Juan C Troncoso

Professor

1981 …2019
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Research Output 1981 2019

2019

A comprehensive screening of copy number variability in dementia with Lewy bodies

Kun-Rodrigues, C., Orme, T., Carmona, S., Hernandez, D. G., Ross, O. A., Eicher, J. D., Shepherd, C., Parkkinen, L., Darwent, L., Heckman, M. G., Scholz, S. W., Troncoso, J. C., Pletnikova, O., Dawson, T. M., Rosenthal, L. I. S., Ansorge, O., Clarimon, J., Lleo, A., Morenas-Rodriguez, E., Clark, L. & 48 others, Honig, L. S., Marder, K., Lemstra, A., Rogaeva, E., St. George-Hyslop, P., Londos, E., Zetterberg, H., Barber, I., Braae, A., Brown, K., Morgan, K., Troakes, C., Al-Sarraj, S., Lashley, T., Holton, J., Compta, Y., Van Deerlin, V., Serrano, G. E., Beach, T. G., Lesage, S., Galasko, D., Masliah, E., Santana, I., Pastor, P., Diez-Fairen, M., Aguilar, M., Tienari, P. J., Myllykangas, L., Oinas, M., Revesz, T., Lees, A., Boeve, B. F., Petersen, R. C., Ferman, T. J., Escott-Price, V., Graff-Radford, N., Cairns, N. J., Morris, J. C., Pickering-Brown, S., Mann, D., Halliday, G. M., Hardy, J., Trojanowski, J. Q., Dickson, D. W., Singleton, A., Stone, D. J., Guerreiro, R. & Bras, J., Mar 1 2019, In : Neurobiology of Aging. 75, p. 223.e1-223.e10

Research output: Contribution to journalArticle

Lewy Body Disease
Genome
Neurodegenerative Diseases
Genes
Dementia

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB) & The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Aug 1 2019, In : Acta neuropathologica. 138, 2, p. 237-250 14 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Frontotemporal Dementia
Alzheimer Disease
Mutation
Neurodegenerative Diseases

Assessment of APOE in atypical parkinsonism syndromes

Sabir, M. S., Blauwendraat, C., Ahmed, S., Serrano, G. E., Beach, T. G., Perkins, M., Rice, A. C., Masliah, E., Morris, C. M., Pihlstrom, L., Pantelyat, A., Resnick, S. M., Cookson, M. R., Hernandez, D. G., Albert, M., Dawson, T. M., Rosenthal, L. I. S., Houlden, H., Pletnikova, O., Troncoso, J. C. & 1 others, Scholz, S. W., Jul 1 2019, In : Neurobiology of Disease. 127, p. 142-146 5 p.

Research output: Contribution to journalArticle

Parkinsonian Disorders
Lewy Body Disease
Progressive Supranuclear Palsy
Multiple System Atrophy
Alzheimer Disease

C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy

Cali, C. P., Patino, M., Tai, Y. K., Ho, W. Y., McLean, C. A., Morris, C. M., Seeley, W. W., Miller, B. L., Gaig, C., Vonsattel, J. P. G., White, C. L., Roeber, S., Kretzschmar, H., Troncoso, J. C., Troakes, C., Gearing, M., Ghetti, B., Van Deerlin, V. M., Lee, V. M. Y., Trojanowski, J. Q. & 6 others, Mok, K. Y., Ling, H., Dickson, D. W., Schellenberg, G. D., Ling, S. C. & Lee, E. B., Nov 1 2019, In : Acta neuropathologica. 138, 5, p. 795-811 17 p.

Research output: Contribution to journalArticle

Autophagy
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Autopsy
Clustered Regularly Interspaced Short Palindromic Repeats
Open Access
Inflammasomes
Haplotypes
Publications
Alzheimer Disease
Protein Isoforms

Erratum: Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease (Neuron (2018) 99(5) (925–940.e7), (S0896627318306378) (10.1016/j.neuron.2018.07.039))

Eftekharzadeh, B., Daigle, J. G., Kapinos, L. E., Coyne, A., Schiantarelli, J., Carlomagno, Y., Cook, C., Miller, S. J., Dujardin, S., Amaral, A. S., Grima, J. C., Bennett, R. E., Tepper, K., DeTure, M., Vanderburg, C. R., Corjuc, B. T., DeVos, S. L., Gonzalez, J. A., Chew, J., Vidensky, S. & 10 others, Gage, F. H., Mertens, J., Troncoso, J., Mandelkow, E., Salvatella, X., Lim, R. Y. H., Petrucelli, L., Wegmann, S., Rothstein, J. D. & Hyman, B. T., Jan 16 2019, In : Neuron. 101, 2, 1 p.

Research output: Contribution to journalComment/debate

tau Proteins
Cell Nucleus Active Transport
Names
Publications
Alzheimer Disease

Expanding the Computational Anatomy Gateway from clinical imaging to basic neuroscience research

Tward, D., Kolasny, A., Khan, F., Troncoso, J. C. & Miller, M., Jul 28 2019, Proceedings of the Practice and Experience in Advanced Research Computing: Rise of the Machines (Learning), PEARC 2019. Association for Computing Machinery, 3332217. (ACM International Conference Proceeding Series).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Medical imaging
Tissue
Supercomputers
Magnetic resonance
Imaging systems

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Mar 1 2019, In : Nature genetics. 51, 3, p. 414-430 17 p.

Research output: Contribution to journalArticle

Meta-Analysis
Immunity
Alzheimer Disease
Lipids
Serum Amyloid A Protein

Heritability and genetic variance of dementia with Lewy bodies

for the International Parkinson's Disease Genomics Consortium, Jul 1 2019, In : Neurobiology of Disease. 127, p. 492-501 10 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Alzheimer Disease
Single Nucleotide Polymorphism
Parkinson Disease
Inborn Genetic Diseases

MAPT p.V363I mutation A rare cause of corticobasal degeneration

Ahmed, S., Fairen, M. D., Sabir, M. S., Pastor, P., Ding, J., Ispierto, L., Butala, A., Morris, C. M., Schulte, C., Gasser, T., Jabbari, E., Pletnikova, O., Morris, H. R., Troncoso, J., Gelpi, E., Pantelyat, A. & Scholz, S. W., Aug 1 2019, In : Neurology: Genetics. 5, 4, 347.

Research output: Contribution to journalArticle

Open Access
Microtubule-Associated Proteins
Mutation
Apraxias
Aphasia
Parkinsonian Disorders

Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease

Hishimoto, A., Pletnikova, O., Lang, D. L., Troncoso, J. C., Egan, J. M. & Liu, Q. R., Mar 21 2019, In : Alzheimer's Research and Therapy. 11, 1, 28.

Research output: Contribution to journalArticle

Open Access
Inflammasomes
Haplotypes
Alzheimer Disease
Protein Isoforms
Neurons

Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology

Snowden, S. G., Ebshiana, A. A., Hye, A., Pletnikova, O., O'Brien, R., Yang, A., Troncoso, J., Legido-Quigley, C. & Thambisetty, M., Jan 1 2019, In : Journal of Alzheimer's Disease. 72, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

Brain Diseases
Neurotransmitter Agents
Alzheimer Disease
Pathology
Asymptomatic Diseases

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

Horti, A., Naik, R., Foss, C., Minn, I., Misheneva, V., Du, Y., Wang, Y., Mathews, W. B., Wu, Y., Hall, A., LaCourse, C., Ahn, H. H., Nam, H., Lesniak, W., Valentine, H., Pletnikova, O., Troncoso, J. C., Smith, M. D., Calabresi, P., Savonenko, A. & 3 others, Dannals, R. F., Pletnikov, M. & Pomper, M. G., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1686-1691 6 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Microglia
Alzheimer Disease
Demyelinating Diseases

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

The ITALSGEN Consortium & The International ALS Genomics Consortium, Apr 1 2019, In : Annals of neurology. 85, 4, p. 470-481 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Genome-Wide Association Study
Linkage Disequilibrium
Random Allocation
Smoking
Open Access
Pathology
Medicine
Students
Medical Students
North American Indians
2018

Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia

Oh, E., Blennow, K., Bigelow, G., Inouye, S. K., Marcantonio, E. R., Neufeld, K. J., Rosenberg, P. B., Troncoso, J. C., Wang, N. Y., Zetterberg, H., Sieber, F. & Lyketsos, C. G., Sep 1 2018, In : PLoS One. 13, 9, e0204695.

