John Thomas Schroeder

Associate Professor

1985 …2019
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Research Output 1985 2019

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Article
2019
Galectin 3
Basophils
Immunoglobulin E
Epithelial Cells
Lung
2018

Enhanced antigen presenting and T cell functions during late-phase allergic responses in the lung

Liu, M. C. H., Xiao, H., Breslin, L. M., Bochner, B. S. & Schroeder, J. T., Mar 1 2018, In : Clinical and Experimental Allergy. 48, 3, p. 334-342 9 p.

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Allergens
Neuropilin-1
Bronchoalveolar Lavage
T-Lymphocytes
2017

Activation of human basophils by A549 lung epithelial cells reveals a novel IgE-dependent response independent of allergen

Schroeder, J. T. & Bieneman, A. P., Aug 1 2017, In : Journal of Immunology. 199, 3, p. 855-865 11 p.

Research output: Contribution to journalArticle

Basophils
Allergens
Immunoglobulin E
Epithelial Cells
Lung

N-glycan in cockroach allergen regulates human basophil function

Do, D., Yang, S., Yao, X., Hamilton, R. G., Schroeder, J. T. & Gao, P., Jan 1 2017, In : Immunity Inflammation and Disease. 5, 4, p. 386-399 14 p.

Research output: Contribution to journalArticle

Cockroaches
Basophils
Allergens
Polysaccharides
Histamine Release
2016

Isolation of Human Basophils

Schroeder, J. T. & Bieneman, A. P., Feb 2 2016, In : Current Protocols in Immunology. 112

Research output: Contribution to journalArticle

Basophils
Granulocytes
Immunoglobulin E
Cell Biology
Leukocytes
2015

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy

Narisety, S. D., Frischmeyer-Guerrerio, P. A., Keet, C., Gorelik, M., Schroeder, J. T., Hamilton, R. G. & Wood, R. A., May 1 2015, In : The Journal of Allergy and Clinical Immunology. 135, 5, p. 1275-1286e6

Research output: Contribution to journalArticle

Peanut Hypersensitivity
Sublingual Immunotherapy
Immunotherapy
Placebos
Active Immunotherapy

IL-3 synergises with basophil-derived IL-4 and IL-13 to promote the alternative activation of human monocytes

Borriello, F., Longo, M., Spinelli, R., Pecoraro, A., Granata, F., Staiano, R. I., Loffredo, S., Spadaro, G., Beguinot, F., Schroeder, J. T. & Marone, G., Jul 1 2015, In : European Journal of Immunology. 45, 7, p. 2042-2051 10 p.

Research output: Contribution to journalArticle

Interleukin-13
Basophils
Interleukin-3
Interleukin-4
Monocytes

Suppression of the immunologic response to peanut during immunotherapy is often transient

Gorelik, M., Narisety, S. D., Guerrerio, A. L., Chichester, K. L., Keet, C., Bieneman, A. P., Hamilton, R. G., Wood, R. A., Schroeder, J. T. & Frischmeyer-Guerrerio, P. A., May 1 2015, In : The Journal of Allergy and Clinical Immunology. 135, 5, p. 1283-1292 10 p.

Research output: Contribution to journalArticle

Immunotherapy
Sublingual Immunotherapy
Dendritic Cells
Basophils
Coculture Techniques
2014

A draft map of the human proteome

Kim, M. S., Pinto, S. M., Getnet, D., Nirujogi, R. S., Manda, S. S., Chaerkady, R., Madugundu, A. K., Kelkar, D. S., Isserlin, R., Jain, S., Thomas, J. K., Muthusamy, B., Leal-Rojas, P., Kumar, P., Sahasrabuddhe, N. A., Balakrishnan, L., Advani, J., George, B., Renuse, S., Selvan, L. D. N. & 52 others, Patil, A. H., Nanjappa, V., Radhakrishnan, A., Prasad, S., Subbannayya, T., Raju, R., Kumar, M., Sreenivasamurthy, S. K., Marimuthu, A., Sathe, G. J., Chavan, S., Datta, K. K., Subbannayya, Y., Sahu, A., Yelamanchi, S. D., Jayaram, S., Rajagopalan, P., Sharma, J., Murthy, K. R., Syed, N., Goel, R., Khan, A. A., Ahmad, S., Dey, G., Mudgal, K., Chatterjee, A., Huang, T. C., Zhong, J., Wu, X., Shaw, P. G., Freed, D., Zahari, M. S., Mukherjee, K. K., Shankar, S., Mahadevan, A., Lam, H., Mitchell, C. J., Shankar, S. K., Satishchandra, P., Schroeder, J. T., Sirdeshmukh, R., Maitra, A., Leach, S. D., Drake, C. G., Halushka, M. K., Prasad, T. S. K., Hruban, R. H., Kerr, C. L., Bader, G. D., Iacobuzio-Donahue, C. A., Gowda, H. & Pandey, A., 2014, In : Nature. 509, 7502, p. 575-581 7 p.

