Research Output 1988 2017

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2017

MTORC1 promotes T-bet phosphorylation to regulate Th1 differentiation

Chornoguz, O., Hagan, R. S., Haile, A., Arwood, M. L., Gamper, C. J., Banerjee, A. & Powell, J. D. May 15 2017 In : Journal of Immunology. 198, 10, p. 3939-3948 10 p.

Research output: Research - peer-reviewArticle

Phosphorylation
mechanistic target of rapamycin complex 1
T-Lymphocytes
Sirolimus
Mass Spectrometry

mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages

Oh, M. H., Collins, S. L., Sun, I. H., Tam, A. J., Patel, C. H., Arwood, M. L., Chan-Li, Y., Powell, J. D. & Horton, M. R. Sep 5 2017 In : Cell Reports. 20, 10, p. 2439-2454 16 p.

Research output: Research - peer-reviewArticle

Peritoneal Macrophages
TOR complex 2
Macrophages
Tissue
Cues

MTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

Hallowell, R. W., Collins, S. L., Craig, J. M., Zhang, Y., Oh, M., Illei, P. B., Chan-Li, Y., Vigeland, C. L., Mitzner, W., Scott, A. L., Powell, J. D. & Horton, M. R. Jan 27 2017 In : Nature Communications. 8, 14208

Research output: Research - peer-reviewArticle

Thermogenesis
Helminths
Macrophages
Infection
macrophages

Murine full-thickness skin transplantation

Cheng, C. H., Lee, C. F., Fryer, M., Furtmüller, G. J., Oh, B., Powell, J. D. & Brandacher, G. Jan 2 2017 In : Journal of Visualized Experiments. 2017, 119, e55105

Research output: Research - peer-reviewArticle

Skin Transplantation
Transplants
Grafts
Skin
Graft Rejection

The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment

Williams, J. B., Horton, B. L., Zheng, Y., Duan, Y., Powell, J. D. & Gajewski, T. F. 2017 In : Journal of Experimental Medicine. 214, 2, p. 381-400 20 p.

Research output: Research - peer-reviewArticle

CD8 Antigens
Tumor-Infiltrating Lymphocytes
Tumor Microenvironment
T-Lymphocytes
Neoplasms
2016

An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine2A Receptor

Hsiao, P. Y., Kalin, J. H., Sun, I. H., Amin, M. N., Lo, Y. C., Chiang, M. J., Giddens, J., Sysa-Shah, P., Gabrielson, K., Wang, L. X., Powell, J. D. & Cole, P. A. 2016 (Accepted/In press) In : ChemBioChem.

Research output: Research - peer-reviewArticle

Molecules
Pharmacokinetics
Brain
Proteins
Assays

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

Pollizzi, K. N., Sun, I. H., Patel, C. H., Lo, Y. C., Oh, M. H., Waickman, A. T., Tam, A. J., Blosser, R. L., Wen, J., Delgoffe, G. M. & Powell, J. D. Apr 11 2016 (Accepted/In press) In : Nature Immunology.

Research output: Research - peer-reviewArticle

Cell Differentiation
Phosphotransferases
T-Lymphocytes
mechanistic target of rapamycin complex 1
T-Lymphoid Precursor Cells

Deletion of mtorc1 activity in CD4+ T cells is associated with lung fibrosis and increased γδ T cells

Vigeland, C. L., Collins, S. L., Chan-Li, Y., Hughes, A. H., Oh, M. H., Powell, J. D. & Horton, M. R. Sep 1 2016 In : PLoS One. 11, 9, e0163288

Research output: Research - peer-reviewArticle

Fibrosis
T-Lymphocytes
Lung
fibrosis
T-lymphocytes

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation

Ladle, B. H., Li, K. P., Phillips, M. J., Pucsek, A. B., Haile, A., Powell, J. D., Jaffee, E. M., Hildeman, D. A. & Gamper, C. J. Sep 20 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. 10631-10636 6 p.

Research output: Research - peer-reviewArticle

DNA Methylation
T-Lymphocytes
DNA methyltransferase 3A
Wild Animals
Methyltransferases

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Sadtler, K., Estrellas, K., Allen, B. W., Wolf, M. T., Fan, H., Tam, A. J., Patel, C. H., Luber, B. S., Wang, H., Wagner, K. R., Powell, J. D., Housseau, F., Pardoll, D. M. & Elisseeff, J. H. Apr 15 2016 In : Science. 352, 6283, p. 366-370 5 p.

Research output: Research - peer-reviewArticle

Th2 Cells
Biocompatible Materials
Regeneration
Muscles
Interleukin-4

Discovery of 6-Diazo-5-oxo- l -norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

Rais, R., Jančařík, A., Tenora, L., Nedelcovych, M., Alt, J., Englert, J., Rojas, C., Le, A., Elgogary, A., Tan, J., Monincová, L., Pate, K., Adams, R., Ferraris, D., Powell, J., Majer, P. & Slusher, B. S. Sep 22 2016 In : Journal of Medicinal Chemistry. 59, 18, p. 8621-8633 13 p.

Research output: Research - peer-reviewArticle

Diazooxonorleucine
Prodrugs
Glioblastoma
Haplorhini
Therapeutics
2015

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy

Leone, R. D., Lo, Y. C. & Powell, J. D. 2015 In : Computational and Structural Biotechnology Journal. 13, p. 265-272 8 p.

Research output: Research - peer-reviewArticle

Immunotherapy
Neoplasms
Tumors
Adenosine
Chemical activation
Adoptive Transfer
Multiple Myeloma
Immunity
Bone Marrow
Lymphocytes

Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition

Pollizzi, K. N., Waickman, A. T., Patel, C. H., Sun, I. H. & Powell, J. D. Apr 7 2015 In : PLoS One. 10, 4, e0121710

Research output: Research - peer-reviewArticle

T-Lymphocytes
Antigens
T-lymphocytes
antigens
cells

Dysregulated Macrophages Are Present in Bleomycin-Induced Murine Laryngotracheal Stenosis

Hillel, A. T., Samad, I., Ma, G., Ding, D., Sadtler, K., Powell, J. D., Lane, A. P. & Horton, M. R. Aug 25 2015 In : Otolaryngology - Head and Neck Surgery. 153, 2, p. 244-250 7 p.

Research output: Research - peer-reviewArticle

Pathologic Constriction
Macrophages
Wounds and Injuries
indium-bleomycin
Fibrosis

Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion

Delgoffe, G. M. & Powell, J. D. Dec 1 2015 In : Molecular Immunology. 68, 2, p. 492-496 5 p.

Research output: Research - peer-reviewArticle

T-Lymphocytes
Infection Control
Cytokines

Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger

Prevot, N., Pyaram, K., Bischoff, E., Sen, J. M., Powell, J. D. & Chang, C. H. Jan 1 2015 In : Journal of Immunology. 194, 1, p. 223-230 8 p.

Research output: Research - peer-reviewArticle

Natural Killer T-Cells
Zinc Fingers
Leukemia
TOR complex 2
Sirolimus

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

Pollizzi, K. N., Patel, C. H., Sun, I. H., Oh, M. H., Waickman, A. T., Wen, J., Delgoffe, G. M. & Powell, J. D. May 1 2015 In : Journal of Clinical Investigation. 125, 5, p. 2090-2108 19 p.

Research output: Research - peer-reviewArticle

Cell Differentiation
T-Lymphocytes
TOR complex 2
Brain
Tuberous Sclerosis

Preventing Allograft Rejection by Targeting Immune Metabolism

Lee, C. F., Lo, Y. C., Cheng, C. H., Furtmüller, G. J., Oh, B., Andrade-Oliveira, V., Thomas, A. G., Bowman, C. E., Slusher, B. S., Wolfgang, M. J., Brandacher, G. & Powell, J. D. Oct 27 2015 In : Cell Reports. 13, 4, p. 760-770 11 p.

Research output: Research - peer-reviewArticle

Allografts
T-Lymphocytes
T-cells
Metabolism
Graft Rejection

Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and function in vitro

Namba, D. R., Ma, G., Samad, I., Ding, D., Pandian, V., Powell, J. D., Horton, M. R. & Hillel, A. T. May 9 2015 In : Otolaryngology - Head and Neck Surgery. 152, 5, p. 881-888 8 p.

Research output: Research - peer-reviewArticle

Sirolimus
Pathologic Constriction
Fibroblasts
In Vitro Techniques
Dimethyl Sulfoxide

Regulation of T cells by mTOR: The known knowns and the known unknowns

Pollizzi, K. N. & Powell, J. D. Jan 1 2015 In : Trends in Immunology. 36, 1, p. 13-20 8 p.

Research output: Research - peer-reviewArticle

Sirolimus
T-Lymphocytes
Cues
Cell Biology
Cell Differentiation

Something in the air: Hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy

Leone, R. D., Horton, M. R. & Powell, J. D. Apr 13 2015 In : Cancer Cell. 27, 4, p. 435-436 2 p.

Research output: Research - peer-reviewArticle

Air Conditioning
Translational Medical Research
Tumor Microenvironment
Adenosine
Immunotherapy

Sugar, fat, and protein: New insights into what T cells crave

Delgoffe, G. M. & Powell, J. D. Apr 1 2015 In : Current Opinion in Immunology. 33, p. 49-54 6 p.

Research output: Research - peer-reviewArticle

Fats
T-Lymphocytes
Proteins
Craving
Cytokine Receptors

Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

Gordon, E. B., Hart, G. T., Tran, T. M., Waisberg, M., Akkaya, M., Kim, A. S., Hamilton, S. E., Pena, M., Yazew, T., Qi, C. F., Lee, C. F., Lo, Y. C., Miller, L. H., Powell, J. D. & Pierce, S. K. Oct 20 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. 13075-13080 6 p.

Research output: Research - peer-reviewArticle

Cerebral Malaria
Glutamine
Therapeutics
Diazooxonorleucine
Brain
2014

An Fc domain protein-small molecule conjugate as an enhanced immunomodulator

Chiang, M. J., Holbert, M. A., Kalin, J. H., Ahn, Y. H., Giddens, J., Amin, M. N., Taylor, M. S., Collins, S. L., Chan-Li, Y., Waickman, A., Hsiao, P. Y., Bolduc, D., Leahy, D. J., Horton, M. R., Wang, L. X., Powell, J. D. & Cole, P. A. Mar 5 2014 In : Journal of the American Chemical Society. 136, 9, p. 3370-3373 4 p.

Research output: Research - peer-reviewArticle

Immunologic Factors
Proteins
Therapeutics
Protein Domains
Molecules

Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4- T cells

Chirag, E. A., Patel, A. H., Drake, C. H., Powell, J. D. & Hutson, S. M. Jul 4 2014 In : Journal of Biological Chemistry. 289, 27, p. 18793-18804 12 p.

Research output: Research - peer-reviewArticle

T-cells
Metabolism
branched-chain-amino-acid transaminase
mechanistic target of rapamycin complex 1
T-Lymphocytes
T-Lymphocytes
Growth
T-lymphocytes
T-cells
mice

Erratum: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways (Nature Immunology (2013) 14 (611-618))

Kim, J. S., Sklarz, T., Banks, L. B., Gohil, M., Waickman, A. T., Skuli, N., Krock, B. L., Luo, C. T., Hu, W., Pollizzi, K. N., Li, M. O., Rathmell, J. C., Birnbaum, M. J., Powell, J. D., Jordan, M. S. & Koretzky, G. A. Jan 1 2014 In : Nature Immunology. 15, 10, p. 996 1 p.

Research output: Research - peer-reviewArticle

Graft Rejection
Sirolimus
T-Lymphocytes
Aptitude
Metabolic Networks and Pathways

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses

Pollizzi, K. N. & Powell, J. D. 2014 In : Nature Reviews Immunology. 14, 7, p. 435-446 12 p.

Research output: Research - peer-reviewArticle

T-Lymphocytes
Metabolic Networks and Pathways
Hypoxia-Inducible Factor 1
AMP-Activated Protein Kinases
Autophagy

Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype

Hsieh, M. M., Fitzhugh, C. D., Weitzel, R. P., Link, M. E., Coles, W. A., Zhao, X., Rodgers, G. P., Powell, J. D. & Tisdale, J. F. 2014 In : Journal of the American Medical Association. 312, 1, p. 48-56 9 p.

