John J Laterra

Professor

1977 …2018
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Research Output 1977 2018

2018
Central Nervous System Neoplasms
Insulinoma
Brain
Proteins
Staining and Labeling

Targeting UDP-α-d-glucose 6-dehydrogenase inhibits glioblastoma growth and migration

Oyinlade, O., Wei, S., Lal, B., Laterra, J., Zhu, H., Goodwin, C. R., Wang, S., Ma, D., Wan, J. & Xia, S. Feb 26 2018 (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Uridine Diphosphate Glucose Dehydrogenase
Glucose 1-Dehydrogenase
Uridine Diphosphate
Glioblastoma
Growth
2017
Image-Guided Biopsy
Amides
Glioma
Protons
Magnetic Resonance Spectroscopy

Neuro-Oncology: Current Concepts and Emerging Therapeutics

Nabors, B. & Laterra, J. Apr 1 2017 In : Neurotherapeutics. 14, 2, p. 253-255 3 p.

Research output: Contribution to journalEditorial

Therapeutics

Prostate-Specific Membrane Antigen–Targeted Imaging With [18F]DCFPyL in High-Grade Gliomas

Salas Fragomeni, R. A., Menke, J. R., Holdhoff, M., Ferrigno, C., Laterra, J. J., Solnes, L. B., Javadi, M. S., Szabo, Z., Pomper, M. G. & Rowe, S. P. Jul 22 2017 (Accepted/In press) In : Clinical Nuclear Medicine.

Research output: Contribution to journalArticle

Glioma
Astrocytoma
Residual Neoplasm
Glioblastoma
Brain Neoplasms

TET1 deficiency attenuates the DNA damage response and promotes resistance to DNA damaging agents

Coulter, J. B., Lopez-Bertoni, H., Kuhns, K. J., Lee, R. S., Laterra, J. & Bressler, J. P. Nov 1 2017 (Accepted/In press) In : Epigenetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

DNA Damage
Cyclin B1
Genomic Instability
DNA
Ionizing Radiation
2016

A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis

Sun, H., Luo, L., Lal, B., Ma, X., Chen, L., Hann, C. L., Fulton, A. M., Leahy, D. J., Laterra, J. & Li, M. Feb 4 2016 In : Nature Communications. 7, 10339

Research output: Contribution to journalArticle

metastasis
antibodies
Tumors
tumors
cancer

Epigenetic modulation of a miR-296-5p: HMGA1 axis regulates Sox2 expression and glioblastoma stem cells

Lopez-Bertoni, H., Lal, B., Michelson, N., Guerrero-Cázares, H., Quiñones-Hinojosa, A., Li, Y. & Laterra, J. Feb 22 2016 (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Glioblastoma
Epigenomics
Stem Cells
Neoplastic Stem Cells
Neoplasms

Investigational new drugs for brain cancer

Staedtke, V., Bai, R. Y. & Laterra, J. Aug 2 2016 In : Expert Opinion on Investigational Drugs. 25, 8, p. 937-956 20 p.

Research output: Contribution to journalReview article

Investigational Drugs
Brain Neoplasms
Epigenomics
Therapeutics
Glioma

Microarray-based phospho-proteomic profiling of complex biological systems

Goodwin, C. R., Woodard, C. L., Zhou, X., Pan, J., Olivi, A., Xia, S., Bettegowda, C., Sciubba, D. M., Pevsner, J., Zhu, H. & Laterra, J. Apr 1 2016 In : Translational Oncology. 9, 2, p. 124-129 6 p.

Research output: Contribution to journalArticle

Protein Array Analysis
Proteomics
Phosphotransferases
Tumor Microenvironment
Glioma

Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151

Tilghman, J., Schiapparelli, P., Lal, B., Ying, M., Quinones-Hinojosa, A., Xia, S. & Laterra, J. 2016 In : Neoplasia. 18, 3, p. 185-198 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Integrins
Stem Cells
Neoplasms
Cell Movement
Salicylic acid
Dendrimers
Salicylic Acid
dendrimers
Magnetic resonance imaging

Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation

Xia, S., Lal, B., Tung, B., Wang, S., Goodwin, C. R. & Laterra, J. Apr 1 2016 In : Neuro-Oncology. 18, 4, p. 507-517 11 p.

Research output: Contribution to journalArticle

Tenascin
Tumor Microenvironment
Glioblastoma
Neoplasms
Brain Neoplasms

Updates from the Neuro-Oncology section of the 2015 American Neurological Association annual meeting

Lukas, R. V., Wainwright, D. A. & Laterra, J. J. Jan 1 2016 In : Future Oncology. 12, 2, p. 143-147 5 p.

