Research Output 1978 2017

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2017

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

Pamies, D., Barreras, P., Block, K., Makri, G., Kumar, A., Wiersma, D., Smirnova, L., Zhang, C., Bressler, J., Christian, K. M., Harris, G., Ming, G. L., Berlinicke, C. J., Kyro, K., Song, H., Pardo, C. A., Hartung, T. & Hogberg, H. T. 2017 In : Altex. 34, 3, p. 362-376 15 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Neuroglia
Brain
Neurons
Myelin Sheath
Waist Circumference
Intercellular Adhesion Molecule-1
Saliva
Methylation
Adipose Tissue

TET1 deficiency attenuates the DNA damage response and promotes resistance to DNA damaging agents

Coulter, J. B., Lopez-Bertoni, H., Kuhns, K. J., Lee, R. S., Laterra, J. & Bressler, J. P. Nov 1 2017 (Accepted/In press) In : Epigenetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

DNA Damage
Cyclin B1
Genomic Instability
DNA
Ionizing Radiation
2015

Methyl CpG binding protein 2 deficiency enhances expression of inflammatory cytokines by sustaining NF-κB signaling in myeloid derived cells

O'Driscoll, C. M., Lima, M. P., Kaufmann, W. E. & Bressler, J. P. Jun 15 2015 In : Journal of Neuroimmunology. 283, p. 23-29 7 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Protein Deficiency
Myeloid Cells
Cytokines
Interleukin-3
2014

Small molecule glutaminase inhibitors block glutamate release from stimulated microglia

Thomas, A. G., O'Driscoll, C. M., Bressler, J., Kaufmann, W., Rojas, C. J. & Slusher, B. S. Jan 3 2014 In : Biochemical and Biophysical Research Communications. 443, 1, p. 32-36 5 p.

Research output: Contribution to journalArticle

Glutaminase
Microglia
Glutamic Acid
Molecules
Assays
2013

Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase

Coulter, J. B., O'Driscoll, C. M. & Bressler, J. P. Oct 4 2013 In : Journal of Biological Chemistry. 288, 40, p. 28792-28800 9 p.

Research output: Contribution to journalArticle

5-Methylcytosine
Dioxygenases
DNA Methylation
Benzene
Cytotoxicity

Induction of a trophoblast-like phenotype by hydralazine in the p19 embryonic carcinoma cell line

O'Driscoll, C. M., Coulter, J. B. & Bressler, J. P. Mar 2013 In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 3, p. 460-467 8 p.

Research output: Contribution to journalArticle

Hydralazine
Trophoblasts
Keratin-8
Carcinoma
Phenotype

MeCP2 deficiency enhances glutamate release through NF-κB signaling in myeloid derived cells

O'Driscoll, C. M., Kaufmann, W. E. & Bressler, J. P. Dec 15 2013 In : Journal of Neuroimmunology. 265, 1-2, p. 61-67 7 p.

Research output: Contribution to journalArticle

Myeloid Cells
Glutaminase
Glutamic Acid
Microglia
Messenger RNA

Relationship between Mecp2 and NFκb signaling during neural differentiation of P19 cells

O'Driscoll, C., Kaufmann, W. E. & Bressler, J. Jan 15 2013 In : Brain Research. 1490, p. 35-42 8 p.

Research output: Contribution to journalArticle

Cell Differentiation
Tumor Necrosis Factor-alpha
Acetates
Tubulin
Reporter Genes

Toward a 3D model of human brain development for studying gene/environment interactions

Hogberg, H. T., Bressler, J., Christian, K. M., Harris, G., Makri, G., O'Driscoll, C., Pamies, D., Smirnova, L., Wen, Z. & Hartung, T. Dec 20 2013 In : Stem Cell Research and Therapy. 4, SUPPL.1, S4

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Gene-Environment Interaction
Human Development
Stem cells
Brain
2012

