John Nicholas

Professor

1988 …2019
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Research Output 1988 2019

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Article
2019

Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

Vo, M. T., Smith, B. J., Nicholas, J. & Choi, Y., Dec 1 2019, In : Nature communications. 10, 1, 3203.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Degradation
Interferon Regulatory Factors
interferon
Herpesviridae
Human Herpesvirus 8
Human herpesvirus 8
Virus Latency
Somatomedin Receptors
Human Herpesvirus 8
somatomedins
2018

Human herpesvirus 8 interferon regulatory factors 1 and 3 mediate replication and latency activities via interactions with USP7 deubiquitinase

Xiang, Q., Ju, H., Li, Q., Mei, S. C., Chen, D., Choi, Y. & Nicholas, J., Apr 1 2018, In : Journal of Virology. 92, 7, e02003-17.

Research output: Contribution to journalArticle

Human herpesvirus 8
Ubiquitin-Specific Proteases
ubiquitin
proteinases
lymphoma
2017

Human herpesvirus 8 interleukin-6 interacts with calnexin cycle components and promotes protein folding

Chen, D., Xiang, Q. & Nicholas, J., Nov 1 2017, In : Journal of Virology. 91, 22, e00965-17.

Research output: Contribution to journalArticle

calnexin
Human herpesvirus 8
Calnexin
Human Herpesvirus 8
protein folding
2015
Human herpesvirus 8
Endoplasmic Reticulum-Associated Degradation
Human Herpesvirus 8
cathepsin D
interleukin-6
2014

Human herpesvirus 8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion lymphoma and endothelial cells

Cousins, E., Gao, Y., Sandford, G. & Nicholas, J., 2014, In : Journal of Virology. 88, 20, p. 12167-12172 6 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
Primary Effusion Lymphoma
Human Herpesvirus 8
Virus Replication
virus replication
2013

Role of human herpesvirus 8 interleukin-6-activated gp130 signal transducer in primary effusion lymphoma cell growth and viability

Cousins, E. & Nicholas, J., 2013, In : Journal of Virology. 87, 19, p. 10816-10827 12 p.

Research output: Contribution to journalArticle

Cytokine Receptor gp130
Human herpesvirus 8
Primary Effusion Lymphoma
Human Herpesvirus 8
lymphoma
2012

Human herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry

Choi, Y., Sandford, G. & Nicholas, J., Jun 2012, In : PLoS Pathogens. 8, 6, e1002748.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
Human Herpesvirus 8
Proteins
Noxae
Apoptosis

Human herpesvirus 8 viral interleukin-6 interacts with splice variant 2 of vitamin K epoxide reductase complex subunit 1

Chen, D., Cousins, E., Sandford, G. & Nicholas, J., Feb 2012, In : Journal of Virology. 86, 3, p. 1577-1588 12 p.

Research output: Contribution to journalArticle

vitamin K epoxide reductase
Vitamin K Epoxide Reductases
Human herpesvirus 8
Human Herpesvirus 8
interleukin-6
2010

Bim nuclear translocation and inactivation by viral interferon regulatory factor

Choi, Y. & Nicholas, J., Aug 2010, In : PLoS Pathogens. 6, 8, p. 13-14 2 p., e1001031.

Research output: Contribution to journalArticle

Human Herpesvirus 8
viral interferon regulatory factors
Antiviral Agents
Apoptosis
Viruses

Human herpesvirus 8-encoded cytokines

Nicholas, J., Mar 2010, In : Future Virology. 5, 2, p. 197-206 10 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Interleukin-6
Cytokines
Kaposi's Sarcoma
Chemokines

Induction of angiogenic chemokine CCL2 by human herpesvirus 8 chemokine receptor

Choi, Y. & Nicholas, J., Feb 20 2010, In : Virology. 397, 2, p. 369-378 10 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Chemokine CCL2
Chemokine Receptors
Viral Proteins
G-Protein-Coupled Receptors
2009

