1990 …2019
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Research Output 1990 2019

2019
Vascular Endothelial Growth Factor Receptor-2
Dimerization
Ligands
Vascular Endothelial Growth Factor A
Human Development

Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling

Gomez-Soler, M., Gehring, M. P., Lechtenberg, B. C., Zapata-Mercado, E., Hristova, K. A. & Pasquale, E. B., Jan 1 2019, In : Journal of Biological Chemistry. 294, 22, p. 8791-8805 15 p.

Research output: Contribution to journalArticle

varespladib methyl
Ligands
Peptides
Ephrins
Crystal structure

Mechanism of Action of Peptides That Cause the pH-Triggered Macromolecular Poration of Lipid Bilayers

Kim, S. Y., Pittman, A. E., Zapata-Mercado, E., King, G. M., Wimley, W. C. & Hristova, K. A., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6706-6718 13 p.

Research output: Contribution to journalArticle

Lipid bilayers
Lipid Bilayers
Peptides
Membranes
Physical Chemistry

Revisiting a controversy: The effect of EGF on EGFR dimer stability

Singh, D. R., King, C., Salotto, M. & Hristova, K. A., Jan 1 2019, In : Biochimica et Biophysica Acta - Biomembranes.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Dimers
Dimerization
Ligands
Receptor Protein-Tyrosine Kinases

The Mechanism of Membrane Permeabilization by Peptides: Still an Enigma

Wimley, W. C. & Hristova, K., Jan 1 2019, (Accepted/In press) In : Australian Journal of Chemistry.

Research output: Contribution to journalReview article

Membranes
Peptides
Lipids
Experiments

The RTK Interactome: Overview and Perspective on RTK Heterointeractions

Paul, M. D. & Hristova, K. A., May 8 2019, In : Chemical Reviews. 119, 9, p. 5881-5921 41 p.

Research output: Contribution to journalReview article

Receptor Protein-Tyrosine Kinases
Thermodynamics
Ligands
Cell growth
Membrane Proteins
Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Modulators
Chemical activation
Dimers
2018
Open Access
EphA2 Receptor
animal communication
Ligands
Biological Sciences
receptors

Dimerization of the Trk receptors in the plasma membrane: Effects of their cognate ligands

Ahmed, F. & Hristova, K. A., Nov 30 2018, In : Biochemical Journal. 475, 22, p. 3669-3685 17 p.

Research output: Contribution to journalArticle

Tropomyosin
Dimerization
Cell membranes
Phosphotransferases
Cell Membrane

Interactions between NRP1 and VEGFR2 molecules in the plasma membrane

King, C., Wirth, D., Workman, S. & Hristova, K. A., Jan 1 2018, (Accepted/In press) In : Biochimica et Biophysica Acta - Biomembranes.

Research output: Contribution to journalArticle

Neuropilin-1
Vascular Endothelial Growth Factor Receptor-2
Cell membranes
Cell Membrane
Molecules

Potent macromolecule-sized poration of lipid bilayers by the macrolittins, a synthetically evolved family of pore-forming peptides

Li, S., Kim, S. Y., Pittman, A. E., King, G. M., Wimley, W. C. & Hristova, K. A., Mar 19 2018, (Accepted/In press) In : Unknown Journal.

Research output: Contribution to journalArticle

Lipid bilayers
Lipid Bilayers
Macromolecules
peptide
Peptides

Single Proteoliposome High Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs

Walsh, S. M., Mathiasen, S., Christensen, S. M., Fay, J. F., King, C., Provasi, D., Borrero, E., Rasmussen, S. G. F., Fung, J. J., Filizola, M., Hristova, K. A., Kobilka, B., Farrens, D. L. & Stamou, D., Jan 1 2018, (Accepted/In press) In : Biophysical Journal.

Research output: Contribution to journalArticle

Hominidae
G-Protein-Coupled Receptors
CCR10 Receptors
Opsins
Cannabinoid Receptors

The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures

Singh, D. R., Kanvinde, P., King, C., Pasquale, E. B. & Hristova, K., Dec 1 2018, In : Communications Biology. 1, 1, 15.

Research output: Contribution to journalArticle

Open Access
EphA2 Receptor
Ligands
receptors
Oligomers
tyrosine
2017

A new method to study heterodimerization of membrane proteins and its application to fibroblast growth factor receptors

Del Piccolo, N., Sarabipour, S. & Hristova, K. A., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1188-1301 114 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Receptor Protein-Tyrosine Kinases
Membrane Proteins
Cell membranes
Cell Membrane

Cooperative interactions between VEGFR2 extracellular Ig-like subdomains ensure VEGFR2 dimerization

King, C., Wirth, D., Workman, S. & Hristova, K. A., Nov 1 2017, In : Biochimica et Biophysica Acta - General Subjects. 1861, 11, p. 2559-2567 9 p.