Evaluation of the interactions between multiwalled carbon nanotubes and caco-2 cells

Clark, K. A., O'Driscoll, C., Cooke, C. A., Smith, B. A., Wepasnick, K., Fairbrother, D. H., Lees, P. S. J. & Bressler, J. P. 2012 In : Journal of Toxicology and Environmental Health - Part A: Current Issues. 75, 1, p. 25-35 11 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Caco-2 Cells
Multiwalled carbon nanotubes (MWCN)
Enterocytes
Microvilli

Maternal antibody reactivity to lymphocytes of offspring with autism

Bressler, J. P., Gillin, P. K., O'Driscoll, C., Kiihl, S., Solomon, M. & Zimmerman, A. W. Nov 2012 In : Pediatric Neurology. 47, 5, p. 337-340 4 p.

Research output: Contribution to journalArticle

Autistic Disorder
Mothers
Lymphocytes
Antibodies
Siblings
2011

Brain derived neurotrophic factor and serotonin transporter binding as markers of clinical response to fluoxetine therapy in children with autism

Makkonen, I., Riikonen, R., Kuikka, J. T., Kokki, H., Bressler, J. P., Marshall, C. & Kaufmann, W. E. 2011 In : Journal of Pediatric Neurology. 9, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Fluoxetine
Brain-Derived Neurotrophic Factor
Autistic Disorder
Biomarkers

Glutathione pathway gene variation and risk of autism spectrum disorders

Bowers, K., Li, Q., Bressler, J., Avramopoulos, D., Newschaffer, C. & Fallin, M. D. Jun 2011 In : Journal of Neurodevelopmental Disorders. 3, 2, p. 132-143 12 p.

Research output: Contribution to journalArticle

Glutathione
Glutaredoxins
Autistic Disorder
Single Nucleotide Polymorphism
Genes

Temporal and regional alterations in NMDA receptor expression in Mecp2-null mice

Blue, M. E., Kaufmann, W. E., Bressler, J., Eyring, C., O'driscoll, C., Naidu, S. & Johnston, M. V. Oct 2011 In : Anatomical Record. 294, 10, p. 1624-1634 11 p.

Research output: Contribution to journalArticle

aspartic acid
N-Methyl-D-Aspartate Receptors
receptors
mice
Rett Syndrome

αB-Crystallin negative astrocytic inclusions

Barnett, B. P., Bressler, J., Chen, T., Hutchins, G. M., Crain, B. J. & Kaufmann, W. E. Apr 2011 In : Brain and Development. 33, 4, p. 349-352 4 p.

Research output: Contribution to journalArticle

Crystallins
Neuroglia
Astrocytes
Cerebral Cortex
Filamins
2010

Hairless expression attenuates apoptosis in a mouse model and the cos cell line; involvement of p53

O'Driscoll, C. & Bressler, J. P. 2010 In : PLoS One. 5, 9, e12911

Research output: Contribution to journalArticle

apoptosis
animal models
Cells
cell lines
Apoptosis
2009

Localization of Zip1 and Zip4 mRNA in the adult rat brain

Belloni-Olivi, L., Marshall, C., Laal, B., Andrews, G. K. & Bressler, J. Nov 1 2009 In : Journal of Neuroscience Research. 87, 14, p. 3221-3230 10 p.

Research output: Contribution to journalArticle

Messenger RNA
Brain
Choroid Plexus
Green Fluorescent Proteins
Astrocytes
2007

ABCG2/BCRP expression modulates D-luciferin-based bioluminescence imaging

Zhang, Y., Bressler, J. P., Neal, J., Lal, B., Bhang, H. E. C., Laterra, J. & Pomper, M. G. Oct 1 2007 In : Cancer Research. 67, 19, p. 9389-9397 9 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
P-Glycoprotein
Heterografts
Firefly Luciferases
Preclinical Drug Evaluations

Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells

Kim, Y., Olivi, L., Cheong, J. H., Maertens, A. & Bressler, J. P. May 1 2007 In : Toxicology and Applied Pharmacology. 220, 3, p. 349-356 8 p.