Determinants of secretion and intracellular localization of human herpesvirus 8 interleukin-6

Chen, D., Choi, Y., Sandford, G. & Nicholas, J., Jul 2009, In : Journal of Virology. 83, 13, p. 6874-6882 9 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
Human Herpesvirus 8
interleukin-6
Interleukin-6
secretion

Intracellular signaling mechanisms and activities of human herpesvirus 8 interleukin-6

Chen, D., Sandford, G. & Nicholas, J., Jan 2009, In : Journal of Virology. 83, 2, p. 722-733 12 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
Human Herpesvirus 8
interleukin-6
Interleukin-6
Primary Effusion Lymphoma

Role of ORF74-encoded viral G protein-coupled receptor in human herpesvirus 8 lytic replication

Sandford, G., Choi, Y. & Nicholas, J., Dec 2009, In : Journal of Virology. 83, 24, p. 13009-13014 6 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
Human Herpesvirus 8
Viral Proteins
G-Protein-Coupled Receptors
viruses
2008

Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines

Choi, Y. & Nicholas, J., Jul 2008, In : Journal of Virology. 82, 13, p. 6501-6513 13 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
Human Herpesvirus 8
chemokines
Virus Replication
virus replication
2007
Human Herpesvirus 8
Viruses
Viral Proteins
Cytokines
Neoplasms
2006

Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding

Verzijl, D., Pardo, L., Van Dijk, M., Gruijthuijsen, Y. K., Jongejan, A., Timmerman, H., Nicholas, J., Schwarz, M., Murphy, P. M., Leurs, R. & Smit, M. J., Nov 17 2006, In : Journal of Biological Chemistry. 281, 46, p. 35327-35335 9 p.

Research output: Contribution to journalArticle

Chemokine Receptors
Chemokines
Human Herpesvirus 8
G-Protein-Coupled Receptors
Ligands
Human herpesvirus 8
Interleukin-6 Receptors
Human Herpesvirus 8
interleukin-6
signal transduction
Human herpesvirus 8
Human Herpesvirus 8
interleukin-6
Interleukin-6
Interleukin-6 Receptors
2005

Human gammaherpesvirus cytokines and chemokine receptors

Nicholas, J., Jul 2005, In : Journal of Interferon and Cytokine Research. 25, 7, p. 373-383 11 p.

Research output: Contribution to journalArticle

Cytokine Receptors
Chemokine Receptors
Human Herpesvirus 8
Virus Replication
G-Protein-Coupled Receptors
2004

Gα Protein Selectivity Determinant Specified by a Viral Chemokine Receptor-Conserved Region in the C Tail of the Human Herpesvirus 8 G Protein-Coupled Receptor

Liu, C., Sandford, G., Fei, G. & Nicholas, J., Mar 2004, In : Journal of Virology. 78, 5, p. 2460-2471 12 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
Chemokine Receptors
Viral Proteins
G-proteins
GTP-Binding Proteins

Molecular Mechanisms for Viral Mimicry of a Human Cytokine: Activation of gp130 by HHV-8 Interleukin-6

Boulanger, M. J., Chow, D. C., Brevnova, E., Martick, M., Sandford, G., Nicholas, J. & Garcia, K. C., Jan 9 2004, In : Journal of Molecular Biology. 335, 2, p. 641-654 14 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Interleukin-6
Cytokines
2003

Human herpesvirus-8-encoded signalling ligands and receptors

Nicholas, J., 2003, In : Journal of Biomedical Science. 10, 5, p. 475-489 15 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Cytokine Receptors
Genes
Virus Diseases
Ligands
2002
Cytokine Receptor gp130
Human herpesvirus 8
Human Herpesvirus 8
interleukin-6
Interleukin-6
2001
Human herpesvirus 8
Interleukin-6 Receptors
Human Herpesvirus 8
interleukin-6
Interleukin-6
Human herpesvirus 8
Autocrine Communication
Primary Effusion Lymphoma
Macrophage Inflammatory Proteins
Human Herpesvirus 8
Human Herpesvirus 8
Herpesviridae
Genes
Proteins
Viruses
2000

Evolutionary aspects of oncogenic herpesviruses

Nicholas, J., 2000, In : Journal of Clinical Pathology. 53, 5, p. 222-237 16 p.

