John Laterra

2023

CEST2022: Amide proton transfer-weighted MRI improves the diagnostic performance of multiparametric non-contrast-enhanced MRI techniques in patients with post-treatment high-grade gliomas

Huang, Q., Wu, J., Le, N., Shen, Y., Guo, P., Schreck, K. C., Kamson, D., Blair, L., Heo, H. Y., Li, X., Li, W., Sair, H. L., Blakeley, J. O., Laterra, J., Holdhoff, M., Grossman, S. A., Mukherjee, D., Bettegowda, C., van Zijl, P., Zhou, J., & 1 othersJiang, S., Oct 2023, In: Magnetic Resonance Imaging. 102, p. 222-228 7 p.

Research output: Contribution to journal › Article › peer-review

Impact of Frontline Ivosidenib on Volumetric Growth Patterns in Isocitrate Dehydrogenase–mutant Astrocytic and Oligodendroglial Tumors

Kamson, D. O., Puri, S., Sang, Y., Shi, M. J., Blair, L., Blakeley, J. O. & Laterra, J., 2023, In: Clinical Cancer Research. 29, 23, p. 4863-4869 7 p.

Research output: Contribution to journal › Article › peer-review

Preclinical Efficacy of LP-184, a Tumor Site Activated Synthetic Lethal Therapeutic, in Glioblastoma

Lal, B., Kulkarni, A., McDermott, J., Rais, R., Alt, J., Wu, Y., Lopez-Bertoni, H., Sall, S., Kathad, U., Zhou, J., Slusher, B. S., Bhatia, K. & Laterra, J., Oct 15 2023, In: Clinical Cancer Research. 29, 20, p. 4209-4218 10 p.

Research output: Contribution to journal › Article › peer-review

Radiomics analysis of amide proton transfer-weighted and structural MR images for treatment response assessment in malignant gliomas

Jiang, S., Guo, P., Heo, H. Y., Zhang, Y., Wu, J., Jin, Y., Laterra, J., Eberhart, C. G., Lim, M. & Blakeley, J. O., Jan 2023, In: NMR in biomedicine. 36, 1, e4824.

Research output: Contribution to journal › Article › peer-review

Open Access

Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid

Douville, C., Curtis, S., Summers, M., Azad, T. D., Rincon-Torroella, J., Wang, Y., Mattox, A., Avigdor, B., Dudley, J., Materi, J., Raj, D., Nair, S., Bhanja, D., Tuohy, K., Dobbyn, L., Popoli, M., Ptak, J., Nehme, N., Silliman, N., Blair, C., & 20 othersJudge, K., Gallia, G. L., Groves, M., Jackson, C. M., Jackson, E. M., Laterra, J., Lim, M., Mukherjee, D., Weingart, J., Naidoo, J., Koschmann, C., Smith, N., Schreck, K. C., Pardo, C. A., Glantz, M., Holdhoff, M., Kinzler, K. W., Papadopoulos, N., Vogelstein, B. & Bettegowda, C., Aug 15 2023, In: Cell Reports Medicine. 4, 8, 101148.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma

Hu, C., Wang, K., Damon, C., Fu, Y., Ma, T., Kratz, L., Lal, B., Ying, M., Xia, S., Cahill, D. P., Jackson, C. M., Lim, M., Laterra, J. & Li, Y., Jun 1 2022, In: Neuro-oncology. 24, 6, p. 888-900 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Exploring glioblastoma stem cell heterogeneity: Immune microenvironment modulation and therapeutic opportunities

Johnson, A. L., Laterra, J. & Lopez-Bertoni, H., Sep 21 2022, In: Frontiers in Oncology. 12, 995498.

Research output: Contribution to journal › Review article › peer-review

Open Access

Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors

Zhou, J., Zaiss, M., Knutsson, L., Sun, P. Z., Ahn, S. S., Aime, S., Bachert, P., Blakeley, J. O., Cai, K., Chappell, M. A., Chen, M., Gochberg, D. F., Goerke, S., Heo, H. Y., Jiang, S., Jin, T., Kim, S. G., Laterra, J., Paech, D., Pagel, M. D., & 16 othersPark, J. E., Reddy, R., Sakata, A., Sartoretti-Schefer, S., Sherry, A. D., Smith, S. A., Stanisz, G. J., Sundgren, P. C., Togao, O., Vandsburger, M., Wen, Z., Wu, Y., Zhang, Y., Zhu, W., Zu, Z. & van Zijl, P. C. M., Aug 2022, In: Magnetic resonance in medicine. 88, 2, p. 546-574 29 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications

Lopez-Bertoni, H., Johnson, A., Rui, Y., Lal, B., Sall, S., Malloy, M., Coulter, J. B., Lugo-Fagundo, M., Shudir, S., Khela, H., Caputo, C., Green, J. J. & Laterra, J., Dec 2022, In: Signal Transduction and Targeted Therapy. 7, 1, 37.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting UDP-α-D-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth

Zhan, D., Yalcin, F., Ma, D., Fu, Y., Wei, S., Lal, B., Li, Y., Dzaye, O., Laterra, J., Ying, M., Lopez-Bertoni, H. & Xia, S., May 2022, In: Genes and Diseases. 9, 3, p. 717-730 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The endosomal pH regulator NHE9 is a driver of stemness in glioblastoma

Ko, M., Makena, M. R., Schiapparelli, P., Suarez-Meade, P., Mekile, A. X., Lal, B., Lopez-Bertoni, H., Kozielski, K. L., Green, J. J., Laterra, J., Quinones-Hinojosa, A. & Rao, R., Mar 1 2022, In: PNAS Nexus. 1, 1, pgac013.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Egfr activates a taz-driven oncogenic program in glioblastoma

Gao, M., Fu, Y., Zhou, W., Gui, G., Lal, B., Li, Y., Xia, S., Ji, H., Eberhart, C. G., Laterra, J. & Ying, M., Jul 1 2021, In: Cancer Research. 81, 13, p. 3580-3592 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Gary W. Goldstein

Laterra, J. & Betz, A. L., Jan 1 2021, Child Neurology: Its Origins, Founders, Growth and Evolution. Elsevier, p. 745-747 3 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Molecular clarification of brainstem astroblastoma with EWSR1‐ BEND2 fusion in a 38‐year‐old man

Smith‐cohn, M. A., Abdullaev, Z., Aldape, K. D., Quezado, M., Rosenblum, M. K., Vanderbilt, C. M., Rodriguez, F. J., Laterra, J. & Eberhart, C. G., Jan 12 2021, In: Free Neuropathology. 2, 16.

Research output: Contribution to journal › Article › peer-review

Monoallelic IDH1 R132H mutation mediates glioma cell response to anticancer therapies via induction of senescence

Zhan, D., Ma, D., Wei, S., Lal, B., Fu, Y., Eberhart, C., Laterra, J., Ying, M., Li, Y., Meeker, A., Lopez-Bertoni, H. & Xia, S., Nov 2021, In: Molecular Cancer Research. 19, 11, p. 1878-1888 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM1

Ma, D., Zhan, D., Fu, Y., Wei, S., Lal, B., Wang, J., Li, Y., Lopez-Bertoni, H., Yalcin, F., Dzaye, O., Eberhart, C. G., Laterra, J., Wilson, M. A., Ying, M. & Xia, S., Oct 1 2021, In: Cancer Letters. 517, p. 35-45 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Opinion: miRNAs – The new wave of molecular cancer therapeutics

Lopez-Bertoni, H. & Laterra, J., Jun 2021, In: Translational Oncology. 14, 6, 101064.

Research output: Contribution to journal › Article › peer-review

Open Access

Reprogramming transcription factors Oct4 and Sox2 induce a BRD-dependent immunosuppressive transcriptome in GBM-propagating cells

Ma, T., Hu, C., Lal, B., Zhou, W., Ma, Y., Ying, M., Prinos, P., Quiñones-Hinojosa, A., Lim, M., Laterra, J. & Li, Y., May 1 2021, In: Cancer Research. 81, 9, p. 2457-2469 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

A Sox2:miR-486-5p axis regulates survival of GBM cells by inhibiting tumor suppressor networks

Lopez-Bertoni, H., Kotchetkov, I. S., Mihelson, N., Lal, B., Rui, Y., Ames, H., Lugo-Fagundo, M., Guerrero-Cazares, H., Quinones-Hinojosa, A., Green, J. J. & Laterra, J., Apr 15 2020, In: Cancer Research. 80, 8, p. 1644-1655 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

d-glucose weighted chemical exchange saturation transfer (glucoCEST)-based dynamic glucose enhanced (DGE) MRI at 3T: early experience in healthy volunteers and brain tumor patients

Xu, X., Sehgal, A. A., Yadav, N. N., Laterra, J., Blair, L., Blakeley, J., Seidemo, A., Coughlin, J. M., Pomper, M. G., Knutsson, L. & van Zijl, P. C. M., Jul 1 2020, In: Magnetic resonance in medicine. 84, 1, p. 247-262 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Hemophagocytic Lymphohistiocytosis Secondary to PD-1 and IDO Inhibition in a Patient with Refractory Glioblastoma

Thummalapalli, R., Heumann, T., Stein, J., Khan, S., Priemer, D. S., Duffield, A. S., Laterra, J., Couzi, R., Lim, M. & Holdhoff, M., 2020, In: Case Reports in Oncology. 13, 2, p. 508-514 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Measuring Cancer Hallmark Mediation of the TET1 Glioma Survival Effect with Linked Neural-Network Based Mediation Experiments

Luechtefeld, T., Lin, N., Paller, C., Kuhns, K., Laterra, J. J. & Bressler, J. P., Dec 1 2020, In: Scientific reports. 10, 1, 8886.