Research output: Contribution to journalArticle

Transferrin
Aluminum
Neuroglia
Iron
Ferritins

Metal transporters in intestine and brain: Their involvement in metal-associated neurotoxicities

Bressler, J. P., Olivi, L., Jae, H. C., Kim, Y., Maerten, A. & Bannon, D. Mar 2007 In : Human and Experimental Toxicology. 26, 3, p. 221-229 9 p.

Research output: Contribution to journalArticle

Intestines
Brain
Metals
Zinc
Iron
2006

Blood-brain barrier and cell-cell interactions: methods for establishing in vitro models of the blood-brain barrier and transport measurements.

Aschner, M., Fitsanakis, V. A., dos Santos, A. P. M., Olivi, L. & Bressler, J. P. 2006 In : Methods in molecular biology (Clifton, N.J.). 341, p. 1-15 15 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Cell Communication
Brain
Microvessels
Permeability
2005

Blood lead is a predictor of homocysteine levels in a population-based study of older adults

Schafer, J. H., Glass, T. A., Bressler, J., Todd, A. C. & Schwartz, B. S. Jan 2005 In : Environmental Health Perspectives. 113, 1, p. 31-35 5 p.

Research output: Contribution to journalArticle

Homocysteine
Blood
blood
Population
Tibia

Blood mercury levels and neurobehavior [3] (multiple letters)

Mutter, J., Naumann, J., Weil, M., Schwartz, B., Glass, T. & Bressler, J. Aug 10 2005 In : Journal of the American Medical Association. 294, 6, p. 679-680 2 p.

Research output: Contribution to journalArticle

Methylmercury Compounds
Nervous System Mercury Poisoning
Mercury
Cognition
Alzheimer Disease

Blood mercury levels and neurobehavioral function

Weil, M., Bressler, J., Parsons, P., Bolla, K., Glass, T. & Schwartz, B. Apr 20 2005 In : Journal of the American Medical Association. 293, 15, p. 1875-1882 8 p.

Research output: Contribution to journalArticle

Mercury
Baltimore
Urban Population
Fishes
Confidence Intervals

Identification of myristoylated alanine-rich C kinase substrate (MARCKS) in astrocytes

Vitkovic, L., Aloyo, V. J., Maeda, S., Benzil, D. L., Bressler, J. P. & Hilt, D. C. 2005 In : Frontiers in bioscience : a journal and virtual library. 10, 1, p. 160-165 6 p.

Research output: Contribution to journalArticle

Astrocytes
Protein Kinase C
Phosphorylation
Substrates
Phosphoproteins
2004

Activity-dependent expression of Egr1 mRNA in somatosensory cortex of developing rats

Patra, R. C., Blue, M. E., Johnston, M. V., Bressler, J. & Wilson, M. A. Oct 15 2004 In : Journal of Neuroscience Research. 78, 2, p. 235-244 10 p.

Research output: Contribution to journalArticle

Somatosensory Cortex
Vibrissae
Messenger RNA
Transcription Factors
Magnetic Fields

Different mechanisms mediate uptake of lead in a rat astroglial cell line

Cheong, J. H., Bannon, D., Olivi, L., Kim, Y. & Bressler, J. Feb 2004 In : Toxicological Sciences. 77, 2, p. 334-340 7 p.

Research output: Contribution to journalArticle

Rats
Buffers
Cells
Cell Line
Iron

Disparities in cognitive functioning by race/ethnicity in the Baltimore Memory Study

Schwartz, B. S., Glass, T. A., Bolla, K. I., Stewart, W. F., Glass, G., Rasmussen, M., Bressler, J., Shi, W. & Bandeen-Roche, K. Mar 2004 In : Environmental Health Perspectives. 112, 3, p. 314-320 7 p.

