Research output per year
Research output per year
- 1 - 50 out of 209 results
Search results
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2023
Combination immunotherapy of glioblastoma with dendritic cell cancer vaccines, anti-PD-1 and poly I:C
Zhu, P., Li, S. Y., Ding, J., Fei, Z., Sun, S. N., Zheng, Z. H., Wei, D., Jiang, J., Miao, J. L., Li, S. Z., Luo, X., Zhang, K., Wang, B., Zhang, K., Pu, S., Wang, Q. T., Zhang, X. Y., Wen, G. L., Liu, J. O., August, J. T., & 3 others, Jun 2023, In: Journal of Pharmaceutical Analysis. 13, 6, p. 616-624 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Dimethyl Fumarate Protects against Lipopolysaccharide- (LPS-) Induced Sepsis through Inhibition of NF- κ B Pathway in Mice
Fang, H., Wang, X., Damarla, M., Sun, R., He, Q., Li, R., Luo, P., Liu, J. O. & Xia, Z., 2023, In: Mediators of inflammation. 2023, 5133505.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease
Park, H., Kam, T. I., Peng, H., Chou, S. C., Mehrabani-Tabari, A. A., Song, J. J., Yin, X., Karuppagounder, S. S., Umanah, G. K., Rao, A. V. S., Choi, Y. R., Aggarwal, A., Chang, S., Kim, H., Byun, J., Liu, J. O., Dawson, T. M. & Dawson, V. L., May 26 2022, In: Cell. 185, 11, p. 1943-1959.e21Research output: Contribution to journal › Article › peer-review
Open Access -
Total Synthesis of Rameswaralide Utilizing a Pharmacophore-Directed Retrosynthetic Strategy
Truax, N. J., Ayinde, S., Liu, J. O. & Romo, D., Oct 12 2022, In: Journal of the American Chemical Society. 144, 40, p. 18575-18585 11 p.Research output: Contribution to journal › Article › peer-review
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2021
Arsenicals, the integrated stress response, and epstein–barr virus lytic gene expression
Lee, J., Stone, J., Desai, P., Kosowicz, J. G., Liu, J. O. & Ambinder, R. F., May 2021, In: Viruses. 13, 5, 812.Research output: Contribution to journal › Article › peer-review
Open Access -
CRYβB2 enhances tumorigenesis through upregulation of nucleolin in triple negative breast cancer
Yan, Y., Narayan, A., Cho, S., Cheng, Z., Liu, J. O., Zhu, H., Wang, G., Wharram, B., Lisok, A., Brummet, M., Saeki, H., Huang, T., Gabrielson, K., Gabrielson, E., Cope, L., Kanaan, Y. M., Afsari, A., Naab, T., Yfantis, H. G., Ambs, S., & 3 others, Sep 23 2021, In: Oncogene. 40, 38, p. 5752-5763 12 p.Research output: Contribution to journal › Article › peer-review
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Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes
Cui, Z., Liu, Y., Wan, W., Xu, Y., Hu, Y., Ding, M., Dou, X., Wang, R., Li, H., Meng, Y., Li, W., Jiang, W., Li, Z., Li, Y., Tan, M., Ma, D. K., Ding, Y., Liu, J. O., Luo, C., Yu, B., & 2 others, Jun 2021, In: Protein and Cell. 12, 6, p. 493-501 9 p.Research output: Contribution to journal › Letter › peer-review
Open Access1 Scopus citations -
Influence of stereochemistry on the activity of rapadocin, an isoform-specific inhibitor of the nucleoside transporter ENT1
Wang, Y., Peng, H., Guo, Z., Ullman, B. R., Yamamoto, K., Hong, S. Y. & Liu, J. O., Sep 14 2021, In: Chemical Science. 12, 34, p. 11484-11489 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa
Zhang, L., Chen, C., Fu, J., Lilley, B., Berlinicke, C., Hansen, B., Ding, D., Wang, G., Wang, T., Shou, D., Ye, Y., Mulligan, T., Emmerich, K., Saxena, M. T., Hall, K. R., Sharrock, A. V., Brandon, C., Park, H., Kam, T. I., Dawson, V. L., & 10 others, Jun 2021, In: eLife. 10Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting Neoantigens in Hepatocellular Carcinoma for Immunotherapy: A Futile Strategy?