Research output: Contribution to journalArticle

Proteome
Human Genome
Open Reading Frames
Biomedical Research
Untranslated RNA

Modulation of dendritic cell innate and adaptive immune functions by oral and sublingual immunotherapy

Frischmeyer-Guerrerio, P. A., Keet, C., Guerrerio, A. L., Chichester, K. L., Bieneman, A. P., Hamilton, R. G., Wood, R. A. & Schroeder, J. T., Aug 19 2014, In : Clinical Immunology. 155, 1, p. 47-59 13 p.

Research output: Contribution to journalArticle

Sublingual Immunotherapy
Immunotherapy
Dendritic Cells
Toll-Like Receptors
Innate Immunity

Relationship of IgE to basophil phenotypes in peanut-sensitized adults

McGowan, E. C., Savage, J. H., Courneya, J. P., Sterba, P. M., Parihar, S., Lin, J., Gimenez, G., Sampson, H. A., Schroeder, J. T., Macglashan, D., Wood, R. A., Hamilton, R. G. & Saini, S. S., Sep 1 2014, In : The Journal of Allergy and Clinical Immunology. 134, 3, p. 746-749 4 p.

Research output: Contribution to journalArticle

Plant 2S Albumins
CD63 Antigen
Plant Antigens
Peanut Hypersensitivity
Seed Storage Proteins
2013

Scratching the surface of allergic transfusion reactions

Savage, W. J., Tobian, A. A., Savage, J. H., Wood, R. A., Schroeder, J. T. & Ness, P. M., Jun 2013, In : Transfusion. 53, 6, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

Hypersensitivity
Blood Platelets
Transfusion Reaction
Costs and Cost Analysis
Antibodies
2012

Allergic agonists in apheresis platelet products are associated with allergic transfusion reactions

Savage, W. J., Savage, J. H., Tobian, A. A., Thoburn, C., Hamilton, R. G., Schroeder, J. T. & Ness, P. M., Mar 2012, In : Transfusion. 52, 3, p. 575-581 7 p.

Research output: Contribution to journalArticle

Blood Component Removal
Hypersensitivity
Blood Platelets
Basophils
Brain-Derived Neurotrophic Factor

Association of vitamin D and antimicrobial peptide production during late-phase allergic responses in the lung

Liu, M. C. H., Xiao, H., Brown, A. J., Ritter, C. S. & Schroeder, J. T., Mar 2012, In : Clinical and Experimental Allergy. 42, 3, p. 383-391 9 p.

Research output: Contribution to journalArticle

Vitamin D
Allergens
Lung
Peptides
Bronchoalveolar Lavage

Cellular immune response parameters that influence IgE sensitization

Frischmeyer-Guerrerio, P. A. & Schroeder, J. T., Sep 28 2012, In : Journal of Immunological Methods. 383, 1-2, p. 21-29 9 p.

Research output: Contribution to journalArticle

Basophils
Cellular Immunity
Dendritic Cells
Immunoglobulin E
Immunomodulation

The safety and efficacy of sublingual and oral immunotherapy for milk allergy

Keet, C., Frischmeyer-Guerrerio, P. A., Wessel, F., Thyagarajan, A., Schroeder, J. T., Hamilton, R. G., Boden, S., Steele, P., Driggers, S., Burks, A. W. & Wood, R. A., Jan 2012, In : Revista Portuguesa de Imunoalergologia. 20, 1, p. 66-67 2 p.

Research output: Contribution to journalArticle

The safety and efficacy of sublingual and oral immunotherapy for milk allergy

Keet, C., Frischmeyer-Guerrerio, P. A., Thyagarajan, A., Schroeder, J. T., Hamilton, R. G., Boden, S., Steele, P., Driggers, S., Burks, A. W. & Wood, R. A., Feb 2012, In : The Journal of Allergy and Clinical Immunology. 129, 2

Research output: Contribution to journalArticle

Sublingual Immunotherapy
Milk Hypersensitivity
Immunotherapy
Safety
Milk
2011

Basophils: Emerging roles in the pathogenesis of allergic disease

Schroeder, J. T., Jul 2011, In : Immunological Reviews. 242, 1, p. 144-160 17 p.

