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Joo Heon Shin

20052020

Research output per year

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Research Output

2020

Characterizing the nuclear and cytoplasmic transcriptomes in developing and mature human cortex uncovers new insight into psychiatric disease gene regulation

Price, A. J., Hwang, T., Tao, R., Burke, E. E., Rajpurohit, A., Shin, J. H., Hyde, T. M., Kleinman, J. E., Jaffe, A. E. & Weinberger, D. R., Jan 1 2020, In : Genome research. 30, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access

NurR1 and ERR1 modulate the expression of genes of a DRD2 coexpression network enriched for schizophrenia risk

Torretta, S., Rampino, A., Basso, M., Pergola, G., Carlo, P. D., Shin, J. H., Kleinman, J. E., Hyde, T. M., Weinberger, D. R., Masellis, R., Blasi, G., Pennuto, M. & Bertolino, A., Jan 22 2020, In : Journal of Neuroscience. 40, 4, p. 932-941 10 p.

Research output: Contribution to journalArticle

Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors

Choi, I. Y., Lim, H., Cho, H. J., Oh, Y., Chou, B. K., Bai, H., Cheng, L., Kim, Y. J., Hyun, S. H., Kim, H., Shin, J. H. & Lee, G., Feb 3 2020, In : eLife. 9

Research output: Contribution to journalArticle

Open Access
2019

Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq

The BrainSeq Consortium¶, Jun 1 2019, In : PloS one. 14, 6, e0217765.

Research output: Contribution to journalArticle

Open Access

Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation

Price, A. J., Collado-Torres, L., Ivanov, N. A., Xia, W., Burke, E. E., Shin, J. H., Tao, R., Ma, L., Jia, Y., Hyde, T. M., Kleinman, J. E., Weinberger, D. R. & Jaffe, A. E., Sep 26 2019, In : Genome biology. 20, 1, 196.

Research output: Contribution to journalArticle

Open Access

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease

Semick, S. A., Bharadwaj, R. A., Collado-Torres, L., Tao, R., Shin, J. H., Deep-Soboslay, A., Weiss, J. R., Weinberger, D., Hyde, T., Kleinman, J., Jaffe, A. & Mattay, V., Jan 1 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticle

KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits

Ren, M., Hu, Z., Chen, Q., Jaffe, A., Li, Y., Sadashivaiah, V., Zhu, S., Rajpurohit, N., Heon Shin, J., Xia, W., Jia, Y., Wu, J., Lang Qin, S., Li, X., Zhu, J., Tian, Q., Paredes, D., Zhang, F., Hong Wang, K., Mattay, V. S. & 4 others, Callicott, J. H., Berman, K. F., Weinberger, D. R. & Yang, F., Jan 1 2019, (Accepted/In press) In : Molecular psychiatry.

Research output: Contribution to journalArticle

Prefrontal Coexpression of Schizophrenia Risk Genes Is Associated With Treatment Response in Patients

Pergola, G., Di Carlo, P., Jaffe, A., Papalino, M., Chen, Q., Hyde, T., Kleinman, J., Shin, J. H., Rampino, A., Blasi, G., Weinberger, D. & Bertolino, A., Jan 1 2019, In : Biological psychiatry.

Research output: Contribution to journalArticle

Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia

BrainSeq Consortium, Jul 17 2019, In : Neuron. 103, 2, p. 203-216.e8

Research output: Contribution to journalArticle

2018

Association of a Noncoding RNA Postmortem With Suicide by Violent Means and In Vivo With Aggressive Phenotypes

Punzi, G., Ursini, G., Viscanti, G., Radulescu, E., Shin, J. H., Quarto, T., Catanesi, R., Blasi, G., Jaffe, A., Deep-Soboslay, A., Hyde, T., Kleinman, J., Bertolino, A. & Weinberger, D., Jan 1 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

BDNF-TrkB signaling in oxytocin neurons contributes to maternal behavior

Maynard, K. R., Hobbs, J. W., Phan, B. D. N., Gupta, A., Rajpurohit, S., Williams, C., Rajpurohit, A., Shin, J. H., Jaffe, A. & Martinowich, K., Sep 7 2018, In : eLife. 7

Research output: Contribution to journalArticle

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

The BrainSeq Consortium, Aug 1 2018, In : Nature Neuroscience. 21, 8, p. 1117-1125 9 p.