Lu, L., Jiang, J., Zhan, M., Zhang, H., Wang, Q. T., Sun, S. N., Guo, X. K., Yin, H., Wei, Y., Liu, J. O., Li, S. Y., Li, Y. & He, Y. W., Jan 2021, In: Hepatology. 73, 1, p. 414-421 8 p.Research output: Contribution to journal › Review article › peer-review
8 Scopus citations -
Targeting Tumor-Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies
Lu, L., Jiang, J., Zhan, M., Zhang, H., Wang, Q. T., Sun, S. N., Guo, X. K., Yin, H., Wei, Y., Li, S. Y., Liu, J. O., Li, Y. & He, Y. W., Feb 2021, In: Hepatology. 73, 2, p. 821-832 12 p.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Triptolide: Reflections on two decades of research and prospects for the future
Tong, L., Zhao, Q., Datan, E., Lin, G. Q., Minn, I., Pomper, M. G., Yu, B., Romo, D., He, Q. L. & Liu, J. O., Apr 2021, In: Natural Product Reports. 38, 4, p. 843-860 18 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
2020
A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under Hypoxia
Datan, E., Minn, I., Xu, P., He, Q. L., Ahn, H. H., Yu, B., Pomper, M. G. & Liu, J. O., Sep 25 2020, In: iScience. 23, 9, 101536.Research output: Contribution to journal › Article › peer-review
Open Access -
Design and Synthesis of Tetrazole- And Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors
Li, Y., Pasunooti, K. K., Peng, H., Li, R. J., Shi, W. Q., Liu, W., Cheng, Z., Head, S. A., Liu, J. O. & Liu, J. O., Jun 11 2020, In: ACS Medicinal Chemistry Letters. 11, 6, p. 1111-1117 7 p.Research output: Contribution to journal › Article › peer-review
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Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis
Liberti, M. V., Allen, A. E., Ramesh, V., Dai, Z., Singleton, K. R., Guo, Z., Liu, J. O., Wood, K. C. & Locasale, J. W., Jan 3 2020, In: Journal of Biological Chemistry. 295, 1, p. 111-124 14 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Synthetic Fluorinated l -Fucose Analogs Inhibit Proliferation of Cancer Cells and Primary Endothelial Cells
Dai, Y., Hartke, R., Li, C., Yang, Q., Liu, J. O. & Wang, L. X., Oct 16 2020, In: ACS chemical biology. 15, 10, p. 2662-2672 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Use of aspirin and statins in relation to inflammation in benign prostate tissue in the placebo arm of the prostate cancer prevention trial
Hurwitz, L. M., Kulac, I., Gumuskaya, B., Baena Del Valle, J. A., Benedetti, I., Pan, F., Liu, J. O., Marrone, M. T., Arnold, K. B., Goodman, P. J., Tangen, C. M., Lucia, M. S., Thompson, I. M., Drake, C. G., Isaacs, W. B., Nelson, W. G., de Marzo, A. M. & Platz, E. A., Oct 1 2020, In: Cancer Prevention Research. 13, 10, p. 853-861 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing
Peiffer, B. J., Qi, L., Ahmadi, A. R., Wang, Y., Guo, Z., Peng, H., Sun, Z. & Liu, J. O., May 16 2019, In: Cell Chemical Biology. 26, 5, p. 652-661.e4Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays
Guo, Z., Cheng, Z., Wang, J., Liu, W., Peng, H., Wang, Y., Rao, A. V. S., Li, R. J., Ying, X., Korangath, P., Liberti, M. V., Li, Y., Xie, Y., Hong, S. Y., Schiene-Fischer, C., Fischer, G., Locasale, J. W., Sukumar, S., Zhu, H. & Liu, J. O., Nov 25 2019, In: Angewandte Chemie - International Edition. 58, 48, p. 17158-17162 5 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
One-step Heck Reaction Generates Nonimmunosuppressive FK506 Analogs for Pharmacological BMP Activation
Wang, Y., Peiffer, B. J., Su, Q. & Liu, J. O., Sep 12 2019, In: ACS Medicinal Chemistry Letters. 10, 9, p. 1279-1283 5 p.Research output: Contribution to journal › Article › peer-review
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Pharmacologic activation of Lytic Epstein-Barr Virus gene expression without virion production
Lee, J., Kosowicz, J. G., Hayward, S. D., Desai, P., Stone, J., Lee, J. M., Liu, J. O. & Ambinder, R. F., Oct 1 2019, In: Journal of virology. 93, 20, e00998-19.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Pharmacophore-Directed Retrosynthesis Applied to Rameswaralide: Synthesis and Bioactivity of Sinularia Natural Product Tricyclic Cores
