Research Output 1978 2017

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2017

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

Pamies, D., Barreras, P., Block, K., Makri, G., Kumar, A., Wiersma, D., Smirnova, L., Zhang, C., Bressler, J., Christian, K. M., Harris, G., Ming, G. L., Berlinicke, C. J., Kyro, K., Song, H., Pardo, C. A., Hartung, T. & Hogberg, H. T. 2017 In : Altex. 34, 3, p. 362-376 15 p.

Research output: Research - peer-reviewArticle

Induced Pluripotent Stem Cells
Brain
Neuroglia
Neurons
Myelin Sheath
Waist Circumference
Intercellular Adhesion Molecule-1
Saliva
Methylation
Adipose Tissue
2015

Methyl CpG binding protein 2 deficiency enhances expression of inflammatory cytokines by sustaining NF-κB signaling in myeloid derived cells

O'Driscoll, C. M., Lima, M. P., Kaufmann, W. E. & Bressler, J. P. Jun 15 2015 In : Journal of Neuroimmunology. 283, p. 23-29 7 p.

Research output: Research - peer-reviewArticle

Methyl-CpG-Binding Protein 2
Protein Deficiency
Myeloid Cells
Cytokines
Interleukin-6
2014

Small molecule glutaminase inhibitors block glutamate release from stimulated microglia

Thomas, A. G., O'Driscoll, C. M., Bressler, J., Kaufmann, W., Rojas, C. J. & Slusher, B. S. Jan 3 2014 In : Biochemical and Biophysical Research Communications. 443, 1, p. 32-36 5 p.

Research output: Research - peer-reviewArticle

Glutaminase
Glutamic Acid
Molecules
Microglia
Assays
2013

Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase

Coulter, J. B., O'Driscoll, C. M. & Bressler, J. P. Oct 4 2013 In : Journal of Biological Chemistry. 288, 40, p. 28792-28800 9 p.

Research output: Research - peer-reviewArticle

5-Methylcytosine
Dioxygenases
5-hydroxymethylcytosine
hydroquinone
1-methylcytosine

Induction of a trophoblast-like phenotype by hydralazine in the p19 embryonic carcinoma cell line

O'Driscoll, C. M., Coulter, J. B. & Bressler, J. P. Mar 2013 In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 3, p. 460-467 8 p.

Research output: Research - peer-reviewArticle

Hydralazine
Trophoblasts
Carcinoma
Phenotype
Cell Line

MeCP2 deficiency enhances glutamate release through NF-κB signaling in myeloid derived cells

O'Driscoll, C. M., Kaufmann, W. E. & Bressler, J. P. Dec 15 2013 In : Journal of Neuroimmunology. 265, 1-2, p. 61-67 7 p.

Research output: Research - peer-reviewArticle

Myeloid Cells
Glutamic Acid
Glutaminase
Messenger RNA
Microglia

Relationship between Mecp2 and NFκb signaling during neural differentiation of P19 cells

O'Driscoll, C., Kaufmann, W. E. & Bressler, J. Jan 15 2013 In : Brain Research. 1490, p. 35-42 8 p.

Research output: Research - peer-reviewArticle

Cell Differentiation
Tumor Necrosis Factor-alpha
Acetates
phorbol-12-myristate
Tubulin

Toward a 3D model of human brain development for studying gene/environment interactions

Hogberg, H. T., Bressler, J., Christian, K. M., Harris, G., Makri, G., O'Driscoll, C., Pamies, D., Smirnova, L., Wen, Z. & Hartung, T. Dec 20 2013 In : Stem Cell Research and Therapy. 4, SUPPL.1, S4

Research output: Research - peer-reviewArticle

Induced Pluripotent Stem Cells
Gene-Environment Interaction
Human Development
Brain
Genes
2012

Evaluation of the interactions between multiwalled carbon nanotubes and caco-2 cells

Clark, K. A., O'Driscoll, C., Cooke, C. A., Smith, B. A., Wepasnick, K., Fairbrother, D. H., Lees, P. S. J. & Bressler, J. P. 2012 In : Journal of Toxicology and Environmental Health - Part A: Current Issues. 75, 1, p. 25-35 11 p.

Research output: Research - peer-reviewArticle

Carbon Nanotubes
Caco-2 Cells
Enterocytes
Multiwalled carbon nanotubes (MWCN)
Microvilli

Maternal antibody reactivity to lymphocytes of offspring with autism

Bressler, J. P., Gillin, P. K., O'Driscoll, C., Kiihl, S., Solomon, M. & Zimmerman, A. W. Nov 2012 In : Pediatric Neurology. 47, 5, p. 337-340 4 p.