Research output: Contribution to journalArticle

Basophils
Interleukin-4
Inflammation
Interleukin-13
Antigen-Presenting Cells

Dendritic cell and T cell responses in children with food allergy

Frischmeyer-Guerrerio, P. A., Guerrerio, A. L., Chichester, K. L., Bieneman, A. P., Hamilton, R. G., Wood, R. A. & Schroeder, J. T., Jan 2011, In : Clinical and Experimental Allergy. 41, 1, p. 61-71 11 p.

Research output: Contribution to journalArticle

Food Hypersensitivity
Dendritic Cells
T-Lymphocytes
Cytokines
Milk Hypersensitivity

Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor

Macglashan, D., Honigberg, L. A., Smith, A., Buggy, J. & Schroeder, J. T., Apr 2011, In : International Immunopharmacology. 11, 4, p. 475-479 5 p.

Research output: Contribution to journalArticle

Basophils
Immunoglobulin E
methionyl-leucyl-phenylalanine
Leukotriene C4
Interleukin-13
2010

CD14, a key candidate gene associated with a specific immune response to cockroach

Gao, P., Grigoryev, D. N., Rafaels, N. M., Mu, D., Wright, J. M., Cheadle, C., Togias, A., Beaty, T. L., Mathias, R., Schroeder, J. T. & Barnes, K. C., Sep 2010, In : Clinical and Experimental Allergy. 40, 9, p. 1353-1364 12 p.

Research output: Contribution to journalArticle

Cockroaches
Genes
Dendritic Cells
Antigens
Interleukin-13
Dendritic Cells
Immunoglobulin E
Allergens
T-Lymphocytes
Cats

Functional changes of dendritic cells in hypersensitivity reactions to amoxicillin

Lima, C. M. F., Schroeder, J. T., Galvão, C. E. S., Castro, F. M., Kalil, J. & Adkinson, N. F., Oct 2010, In : Brazilian Journal of Medical and Biological Research. 43, 10, p. 964-968 5 p.

Research output: Contribution to journalArticle

Amoxicillin
Dendritic Cells
Hypersensitivity
Allergies
Drug Hypersensitivity

Pulmonary allergic responses augment interleukin-13 secretion by circulating basophils yet suppress interferon-α from plasmacytoid dendritic cells

Schroeder, J. T., Bieneman, A. P., Chichester, K. L., Breslin, L., Xiao, H. & Liu, M. C. H., May 2010, In : Clinical and Experimental Allergy. 40, 5, p. 745-754 10 p.

Research output: Contribution to journalArticle

Interleukin-13
Basophils
Dendritic Cells
Interferons
Allergens

Response by G. Celik, J. Schroeder and N.F. Adkinson

Celik, G., Schroeder, J. T. & Adkinson, N. F., Mar 2010, In : Clinical and Experimental Allergy. 40, 3, p. 520-521 2 p.

Research output: Contribution to journalArticle

SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung

Zhang, L., Oh, S. Y., Wu, X., Oh, M. H., Wu, F., Schroeder, J. T., Takemoto, C. M., Zheng, T. & Zhu, Z., Feb 1 2010, In : Journal of Immunology. 184, 3, p. 1180-1190 11 p.

Research output: Contribution to journalArticle

Mast Cells
Pneumonia
Cytokines
Interleukin-13
Phenotype

Subcutaneous allergen immunotherapy restores human dendritic cell innate immune function

Tversky, J. R., Bieneman, A. P., Chichester, K. L., Hamilton, R. G. & Schroeder, J. T., Jan 2010, In : Clinical and Experimental Allergy. 40, 1, p. 94-102 9 p.

Research output: Contribution to journalArticle

Immunologic Desensitization
Dendritic Cells
Toll-Like Receptor 9
Blood Cells
Mites
2009

Chapter 4 Basophils. Beyond Effector Cells of Allergic Inflammation

Schroeder, J. T., 2009, In : Advances in Immunology. 101, C, p. 123-161 39 p.