Truax, N. J., Ayinde, S., Van, K., Liu, J. O. & Romo, D., Sep 20 2019, In: Organic Letters. 21, 18, p. 7394-7399 6 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Rapamycin-inspired macrocycles with new target specificity
Guo, Z., Hong, S. Y., Wang, J., Rehan, S., Liu, W., Peng, H., Das, M., Li, W., Bhat, S., Peiffer, B., Ullman, B. R., Tse, C. M., Tarmakova, Z., Schiene-Fischer, C., Fischer, G., Coe, I., Paavilainen, V. O., Sun, Z. & Liu, J. O., Mar 1 2019, In: Nature Chemistry. 11, 3, p. 254-263 10 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2018
Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking
Lyu, J., Yang, E. J., Head, S. A., Ai, N., Zhang, B., Wu, C., Li, R. J., Liu, Y., Chakravarty, H., Zhang, S., Tam, K. Y., Dang, Y., Kwon, H. J., Ge, W., Liu, J. O. & Shim, J. S., Jun 23 2018, In: International Journal of Biological Sciences. 14, 10, p. 1175-1185 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition
Li, Y., Pasunooti, K. K., Li, R. J., Liu, W., Head, S. A., Shi, W. Q. & Liu, J. O., Dec 27 2018, In: Journal of medicinal chemistry. 61, 24, p. 11158-11168 11 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin
Jiang, W., Zhou, X., Li, Z., Liu, K., Wang, W., Tan, R., Cong, X., Shan, J., Zhan, Y., Cui, Z., Jiang, L., Li, Q., Shen, S., Bai, M., Cheng, Y., Li, B., Tan, M., Ma, D. K., Liu, J. O. & Dang, Y., Mar 22 2018, In: Blood. 131, 12, p. 1325-1336 12 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment
Lam, C., Ferguson, I. D., Mariano, M. C., Lin, Y. H. T., Murnane, M., Liu, H., Smith, G. A., Wong, S. W., Taunton, J., Liu, J. O., Mitsiades, C. S., Hann, B. C., Aftab, B. T. & Wiita, A. P., Jul 3 2018, In: Haematologica. 103, 7, p. 1218-1228 11 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)
Bauer, L., Ferla, S., Head, S. A., Bhat, S., Pasunooti, K. K., Shi, W. Q., Albulescu, L., Liu, J. O., Brancale, A., van Kuppeveld, F. J. M. & Strating, J. R. P. M., Aug 2018, In: Antiviral Research. 156, p. 55-63 9 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1
Li, Z., Cheng, Z., Raghothama, C., Cui, Z., Liu, K., Li, X., Jiang, C., Jiang, W., Tan, M., Ni, X., Pandey, A., Liu, J. O. & Dang, Y., Jan 25 2018, In: Nucleic acids research. 46, 2, p. 823-839 17 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2017
Drug modulators of B cell signaling pathways and Epstein-Barr virus lytic activation
Kosowicz, J. G., Lee, J., Peiffer, B., Guo, Z., Chen, J., Liao, G., Diane Hayward, S., Liu, J. O. & Ambinder, R. F., Aug 1 2017, In: Journal of virology. 91, 16, e00747-17.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A
McClary, B., Zinshteyn, B., Meyer, M., Jouanneau, M., Pellegrino, S., Yusupova, G., Schuller, A., Reyes, J. C. P., Lu, J., Guo, Z., Ayinde, S., Luo, C., Dang, Y., Romo, D., Yusupov, M., Green, R. & Liu, J. O., May 18 2017, In: Cell Chemical Biology. 24, 5, p. 605-613.e5Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth
Lyu, J., Yang, E. J., Head, S. A., Ai, N., Zhang, B., Wu, C., Li, R. J., Liu, Y., Yang, C., Dang, Y., Kwon, H. J., Ge, W., Liu, J. O. & Shim, J. S., Nov 28 2017, In: Cancer Letters. 409, p. 91-103 13 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of MTOR signaling and angiogenesis
Head, S. A., Shi, W. Q., Yang, E. J., Nacev, B. A., Hong, S. Y., Pasunooti, K. K., Li, R. J., Shim, J. S. & Liu, J. O., Jan 20 2017, In: ACS chemical biology. 12, 1, p. 174-182 9 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
2016
Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway
Cho, Y. S., Yen, C. N., Shim, J. S., Kang, D. H., Kang, S. W., Liu, J. O. & Kwon, H. J., Oct 3 2016, In: Scientific reports. 6, 34655.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs
Fox, J. M., Moynihan, J. R., Mott, B. T., Mazzone, J. R., Anders, N. M., Brown, P. A., Rudek, M. A., Liu, J. O., Arav-Boger, R., Posner, G. H., Civin, C. I. & Chen, X., 2016, In: Oncotarget. 7, 6, p. 7268-7279 12 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis
John, S. F., Aniemeke, E., Ha, N. P., Chong, C. R., Gu, P., Zhou, J., Zhang, Y., Graviss, E. A., Liu, J. O. & Olaleye, O. A., Dec 1 2016, In: Tuberculosis. 101, p. S73-S77Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe
Jouanneau, M., McClary, B., Reyes, J. C. P., Chen, R., Chen, Y., Plunkett, W., Cheng, X., Milinichik, A. Z., Albone, E. F., Liu, J. O. & Romo, D., Apr 15 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 8, p. 2092-2097 6 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Divergence of antiangiogenic activity and hepatotoxicity of different stereoisomers of itraconazole
Shim, J. S., Li, R. J., Bumpus, N. N., Head, S. A., Pasunooti, K. K., Yang, E. J., Lv, J., Shi, W. & Liu, J. O., Jun 1 2016, In: Clinical Cancer Research. 22, 11, p. 2709-2720 12 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Editorial: Strategies for cellular target identification of natural products
Romo, D. & Liu, J. O., May 2016, In: Natural Product Reports. 33, 5, p. 592-594 3 p.Research output: Contribution to journal › Review article › peer-review
6 Scopus citations -
Identification of small molecule-binding proteins in a native cellular environment by live-cell photoaffinity labeling
Head, S. A. & Liu, J. O., Sep 20 2016, In: Journal of Visualized Experiments. 2016, 115, e54529.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Insights into the structure-activity relationship of the anticancer compound ZJ-101: A critical role played by the cyclohexene ring
Shah, A. K., Qian, S., Zhang, D., Head, S. A., Liu, J. O. & Jin, Z., Jun 15 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 12, p. 2890-2892 3 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A critical role played by the conjugated trienyl lactone moiety
Qian, S., Shah, A. K., Head, S. A., Liu, J. O. & Jin, Z., 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 15, p. 3411-3413 3 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A role played by the lactone moiety
Qiu, H., Qian, S., Head, S. A., Liu, J. O. & Jin, Z., 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 19, p. 4702-4704 3 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Regulation of mTORC1 by lysosomal calcium and calmodulin
Li, R. J., Xu, J., Fu, C., Zhang, J., Zheng, Y. G., Jia, H., Liu, J. O. & Czech, M., Oct 27 2016, In: eLife. 5, OCTOBER2016, e19360.Research output: Contribution to journal › Article › peer-review
Open Access61 Scopus citations -
Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier
Wang, X., Maruvada, R., Morris, A. J., Liu, J. O., Wolfgang, M. J., Baek, D. J., Bittman, R. & Kim, K. S., Oct 2016, In: PLoS pathogens. 12, 10, e1005926.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation
He, Q. L., Minn, I., Wang, Q., Xu, P., Head, S. A., Datan, E., Yu, B., Pomper, M. G. & Liu, J. O., Sep 19 2016, In: Angewandte Chemie - International Edition. 55, 39, p. 12035-12039 5 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
2015
A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation
Lu, J., Jiang, C., Li, X., Jiang, L., Li, Z., Schneider-Poetsch, T., Liu, J., Yu, K., Liu, J. O., Jiang, H., Luo, C. & Dang, Y., 2015, In: Nucleic acids research. 43, 21, p. 10157-10167 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells
Head, S. A., Shi, W., Zhao, L., Gorshkov, K., Pasunooti, K., Chen, Y., Deng, Z., Li, R. J., Shim, J. S., Tan, W., Hartung, T., Zhang, J., Zhao, Y., Colombini, M. & Liu, J. O., Dec 29 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. E7276-E7285Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide
He, Q. L., Titov, D. V., Li, J., Tan, M., Ye, Z., Zhao, Y., Romo, D. & Liu, J. O., Feb 9 2015, In: Angewandte Chemie - International Edition. 54, 6, p. 1859-1863 5 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors
He, R., Yu, Z. H., Zhang, R. Y., Wu, L., Gunawan, A. M., Lane, B. S., Shim, J. S., Zeng, L. F., He, Y., Chen, L., Wells, C. D., Liu, J. O. & Zhang, Z. Y., Jul 9 2015, In: ACS Medicinal Chemistry Letters. 6, 7, p. 782-786 5 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations