Jonathan Alder

Assistant Professor

20022020

Research output per year

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Research Output

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2020

Idiopathic pulmonary fibrosis lung transplant recipients are at increased risk for EBV-associated posttransplant lymphoproliferative disorder and worse survival

Iasella, C. J., Winters, S. A., Kois, A., Cho, J., Hannan, S. J., Koshy, R., Moore, C. A., Ensor, C. R., Lendermon, E. A., Morrell, M. R., Pilewski, J. M., Sanchez, P. G., Kass, D. J., Alder, J. K., Nouraie, S. M. & McDyer, J. F., May 1 2020, In : American Journal of Transplantation. 20, 5, p. 1439-1446 8 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis Lung Transplant Recipients are at Increased Risk for Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disorder

Iasella, C. J., Winters, S., Kois, A., Cho, J., Hannan, S. J., Koshy, R., Moore, C., Lendermon, E. A., Pilewski, J., Morrell, M., Sanchez, P. G., Kass, D., Alder, J. K., Nouriea, S. M. & McDyer, J., Apr 1 2020, In : The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 39, 4, p. S382-S383

Research output: Contribution to journalArticle

2019

GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis

Zhang, Y., Jiang, M., Nouraie, M., Roth, M. G., Tabib, T., Winters, S., Chen, X., Sembrat, J., Chu, Y., Cardenes, N., Tuder, R. M., Herzog, E. L., Ryu, C., Rojas, M., Lafyatis, R., Gibson, K. F., McDyer, J. F., Kass, D. J. & Alder, J. K., Oct 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 317, 4, p. L510-L521

Research output: Contribution to journalArticle

G-quadruplex dynamics contribute to regulation of mitochondrial gene expression

Falabella, M., Kolesar, J. E., Wallace, C., de Jesus, D., Sun, L., Taguchi, Y. V., Wang, C., Wang, T., Xiang, I. M., Alder, J. K., Maheshan, R., Horne, W., Turek-Herman, J., Pagano, P. J., St. Croix, C. M., Sondheimer, N., Yatsunyk, L. A., Johnson, F. B. & Kaufman, B. A., Dec 1 2019, In : Scientific reports. 9, 1, 5605.

Research output: Contribution to journalArticle

Open Access

RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia

Voic, H., Li, X., Jang, J. H., Zou, C., Sundd, P., Alder, J., Rojas, M., Chandra, D., Randell, S., Mallampalli, R. K., Tesfaigzi, Y., Ryba, T. & Nyunoya, T., Jan 9 2019, In : BMC genomics. 20, 1, 22.

Research output: Contribution to journalArticle

2018

Comparative analysis of lipid-mediated CRISPR-Cas9 genome editing techniques

Ringer, K. P., Roth, M. G., Garey, M. S., Piorczynski, T. B., Suli, A., Hansen, J. M. & Alder, J., Jul 1 2018, In : Cell Biology International. 42, 7, p. 849-858 10 p.

Research output: Contribution to journalArticle

Diagnostic utility of telomere length testing in a hospital-based setting

Alder, J., Hanumanthu, V. S., Strong, M. A., Dezern, A., Stanley, S. E., Takemoto, C. M., Danilova, L. V., Applegate, C. D., Bolton, S. G., Mohr, D. W., Brodsky, R. A., Casella, J. F., Greider, C. W., Brooks Jackson, J. & Armanios, M., Mar 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 10, p. E2358-E2365

Research output: Contribution to journalArticle

Short telomere syndromes cause a primary T cell immunodeficiency

Wagner, C. L., Hanumanthu, V. S., Conover Talbot, C., Abraham, R. S., Hamm, D., Gable, D. L., Kanakry, C. G., Applegate, C. D., Siliciano, J. M., Brooks Jackson, J., Desiderio, S., Alder, J., Luznik, L. & Armanios, M., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5222-5234 13 p.

Research output: Contribution to journalArticle

2016

CRISPR-Cas9 directed knock-out of a constitutively expressed gene using lance array nanoinjection

Sessions, J. W., Skousen, C. S., Price, K. D., Hanks, B. W., Hope, S., Alder, J. & Jensen, B. D., Dec 1 2016, In : SpringerPlus. 5, 1, 1521.

Research output: Contribution to journalArticle

Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema

Stanley, S. E., Gable, D. L., Wagner, C. L., Carlile, T. M., Hanumanthu, V. S., Podlevsky, J. D., Khalil, S. E., Dezern, A., Rojas-Duran, M. F., Applegate, C. D., Alder, J., Parry, E. M., Gilbert, W. V. & Armanios, M., Aug 10 2016, In : Science Translational Medicine. 8, 351, 351ra107.

Research output: Contribution to journalArticle

2015

Exome sequencing identifi es mutant TINF2 in a family with pulmonary fibrosis

Alder, J. K., Stanley, S. E., Wagner, C. L., Hamilton, M., Hanumanthu, V. S. & Armanios, M., May 1 2015, In : CHEST. 147, 5, p. 1361-1368 8 p.

Research output: Contribution to journalArticle

Telomerase mutations in smokers with severe emphysema

Stanley, S. E., Chen, J. J. L., Podlevsky, J. D., Alder, J. K., Hansel, N. N., Mathias, R. A., Qi, X., Rafaels, N. M., Wise, R. A., Silverman, E. K., Barnes, K. C. & Armanios, M., Feb 2 2015, In : Journal of Clinical Investigation. 125, 2, p. 563-570 8 p.