Research output: Contribution to journalArticle

Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome

Semick, S. A., Collado-Torres, L., Markunas, C. A., Shin, J. H., Deep-Soboslay, A., Tao, R., Huestis, M. A., Bierut, L. J., Maher, B., Johnson, E. O., Hyde, T., Weinberger, D., Hancock, D. B., Kleinman, J. & Jaffe, A., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

Radulescu, E., Jaffe, A., Straub, R. E., Chen, Q., Shin, J. H., Hyde, T., Kleinman, J. & Weinberger, D., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

BrainSpan Consortium, PsychENCODE Consortium & PsychENCODE Developmental Subgroup, Dec 14 2018, In : Science. 362, 6420, 1264.

Research output: Contribution to journalArticle

Investigating the neuroimmunogenic architecture of schizophrenia

Birnbaum, R., Jaffe, A., Chen, Q., Shin, J. H., Kleinman, J., Hyde, T. & Weinberger, D., May 1 2018, In : Molecular Psychiatry. 23, 5, p. 1251-1260 10 p.

Research output: Contribution to journalArticle

XMD-miRNA-seq to generate near in vivo miRNA expression estimates in colon epithelial cells

Rosenberg, A. Z., Wright, C., Fox-Talbot, K., Rajpurohit, A., Williams, C., Porter, C., Kovbasnjuk, O., McCall, M. N., Shin, J. H. & Halushka, M. K., Dec 1 2018, In : Scientific Reports. 8, 1, 9783.

Research output: Contribution to journalArticle

2017

A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue

Hoseth, E. Z., Ueland, T., Dieset, I., Birnbaum, R., Shin, J. H., Kleinman, J., Hyde, T., Mørch, R. H., Hope, S., Lekva, T., Abraityte, A. J., Michelsen, A. E., Melle, I., Westlye, L. T., Ueland, T., Djurovic, S., Aukrust, P., Weinberger, D. & Andreassen, O. A., Jul 1 2017, In : Schizophrenia Bulletin. 43, 4, p. 881-890 10 p.

Research output: Contribution to journalArticle

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

Brain Somatic Mosaicism Network, Apr 28 2017, In : Science. 356, 6336, 395.

Research output: Contribution to journalArticle

QSVA framework for RNA quality correction in differential expression analysis

Jaffe, A., Tao, R., Norris, A. L., Kealhofer, M., Nellore, A., Shin, J. H., Kim, D., Jia, Y., Hyde, T., Kleinman, J., Straub, R. E., Leek, J. T. & Weinberger, D., Jul 3 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 27, p. 7130-7135 6 p.

Research output: Contribution to journalArticle

2016

Dynamic regulation of RNA editing in human brain development and disease

Hwang, T., Park, C. K., Leung, A. K. L., Gao, Y., Hyde, T., Kleinman, J., Rajpurohit, A., Tao, R., Shin, J. H. & Weinberger, D., Aug 1 2016, In : Nature Neuroscience. 19, 8, p. 1093-1099 7 p.

Research output: Contribution to journalArticle

GAD2 alternative transcripts in the human prefrontal cortex, and in schizophrenia and affective disorders

Davis, K. N., Tao, R., Li, C., Gao, Y., Gondré-Lewis, M. C., Lipska, B. K., Shin, J. H., Xie, B., Ye, T., Weinberger, D., Kleinman, J. & Hyde, T., Feb 1 2016, In : PLoS One. 11, 2, e0148558.

Research output: Contribution to journalArticle

Genetic risk mechanisms of posttraumatic stress disorder in the human brain

Bharadwaj, R. A., Jaffe, A., Chen, Q., Deep-Soboslay, A., Goldman, A. L., Mighdoll, M. I., Cotoia, J. A., Brandtjen, A. C., Shin, J. H., Hyde, T., Mattay, V., Weinberger, D. & Kleinman, J., 2016, (Accepted/In press) In : Journal of Neuroscience Research.

Research output: Contribution to journalArticle

Genomic structure and expression of the human serotonin 2A receptor gene (HTR2A) locus: Identification of novel HTR2A and antisense (HTR2A-AS1) exons

Ruble, C. L., Smith, R. M., Calley, J., Munsie, L., Airey, D. C., Gao, Y., Shin, J. H., Hyde, T., Straub, R. E., Weinberger, D. & Nisenbaum, L. K., Jan 6 2016, In : BMC Genetics. 17, 1, 16.

