Research output per year
Research output per year
- 39 results
Search results
-
2023
Cadenza ad libitum: cGAS and STING showcase their versatile virtuosities in the Ca2+-dependent rescue of stalled replication forks
Sohn, J., Feb 16 2023, In: Molecular cell. 83, 4, p. 502-503 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Filament assembly underpins the double-stranded DNA specificity of AIM2-like receptors
Garg, A., Stallings, C. M. & Sohn, J., Apr 11 2023, In: Nucleic acids research. 51, 6, p. 2574-2585 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps
Antiochos, B., Trejo-Zambrano, D., Fenaroli, P., Rosenberg, A., Baer, A., Garg, A., Sohn, J., Li, J., Petri, M., Goldman, D. W., Mecoli, C., Casciola-Rosen, L. & Rosen, A., May 2022, In: eLife. 11, e72103.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Allosteric coupling between Mn2+and dsDNA controls the catalytic efficiency and fidelity of cGAS
Hooy, R. M., Massaccesi, G., Rousseau, K. E., Chattergoon, M. A. & Sohn, J., 2021, In: Nucleic acids research. 48, 8, p. 4435-4447 13 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome
Matyszewski, M., Zheng, W., Lueck, J., Mazanek, Z., Mohideen, N., Lau, A. Y., Egelman, E. H. & Sohn, J., Dec 1 2021, In: Nature communications. 12, 1, 2735.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Helping Scholars Overcome Socioeconomic Barriers to Medical and Biomedical Careers: Creating a Pipeline Initiative
Crews, D. C., Wilson, K. L., Sohn, J., Kabacoff, C. M., Poynton, S. L., Murphy, L. R., Bolz, J., Wolfe, A., White, P. T., Will, C., Collins, C., Gauda, E. & Robinson, D. N., Aug 7 2020, In: Teaching and Learning in Medicine. 32, 4, p. 422-433 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2019
A pyrophosphatase-coupled assay to monitor the NTase activity of cGAS
Hooy, R. & Sohn, J., 2019, DNA Sensors and Inflammasomes. Sohn, J. (ed.). Academic Press Inc., p. 77-86 10 p. (Methods in Enzymology; vol. 625).Research output: Chapter in Book/Report/Conference proceeding › Chapter
3 Scopus citations -
Characterization of DNA bound cyclic GMP-AMP synthase using atomic force microscopy imaging
Lushnikov, A., Hooy, R., Sohn, J. & Krasnoslobodtsev, A., 2019, DNA Sensors and Inflammasomes. Sohn, J. (ed.). Academic Press Inc., p. 157-166 10 p. (Methods in Enzymology; vol. 625).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
Jiang, H., Xue, X., Panda, S., Kawale, A., Hooy, R. M., Liang, F., Sohn, J., Sung, P. & Gekara, N. O., Oct 4 2019, In: EMBO Journal. 38, 21, e102718.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
Preface
Sohn, J., 2019, DNA Sensors and Inflammasomes. Sohn, J. (ed.). Academic Press Inc., p. xvii (Methods in Enzymology; vol. 625).Research output: Chapter in Book/Report/Conference proceeding › Foreword/postscript
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Preparation of filamentous proteins for electron microscopy visualization and reconstruction
Matyszewski, M. & Sohn, J., 2019, DNA Sensors and Inflammasomes. Sohn, J. (ed.). Academic Press Inc., p. 167-176 10 p. (Methods in Enzymology; vol. 625).Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
Tracking the polymerization of DNA sensors and inflammasomes using FRET
Mazanek, Z. & Sohn, J., 2019, DNA Sensors and Inflammasomes. Sohn, J. (ed.). Academic Press Inc., p. 87-94 8 p. (Methods in Enzymology; vol. 625).Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Scopus citations -
2018
Cryo-EM structure of the NLRC4CARD filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly
Matyszewski, M., Zheng, W., Lueck, J., Antiochos, B., Egelman, E. H. & Sohn, J., Dec 28 2018, In: Journal of Biological Chemistry. 293, 52, p. 20240-20248 9 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Digital signaling network drives the assembly of the AIM2- ASC inflammasome
Matyszewski, M., Morrone, S. R. & Sohn, J., Feb 27 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. E1963-E1972Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
IFI16 filament formation in salivary epithelial cells shapes the anti-IFI16 immune response in Sjögren's syndrome
Antiochos, B., Matyszewski, M., Sohn, J., Casciola-Rosen, L. & Rosen, A., Sep 20 2018, In: JCI Insight. 3, 18Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
The allosteric activation of cGAS underpins its dynamic signaling landscape
Hooy, R. M. & Sohn, J., Oct 2018, In: eLife. 7, e39984.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
2017
Reply
Baer, A. N., Petri, M., Sohn, J., Rosen, A. & Casciola-Rosen, L., Mar 1 2017, In: Arthritis Care and Research. 69, 3, p. 454 1 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
2016
Association of Antibodies to Interferon-Inducible Protein-16 with Markers of More Severe Disease in Primary Sjögren's Syndrome
Baer, A. N., Petri, M., Sohn, J., Rosen, A. & Casciola-Rosen, L., Feb 1 2016, In: Arthritis Care and Research. 68, 2, p. 254-260 7 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Filament assemblies in foreign nucleic acid sensors
Sohn, J. & Hur, S., Apr 1 2016, In: Current Opinion in Structural Biology. 37, p. 134-144 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access36 Scopus citations -
2015
A conserved activation cluster is required for allosteric communication in htra-family proteases