Research output: Research - peer-reviewArticle

Autistic Disorder
Mothers
Lymphocytes
Antibodies
Serum
2011

Brain derived neurotrophic factor and serotonin transporter binding as markers of clinical response to fluoxetine therapy in children with autism

Makkonen, I., Riikonen, R., Kuikka, J. T., Kokki, H., Bressler, J. P., Marshall, C. & Kaufmann, W. E. 2011 In : Journal of Pediatric Neurology. 9, 1, p. 1-8 8 p.

Research output: Research - peer-reviewArticle

Serotonin Plasma Membrane Transport Proteins
Fluoxetine
Brain-Derived Neurotrophic Factor
Autistic Disorder
Biomarkers

Glutathione pathway gene variation and risk of autism spectrum disorders

Bowers, K., Li, Q., Bressler, J., Avramopoulos, D., Newschaffer, C. & Fallin, M. D. Jun 2011 In : Journal of Neurodevelopmental Disorders. 3, 2, p. 132-143 12 p.

Research output: Research - peer-reviewArticle

Glutathione
Genes
Autism Spectrum Disorder
Autistic Disorder
Single Nucleotide Polymorphism

Temporal and regional alterations in NMDA receptor expression in Mecp2-null mice

Blue, M. E., Kaufmann, W. E., Bressler, J., Eyring, C., O'driscoll, C., Naidu, S. & Johnston, M. V. Oct 2011 In : Anatomical Record. 294, 10, p. 1624-1634 11 p.

Research output: Research - peer-reviewArticle

aspartic acid
receptors
mice
N-Methyl-D-Aspartate Receptors
Brain

αB-Crystallin negative astrocytic inclusions

Barnett, B. P., Bressler, J., Chen, T., Hutchins, G. M., Crain, B. J. & Kaufmann, W. E. Apr 2011 In : Brain and Development. 33, 4, p. 349-352 4 p.

Research output: Research - peer-reviewArticle

Crystallins
Neuroglia
Astrocytes
Cerebral Cortex
Brain
2010

Hairless expression attenuates apoptosis in a mouse model and the cos cell line; involvement of p53

O'Driscoll, C. & Bressler, J. P. 2010 In : PLoS One. 5, 9, e12911

Research output: Research - peer-reviewArticle

apoptosis
animal models
cell lines
mice
Apoptosis
2009

Localization of Zip1 and Zip4 mRNA in the adult rat brain

Belloni-Olivi, L., Marshall, C., Laal, B., Andrews, G. K. & Bressler, J. Nov 1 2009 In : Journal of Neuroscience Research. 87, 14, p. 3221-3230 10 p.

Research output: Research - peer-reviewArticle

Messenger RNA
Brain
Choroid Plexus
Green Fluorescent Proteins
Astrocytes
2007

ABCG2/BCRP expression modulates D-luciferin-based bioluminescence imaging

Zhang, Y., Bressler, J. P., Neal, J., Lal, B., Bhang, H. E. C., Laterra, J. & Pomper, M. G. Oct 1 2007 In : Cancer Research. 67, 19, p. 9389-9397 9 p.

Research output: Research - peer-reviewArticle

D-luciferin
ATP-Binding Cassette Transporters
P-Glycoprotein
Heterografts
In Vitro Techniques

Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells

Kim, Y., Olivi, L., Cheong, J. H., Maertens, A. & Bressler, J. P. May 1 2007 In : Toxicology and Applied Pharmacology. 220, 3, p. 349-356 8 p.

Research output: Research - peer-reviewArticle

Transferrin
Aluminum
Neuroglia
Iron
Ferritins

Metal transporters in intestine and brain: Their involvement in metal-associated neurotoxicities

Bressler, J. P., Olivi, L., Jae, H. C., Kim, Y., Maerten, A. & Bannon, D. Mar 2007 In : Human and Experimental Toxicology. 26, 3, p. 221-229 9 p.

Research output: Research - peer-reviewArticle

Intestines
Metals
Brain
Iron
Zinc
2006

Blood-brain barrier and cell-cell interactions: methods for establishing in vitro models of the blood-brain barrier and transport measurements.

Aschner, M., Fitsanakis, V. A., dos Santos, A. P. M., Olivi, L. & Bressler, J. P. 2006 In : Methods in molecular biology (Clifton, N.J.). 341, p. 1-15 15 p.

Research output: Research - peer-reviewArticle

Blood-Brain Barrier
Cell Communication
In Vitro Techniques
Brain
Microvessels
2005

Blood lead is a predictor of homocysteine levels in a population-based study of older adults

Schafer, J. H., Glass, T. A., Bressler, J., Todd, A. C. & Schwartz, B. S. Jan 2005 In : Environmental Health Perspectives. 113, 1, p. 31-35 5 p.

Research output: Research - peer-reviewArticle

Homocysteine
Population
Lead
Blood
blood

Blood mercury levels and neurobehavior [3] (multiple letters)

Mutter, J., Naumann, J., Weil, M., Schwartz, B., Glass, T. & Bressler, J. Aug 10 2005 In : Journal of the American Medical Association. 294, 6, p. 679-680 2 p.