Research output: Contribution to journalArticle

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

Jo, J., Xiao, Y., Sun, A. X., Cukuroglu, E., Tran, H. D., Göke, J., Tan, Z. Y., Saw, T. Y., Tan, C. P., Lokman, H., Lee, Y., Kim, D., Ko, H. S., Kim, S. O., Park, J. H., Cho, N. J., Hyde, T., Kleinman, J., Shin, J. H., Weinberger, D. & 3 others, Tan, E. K., Je, H. S. & Ng, H. H., Aug 4 2016, In : Cell Stem Cell. 19, 2, p. 248-257 10 p.

Research output: Contribution to journalArticle

2015

DEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain

Ohi, K., Ursini, G., Li, M., Shin, J. H., Ye, T., Chen, Q., Tao, R., Kleinman, J., Hyde, T., Hashimoto, R. & Weinberger, D., May 26 2015, In : Translational Psychiatry. 5, 4, e550.

Research output: Contribution to journalArticle

Developmental regulation of human cortex transcription and its clinical relevance at single base resolution

Jaffe, A., Shin, J. H., Collado-Torres, L., Leek, J. T., Tao, R., Li, C., Gao, Y., Jia, Y., Maher, B., Hyde, T., Kleinman, J. & Weinberger, D., Jan 1 2015, In : Nature Neuroscience. 18, 1, p. 154-161 8 p.

Research output: Contribution to journalArticle

Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1

Rannals, M. D., Hamersky, G. R., Page, S. C., Campbell, M. N., Briley, A., Gallo, R. A., Phan, B. N., Hyde, T., Kleinman, J., Shin, J. H., Jaffe, A., Weinberger, D. & Maher, B., Mar 19 2015, (Accepted/In press) In : Neuron.

Research output: Contribution to journalArticle

2014

A high-resolution whole-genome map of the distinctive epigenomic landscape induced by butyrate in bovine cells

Shin, J. H., Xu, L., Li, R. W., Gao, Y., Bickhart, D., Liu, G. E., Baldwin, R. & Li, C. J., Jan 1 2014, In : Animal Genetics. 45, SUPPL.1, p. 40-50 11 p.

Research output: Contribution to journalArticle

Differential effects of common variants in SCN2A on general cognitive ability, brain physiology, and messenger RNA expression in schizophrenia cases and control individuals

Dickinson, D., Straub, R. E., Trampush, J. W., Gao, Y., Feng, N., Xie, B., Shin, J. H., Lim, H. K., Ursini, G., Bigos, K., Kolachana, B., Hashimoto, R., Takeda, M., Baum, G. L., Rujescu, D., Callicott, J. H., Hyde, T., Berman, K. F., Kleinman, J. & Weinberger, D., 2014, In : JAMA Psychiatry. 71, 6, p. 647-656 10 p.

Research output: Contribution to journalArticle

Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder a novel transcript fetally regulated by the psychosis risk variant rs1344706

Tao, R., Cousijn, H., Jaffe, A., Burnet, P. W. J., Edwards, F., Eastwood, S. L., Shin, J. H., Lane, T. A., Walker, M. A., Maher, B., Weinberger, D., Harrison, P. J., Hyde, T. & Kleinman, J., Oct 1 2014, In : JAMA Psychiatry. 71, 10, p. 1112-1120 9 p.

Research output: Contribution to journalArticle

Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain

Guo, J. U., Szulwach, K. E., Su, Y., Li, Y., Yao, B., Xu, Z., Shin, J. H., Xie, B., Gao, Y., Ming, G. L., Jin, P. & Song, H., Feb 2014, In : Frontiers in Biology. 9, 1, p. 66-74 9 p.

Research output: Contribution to journalArticle

Mathematical framework for analyzing genome-wide association study data with rational classes

Valente, A. X. C. N., Sarkar, A., Shin, J. H., Wu, J. & Gao, Y., Jan 1 2014, Recent Advances in Systems Biology Research. Nova Science Publishers, Inc., p. 37-48 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Modeling a genetic risk for schizophrenia in iPSCs and Mice reveals neural stem cell deficits associated with adherens junctions and polarity

Yoon, K. J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N. S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Hussaini, S. M. Q., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J., Hyde, T. & 6 others, Krauss, G., Christian, K. M., Rapoport, J. L., Weinberger, D., Song, H. & Ming, G. L., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 79-91 13 p.

Research output: Contribution to journalArticle

Variant GADL1 and response to lithium in bipolar I disorder

Birnbaum, R., Shin, J. H. & Weinberger, D., Jan 1 2014, In : New England Journal of Medicine. 370, 19, p. 1855-1860 6 p.

Research output: Contribution to journalLetter

2013