Research output: Contribution to journalArticle

Dimerization
Cell membranes
Photons
Oligomers
Dimers

Ebola virus delta peptide is a viroporin

He, J., Melnik, L. I., Komin, A., Wiedman, G., Fuselier, T., Morris, C. F., Starr, C. G., Searson, P. C., Gallaher, W. R., Hristova, K. A., Garry, R. F. & Wimley, W. C., Aug 1 2017, In : Journal of Virology. 91, 16, e00438-17.

Research output: Contribution to journalArticle

Ebolavirus
peptides
Peptides
Ebola Hemorrhagic Fever
polypeptides

Interactions between membrane receptors in cellular membranes

Hristova, K. A., Sep 1 2017, In : Biochimica et Biophysica Acta - Biomembranes. 1859, 9, p. 1397 1 p.

Research output: Contribution to journalEditorial

Intracellular Domain Contacts Contribute to Ecadherin Constitutive Dimerization in the Plasma Membrane

Singh, D. R., Ahmed, F., Sarabipour, S. & Hristova, K. A., Jul 7 2017, In : Journal of Molecular Biology. 429, 14, p. 2231-2245 15 p.

Research output: Contribution to journalArticle

Dimerization
Cadherins
Cell Membrane
Adherens Junctions
Fluorescence Resonance Energy Transfer

pH-triggered, macromolecule-sized poration of lipid bilayers by synthetically evolved peptides

Wiedman, G., Kim, S. Y., Zapata-Mercado, E., Wimley, W. C. & Hristova, K. A., Jan 18 2017, In : Journal of the American Chemical Society. 139, 2, p. 937-945 9 p.

Research output: Contribution to journalArticle

Lipid bilayers
Lipid Bilayers
Macromolecules
Peptides
Membranes

Quantifying the Interaction between EGFR Dimers and Grb2 in Live Cells

Del Piccolo, N. & Hristova, K. A., 2017, (Accepted/In press) In : Biophysical Journal.

Research output: Contribution to journalArticle

GRB2 Adaptor Protein
Epidermal Growth Factor Receptor
Membrane Proteins
Proteins
Energy Transfer

The SAM domain inhibits EphA2 interactions in the plasma membrane

Singh, D. R., Ahmed, F., Paul, M. D., Gedam, M., Pasquale, E. B. & Hristova, K. A., Jan 1 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Cell Membrane
EphA3 Receptor
Tyrosine
Phosphorylation
Eph Family Receptors

Understanding the FRET signatures of interacting membrane proteins

King, C., Raicu, V. & Hristova, K. A., Mar 31 2017, In : Journal of Biological Chemistry. 292, 13, p. 5291-5310 20 p.

Research output: Contribution to journalArticle

Membrane Proteins
Quenching
Kinetic theory
Fluorophores
Proteins
2016

A small peptide promotes EphA2 kinase-dependent signaling by stabilizing EphA2 dimers

Singh, D. R., Pasquale, E. B. & Hristova, K. A., Sep 1 2016, In : Biochimica et Biophysica Acta - General Subjects. 1860, 9, p. 1922-1928 7 p.

Research output: Contribution to journalArticle

Phosphorylation
Dimers
Ephrins
Phosphotransferases
Peptides
Achondroplasia
Dimerization
Energy Transfer
Cell membranes
Energy transfer

Fully quantified spectral imaging reveals in vivo membrane protein interactions

King, C., Stoneman, M., Raicu, V. & Hristova, K. A., Feb 1 2016, In : Integrative Biology (United Kingdom). 8, 2, p. 216-229 14 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Membrane Proteins
Association reactions
Cell membranes
Imaging techniques

Mechanism of FGF receptor dimerization and activation

Sarabipour, S. & Hristova, K. A., Jan 4 2016, In : Nature Communications. 7, 10262.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Dimerization
dimerization
Dimers
Chemical activation

Pathogenic Cysteine Removal Mutations in FGFR Extracellular Domains Stabilize Receptor Dimers and Perturb the TM Dimer Structure

Sarabipour, S. & Hristova, K. A., Oct 9 2016, In : Journal of Molecular Biology. 428, 20, p. 3903-3910 8 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Cysteine
Receptor Protein-Tyrosine Kinases
Mutation
Dimerization

Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: Mechanisms and challenges

Komin, A., Russell, L. M., Hristova, K. A. & Searson, P. C., Apr 5 2016, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Contribution to journalArticle

Transcytosis
Peptides
Benchmarking
Drug Delivery Systems
Phagocytosis

VEGFR-2 conformational switch in response to ligand binding

Sarabipour, S., Ballmer-Hofer, K. & Hristova, K. A., Apr 7 2016, In : eLife. 5, APRIL2016, e13876.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Switches
Ligands
Dimers
Conformations
2015

A high-capacitance salt-free dielectric for self-healable, printable, and flexible organic field effect transistors and chemical sensor

Huang, W., Besar, K., Zhang, Y., Yang, S., Wiedman, G., Liu, Y., Guo, W., Song, J., Hemker, K., Hristova, K. A., Kymissis, I. J. & Katz, H. E., Jun 1 2015, In : Advanced Functional Materials. 25, 24, p. 3745-3755 11 p.

Research output: Contribution to journalArticle

Organic field effect transistors
healing
Chemical sensors
Transistors
Capacitance

Analytical characterization of plasma membrane-derived vesicles produced via osmotic and chemical vesiculation

Sarabipour, S., Chan, R. B., Zhou, B., Di Paolo, G. & Hristova, K. A., Jul 1 2015, In : BBA - Biomembranes. 1848, 7, p. 1591-1598 8 p.

Research output: Contribution to journalArticle

Cell membranes
Cells
Cell Membrane
Membranes
Lipids

Characterization of Membrane Protein Interactions in Plasma Membrane Derived Vesicles with Quantitative Imaging Förster Resonance Energy Transfer

Sarabipour, S., Del Piccolo, N. & Hristova, K. A., Aug 5 2015, In : Accounts of Chemical Research. 48, 8, p. 2262-2269 8 p.

Research output: Contribution to journalArticle

Dimerization
Receptor, Fibroblast Growth Factor, Type 3
Cell membranes
Energy transfer
Membrane Proteins

Effect of thanatophoric dysplasia type i mutations on FGFR3 dimerization

Del Piccolo, N., Placone, J. & Hristova, K. A., Jan 20 2015, In : Biophysical Journal. 108, 2, p. 272-278 7 p.

Research output: Contribution to journalArticle

Thanatophoric Dysplasia
Receptor, Fibroblast Growth Factor, Type 3
Dimerization
Mutation
Receptor Protein-Tyrosine Kinases

EphA2 receptor unliganded dimers suppress EphA2 pro-tumorigenic signaling

Singh, D. R., Ahmed, F., King, C., Gupta, N., Salotto, M., Pasquale, E. B. & Hristova, K. A., Nov 6 2015, In : Journal of Biological Chemistry. 290, 45, p. 27271-27279 9 p.

Research output: Contribution to journalArticle

EphA2 Receptor
Phosphorylation
Dimers
Cell Movement
Tyrosine

Of rafts and lipid chain lengths

Hristova, K. A. & Hinderliter, A., May 5 2015, In : Biophysical Journal. 108, 9, p. 2096 1 p.

Research output: Contribution to journalArticle

Membrane Microdomains
Unilamellar Liposomes
Sphingomyelins
Cholesterol
Lipids

Testing the limits of rational design by engineering pH sensitivity into membrane-active peptides

Wiedman, G., Wimley, W. C. & Hristova, K. A., 2015, In : BBA - Biomembranes. 1848, 4, p. 951-957 7 p.

Research output: Contribution to journalArticle

Membranes
Peptides
Testing
Lipid bilayers
Macromolecules

Unliganded EphA3 dimerization promoted by the SAM domain

Singh, D. R., Cao, Q., King, C., Salotto, M., Ahmed, F., Zhou, X. Y., Pasquale, E. B. & Hristova, K. A., Oct 1 2015, In : Biochemical Journal. 471, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

Dimerization
Erythropoietin
Hepatocellular Carcinoma
Dimers
Chemical activation
2014

FGFR3 unliganded dimer stabilization by the juxtamembrane domain

Sarabipour, S. & Hristova, K. A., 2014, In : Journal of Molecular Biology. 427, 8, p. 1705-1714 10 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Mutation
Dimerization
Phosphotransferases
Cell Membrane

Highly efficient macromolecule-sized poration of lipid bilayers by a synthetically evolved peptide

Wiedman, G., Fuselier, T., He, J., Searson, P. C., Hristova, K. A. & Wimley, W. C., Mar 26 2014, In : Journal of the American Chemical Society. 136, 12, p. 4724-4731 8 p.