Research output: Contribution to journalArticle

hip fractures
Cerebrospinal fluid
dementia
Hip Fractures
cerebrospinal fluid

Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques

Kageyama, Y., Saito, A., Pletnikova, O., Rudow, G. L., Irie, Y., An, Y., Murakami, K., Irie, K., Resnick, S. M., Fowler, D. R., Martin, L. J. & Troncoso, J. C., Dec 1 2018, In : Scientific Reports. 8, 1, 16895.

Research output: Contribution to journalArticle

Parietal Lobe
Poisons
Amyloid Plaques
Extracellular Space
Amyloid

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

Varma, V. R., Oommen, A. M., Varma, S., Casanova, R., An, Y., Andrews, R. M., O’Brien, R., Pletnikova, O., Troncoso, J. C., Toledo, J., Baillie, R., Arnold, M., Kastenmueller, G., Nho, K., Doraiswamy, P. M., Saykin, A. J., Kaddurah-Daouk, R., Legido-Quigley, C. & Thambisetty, M., Jan 1 2018, In : PLoS Medicine. 15, 1, e1002482.

Research output: Contribution to journalArticle

Metabolomics
Alzheimer Disease
Pathology
Brain
Sphingomyelins

Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

Johnson, E. C. B., Dammer, E. B., Duong, D. M., Yin, L., Thambisetty, M., Troncoso, J. C., Lah, J. J., Levey, A. I. & Seyfried, N. T., Oct 4 2018, In : Molecular Neurodegeneration. 13, 1, 52.

Research output: Contribution to journalArticle

Protein Splicing
RNA Splicing
RNA-Binding Proteins
Proteomics
Alzheimer Disease

Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini

Na, C-H., Barbhuiya, M. A., Kim, M. S., Verbruggen, S., Eacker, S., Pletnikova, O., Troncoso, J. C., Halushka, M. K., Menschaert, G., Overall, C. M. & Pandey, A., Jan 1 2018, In : Genome Research. 28, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

Ribosomes
Methionine
Translational Peptide Chain Initiation
Proteins
Initiator Codon

Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis

Chiang, A. C. A., Fowler, S. W., Reddy, R., Pletnikova, O., Troncoso, J. C., Sherman, M. A., Lesne, S. E. & Jankowsky, J. L., Mar 1 2018, In : American Journal of Pathology. 188, 3, p. 739-756 18 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Detergents
Trans-Activators
Amyloid beta-Protein Precursor

Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease

International Genomics of Alzheimer's Project (IGAP), ARUK Consortium & GERAD/PERADES, CHARGE, ADGC, EADI, Jan 1 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 595-598 4 p.

Research output: Contribution to journalArticle

Cholesterol Ester Transfer Proteins
HDL Cholesterol
Alzheimer Disease
Genes
Single Nucleotide Polymorphism

Genetic analysis of neurodegenerative diseases in a pathology cohort

Blauwendraat, C., Pletnikova, O., Geiger, J. T., Murphy, N. A., Abramzon, Y., Rudow, G., Mamais, A., Sabir, M. S., Crain, B., Ahmed, S., Rosenthal, L. I. S., Bakker, C. C., Faghri, F., Chia, R., Ding, J., Dawson, T. M., Pantelyat, A., Albert, M., Nalls, M. A., Resnick, S. M. & 5 others, Ferrucci, L., Cookson, M. R., Hillis-Trupe, A., Troncoso, J. C. & Scholz, S. W., Jan 1 2018, (Accepted/In press) In : Neurobiology of Aging.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Pathology
Mutation
Phenotype
Genetic Research

