Justin S Hanes

Professor

19942018
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Research Output 1994 2018

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy

Duncan, G. A., Kim, N., Colon-Cortes, Y., Rodriguez, J., Mazur, M., Birket, S. E., Rowe, S. M., West, N. E., Livraghi-Butrico, A., Boucher, R. C., Hanes, J., Aslanidi, G. & Suk, J. S. Jun 15 2018 In : Molecular Therapy - Methods and Clinical Development. 9, p. 296-304 9 p.

Research output: Contribution to journalArticle

Mucus
Genetic Therapy
Dependovirus
Transgenes
Cystic Fibrosis

Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema

Hoang, T., Date, A. A., Ortiz, J. O., Young, T. W., Bensouda, S., Xiao, P., Marzinke, M., Rohan, L., Fuchs, E. J., Hendrix, C., Gumber, S., Villinger, F., Cone, R. A., Hanes, J. & Ensign, L. M. Jan 1 2018 (Accepted/In press) In : European Journal of Pharmaceutics and Biopharmaceutics.

Research output: Contribution to journalArticle

Tenofovir
Enema
Prodrugs
Anti-Infective Agents
Sexual Behavior

Effects of enzymatic degradation on dynamic mechanical properties of the vitreous and intravitreal nanoparticle mobility

Huang, D., Chen, Y. S., Xu, Q., Hanes, J. & Rupenthal, I. D. Jun 15 2018 In : European Journal of Pharmaceutical Sciences. 118, p. 124-133 10 p.

Research output: Contribution to journalArticle

Nanoparticles
Retinal Diseases
Hyaluronoglucosaminidase
Fluorescence Spectrometry
Collagenases

Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation

Patil, H. P., Freches, D., Karmani, L., Duncan, G. A., Ucakar, B., Suk, J. S., Hanes, J., Gallez, B. & Vanbever, R. Feb 28 2018 In : Journal of Controlled Release. 272, p. 62-71 10 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Pneumonia
Lung
Interleukin-17
Immunoglobulin Fab Fragments

Hypo-osmolar formulation of tenofovir (TFV) enema promotes uptake and metabolism of TFV in tissues, leading to prevention of SHIV/SIV infection

Xiao, P., Gumber, S., Marzinke, M. A., Date, A. A., Hoang, T., Hanes, J., Ensign, L. M., Wang, L., Rohan, L., Fuchs, E. J., Hendrix, C. & Villinger, F. Jan 1 2018 In : Antimicrobial Agents and Chemotherapy. 62, 1, e01644-17

Research output: Contribution to journalArticle

Tenofovir
Enema
Haplorhini
Infection
Pharmacokinetics