Research output: Contribution to journalArticle

Baltimore
ethnicity
socioeconomic status
Social Class
Health

Divalent metal transporter 1 in lead and cadmium transport

Bressler, J. P., Olivi, L., Cheong, J. H., Kim, Y. & Bannon, D. 2004 In : Annals of the New York Academy of Sciences. 1012, p. 142-152 11 p.

Research output: Contribution to journalArticle

Cadmium
Iron
Nutrition
Metals
Diet

Interactive effects of paraoxon and pyridostigmine on blood-brain barrier integrity and cholinergic toxicity

Song, X., Pope, C., Murthy, R., Shaikh, J., Lal, B. & Bressler, J. P. Apr 2004 In : Toxicological Sciences. 78, 2, p. 241-247 7 p.

Research output: Contribution to journalArticle

Pyridostigmine Bromide
Paraoxon
Blood-Brain Barrier
Cholinergic Agents
Toxicity
2003

Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells

Bannon, D. I., Abounader, R., Lees, P. S. J. & Bressler, J. P. Jan 1 2003 In : American Journal of Physiology - Cell Physiology. 284, 1 53-1

Research output: Contribution to journalArticle

Caco-2 Cells
Cadmium
Iron
Metals
Poisons

The involvement of lipid activators of protein kinase C in the induction of zif268 in PC12 cells exposed to lead

Olivi, L., Sisk, J. & Bressler, J. Jan 1 2003 In : Neurochemical Research. 28, 1, p. 65-71 7 p.

Research output: Contribution to journalArticle

PC12 Cells
Protein Kinase C
Diglycerides
Lipids
Phosphatidylinositol 3-Kinase
2002

Acute and repeated restraint stress have little effect on pyridostigmine toxicity or brain regional cholinesterase inhibition in rats

Song, X., Tian, H., Bressler, J., Pruett, S. & Pope, C. Sep 2002 In : Toxicological Sciences. 69, 1, p. 157-164 8 p.

Research output: Contribution to journalArticle

Pyridostigmine Bromide
Cholinesterases
Toxicity
Rats
Brain
AIDS-Related Complex
Electroshock
Protein Kinase C
Convulsants
Messenger RNA

Mobilization of intracellular calcium in kidney epithelial cells is inhibited by lead

Olivi, L., Cascio, S., Wang, S. & Bressler, J. Jul 1 2002 In : Toxicology. 176, 1-2, p. 1-9 9 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Epithelial Cells
Calcium
Kidney
Adenosine Diphosphate

Neither forced running nor forced swimming affect acute pyridostigmine toxicity or brain-regional cholinesterase inhibition in rats

Tian, H., Song, X., Bressler, J., Pruett, S. & Pope, C. N. Jul 1 2002 In : Toxicology. 176, 1-2, p. 39-50 12 p.

Research output: Contribution to journalArticle

Pyridostigmine Bromide
Cholinesterases
Running
Toxicity
Rats

Protein kinase C activity and the relations between blood lead and neurobehavioral function in lead workers

Hwang, K. Y., Lee, B. K., Bressler, J. P., Bolla, K. I., Stewart, W. F. & Schwartz, B. S. 2002 In : Environmental Health Perspectives. 110, 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

Protein Kinase C
Blood
blood
Phosphorylation
protein

Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells

I. Bannon, D., Portnoy, M. E., Olivi, L., Lees, P. S. J., Culotta, V. C. & Bressler, J. P. 2002 In : Biochemical and Biophysical Research Communications. 295, 4, p. 978-984 7 p.

Research output: Contribution to journalArticle

Yeast
Iron
Yeasts
Cells
HEK293 Cells
2001

Associations of lead exposure and dose measures with erythrocyte protein kinase C activity in 212 current Korean lead workers

Hwang, K. Y., Schwartz, B. S., Lee, B. K., Strickland, P. T., Todd, A. C. & Bressler, J. P. 2001 In : Toxicological Sciences. 62, 2, p. 280-288 9 p.