Research output: Contribution to journalArticle

Herpesviridae
Viruses
Genes
Genetic Loci
Biodiversity
1999

Heterogeneity of viral IL-6 expression in HHV-8-associated diseases

Cannon, J. S., Nicholas, J., Orenstein, J. M., Mann, R. B., Murray, P. G., Browning, P. J., DiGiuseppe, J. A., Cesarman, E., Hayward, G. S. & Ambinder, R. F., 1999, In : Journal of Infectious Diseases. 180, 3, p. 824-828 5 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Interleukin-6
Primary Effusion Lymphoma
Giant Lymph Node Hyperplasia
Kaposi's Sarcoma

High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations

Zong, J., Ciufo, D. M., Alcendor, D. J., Wan, X., Nicholas, J., Browning, P. J., Rady, P. L., Tyring, S. K., Orenstein, J. M., Rabkin, C. S., Su, I. J., Powell, K. F., Croxson, M., Foreman, K. E., Nickoloff, B. J., Alkan, S. & Hayward, G. S., 1999, In : Journal of Virology. 73, 5, p. 4156-4170 15 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
Human Herpesvirus 8
Kaposi's Sarcoma
membrane proteins
human population

Human herpesvirus 8-encoded thymidine kinase and phoshpotransferase homologues confer sensitivity to ganciclovir

Cannon, J. S., Hamzeh, F., Moore, S., Nicholas, J. & Ambinder, R. F., 1999, In : Journal of Virology. 73, 6, p. 4786-4793 8 p.

Research output: Contribution to journalArticle

Human herpesvirus 8
thymidine kinase
Human Herpesvirus 8
Ganciclovir
Thymidine Kinase
Human herpesvirus 8
Human Herpesvirus 8
binding properties
interleukin-6
Interleukin-6
1998

Novel organizational features, captured cellular genes, and strain variability within the genome of KSHV/HHV8.

Nicholas, J., Zong, J., Alcendor, D. J., Ciufo, D. M., Poole, L. J., Sarisky, R. T., Chiou, C. J., Zhang, X., Wan, X., Guo, H. G., Reitz, M. S. & Hayward, G. S., 1998, In : Journal of the National Cancer Institute. Monographs. 23, p. 79-88 10 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Genome
CC Chemokines
Open Reading Frames
Genes
1997
Satellite Viruses
Human Herpesvirus 8
Kaposi's Sarcoma
bcl-2 Homologous Antagonist-Killer Protein
Saimiriine Herpesvirus 2
Human herpesvirus 8
Human Herpesvirus 8
Open Reading Frames
open reading frames
Genome

Characterization of a chemokine receptor-related gene in human herpesvirus 8 and its expression in Kaposi's sarcoma

Guo, H. G., Browning, P., Nicholas, J., Hayward, G. S., Tschachler, E., Jiang, Y. W., Sadowska, M., Raffeld, M., Colombini, S., Gallo, R. C. & Reitz, M. S., Feb 17 1997, In : Virology. 228, 2, p. 371-378 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Chemokine Receptors
Kaposi's Sarcoma
Saimiriine Herpesvirus 2
Genes

Identification and analysis of a lytic-phase origin of DNA replication in human herpesvirus 7

Van Loon, N., Dykes, C., Deng, H., Dominguez, G., Nicholas, J. & Dewhurst, S., 1997, In : Journal of Virology. 71, 4, p. 3279-3284 6 p.