Research output: Research - peer-reviewArticle

Blood mercury levels and neurobehavioral function

Weil, M., Bressler, J., Parsons, P., Bolla, K., Glass, T. & Schwartz, B. Apr 20 2005 In : Journal of the American Medical Association. 293, 15, p. 1875-1882 8 p.

Research output: Research - peer-reviewArticle

Mercury
Baltimore
Urban Population
Fishes
Confidence Intervals

Identification of myristoylated alanine-rich C kinase substrate (MARCKS) in astrocytes

Vitkovic, L., Aloyo, V. J., Maeda, S., Benzil, D. L., Bressler, J. P. & Hilt, D. C. 2005 In : Frontiers in bioscience : a journal and virtual library. 10, 1, p. 160-165 6 p.

Research output: Research - peer-reviewArticle

Astrocytes
myristoylated alanine-rich C kinase substrate
Protein Kinase C
Substrates
Phosphorylation
2004

Activity-dependent expression of Egr1 mRNA in somatosensory cortex of developing rats

Patra, R. C., Blue, M. E., Johnston, M. V., Bressler, J. & Wilson, M. A. Oct 15 2004 In : Journal of Neuroscience Research. 78, 2, p. 235-244 10 p.

Research output: Research - peer-reviewArticle

Somatosensory Cortex
Messenger RNA
Vibrissae
Transcription Factors
Magnetic Fields

Different mechanisms mediate uptake of lead in a rat astroglial cell line

Cheong, J. H., Bannon, D., Olivi, L., Kim, Y. & Bressler, J. Feb 2004 In : Toxicological Sciences. 77, 2, p. 334-340 7 p.

Research output: Research - peer-reviewArticle

Rats
Buffers
Cells
Lead
Cell Line

Disparities in cognitive functioning by race/ethnicity in the Baltimore Memory Study

Schwartz, B. S., Glass, T. A., Bolla, K. I., Stewart, W. F., Glass, G., Rasmussen, M., Bressler, J., Shi, W. & Bandeen-Roche, K. Mar 2004 In : Environmental Health Perspectives. 112, 3, p. 314-320 7 p.

Research output: Research - peer-reviewArticle

ethnicity
test
health
Baltimore
Health

Divalent metal transporter 1 in lead and cadmium transport

Bressler, J. P., Olivi, L., Cheong, J. H., Kim, Y. & Bannon, D. 2004 In : Annals of the New York Academy of Sciences. 1012, p. 142-152 11 p.

Research output: Research - peer-reviewArticle

Cadmium
Lead
solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2
Metals
Iron

Interactive effects of paraoxon and pyridostigmine on blood-brain barrier integrity and cholinergic toxicity

Song, X., Pope, C., Murthy, R., Shaikh, J., Lal, B. & Bressler, J. P. Apr 2004 In : Toxicological Sciences. 78, 2, p. 241-247 7 p.

Research output: Research - peer-reviewArticle

Pyridostigmine Bromide
Paraoxon
Cholinergic Agents
Toxicity
Rats
2003

Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells

Bannon, D. I., Abounader, R., Lees, P. S. J. & Bressler, J. P. Jan 1 2003 In : American Journal of Physiology - Cell Physiology. 284, 1 53-1

Research output: Research - peer-reviewArticle

Caco-2 Cells
Cadmium
Iron
Lead
Metals

The involvement of lipid activators of protein kinase C in the induction of zif268 in PC12 cells exposed to lead

Olivi, L., Sisk, J. & Bressler, J. Jan 1 2003 In : Neurochemical Research. 28, 1, p. 65-71 7 p.

Research output: Research - peer-reviewArticle

PC12 Cells
Protein Kinase C
Lipids
Diglycerides
Phosphatidylinositol 3-Kinase
2002

Acute and repeated restraint stress have little effect on pyridostigmine toxicity or brain regional cholinesterase inhibition in rats

Song, X., Tian, H., Bressler, J., Pruett, S. & Pope, C. Sep 2002 In : Toxicological Sciences. 69, 1, p. 157-164 8 p.

Research output: Research - peer-reviewArticle

Pyridostigmine Bromide
Cholinesterases
Toxicity
Rats
Brain
AIDS-Related Complex
Electroshock
Protein Kinase C
Messenger RNA
Lead

Mobilization of intracellular calcium in kidney epithelial cells is inhibited by lead

Olivi, L., Cascio, S., Wang, S. & Bressler, J. Jul 1 2002 In : Toxicology. 176, 1-2, p. 1-9 9 p.