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

Research output: Contribution to journalArticle

Kinesin
Genome
Mutation
Genes
Genome-Wide Association Study

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

Guerreiro, R., Ross, O. A., Kun-Rodrigues, C., Hernandez, D. G., Orme, T., Eicher, J. D., Shepherd, C. E., Parkkinen, L., Darwent, L., Heckman, M. G., Scholz, S. W., Troncoso, J. C., Pletnikova, O., Ansorge, O., Clarimon, J., Lleo, A., Morenas-Rodriguez, E., Clark, L., Honig, L. S., Marder, K. & 45 others, Lemstra, A., Rogaeva, E., St George-Hyslop, P., Londos, E., Zetterberg, H., Barber, I., Braae, A., Brown, K., Morgan, K., Troakes, C., Al-Sarraj, S., Lashley, T., Holton, J., Compta, Y., Van Deerlin, V., Serrano, G. E., Beach, T. G., Lesage, S., Galasko, D., Masliah, E., Santana, I., Pastor, P., Diez-Fairen, M., Aguilar, M., Tienari, P. J., Myllykangas, L., Oinas, M., Revesz, T., Lees, A., Boeve, B. F., Petersen, R. C., Ferman, T. J., Escott-Price, V., Graff-Radford, N., Cairns, N. J., Morris, J. C., Pickering-Brown, S., Mann, D., Halliday, G. M., Hardy, J., Trojanowski, J. Q., Dickson, D. W., Singleton, A., Stone, D. J. & Bras, J., Jan 1 2018, In : The Lancet Neurology. 17, 1, p. 64-74 11 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Genome-Wide Association Study
Odds Ratio
Dementia
Lewy Bodies

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

Bell, W. R., An, Y., Kageyama, Y., English, C., Rudow, G. L., Pletnikova, O., Thambisetty, M., O'Brien, R., Moghekar, A. R., Albert, M., Rabins, P. V., Resnick, S. M. & Troncoso, J. C., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Tauopathies
Alzheimer Disease
Apolipoprotein E4
Baltimore
Health Planning

Onset and Remission of Psychosis in Parkinson's Disease: Pharmacologic and Motoric Markers

Hinkle, J. T., Perepezko, K., Bakker, C. C., Broen, M. P. G., Chin, K., Dawson, T. M., Johnson, V., Mari, Z., Marvel, C. L., Mills, K. A., Pantelyat, A., Pletnikova, O., Rosenthal, L. S., Shepard, M. D., Stevens, D. A., Troncoso, J. C., Wang, J. & Pontone, G. M., Jan 1 2018, In : Movement Disorders Clinical Practice. 5, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Psychotic Disorders
Parkinson Disease
Dopamine Agonists
Cholinergic Antagonists
Psychiatry

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T-I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S., Umanah, G., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. I. S. & 2 others, Dawson, T. M. & Dawson, V., Nov 2 2018, In : Science. 362, 6414, eaat8407.

Research output: Contribution to journalArticle

Synucleins
Poly Adenosine Diphosphate Ribose
Parkinson Disease
Adenosine
Poisons

SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F

Ayhan, F., Perez, B. A., Shorrock, H. K., Zu, T., Banez-Coronel, M., Reid, T., Furuya, H., Clark, H. B., Troncoso, J. C., Ross, C. A., Subramony, S. H., Ashizawa, T., Wang, E. T., Yachnis, A. T. & Ranum, L. P. W., Jan 1 2018, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

Proteins
Eukaryotic Initiation Factors
Poisons
Demyelinating Diseases
Modulators

Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau

Alzheimer's Disease Genetics Consortium and the Alzheimer's Disease Neuroimaging Initiative, Aug 1 2018, In : JAMA Neurology. 75, 8, p. 989-998 10 p.