Research output: Contribution to journalArticle

Immunotherapy
National Institute of Neurological Disorders and Stroke
Neurocutaneous Syndromes
Dioxygenases
Tuberous Sclerosis
2015

Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature

Khattab, M. H., Marciscano, A. E., Lo, S. S., Lim, M., Laterra, J. J., Kleinberg, L. R. & Redmond, K. J. Jan 1 2015 In : Case Reports in Oncological Medicine. 2015, 431819

Research output: Contribution to journalReview article

Glioblastoma
Neoplasm Metastasis
Therapeutics
Life Expectancy
Molecular Biology

DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2

Lopez-Bertoni, H., Lal, B., Li, A., Caplan, M., Guerrero-Cázares, H., Eberhart, C. G., Quiñones-Hinojosa, A., Glas, M., Scheffler, B., Laterra, J. & Li, Y. Jul 23 2015 In : Oncogene. 34, 30, p. 3994-4004 11 p.

Research output: Contribution to journalArticle

Transferases
MicroRNAs
Phenotype
DNA
Neoplasms
Blood Volume
Blood-Brain Barrier
Brain Neoplasms
Glucose
Area Under Curve

Extraneural Glioblastoma Multiforme Vertebral Metastasis

Goodwin, C. R., Liang, L., Abu-Bonsrah, N., Hdeib, A., Elder, B. D., Kosztowski, T., Bettegowda, C., Laterra, J., Burger, P. & Sciubba, D. M. Aug 21 2015 (Accepted/In press) In : World Neurosurgery.

Research output: Contribution to journalArticle

Glioblastoma
Neoplasm Metastasis
Survival
Central Nervous System Neoplasms
Neurologic Manifestations

Identification of Global DNA Methylation Signatures in Glioblastoma-Derived Cancer Stem Cells

Lee, E. J., Rath, P., Liu, J., Ryu, D., Pei, L., Noonepalle, S. K., Shull, A. Y., Feng, Q., Litofsky, N. S., Miller, D. C., Anthony, D. C., Kirk, M. D., Laterra, J., Deng, L., Xin, H. B., Wang, X., Choi, J. H. & Shi, H. Jul 20 2015 In : Journal of Genetics and Genomics. 42, 7, p. 355-371 17 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
DNA Methylation
Glioblastoma
Epigenomics
Neoplasms
Noise
Glioblastoma
Principal Component Analysis
Protons
Neoplasms

Parallel reconstruction in accelerated multivoxel MR spectroscopy

Boer, V. O., Klomp, D. W. J., Laterra, J. & Barker, P. B. Sep 1 2015 In : Magnetic Resonance in Medicine. 74, 3, p. 599-606 8 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Oligodendroglioma
Motor Cortex
Artifacts
Noise
temozolomide
Prolactinoma
Retreatment
Pituitary Neoplasms
Prolactin
2014

HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells

Tilghman, J., Wu, H., Sang, Y., Shi, X., Guerrero-Cazares, H., Quinones-Hinojosa, A., Eberhart, C. G., Laterra, J. & Ying, M. Jun 1 2014 In : Cancer Research. 74, 11, p. 3168-3179 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Stem Cells
Neoplastic Stem Cells
Neoplasms
Therapeutics

Kruppel-like factor-9 (KLF9) inhibits glioblastoma stemness through global transcription repression and integrin α6 inhibition

Ying, M., Tilghman, J., Wei, Y., Guerrero-Cazares, H., Quinones-Hinojosa, A., Ji, H. & Laterra, J. Nov 21 2014 In : Journal of Biological Chemistry. 289, 47, p. 32742-32756 15 p.

Research output: Contribution to journalArticle

Kruppel-Like Transcription Factors
Transcription
Glioblastoma
Integrins
Cell Differentiation

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity

Sun, P., Xia, S., Lal, B., Shi, X., Yang, K. S., Watkins, P. A. & Laterra, J. Jun 4 2014 In : BMC Cancer. 14, 1, 401

Research output: Contribution to journalArticle

Coenzyme A Ligases
Glioblastoma
Lipid Metabolism
Stem Cells
Maintenance
Pluripotent Stem Cells
Dopaminergic Neurons
Transcription Factors
Parkinson Disease
Neurons

Quantitative multiparametric MRI assessment of glioma response to radiotherapy in a rat model

Hong, X., Liu, L., Wang, M., Ding, K., Fan, Y., Ma, B., Lal, B., Tyler, B., Mangraviti, A., Wang, S., Wong, J., Laterra, J. & Zhou, J. 2014 In : Neuro-Oncology. 16, 6, p. 856-867 12 p.