Research output: Contribution to journalArticle

Telomere dysfunction causes alveolar stem cell failure

Aldera, J. K., Barkauskas, C. E., Limjunyawong, N., Stanley, S. E., Kembou, F., Tuder, R. M., Hogan, B. L. M., Mitzner, W. & Armanios, M., Apr 21 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 16, p. 5099-5104 6 p.

Research output: Contribution to journalArticle

2013

Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene

Alder, J. K., Parry, E. M., Yegnasubramanian, S., Wagner, C. L., Lieblich, L. M., Auerbach, R., Auerbach, A. D., Wheelan, S. J. & Armanios, M., Nov 1 2013, In : Human mutation. 34, 11, p. 1481-1485 5 p.

Research output: Contribution to journalArticle

2011

Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis

Alder, J. K., Cogan, J. D., Brown, A. F., Anderson, C. J., Lawson, W. E., Lansdorp, P. M., Phillips, J. A., Loyd, J. E., Chen, J. J. L. & Armanios, M., Mar 1 2011, In : PLoS genetics. 7, 3, e1001352.

Research output: Contribution to journalArticle

Decreased dyskerin levels as a mechanism of telomere shortening in X-linked dyskeratosis congenita

Parry, E. M., Alder, J. K., Lee, S. S., Phillips, J. A., Loyd, J. E., Duggal, P. & Armanios, M., May 1 2011, In : Journal of medical genetics. 48, 5, p. 327-333 7 p.

Research output: Contribution to journalArticle

Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase

Parry, E. M., Alder, J. K., Qi, X., Chen, J. J. L. & Armanios, M., May 26 2011, In : Blood. 117, 21, p. 5607-5611 5 p.

Research output: Contribution to journalArticle

Telomere length is a determinant of emphysema susceptibility

Alder, J. K., Guo, N., Kembou, F., Parry, E. M., Anderson, C. J., Gorgy, A. I., Walsh, M. F., Sussan, T., Biswal, S., Mitzner, W., Tuder, R. M. & Armanios, M., Oct 15 2011, In : American journal of respiratory and critical care medicine. 184, 8, p. 904-912 9 p.

Research output: Contribution to journalArticle

2010

Cutting edge: The transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORγt

Lebson, L., Gocke, A., Rosenzweig, J., Alder, J., Civin, C., Calabresi, P. A. & Whartenby, K. A., Dec 15 2010, In : Journal of Immunology. 185, 12, p. 7161-7164 4 p.

Research output: Contribution to journalArticle

Id1 overexpression is independent of repression and epigenetic silencing of tumor suppressor genes in melanoma

Healey, M. A., Deaton, S. L., Alder, J. K., Winnepenninckx, V., Casero, R. A. & Herman, J. G., Jul 1 2010, In : Epigenetics. 5, 5

Research output: Contribution to journalArticle

Open Access
2009

Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging

Armanios, M., Alder, J. K., Parry, E. M., Karim, B., Strong, M. A. & Greider, C. W., Dec 11 2009, In : American journal of human genetics. 85, 6, p. 823-832 10 p.

Research output: Contribution to journalArticle

2008

Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo

Alder, J. K., Georgantas, R. W., Hildreth, R. L., Kaplan, I. M., Morisot, S., Yu, X., Mcdevitt, M. & Civin, C. I., Apr 15 2008, In : Journal of Immunology. 180, 8, p. 5645-5652 8 p.

Research output: Contribution to journalArticle

Open Access

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

Alder, J. K., Chen, J. J. L., Lancaster, L., Danoff, S., Su, S. C., Cogan, J. D., Vulto, I., Xie, M., Qi, X., Tuder, R. M., Phillips, J. A., Lansdorp, P. M., Loyd, J. E. & Armanios, M. Y., Sep 2 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 35, p. 13051-13056 6 p.

Research output: Contribution to journalArticle

2007

CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control

Georgantas, R. W., Hildreth, R., Morisot, S., Alder, J., Liu, C. G., Heimfeld, S., Calin, G. A., Croce, C. M. & Civin, C. I., Feb 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 8, p. 2750-2755 6 p.

Research output: Contribution to journalArticle

Telomerase mutations in families with idiopathic pulmonary fibrosis

Armanios, M. Y., Chen, J. J. L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., Lansdorp, P. M., Greider, C. W. & Loyd, J. E., Mar 29 2007, In : New England Journal of Medicine. 356, 13, p. 1317-1326 10 p.

Research output: Contribution to journalArticle

2006

HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding

Yu, X., Alder, J. K., Jong, H. C., Friedman, A. D., Heimfeld, S., Cheng, L. & Civin, C. I., Apr 1 2006, In : Stem Cells. 24, 4, p. 876-888 13 p.

Research output: Contribution to journalArticle

2003

Rapid direct sequence analysis of the dystrophin gene

Flanigan, K. M., Von Niederhausern, A., Dunn, D. M., Alder, J., Mendell, J. R. & Weiss, R. B., Apr 1 2003, In : American journal of human genetics. 72, 4, p. 931-939 9 p.

Research output: Contribution to journalArticle

Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1- and SIR-dependent transcriptional silencing

De Las Peñas, A., Pan, S. J., Castaño, I., Alder, J., Cregg, R. & Cormack, B. P., Sep 15 2003, In : Genes and Development. 17, 18, p. 2245-2258 14 p.

Research output: Contribution to journalArticle

2002

Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript

Dunn, D. M., Ishigami, T., Pankow, J., Von Niederhausern, A., Alder, J., Hunt, S. C., Leppert, M. F., Lalouel, J. M. & Weiss, R. B., Dec 1 2002, In : Journal of Human Genetics. 47, 12, p. 665-676 12 p.

Research output: Contribution to journalArticle