Research output: Contribution to journal › Article › peer-review

Open Access

ShRNA-based POLD2 expression knockdown sensitizes glioblastoma to DNA-Damaging therapeutics

Xu, Q., Hu, C., Zhu, Y., Wang, K., Lal, B., Li, L., Tang, J., Wei, S., Huang, G., Xia, S., Lv, S., Laterra, J., Jiang, Y. & Li, Y., Jul 10 2020, In: Cancer Letters. 482, p. 126-135 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2019

CEST MRI of 3-O-methyl-D-glucose uptake and accumulation in brain tumors

Sehgal, A. A., Li, Y., Lal, B., Yadav, N. N., Xu, X., Xu, J., Laterra, J. & van Zijl, P. C. M., Mar 2019, In: Magnetic resonance in medicine. 81, 3, p. 1993-2000 8 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Extracellular matrix protein tenascin C increases phagocytosis mediated by CD47 Loss of function in glioblastoma

Ma, D., Liu, S., Lal, B., Wei, S., Wang, S., Zhan, D., Zhang, H., Lee, R. S., Gao, P., Lopez-Bertoni, H., Ying, M., Li, J. J., Laterra, J., Wilson, M. A. & Xia, S., 2019, In: Cancer Research. 79, 10, p. 2697-2708 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Identifying recurrent malignant glioma after treatment using amide proton transfer-weighted MR imaging: A validation study with image-guided stereotactic biopsy

Jiang, S., Eberhart, C. G., Lim, M., Heo, H. Y., Zhang, Y., Blair, L., Wen, Z., Holdhoff, M., Lin, D., Huang, P., Qin, H., Quinones-Hinojosa, A., Weingart, J. D., Barker, P. B., Pomper, M. G., Laterra, J., Van Zijl, P. C. M., Blakeley, J. O. & Zhou, J., Jan 15 2019, In: Clinical Cancer Research. 25, 2, p. 552-561 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Prospective acceleration of parallel RF transmission-based 3D chemical exchange saturation transfer imaging with compressed sensing

Heo, H. Y., Xu, X., Jiang, S., Zhao, Y., Keupp, J., Redmond, K. J., Laterra, J., van Zijl, P. C. M. & Zhou, J., Nov 2019, In: Magnetic resonance in medicine. 82, 5, p. 1812-1821 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Xue, Y., Zhan, X., Sun, S., Karuppagounder, S., Xia, S., Dawson, V. L., Dawson, T. M., Laterra, J., Zhang, J. & Ying, M., Feb 2019, In: Stem Cells Translational Medicine. 8, 2, p. 112-123 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma

Xu, X., Xu, J., Knutsson, L., Liu, J., Liu, H., Li, Y., Lal, B., Laterra, J., Artemov, D., Liu, G., van Zijl, P. C. M. & Chan, K. W. Y., Jun 2019, In: Magnetic resonance in medicine. 81, 6, p. 3798-3807 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2018

Bioreducible Polymeric Nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival

Lopez-Bertoni, H., Kozielski, K. L., Rui, Y., Lal, B., Vaughan, H., Wilson, D. R., Mihelson, N., Eberhart, C. G., Laterra, J. & Green, J. J., Jul 11 2018, In: Nano Letters. 18, 7, p. 4086-4094 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

INSM1 expression is frequent in primary central nervous system neoplasms but not in the adult brain parenchyma

Ames, H. M., Rooper, L. M., Laterra, J. J., Eberhart, C. G. & Rodriguez, F. J., May 1 2018, In: Journal of neuropathology and experimental neurology. 77, 5, p. 374-382 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Krüppel-like factor 9 and histone deacetylase inhibitors synergistically induce cell death in glioblastoma stem-like cells

Tung, B., Ma, D., Wang, S., Oyinlade, O., Laterra, J., Ying, M., Lv, S. Q., Wei, S. & Xia, S., Oct 22 2018, In: BMC cancer. 18, 1, 1025.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Re-irradiation for malignant glioma: Toward patient selection and defining treatment parameters for salvage