Research output: Contribution to journalArticle

Basophils
Inflammation
Interleukin-13
Granulocytes
Innate Immunity
Basophils
Aspirin
Leukotriene C4
Interleukin-4
In Vitro Techniques

Human basophils secrete IL-3: Evidence of autocrine priming for phenotypic and functional responses in allergic disease

Schroeder, J. T., Chichester, K. L. & Bieneman, A. P., Feb 15 2009, In : Journal of Immunology. 182, 4, p. 2432-2438 7 p.

Research output: Contribution to journalArticle

Basophils
Interleukin-3
Immunoglobulin E
Interleukin-13
Interleukin-3 Receptors

Interferons modulate FcεRI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells

Le, T., Tversky, J. R., Chichester, K. L., Bieneman, A. P., Huang, S. K., Wood, R. A. & Schroeder, J. T., Jan 2009, In : The Journal of Allergy and Clinical Immunology. 123, 1, p. 217-223 7 p.

Research output: Contribution to journalArticle

Interleukin-10
Dendritic Cells
Interferons
Toll-Like Receptor 9
Cytokines

Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling

Zheng, T., Oh, M. H., Oh, S. Y., Schroeder, J. T., Glick, A. B. & Zhu, Z., Mar 2009, In : Journal of Investigative Dermatology. 129, 3, p. 742-751 10 p.

Research output: Contribution to journalArticle

Dermatitis
Interleukin-13
Skin
Atopic Dermatitis
Phenotype
2008
Basophils
Histamine Release
Mast Cells
Small Interfering RNA
Transfection

Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-α via toll-like receptor 9

Tversky, J. R., Le, T. V., Bieneman, A. P., Chichester, K. L., Hamilton, R. G. & Schroeder, J. T., May 2008, In : Clinical and Experimental Allergy. 38, 5, p. 781-788 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Dendritic Cells
Interferons
Blood Cells
Cytokines

Human IgE+ and IgE- are not equivalent to mouse highly cytokinergic IgE

Xie, L., Schroeder, J. T., Langdon, J. M., Sora-Scott, R. S., Kawakami, T. & MacDonald, S. M., Apr 2008, In : The Journal of Allergy and Clinical Immunology. 121, 4, p. 1027-1033 7 p.

Research output: Contribution to journalArticle

Immunoglobulin E
Basophils
Histamine Release
Mast Cells
Extracellular Signal-Regulated MAP Kinases

Toll-like receptor 9 suppression in plasmacytoid dendritic cells after IgE-dependent activation is mediated by autocrine TNF-α

Schroeder, J. T., Chichester, K. L. & Bieneman, A. P., Feb 2008, In : The Journal of Allergy and Clinical Immunology. 121, 2, p. 486-491 6 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Dendritic Cells
Immunoglobulin E
Interleukin-6
Cytokines
2007

Bacterial c-di-GMP is an immunostimulatory molecule

Karaolis, D. K. R., Means, T. K., Yang, D., Takahashi, M., Yoshimura, T., Muraille, E., Philpott, D., Schroeder, J. T., Hyodo, M., Hayakawa, Y., Talbot, B. G., Brouillette, E. & Malouin, F., Feb 15 2007, In : Journal of Immunology. 178, 4, p. 2171-2181 11 p.

Research output: Contribution to journalArticle

Dendritic Cells
Staphylococcus aureus
bis(3',5')-cyclic diguanylic acid
Chemokine CCL5
Chemokine Receptors

Expression of activation markers on basophils in a controlled model of anaphylaxis

Gober, L. M., Eckman, J. A., Sterba, P. M., Vasagar, K., Schroeder, J. T., Golden, D. B. K. & Saini, S. S., May 2007, In : The Journal of Allergy and Clinical Immunology. 119, 5, p. 1181-1188 8 p.

Research output: Contribution to journalArticle

Basophils
Anaphylaxis
Bites and Stings
Venoms
Immunotherapy

Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung

Oh, S. Y., Zheng, T., Bailey, M. L., Barber, D. L., Schroeder, J. T., Kim, Y. K. & Zhu, Z., Jan 2007, In : The Journal of Allergy and Clinical Immunology. 119, 1, p. 123-131 9 p.

Research output: Contribution to journalArticle

Pneumonia
Inflammation
Lung
1-Phosphatidylinositol 4-Kinase
Bronchoalveolar Lavage

The authors reply [3]

Creticos, P. S., Schroeder, J. T. & Broide, D., Jan 4 2007, In : New England Journal of Medicine. 356, 1, p. 87 1 p.