Research output: Contribution to journalArticle

Human herpesvirus 7
Human herpesvirus 6
Human Herpesvirus 7
Human Herpesvirus 6
Replication Origin

Identification of envelope glycoproteins H and B homologues of human herpesvirus 71

Secchiero, P., Berneman, Z. N., Sun, D., Nicholas, J. & Reitz, M. S., Jul 1997, In : Intervirology. 40, 1, p. 22-32 11 p.

Research output: Contribution to journalArticle

Human Herpesvirus 7
Herpesviridae
Glycoproteins
Clone Cells
Human Herpesvirus 6

Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6

Nicholas, J., Ruvolo, V. R., Burns, W. H., Sandford, G., Wan, X., Ciufo, D., Hendrickson, S. B., Guo, H. G., Hayward, G. S. & Reitz, M. S., 1997, In : Nature Medicine. 3, 3, p. 287-292 6 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Human Herpesvirus 8
Interleukin-6
B-Cell Lymphoma
CCR Receptors
Human herpesvirus 8
Human Herpesvirus 8
Kaposi's Sarcoma
Acquired Immunodeficiency Syndrome
Genome
1996

Cloning, restriction endonuclease mapping and partial sequence analysis of the genome of human herpesvirus 7 strain JI

Ruvolo, V. R., Berneman, Z., Secchiero, P. & Nicholas, J., Aug 1996, In : Journal of General Virology. 77, 8, p. 1901-1912 12 p.

Research output: Contribution to journalArticle

Human Herpesvirus 7
Restriction Mapping
Sequence Analysis
Organism Cloning
Clone Cells

Determination and analysis of the complete nucleotide sequence of human herpesvirus 7

Nicholas, J., Sep 1996, In : Journal of Virology. 70, 9, p. 5975-5989 15 p.

Research output: Contribution to journalArticle

Human herpesvirus 7
Human Herpesvirus 7
Human herpesvirus 6
Human Herpesvirus 6
nucleotide sequences
1995
Human Herpesvirus 6
Herpesviridae
Glycoproteins
Carrier Proteins
Genome

Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: Structural analysis and heterogeneity

Secchiero, P., Nicholas, J., Deng, H., Xiaopeng, T., Van Loon, N., Ruvolo, V. R., Berneman, Z. N., Reitz, M. S. & Dewhurst, S., 1995, In : Journal of Virology. 69, 12, p. 8041-8045 5 p.

Research output: Contribution to journalArticle

Human herpesvirus 7
Human Herpesvirus 7
Human herpesvirus 6
Forensic Anthropology
Human Herpesvirus 6

The DNA Sequence of Human Herpesvirus-6: Structure, Coding Content, and Genome Evolution

Gompels, U. A., Nicholas, J., Lawrence, G., Jones, M., Thomson, B. J., Martin, M. E. D., Efstathiou, S., Craxton, M. & Macaulay, H. A., May 10 1995, In : Virology. 209, 1, p. 29-51 23 p.

Research output: Contribution to journalArticle

Human Herpesvirus 6
Genome
Genes
Herpesviridae
Cytomegalovirus
1994
Human Herpesvirus 6
Immediate-Early Genes
Cytomegalovirus
Sequence Analysis
Genome
Human herpesvirus 6
Human herpesvirus 5
Human Herpesvirus 6
Immediate-Early Genes
Cytomegalovirus
1993

Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein

Liu, D. X., Gompels, U. A., Nicholas, J. & Lelliott, C., 1993, In : Journal of General Virology. 74, 9, p. 1847-1857 11 p.

Research output: Contribution to journalArticle

Human Herpesvirus 6
Glycoproteins
Cytomegalovirus
Serum
Simplexvirus
1992

Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: General conservation of genetic organization between HVS and Epstein-Barr virus

Nicholas, J., Cameron, K. R., Coleman, H., Newman, C. & Honess, R. W., 1992, In : Virology. 188, 1, p. 296-310 15 p.

Research output: Contribution to journalArticle

Saimiriine Herpesvirus 2
Human Herpesvirus 4
DNA
Genes
Thymidylate Synthase