Shen, C. J., Kummerlowe, M. N., Redmond, K. J., Martinez-Gutierrez, J. C., Usama, S. M., Holdhoff, M., Grossman, S. A., Laterra, J. J., Strowd, R. E. & Kleinberg, L. R., Oct 1 2018, In: Advances in Radiation Oncology. 3, 4, p. 582-590 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Targeting UDP-α-d-glucose 6-dehydrogenase inhibits glioblastoma growth and migration

Oyinlade, O., Wei, S., Lal, B., Laterra, J., Zhu, H., Goodwin, C. R., Wang, S., Ma, D., Wan, J. & Xia, S., May 1 2018, In: Oncogene. 37, 20, p. 2615-2629 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2017

Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas

Jiang, S., Eberhart, C. G., Zhang, Y., Heo, H. Y., Wen, Z., Blair, L., Qin, H., Lim, M., Quinones-Hinojosa, A., Weingart, J. D., Barker, P. B., Pomper, M. G., Laterra, J., van Zijl, P. C. M., Blakeley, J. O. & Zhou, J., Sep 2017, In: European Journal of Cancer. 83, p. 9-18 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Language Mapping Using T2-Prepared BOLD Functional MRI in the Presence of Large Susceptibility Artifacts-Initial Results in Patients With Brain Tumor and Epilepsy

Hua, J., Miao, X., Agarwal, S., Bettegowda, C., Quiñones-Hinojosa, A., Laterra, J., Van Zijl, P. C. M., Pekar, J. J. & Pillai, J. J., Jun 1 2017, In: Tomography (Ann Arbor, Mich.). 3, 2, p. 105-113 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Neuro-Oncology: Current Concepts and Emerging Therapeutics

Nabors, B. & Laterra, J., Apr 1 2017, In: Neurotherapeutics. 14, 2, p. 253-255 3 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Prostate-Specific Membrane Antigen-Targeted Imaging With [18F]DCFPyL in High-Grade Gliomas

Salas Fragomeni, R. A., Menke, J. R., Holdhoff, M., Ferrigno, C., Laterra, J. J., Solnes, L. B., Javadi, M. S., Szabo, Z., Pomper, M. G. & Rowe, S. P., Oct 1 2017, In: Clinical nuclear medicine. 42, 10, p. e433-e435

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

TET1 deficiency attenuates the DNA damage response and promotes resistance to DNA damaging agents

Coulter, J. B., Lopez-Bertoni, H., Kuhns, K. J., Lee, R. S., Laterra, J. & Bressler, J. P., Oct 3 2017, In: Epigenetics. 12, 10, p. 854-864 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2016

A monoclonal antibody against KCNK9 K⁺ channel extracellular domain inhibits tumour growth and metastasis

Sun, H., Luo, L., Lal, B., Ma, X., Chen, L., Hann, C. L., Fulton, A. M., Leahy, D. J., Laterra, J. & Li, M., Feb 4 2016, In: Nature communications. 7, 10339.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Epigenetic modulation of a miR-296-5p:HMGA1 axis regulates Sox2 expression and glioblastoma stem cells

Lopez-Bertoni, H., Lal, B., Michelson, N., Guerrero-Cázares, H., Quinõnes-Hinojosa, A., Li, Y. & Laterra, J., Sep 15 2016, In: Oncogene. 35, 37, p. 4903-4913 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Extraneural Glioblastoma Multiforme Vertebral Metastasis

Goodwin, C. R., Liang, L., Abu-Bonsrah, N., Hdeib, A., Elder, B. D., Kosztowski, T., Bettegowda, C., Laterra, J., Burger, P. & Sciubba, D. M., May 1 2016, In: World neurosurgery. 89, p. 578-582.e3

Research output: Contribution to journal › Review article › peer-review

Open Access

23 Scopus citations

Investigational new drugs for brain cancer

Staedtke, V., Bai, R. Y. & Laterra, J., Aug 2 2016, In: Expert Opinion on Investigational Drugs. 25, 8, p. 937-956 20 p.

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Microarray-based phospho-proteomic profiling of complex biological systems

Goodwin, C. R., Woodard, C. L., Zhou, X., Pan, J., Olivi, A., Xia, S., Bettegowda, C., Sciubba, D. M., Pevsner, J., Zhu, H. & Laterra, J., Apr 1 2016, In: Translational Oncology. 9, 2, p. 124-129 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151

Tilghman, J., Schiapparelli, P., Lal, B., Ying, M., Quinones-Hinojosa, A., Xia, S. & Laterra, J., 2016, In: Neoplasia (United States). 18, 3, p. 185-198 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access