Research output: Contribution to journalArticle

Apolipoproteins
Apolipoproteins E
Cerebrospinal Fluid
Alzheimer Disease
Neurofibrillary Tangles

Sex-specific genetic predictors of Alzheimer’s disease biomarkers

Alzheimer’s Disease Neuroimaging Initiative (ADNI) & The Alzheimer Disease Genetics Consortium (Adgc), Jul 2 2018, (Accepted/In press) In : Acta Neuropathologica. p. 1-16 16 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Biomarkers
Genome-Wide Association Study
Amyloid
Endophenotypes

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease

Eftekharzadeh, B., Daigle, J. G., Kapinos, L. E., Coyne, A., Schiantarelli, J., Carlomagno, Y., Cook, C., Miller, S. J., Dujardin, S., Amaral, A. S., Grima, J. C., Bennett, R. E., Tepper, K., DeTure, M., Vanderburgh, C. R., Corjuc, B. T., DeVos, S. L., Gonzalez, J. A., Chew, J., Vidensky, S. & 10 others, Gage, F. H., Mertens, J., Troncoso, J. C., Mandelkow, E., Salvatella, X., Lim, R. Y. H., Petrucelli, L., Wegmann, S., Rothstein, J. D. & Hyman, B. T., Sep 5 2018, In : Neuron. 99, 5, p. 925-940.e7

Research output: Contribution to journalArticle

Nuclear Pore
tau Proteins
Cell Nucleus Active Transport
Alzheimer Disease
Nuclear Pore Complex Proteins

The spectrum of preclinical Alzheimer's disease pathology and its modulation by ApoE genotype

Pletnikova, O., Kageyama, Y., Rudow, G., LaClair, K. D., Albert, M., Crain, B. J., Tian, J., Fowler, D. & Troncoso, J. C., Nov 1 2018, In : Neurobiology of Aging. 71, p. 72-80 9 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Apolipoproteins E
Apolipoprotein E4
Alzheimer Disease
Parietal Lobe

Ventricular and periventricular anomalies in the aging and cognitively impaired brain

for the Alzheimer's Disease Neuroimaging Initiative, Jan 12 2018, In : Frontiers in Aging Neuroscience. 9, JAN, 445.

Research output: Contribution to journalArticle

Brain
Edema
Gliosis
Magnetic Resonance Imaging
Baltimore
2017

ADORA1 mutations are not a common cause of Parkinson's disease and dementia with Lewy bodies

for the International Parkinson's Disease Genomics Consortium, Feb 1 2017, In : Movement Disorders. 32, 2, p. 298-299 2 p.

Research output: Contribution to journalLetter

Alpha-2 macroglobulin in Alzheimer's disease: A marker of neuronal injury through the RCAN1 pathway

Varma, V. R., Varma, S., An, Y., Hohman, T. J., Seddighi, S., Casanova, R., Beri, A., Dammer, E. B., Seyfried, N. T., Pletnikova, O., Moghekar, A. R., Wilson, M. R., Lah, J. J., O'Brien, R. J., Levey, A. I., Troncoso, J. C., Albert, M. & Thambisetty, M., Jan 1 2017, In : Molecular Psychiatry. 22, 1, p. 13-23 11 p.

Research output: Contribution to journalArticle

alpha-Macroglobulins
Alzheimer Disease
Wounds and Injuries
Calcineurin
Gene Expression

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease

Seyfried, N. T., Dammer, E. B., Swarup, V., Nandakumar, D., Duong, D. M., Yin, L., Deng, Q., Nguyen, T., Hales, C. M., Wingo, T., Glass, J., Gearing, M., Thambisetty, M., Troncoso, J. C., Geschwind, D. H., Lah, J. J. & Levey, A. I., Jan 25 2017, In : Cell Systems. 4, 1, p. 60-72.e4

Research output: Contribution to journalArticle

Alzheimer Disease
Proteins
Proteome
Proteomics
RNA

Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies

Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., Troncoso, J. C., Ungvari, Z., Galvan, V. & Kayed, R., 2017, In : Aging and Disease. 8, 3, p. 257-266 10 p.

Research output: Contribution to journalArticle

Tauopathies
Alzheimer Disease
Blood Vessels
Microvessels
Progressive Supranuclear Palsy
Social Behavior
Purkinje Cells
Emotions
corrigendum

Cryptic exon incorporation occurs in Alzheimer’s brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43

Sun, M., Bell, W., LaClair, K. D., Ling, J. P., Han, H., Kageyama, Y., Pletnikova, O., Troncoso, J. C., Wong, P. C. & Chen, L. L., Mar 22 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-9 9 p.