Research output: Contribution to journalArticle

2006

Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis

Creticos, P. S., Schroeder, J. T., Hamilton, R. G., Balcer-Whaley, S. L., Khattignavong, A. P., Lindblad, R., Li, H., Coffman, R., Seyfert, V., Eiden, J. J. & Broide, D., Oct 5 2006, In : New England Journal of Medicine. 355, 14, p. 1445-1455 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Ambrosia
Immunotherapy
Vaccines
Rhinitis

Interleukin-10 and Th2 cytokines differentially regulate osteopontin expression in human monocytes and dendritic cells

Konno, S., Eckman, J. A., Plunkett, B., Li, X., Berman, J. S., Schroeder, J. T. & Huang, S. K., Aug 2006, In : Journal of Interferon and Cytokine Research. 26, 8, p. 562-567 6 p.

Research output: Contribution to journalArticle

Osteopontin
Interleukin-10
Dendritic Cells
Monocytes
Cytokines
2005

Increased expression of osteopontin is associated with long-term bee venom immunotherapy

Konno, S., Golden, D. B. K., Schroeder, J. T., Hamilton, R. G., Lichtenstein, L. M. & Huang, S. K., May 2005, In : The Journal of Allergy and Clinical Immunology. 115, 5, p. 1063-1067 5 p.

Research output: Contribution to journalArticle

Bee Venoms
Immunologic Desensitization
Osteopontin
Venoms
Immunotherapy

Level of osteopontin is increased after bee venom immunotherapy [4]

Konno, S., Golden, D. B. K., Schroeder, J. T., Hamilton, R. G., Lichtenstein, L. M. & Huang, S. K., Jun 2005, In : The Journal of Allergy and Clinical Immunology. 115, 6, p. 1317-1318 2 p.

Research output: Contribution to journalArticle

Insect Bites and Stings
Sialoglycoproteins
Bee Venoms
Osteopontin
Bees

TLR9- and FcεRI-mediated responses oppose one another in plasmacytoid dendritic cells by down-regulating receptor expression

Schroeder, J. T., Bieneman, A. P., Xiao, H., Chichester, K. L., Vasagar, K., Saini, S. S. & Liu, M. C. H., Nov 1 2005, In : Journal of Immunology. 175, 9, p. 5724-5731 8 p.

Research output: Contribution to journalArticle

Dendritic Cells
Oligodeoxyribonucleotides
IgE Receptors
Allergens
Immunoglobulin E

Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion

Bieneman, A. P., Chichester, K. L., Chen, Y. H. & Schroeder, J. T., Feb 2005, In : The Journal of Allergy and Clinical Immunology. 115, 2, p. 295-301 7 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Basophils
Immunoglobulin E
Ligands
Cytokines
2004

New approaches in immunotherapy: Allergen vaccination with immunostimulatory DNA

Creticos, P. S., Chen, Y. H. & Schroeder, J. T., Nov 2004, In : Immunology and Allergy Clinics of North America. 24, 4 SPEC. ISS., p. 569-581 13 p.

Research output: Contribution to journalArticle

Immunologic Desensitization
Immunotherapy
Vaccination
Immunomodulation
Oligodeoxyribonucleotides

Systemic effects of allergen exposure on blood basophil IL-13 secretion and FcεRIβ

Saini, S. S., Bloom, D. C., Bieneman, A., Vasagar, K., Togias, A. & Schroeder, J. T., Oct 2004, In : The Journal of Allergy and Clinical Immunology. 114, 4, p. 768-774 7 p.

Research output: Contribution to journalArticle

Interleukin-13
Basophils
Allergens
Interleukin-4
Messenger RNA
2003

IFN-α inhibits IL-3 priming of human basophil cytokine secretion but not leukotriene C4 and histamine release

Chen, Y. H., Bieneman, A. P., Creticos, P. S., Chichester, K. L. & Schroeder, J. T., Nov 2003, In : The Journal of Allergy and Clinical Immunology. 112, 5, p. 944-950 7 p.

Research output: Contribution to journalArticle

Leukotriene C4
Basophils
Histamine Release
Interleukin-3
Cytokines
2002

Basophils in airway disease.

Macglashan, D., Gauvreau, G. & Schroeder, J. T., Mar 2002, In : Current Allergy and Asthma Reports. 2, 2, p. 126-132 7 p.

Research output: Contribution to journalArticle

Basophils
Asthma
Eosinophils
Lymphocytes
Cytokines