De Regt, A. K., Kim, S., Sohn, J., Grant, R. A., Baker, T. A. & Sauer, R. T., Mar 3 2015, In: Structure. 23, 3, p. 517-526 10 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC
Morrone, S. R., Matyszewski, M., Yu, X., Delannoy, M., Egelman, E. H. & Sohn, J., Jul 22 2015, In: Nature communications. 6, 7827.Research output: Contribution to journal › Article › peer-review
Open Access72 Scopus citations -
Single-molecule imaging at high fluorophore concentrations by local activation of dye
Geertsema, H. J., Schulte, A. C., Spenkelink, L. M., McGrath, W. J., Morrone, S. R., Sohn, J., Mangel, W. F., Robinson, A. & Van Oijen, A. M., Feb 17 2015, In: Biophysical journal. 108, 4, p. 949-956 8 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex
Stratmann, S. A., Morrone, S. R., van Oijen, A. M. & Sohn, J., Dec 16 2015, In: eLife. 4, DECEMBER2015, e11721.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
2014
Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
Morrone, S. R., Wang, T., Constantoulakis, L. M., Hooy, R. M., Delannoy, M. J. & Sohn, J., 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 1, p. E62-E71Research output: Contribution to journal › Article › peer-review
Open Access107 Scopus citations -
2011
Signal integration by DegS and RseB governs the σE- mediated envelope stress response in Escherichia coli
Chaba, R., Alba, B. M., Guo, M. S., Sohn, J., Ahuja, N., Sauer, R. T. & Gross, C. A., Feb 1 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 5, p. 2106-2111 6 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
2010
Allostery is an intrinsic property of the protease domain of DegS: Implications for enzyme function and evolution
Sohn, J., Grant, R. A. & Sauer, R. T., Oct 29 2010, In: Journal of Biological Chemistry. 285, 44, p. 34039-34047 9 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
2009
OMP Peptides Activate the DegS Stress-Sensor Protease by a Relief of Inhibition Mechanism
Sohn, J., Grant, R. A. & Sauer, R. T., Oct 14 2009, In: Structure. 17, 10, p. 1411-1421 11 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
OMP Peptides Modulate the Activity of DegS Protease by Differential Binding to Active and Inactive Conformations
Sohn, J. & Sauer, R. T., Jan 16 2009, In: Molecular cell. 33, 1, p. 64-74 11 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
2007
Allosteric Activation of DegS, a Stress Sensor PDZ Protease
Sohn, J., Grant, R. A. & Sauer, R. T., Nov 2 2007, In: Cell. 131, 3, p. 572-583 12 p.Research output: Contribution to journal › Article › peer-review
Open Access95 Scopus citations -
Kinetic and structural studies of specific protein-protein interactions in substrate catalysis by Cdc25B phosphatase
Sohn, J., Buhrman, G. & Rudolph, J., Jan 23 2007, In: Biochemistry. 46, 3, p. 807-818 12 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Temperature dependence of binding and catalysis for the Cdc25B phosphatase
Sohn, J. & Rudolph, J., Feb 2007, In: Biophysical Chemistry. 125, 2-3, p. 549-555 7 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2006
The Energetic Network of Hotspot Residues between Cdc25B Phosphatase and its Protein Substrate
Sohn, J. & Rudolph, J., Oct 6 2006, In: Journal of molecular biology. 362, 5, p. 1060-1071 12 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2005
Erratum: Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond (Biochemistry (April 12, 2005) 44:14 (5307-5316))
Buhrman, G., Parker, B., Sohn, J., Rudolph, J. & Mattos, C., May 24 2005, In: Biochemistry. 44, 20, p. 7602 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Experimental validation of the docking orientation of Cdc25 with its Cdk2-CycA protein substrate
Sohn, J., Parks, J. M., Buhrman, G., Brown, P., Kristjánsdóttir, K., Safi, A., Edelsbrunner, H., Yang, W. & Rudolph, J., Dec 20 2005, In: Biochemistry. 44, 50, p. 16563-16573 11 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond
Buhrman, G., Parker, B., Sohn, J., Rudolph, J. & Mattos, C., Apr 12 2005, In: Biochemistry. 44, 14, p. 5307-5316 10 p.Research output: Contribution to journal › Article › peer-review
84 Scopus citations -
2004
Remote hot spots mediate protein substrate recognition for the Cdc25 phosphatase
Sohn, J., Kristjánsdóttir, K., Safi, A., Parker, B., Kiburz, B. & Rudolph, J., Nov 23 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 47, p. 16437-16441 5 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
2003
Catalytic and chemical competence of regulation of Cdc25 phosphatase by oxidation/reduction
Sohn, J. & Rudolph, J., Sep 2 2003, In: Biochemistry. 42, 34, p. 10060-10070 11 p.Research output: Contribution to journal › Article › peer-review
153 Scopus citations -
Facile variation of reagent concentrations in rapid quench enzymology
Sohn, J. & Rudolph, J., Jan 1 2003, In: Analytical biochemistry. 312, 1, p. 80-83 4 p.Research output: Contribution to journal › Article › peer-review
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Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones
Sohn, J., Kiburz, B., Li, Z., Deng, L., Safi, A., Pirrung, M. C. & Rudolph, J., Jun 19 2003, In: Journal of medicinal chemistry. 46, 13, p. 2580-2588 9 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations