269 8 p.

Research output: Contribution to journalArticle

Effect of thanatophoric dysplasia type i mutations on FGFR3 dimerization

Del Piccolo, N., Placone, J. & Hristova, K., Jan 20 2015, In : Biophysical journal. 108, 2, p. 272-278 7 p.

Research output: Contribution to journalArticle

EphA2 receptor unliganded dimers suppress EphA2 pro-tumorigenic signaling

Singh, D. R., Ahmed, F., King, C., Gupta, N., Salotto, M., Pasquale, E. B. & Hristova, K., Nov 6 2015, In : Journal of Biological Chemistry. 290, 45, p. 27271-27279 9 p.

Research output: Contribution to journalArticle

FGFR3 unliganded dimer stabilization by the juxtamembrane domain

Sarabipour, S. & Hristova, K., Jan 1 2015, In : Journal of molecular biology. 427, 8, p. 1705-1714 10 p.

Research output: Contribution to journalArticle

Testing the limits of rational design by engineering pH sensitivity into membrane-active peptides

Wiedman, G., Wimley, W. C. & Hristova, K., Apr 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 4, p. 951-957 7 p.

Research output: Contribution to journalArticle

Unliganded EphA3 dimerization promoted by the SAM domain

Singh, D. R., Cao, Q. Q., King, C., Salotto, M., Ahmed, F., Zhou, X. Y., Pasquale, E. B. & Hristova, K., Oct 1 2015, In : Biochemical Journal. 471, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

2014

Highly efficient macromolecule-sized poration of lipid bilayers by a synthetically evolved peptide

Wiedman, G., Fuselier, T., He, J., Searson, P. C., Hristova, K. & Wimley, W. C., Mar 26 2014, In : Journal of the American Chemical Society. 136, 12, p. 4724-4731 8 p.

Research output: Contribution to journalArticle

How IGF-1 activates its receptor

Kavran, J. M., McCabe, J. M., Byrne, P. O., Connacher, M. K., Wang, Z., Ramek, A., Sarabipour, S., Shan, Y., Shaw, D. E., Hristova, K., Cole, P. A. & Leahy, D. J., Sep 25 2014, In : eLife. 3

Research output: Contribution to journalArticle

Strong dimerization of wild-type ErbB2/Neu transmembrane domain and the oncogenic Val664Glu mutant in mammalian plasma membranes

Placone, J., He, L., Del Piccolo, N. & Hristova, K., Sep 2014, In : Biochimica et Biophysica Acta - Biomembranes. 1838, 9, p. 2326-2330 5 p.

Research output: Contribution to journalArticle

The FRET signatures of noninteracting proteins in membranes: Simulations and experiments

King, C., Sarabipour, S., Byrne, P., Leahy, D. J. & Hristova, K., Mar 18 2014, In : Biophysical journal. 106, 6, p. 1309-1317 9 p.

Research output: Contribution to journalArticle

Uninduced high-yield bacterial expression of fluorescent proteins

Sarabipour, S., King, C. & Hristova, K., Mar 15 2014, In : Analytical biochemistry. 449, 1, p. 155-157 3 p.

Research output: Contribution to journalArticle

2013

A membrane-translocating peptide penetrates into bilayers without significant bilayer perturbations

Cruz, J., Mihailescu, M., Wiedman, G., Herman, K., Searson, P. C., Wimley, W. C. & Hristova, K., Jun 4 2013, In : Biophysical journal. 104, 11, p. 2419-2428 10 p.

Research output: Contribution to journalArticle

Direct cytosolic delivery of polar cargo to cells by spontaneous membrane-translocating peptides

He, J., Kauffman, W. B., Fuselier, T., Naveen, S. K., Voss, T. G., Hristova, K. & Wimley, W. C., Oct 11 2013, In : Journal of Biological Chemistry. 288, 41, p. 29974-29986 13 p.

Research output: Contribution to journalArticle

FGFR3 transmembrane domain interactions persist in the presence of its extracellular domain

Sarabipour, S. & Hristova, K., Jul 2 2013, In : Biophysical journal. 105, 1, p. 165-171 7 p.

Research output: Contribution to journalArticle

Multiple Consequences of a Single Amino Acid Pathogenic RTK Mutation: The A391E Mutation in FGFR3

Chen, F., Sarabipour, S. & Hristova, K., Feb 20 2013, In : PloS one. 8, 2, e56521.

Research output: Contribution to journalArticle

Structure of FGFR3 transmembrane domain dimer: Implications for signaling and human pathologies

Bocharov, E. V., Lesovoy, D. M., Goncharuk, S. A., Goncharuk, M. V., Hristova, K. & Arseniev, A. S., Nov 5 2013, In : Structure. 21, 11, p. 2087-2093 7 p.

Research output: Contribution to journalArticle

The electrical response of bilayers to the bee venom toxin melittin: Evidence for transient bilayer permeabilization

Wiedman, G., Herman, K., Searson, P., Wimley, W. C. & Hristova, K., May 1 2013, In : Biochimica et Biophysica Acta - Biomembranes. 1828, 5, p. 1357-1364 8 p.

Research output: Contribution to journalArticle

2012

A highly charged voltage-sensor helix spontaneously translocates across membranes

He, J., Hristova, K. & Wimley, W. C., Jul 16 2012, In : Angewandte Chemie - International Edition. 51, 29, p. 7150-7153 4 p.

Research output: Contribution to journalArticle

Consequences of replacing EGFR juxtamembrane domain with an unstructured sequence

He, L. & Hristova, K., Dec 14 2012, In : Scientific reports. 2, 854.

Research output: Contribution to journalArticle

Direct Assessment of the Effect of the Gly380Arg Achondroplasia Mutation on FGFR3 Dimerization Using Quantitative Imaging FRET

Placone, J. & Hristova, K., Oct 9 2012, In : PloS one. 7, 10, e46678.

Research output: Contribution to journalArticle

Effect of the G375C and G346E achondroplasia mutations on FGFR3 activation

He, L., Serrano, C., Niphadkar, N., Shobnam, N. & Hristova, K., Apr 18 2012, In : PloS one. 7, 4, e34808.

Research output: Contribution to journalArticle

Increased expression of the integral membrane proteins EGFR and FGFR3 in anti-apoptotic Chinese hamster ovary cell lines

Ohsfeldt, E., Huang, S. H., Baycin-Hizal, D., Kristoffersen, L., Le, T. M. T., Li, E., Hristova, K. & Betenbaugh, M. J., May 1 2012, In : Biotechnology and Applied Biochemistry. 59, 3, p. 155-162 8 p.

Research output: Contribution to journalArticle

Interactions of membrane active peptides with planar supported bilayers: An impedance spectroscopy study

Lin, J., Motylinski, J., Krauson, A. J., Wimley, W. C., Searson, P. C. & Hristova, K., Apr 10 2012, In : Langmuir. 28, 14, p. 6088-6096 9 p.

Research output: Contribution to journalArticle