Research output: Contribution to journalArticle

Intranuclear Inclusion Bodies
Exons
Alzheimer Disease
Brain
TDP-43 Proteinopathies

Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis

Hinkle, J. T., Perepezko, K., Bakker, C. C., Dawson, T. M., Johnson, V., Mari, Z., Marvel, C. L., Mills, K. A., Pantelyat, A., Pletnikova, O., Rosenthal, L. S., Shepard, M. D., Stevens, D. A., Troncoso, J. C., Wang, J. & Pontone, G. M., 2017, (Accepted/In press) In : International Journal of Geriatric Psychiatry.

Research output: Contribution to journalArticle

Psychotic Disorders
Parkinson Disease
Language
Odds Ratio
Cognitive Dysfunction

Elucidation of white matter tracts of the human amygdala by detailed comparison between high-resolution postmortem magnetic resonance imaging and histology

Mori, S., Kageyama, Y., Hou, Z., Aggarwal, M., Patel, J., Brown, T., Miller, M. I., Wu, D. & Troncoso, J. C., Mar 14 2017, In : Frontiers in Neuroanatomy. 11, 16.

Research output: Contribution to journalArticle

Amygdala
Histology
Magnetic Resonance Imaging
Anatomy
Substantia Innominata

Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models

Kim, H., Ham, S., Lee, J. Y., Jo, A., Lee, G. H., Lee, Y. S., Cho, M. L., Shin, H. M., Kim, D., Pletnikova, O., Troncoso, J. C., Shin, J. H., Lee, Y. I. & Lee, Y., Jan 1 2017, In : Oncotarget. 8, 63, p. 106721-106739 19 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Parkinson Disease
Cell Death
Poly Adenosine Diphosphate Ribose
Ubiquitin-Protein Ligases

Evidence for brain glucose dysregulation in Alzheimer's disease

An, Y., Varma, V. R., Varma, S., Casanova, R., Dammer, E., Pletnikova, O., Chia, C. W., Egan, J. M., Ferrucci, L., Troncoso, J. C., Levey, A. I., Lah, J., Seyfried, N. T., Legido-Quigley, C., O'Brien, R. & Thambisetty, M., 2017, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Alzheimer Disease
Glucose
Brain
Homeostasis
Baltimore
Social Behavior
Purkinje Cells
Schizophrenia
Cell Size
Carisoprodol

Genome-wide pleiotropy between Parkinson disease and autoimmune diseases

for the International Parkinson's Disease Genomics Consortium (IPDGC), United Kingdom Brain Expression Consortium (UKBEC) Investigators, North American Brain Expression Consortium (NABEC), Jul 1 2017, In : JAMA Neurology. 74, 7, p. 780-792 13 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Parkinson Disease
Genome
Genome-Wide Association Study
Phenotype

MicroRNA-101 modulates autophagy and oligodendroglial alpha-synuclein accumulation in multiple system atrophy

Valera, E., Spencer, B., Mott, J., Trejo, M., Adame, A., Mante, M., Rockenstein, E., Troncoso, J. C., Beach, T. G., Masliah, E. & Desplats, P., Oct 17 2017, In : Frontiers in Molecular Neuroscience. 10, 329.

Research output: Contribution to journalArticle

Multiple System Atrophy
alpha-Synuclein
Autophagy
MicroRNAs
Poisons

Mutant Huntingtin Disrupts the Nuclear Pore Complex

Grima, J. C., Daigle, J. G., Arbez, N., Cunningham, K. C., Zhang, K., Ochaba, J., Geater, C., Morozko, E., Stocksdale, J., Glatzer, J. C., Pham, J. T., Ahmed, I., Peng, Q., Wadhwa, H., Pletnikova, O., Troncoso, J. C., Duan, W., Snyder, S. H., Ranum, L. P. W., Thompson, L. M. & 3 others, Lloyd, T., Ross, C. A. & Rothstein, J. D., Apr 5 2017, In : Neuron. 94, 1, p. 93-107.e6

Research output: Contribution to journalArticle

Nuclear Pore
Nuclear Pore Complex Proteins
Cell Nucleus Active Transport
Huntington Disease
Neurons

Novel genetic loci associated with hippocampal volume

Hibar, D. P., Adams, H. H. H., Jahanshad, N., Chauhan, G., Stein, J. L., Hofer, E., Renteria, M. E., Bis, J. C., Arias-Vasquez, A., Ikram, M. K., Desrivières, S., Vernooij, M. W., Abramovic, L., Alhusaini, S., Amin, N., Andersson, M., Arfanakis, K., Aribisala, B. S., Armstrong, N. J., Athanasiu, L. & 312 others, Axelsson, T., Beecham, A. H., Beiser, A., Bernard, M., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chen, Q., Ching, C. R. K., Chouraki, V., Cuellar-Partida, G., Crivello, F., Den Braber, A., Doan, N. T., Ehrlich, S., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Grimm, O., Griswold, M. E., Guadalupe, T., Gutman, B. A., Hass, J., Haukvik, U. K., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Jørgensen, K. N., Karbalai, N., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liewald, D. C. M., Lopez, L. M., Luciano, M., MacAre, C., Marquand, A. F., Matarin, M., Mather, K. A., Mattheisen, M., McKay, D. R., Milaneschi, Y., Muñoz Maniega, S., Nho, K., Nugent, A. C., Nyquist, P. A., Loohuis, L. M. O., Oosterlaan, J., Papmeyer, M., Pirpamer, L., Pütz, B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-Santiañez, R., Rommelse, N., Ropele, S., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Saremi, A., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Tordesillas-Gutierrez, D., Toro, R., Trabzuni, D., Trompet, S., Vaidya, D., Van Der Grond, J., Van Der Lee, S. J., Van Der Meer, D., Van Donkelaar, M. M. J., Van Eijk, K. R., Van Erp, T. G. M., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Wittfeld, K., Woldehawariat, G., Wolf, C., Wolfers, T., Yanek, L., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., Van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Cheng, C. Y., Cichon, S., Cookson, M. R., Corvin, A., Crespo-Facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Craen, A. J. M., De Geus, E. J. C., De Jager, P. L., De Zubicaray, G. I., Deary, I. J., Debette, S., Decarli, C., Delanty, N., Depondt, C., Destefano, A., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Enzinger, C., Erk, S., Espeseth, T., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Fornage, M., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Håberg, A. K., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B. C., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J. J., Huentelman, M., Pol, H. E. H., Ikeda, M., Jack, C. R., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J. L., Mattay, V., McDonald, C., McIntosh, A. M., McMahon, F. J., McMahon, K. L., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-Myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-Seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schmidt, H., Schofield, P. R., Sigursson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J. C., Tsolaki, M., Tzourio, C., Uitterlinden, A. G., Hernández, M. C. V., Van Der Brug, M., Van Der Lugt, A., Van Der Wee, N. J. A., Van Haren, N. E. M., Van 'T Ent, D., Van Tol, M. J., Vardarajan, B. N., Vellas, B., Veltman, D. J., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, R. H., Zonderman, A. B., Martin, N. G., Van Duijn, C. M., Wright, M. J., Longstreth, W. T., Schumann, G., Grabe, H. J., Franke, B., Launer, L. J., Medland, S. E., Seshadri, S., Thompson, P. M. & Ikram, M. A., Jan 18 2017, In : Nature Communications. 8, 13624.

Research output: Contribution to journalArticle

Genetic Loci
loci
Hippocampus
Genes
Episodic Memory

NPTX2 and cognitive dysfunction in Alzheimer’s Disease

Xiao, M., Xu, D., Craig, M. T., Pelkey, K. A., Chien, C. C., Shi, Y., Zhang, J., Resnick, S., Pletnikova, O., Salmon, D., Brewer, J., Edland, S., Wegiel, J., Tycko, B., Savonenko, A., Reeves, R. H., Troncoso, J. C., McBain, C. J., Galasko, D. & Worley, P. F., Apr 25 2017, In : eLife. 6, p. 1-27 27 p., e23798.

Research output: Contribution to journalComment/debate

Nerve Tissue Proteins
Animal Disease Models
Knockout Mice
Cerebral Cortex
C-Reactive Protein