Research output: Research - peer-reviewArticle

Epithelial Cells
Calcium
Kidney
Lead
Madin Darby Canine Kidney Cells

Neither forced running nor forced swimming affect acute pyridostigmine toxicity or brain-regional cholinesterase inhibition in rats

Tian, H., Song, X., Bressler, J., Pruett, S. & Pope, C. N. Jul 1 2002 In : Toxicology. 176, 1-2, p. 39-50 12 p.

Research output: Research - peer-reviewArticle

Pyridostigmine Bromide
Cholinesterases
Toxicity
Rats
Brain
Protein Kinase C
Blood
Lead
blood
protein

Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells

I. Bannon, D., Portnoy, M. E., Olivi, L., Lees, P. S. J., Culotta, V. C. & Bressler, J. P. 2002 In : Biochemical and Biophysical Research Communications. 295, 4, p. 978-984 7 p.

Research output: Research - peer-reviewArticle

Iron
Yeasts
Lead
solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2
Yeast
2001
Protein Kinase C
Erythrocytes
Lead
Chemical activation
Tibia

Involvement of DMT1 in uptake of Cd in MDCK cells: Role of protein kinase C

Olivi, L., Sisk, J. & Bressler, J. 2001 In : American Journal of Physiology - Cell Physiology. 281, 3 50-3

Research output: Research - peer-reviewArticle

Madin Darby Canine Kidney Cells
Cadmium
Protein Kinase C
solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2
Messenger RNA

Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice

Gabrielson, K. L., Hogue, B. A., Bohr, V. A., Cardounel, A. J., Nakajima, W., Kofler, J., Zweier, J. L., Rodriguez, E. R., Martin, L. J., De Souza-Pinto, N. C. & Bressler, J. 2001 In : American Journal of Pathology. 159, 4, p. 1507-1520 14 p.

Research output: Research - peer-reviewArticle

3-nitropropionic acid
Cardiotoxicity
Succinate Dehydrogenase
Heart Mitochondria
Cardiac Myocytes

Relation of alleles of the sodium-potassium adenosine triphosphatase α2 gene with blood pressure and lead exposure

Glenn, B. S., Stewart, W. F., Schwartz, B. S. & Bressler, J. Mar 15 2001 In : American Journal of Epidemiology. 153, 6, p. 537-545 9 p.

Research output: Research - peer-reviewArticle

Sodium-Potassium-Exchanging ATPase
Alleles
Blood Pressure
Genes
Lead
2000

Immediate early gene expression in PC12 cells exposed to lead: Requirement for protein kinase C

Kim, K. A., Chakraborti, T., Goldstein, G. W. & Bressler, J. P. 2000 In : Journal of Neurochemistry. 74, 3, p. 1140-1146 7 p.

Research output: Research - peer-reviewArticle

Immediate-Early Genes
PC12 Cells
Protein Kinase C
Gene Expression
Messenger RNA

Maitotoxin stimulates Cd influx in Madin-Darby kidney cells by activating Ca-permeable cation channels

Olivi, L. & Bressler, J. Apr 2000 In : Cell Calcium. 27, 4, p. 187-193 7 p.

Research output: Research - peer-reviewArticle

Cadmium
Cations
Kidney
maitotoxin
Madin Darby Canine Kidney Cells
Metals
Ions
Brain
Metal ions
Rats

The role of anion exchange in the uptake of Pb by human erythrocytes and Madin-Darby canine kidney cells

Bannon, D. I., Olivi, L. & Bressler, J. Jun 8 2000 In : Toxicology. 147, 2, p. 101-107 7 p.

Research output: Research - peer-reviewArticle

Madin Darby Canine Kidney Cells
Anions
Erythrocytes
Epithelial Cells
Kidney
1999

Increased AP-1 DNA binding activity in PC12 cells treated with lead

Chakraborti, T., Kim, K. A., Goldstein, G. G. & Bressler, J. P. 1999 In : Journal of Neurochemistry. 73, 1, p. 187-194 8 p.

Research output: Research - peer-reviewArticle

PC12 Cells
Transcription Factor AP-1
DNA
Lead
Protein Kinase C

Molecular mechanisms of lead neurotoxicity

Dressier, J., Kim, K. A., Chakraborti, T. & Goldstein, G. 1999 In : Neurochemical Research. 24, 4, p. 595-600 6 p.

Research output: Research - peer-reviewArticle

Lead
Protein Kinase C
Learning
Calcium
Blood
1997
Porphobilinogen Synthase
Succimer
Hemoglobins
Genotype
Lead

Induction of c-foS mRNA by lead in PC12 cells

Kim, K., Annadata, M., Goldstein, G. W. & Bressler, J. P. Apr 1997 In : International Journal of Developmental Neuroscience. 15, 2, p. 175-182 8 p.

Research output: Research - peer-reviewArticle

PC12 Cells
Messenger RNA
Lead
lead acetate
fos Genes