Research output: Contribution to journalArticle

Lipid bilayers
Lipid Bilayers
Macromolecules
Peptides
Melitten

How IGF-1 activates its receptor

Kavran, J., McCabe, J. M., Byrne, P. O., Connacher, M. K., Wang, Z., Ramek, A., Sarabipour, S., Shan, Y., Shaw, D. E., Hristova, K. A., Cole, P. A. & Leahy, D. J., Sep 25 2014, In : eLife. 3

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Ligands
Insulin Receptor
IGF Type 1 Receptor
Dimers

Interfacially active peptides and proteins

Wimley, W. C. & Hristova, K. A., 2014, In : BBA - Biomembranes. 1838, 9, p. 2139 1 p.

Research output: Contribution to journalArticle

Lipid bilayers
Peptides
Proteins
Protein Binding

Quantification of the effects of mutations on receptor tyrosine kinase (RTK) activation in mammalian cells

He, L. & Hristova, K. A., Oct 15 2014, Receptor Tyrosine Kinases: Methods and Protocols. Springer New York, p. 81-87 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Receptor Protein-Tyrosine Kinases
Chemical activation
Cells
Mutation
Phosphorylation

Strong dimerization of wild-type ErbB2/Neu transmembrane domain and the oncogenic Val664Glu mutant in mammalian plasma membranes

Placone, J., He, L., Del Piccolo, N. & Hristova, K. A., 2014, In : BBA - Biomembranes. 1838, 9, p. 2326-2330 5 p.

Research output: Contribution to journalArticle

Dimerization
Energy Transfer
Cell membranes
Energy transfer
Cell Membrane

The FRET signatures of noninteracting proteins in membranes: Simulations and experiments

King, C., Sarabipour, S., Byrne, P., Leahy, D. J. & Hristova, K. A., Mar 18 2014, In : Biophysical Journal. 106, 6, p. 1309-1317 9 p.

Research output: Contribution to journalArticle

Energy Transfer
Membrane Proteins
Membranes
Biophysics
Cell Membrane

Uninduced high-yield bacterial expression of fluorescent proteins

Sarabipour, S., King, C. & Hristova, K. A., Mar 15 2014, In : Analytical Biochemistry. 449, 1, p. 155-157 3 p.

Research output: Contribution to journalArticle

Thiogalactosides
Proteins
Gold
Escherichia coli
Bacteria
2013

A membrane-translocating peptide penetrates into bilayers without significant bilayer perturbations

Cruz, J., Mihailescu, M., Wiedman, G., Herman, K., Searson, P. C., Wimley, W. C. & Hristova, K. A., Jun 4 2013, In : Biophysical Journal. 104, 11, p. 2419-2428 10 p.

Research output: Contribution to journalArticle

Peptides
Membranes
Neutron Diffraction
Cell-Penetrating Peptides
Lipid Bilayers

Direct cytosolic delivery of polar cargo to cells by spontaneous membrane-translocating peptides

He, J., Kauffman, W. B., Fuselier, T., Naveen, S. K., Voss, T. G., Hristova, K. A. & Wimley, W. C., Oct 11 2013, In : Journal of Biological Chemistry. 288, 41, p. 29974-29986 13 p.

Research output: Contribution to journalArticle

Cell Membrane
Membranes
Peptides
Endocytosis
Coloring Agents

Electrically addressable, biologically relevant surface-supported bilayers

Lin, J., Hristova, K. A. & Searson, P. C., Apr 30 2013, Handbook of Biofunctional Surfaces. Pan Stanford Publishing Pte. Ltd., p. 769-820 52 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

FGFR3 transmembrane domain interactions persist in the presence of its extracellular domain

Sarabipour, S. & Hristova, K. A., Jul 2 2013, In : Biophysical Journal. 105, 1, p. 165-171 7 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 3
Mutation
Energy Transfer
Receptor Protein-Tyrosine Kinases
Cell Membrane

Glycophorin A transmembrane domain dimerization in plasma membrane vesicles derived from CHO, HEK 293T, and A431 cells

Sarabipour, S. & Hristova, K. A., 2013, In : BBA - Biomembranes. 1828, 8, p. 1829-1833 5 p.

Research output: Contribution to journalArticle

Glycophorin
Dimerization
HEK293 Cells
Cell membranes
Cricetulus