Research output: Research - peer-reviewArticle

Hematopoietic Stem Cell Transplantation
Siblings
Phenotype
Tissue Donors
Transplants
Graft vs Host Disease
Cyclophosphamide
Grafts
Transplantation
Bone Marrow

Sprouty-2 regulates HIV-specific T cell polyfunctionality

Chiu, Y. L., Shan, L., Huang, H., Haupt, C., Bessell, C., Canaday, D. H., Zhang, H., Ho, Y. C., Powell, J. D., Oelke, M., Margolick, J. B., Blankson, J. N., Griffin, D. E. & Schneck, J. P. Jan 2 2014 In : Journal of Clinical Investigation. 124, 1, p. 198-208 11 p.

Research output: Research - peer-reviewArticle

HIV-2
T-Lymphocytes
HIV
Antigens
MAP Kinase Signaling System

The AGC kinase SGK1 regulates T H 1 and T H 2 differentiation downstream of the mTORC2 complex

Heikamp, E. B., Patel, C. H., Collins, S., Waickman, A., Oh, M. H., Sun, I. H., Illei, P., Sharma, A., Naray-Fejes-Toth, A., Fejes-Toth, G., Misra-Sen, J., Horton, M. R. & Powell, J. D. 2014 In : Nature Immunology. 15, 5, p. 457-464 8 p.

Research output: Research - peer-reviewArticle

Phosphotransferases
TOR complex 2
Interferon-gamma
T-Lymphocytes
T Cell Transcription Factor 1
2013

A dose-finding study of temsirolimus and liposomal doxorubicin for patients with recurrent and refractory bone and soft tissue sarcoma

Thornton, K. A., Chen, A. R., Trucco, M. M., Shah, P., Wilky, B. A., Gul, N., Carrera-Haro, M. A., Ferreira, M. F., Shafique, U., Powell, J. D., Meyer, C. F. & Loeb, D. M. Aug 15 2013 In : International Journal of Cancer. 133, 4, p. 997-1005 9 p.

Research output: Research - peer-reviewArticle

Sarcoma
Bone and Bones
liposomal doxorubicin
temsirolimus
Sirolimus

A modified model of T-cell differentiation based on mTOR activity and metabolism

Powell, J. D., Heikamp, E. B., Pollizzi, K. N. & Waickman, A. T. 2013 In : Cold Spring Harbor Symposia on Quantitative Biology. 78, 1, p. 125-130 6 p.

Research output: Research - peer-reviewArticle

T-cells
Metabolism
Cell Differentiation
T-Lymphocytes
Data storage equipment

Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3- dependent pathway

Black, K. E., Collins, S. L., Hagan, R. S., Hamblin, M. J., Chan-Li, Y., Hallowell, R. W., Powell, J. D. & Horton, M. R. 2013 In : Journal of Inflammation. 10, 1, 23

Research output: Research - peer-reviewArticle

Hyaluronic Acid
Macrophages
Tissue
Extracellular Matrix
Lung

Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury

Aggarwal, N. R., D'Alessio, F. R., Eto, Y., Chau, E., Avalos, C., Waickman, A. T., Garibaldi, B. T., Mock, J. R., Files, D. C., Sidhaye, V., Polotsky, V. Y., Powell, J., Horton, M. & King, L. S. May 2013 In : American Journal of Respiratory Cell and Molecular Biology. 48, 5, p. 635-645 11 p.

Research output: Research - peer-reviewArticle

Lung Injury
Macrophages
Oxygen
Adult Respiratory Distress Syndrome
Lipopolysaccharides

Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways

Kim, J. S., Sklarz, T., Banks, L. B., Gohil, M., Waickman, A. T., Skuli, N., Krock, B. L., Luo, C. T., Hu, W., Pollizzi, K. N., Li, M. O., Rathmell, J. C., Birnbaum, M. J., Powell, J. D., Jordan, M. S. & Koretzky, G. A. Jun 2013 In : Nature Immunology. 14, 6, p. 611-618 8 p.

Research output: Research - peer-reviewArticle

Th17 Cells
mechanistic target of rapamycin complex 1
Interleukin-17
Protein-Serine-Threonine Kinases
T-Lymphocyte Subsets

Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles

Lo, Y. C., Edidin, M. A. & Powell, J. D. Nov 15 2013 In : Journal of Immunology. 191, 10, p. 5107-5114 8 p.

Research output: Research - peer-reviewArticle

CD27 Antigens
Nanoparticles
T-Lymphocytes
T-Cell Antigen Receptor-CD3 Complex
Immunotherapy

Sirolimus and post transplant Cy synergistically maintain mixed chimerism in a mismatched murine model

Fitzhugh, C. D., Weitzel, R. P., Hsieh, M. M., Phang, O. A., Madison, C., Luznik, L., Powell, J. D. & Tisdale, J. F. Oct 2013 In : Bone Marrow Transplantation. 48, 10, p. 1335-1341 7 p.

Research output: Research - peer-reviewArticle

Chimerism
Sirolimus
Transplants
Tissue Donors
Therapeutics

Slc7a5 helps T cells get with the program

Powell, J. D. May 2013 In : Nature Immunology. 14, 5, p. 422-424 3 p.

Research output: Research - peer-reviewArticle

2012
Sirolimus
T-Lymphocytes
Phosphatidylinositol 3-Kinase
Cell Differentiation
Proto-Oncogene Proteins c-akt

De Novo DNA methylation is required to restrict T helper lineage plasticity

Thomas, R. M., Gamper, C. J., Ladle, B. H., Powell, J. D. & Wells, A. D. Jun 29 2012 In : Journal of Biological Chemistry. 287, 27, p. 22900-22909 10 p.

Research output: Research - peer-reviewArticle

DNA Methylation
T-Lymphocytes
T-cells
Plasticity
Genes

Enhancement of tumor immunotherapy by deletion of the A 2A adenosine receptor

Waickman, A. T., Alme, A., Senaldi, L., Zarek, P. E., Horton, M. & Powell, J. D. Jun 2012 In : Cancer Immunology Immunotherapy. 61, 6, p. 917-926 10 p.

Research output: Research - peer-reviewArticle

Adenosine A2A Receptors
Immunotherapy
Neoplasms
Purinergic P1 Receptors
Adenosine

Fueling Memories

Powell, J. D. & Pollizzi, K. Jan 27 2012 In : Immunity. 36, 1, p. 3-5 3 p.

Research output: Research - peer-reviewArticle

Adaptive Immunity
Immunity

Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells

Waickman, A. T. & Powell, J. D. May 15 2012 In : Journal of Immunology. 188, 10, p. 4721-4729 9 p.

Research output: Research - peer-reviewArticle

Sirolimus
T-Lymphocytes
Antigens
Recognition (Psychology)
Protein-Serine-Threonine Kinases

mTOR, metabolism, and the regulation of T-cell differentiation and function

Waickman, A. T. & Powell, J. D. Sep 2012 In : Immunological Reviews. 249, 1, p. 43-58 16 p.

Research output: Research - peer-reviewArticle

Sirolimus
Cell Differentiation
T-Lymphocytes
Cues
Antigens

Pulmonary vaccination as a novel treatment for lung fibrosis

Collins, S. L., Chan-Li, Y., Hallowell, R. W., Powell, J. D. & Horton, M. R. Feb 17 2012 In : PLoS One. 7, 2, e31299

Research output: Research - peer-reviewArticle

Vaccination
Fibrosis
Lung
Therapeutics
fibrosis

Regulation of CD4+ and CD8+ Effector Responses by Sprouty-1

Collins, S., Waickman, A., Basson, A., Kupfer, A., Licht, J. D., Horton, M. R. & Powell, J. D. Nov 15 2012 In : PLoS One. 7, 11, e49801

Research output: Research - peer-reviewArticle

T-cells
Chemical activation
T-lymphocytes
T-Lymphocytes
neoplasms