Research output: Contribution to journalArticle

Protein Kinase C
Erythrocytes
Chemical activation
Tibia
Assays

Involvement of DMT1 in uptake of Cd in MDCK cells: Role of protein kinase C

Olivi, L., Sisk, J. & Bressler, J. 2001 In : American Journal of Physiology - Cell Physiology. 281, 3 50-3

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Cadmium
Protein Kinase C
Phorbol 12,13-Dibutyrate
Messenger RNA

Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice

Gabrielson, K. L., Hogue, B. A., Bohr, V. A., Cardounel, A. J., Nakajima, W., Kofler, J., Zweier, J. L., Rodriguez, E. R., Martin, L. J., De Souza-Pinto, N. C. & Bressler, J. 2001 In : American Journal of Pathology. 159, 4, p. 1507-1520 14 p.

Research output: Contribution to journalArticle

Succinate Dehydrogenase
Heart Mitochondria
Cardiac Myocytes
Necrosis
Mitochondrial Swelling

Relation of alleles of the sodium-potassium adenosine triphosphatase α2 gene with blood pressure and lead exposure

Glenn, B. S., Stewart, W. F., Schwartz, B. S. & Bressler, J. Mar 15 2001 In : American Journal of Epidemiology. 153, 6, p. 537-545 9 p.

Research output: Contribution to journalArticle

Sodium-Potassium-Exchanging ATPase
Alleles
Blood Pressure
Genes
Hypertension
2000

Immediate early gene expression in PC12 cells exposed to lead: Requirement for protein kinase C

Kim, K. A., Chakraborti, T., Goldstein, G. W. & Bressler, J. P. 2000 In : Journal of Neurochemistry. 74, 3, p. 1140-1146 7 p.

Research output: Contribution to journalArticle

Immediate-Early Genes
PC12 Cells
Gene expression
Protein Kinase C
Gene Expression

Maitotoxin stimulates Cd influx in Madin-Darby kidney cells by activating Ca-permeable cation channels

Olivi, L. & Bressler, J. Apr 2000 In : Cell Calcium. 27, 4, p. 187-193 7 p.

Research output: Contribution to journalArticle

Cadmium
Cations
Kidney
Madin Darby Canine Kidney Cells
Proadifen
Metal ions
Rats
Brain
Metals
Ions

The role of anion exchange in the uptake of Pb by human erythrocytes and Madin-Darby canine kidney cells

Bannon, D. I., Olivi, L. & Bressler, J. Jun 8 2000 In : Toxicology. 147, 2, p. 101-107 7 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Anions
Erythrocytes
Epithelial Cells
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
1999

Increased AP-1 DNA binding activity in PC12 cells treated with lead

Chakraborti, T., Kim, K. A., Goldstein, G. G. & Bressler, J. P. 1999 In : Journal of Neurochemistry. 73, 1, p. 187-194 8 p.

Research output: Contribution to journalArticle

PC12 Cells
Transcription Factor AP-1
Protein Kinase C
DNA
Transcription

Molecular mechanisms of lead neurotoxicity

Dressier, J., Kim, K. A., Chakraborti, T. & Goldstein, G. 1999 In : Neurochemical Research. 24, 4, p. 595-600 6 p.

Research output: Contribution to journalArticle

Protein Kinase C
Blood
Learning
Calcium
Synapses
1997

Associations of subtypes of hemoglobin with delta-aminolevulinic acid dehydratase genotype and dimercaptosuccinic acid-chelatable lead levels

Schwartz, B. S., Lee, B. K., Stewart, W., Ahn, K. D., Kelsey, K. & Bressler, J. 1997 In : Archives of Environmental Health. 52, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

Porphobilinogen Synthase
Succimer
hemoglobin
Hemoglobins
genotype