Research output: Contribution to journalArticle

Glioma
Radiotherapy
Neoplasms
Amides
Protons
2013

In vivo c-Met pathway inhibition depletes human glioma xenografts of tumor-propagating stem-like cells

Rath, P., Lal, B., Ajala, O., Li, Y., Xia, S., Kim, J. & Laterra, J. Apr 2013 In : Translational Oncology. 6, 2, p. 104-111 8 p.

Research output: Contribution to journalArticle

Heterografts
Glioma
Stem Cells
Neoplasms
Neoplastic Stem Cells

Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling.

Woodard, C. L., Goodwin, C. R., Wan, J., Xia, S., Newman, R., Hu, J., Zhang, J., Hayward, S. D., Qian, J., Laterra, J. & Zhu, H. 2013 In : PLoS One. 8, 9, e72671

Research output: Contribution to journalArticle

hepatocyte growth factor
Hepatocyte Growth Factor
protein phosphorylation
Phosphorylation
Protein Array Analysis
Gadolinium
Amides
Glioma
Protons
Brain
2012

Cancer stem cells: Distinct entities or dynamically regulated phenotypes?

Li, Y. & Laterra, J. Feb 1 2012 In : Cancer Research. 72, 3, p. 576-580 5 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Phenotype
Neoplasms
Stem Cells
Cues

Collagen IV and CXC chemokine-derived antiangiogenic peptides suppress glioma xenograft growth

Rosca, E. V., Lal, B., Koskimaki, J. E., Popel, A. S. & Laterra, J. Aug 2012 In : Anti-Cancer Drugs. 23, 7, p. 706-712 7 p.

Research output: Contribution to journalArticle

CXC Chemokines
Heterografts
Glioma
Collagen
Peptides

EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase

Wang, S. D., Rath, P., Lal, B., Richard, J. P., Li, Y., Goodwin, C. R., Laterra, J. & Xia, S. Dec 13 2012 In : Oncogene. 31, 50, p. 5132-5143 12 p.

Research output: Contribution to journalArticle

EphB2 Receptors
Focal Adhesion Protein-Tyrosine Kinases
Glioblastoma
Cell Movement
Cell Proliferation

Evaluation of radiation necrosis and malignant glioma in rat models using diffusion tensor MR imaging

Wang, S., Chen, Y., Lal, B., Ford, E., Tryggestad, E., Armour, M., Yan, K., Laterra, J. & Zhou, J. Mar 2012 In : Journal of Neuro-Oncology. 107, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Diffusion Tensor Imaging
Glioma
Necrosis
Radiation
Gliosarcoma

Influence of bioluminescence imaging dynamics by dluciferin uptake and efflux mechanisms

Zhang, Y., Pullambhatla, M., Laterra, J. & Pomper, M. G. Nov 2012 In : Molecular Imaging. 11, 6, p. 499-506 8 p.

Research output: Contribution to journalArticle

Bioluminescence
bioluminescence
efflux
Imaging techniques
transporter
Neoplastic Stem Cells
DNA-Binding Proteins
Glioblastoma
Transcription Factors
Stem Cells
2011

A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma

Wen, P. Y., Schiff, D., Cloughesy, T. F., Raizer, J. J., Laterra, J., Smitt, M., Wolf, M., Oliner, K. S., Anderson, A., Zhu, M., Loh, E. & Reardon, D. A. Apr 2011 In : Neuro-Oncology. 13, 4, p. 437-446 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Safety
Hepatocyte Growth Factor
Disease-Free Survival
Gliosarcoma

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

Li, Y., Li, A., Glas, M., Lal, B., Ying, M., Sang, Y., Xia, S., Trageser, D., Guerrero-Cázares, H., Eberhart, C. G., Quiñones-Hinojosa, A., Scheffler, B. & Laterra, J. Jun 14 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 24, p. 9951-9956 6 p.

Research output: Contribution to journalArticle

Glioblastoma
Phenotype
Neoplastic Stem Cells
Transcription Factors
Stem Cells

Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides

Zhou, J., Tryggestad, E., Wen, Z., Lal, B., Zhou, T., Grossman, R., Wang, S., Yan, K., Fu, D. X., Ford, E., Tyler, B., Blakeley, J., Laterra, J. & Van Zijl, P. C. M. Jan 2011 In : Nature Medicine. 17, 1, p. 130-134 5 p.

Research output: Contribution to journalArticle

Magnetic resonance
Amides
Glioma
Proton transfer
Protons

Krüppel-like family of transcription factor 9, a differentiation- associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells

Ying, M., Sang, Y., Li, Y., Guerrero-Cazares, H., Quinones-Hinojosa, A., Vescovi, A. L., Eberhart, C. G., Xia, S. & Laterra, J. Jan 2011 In : Stem Cells. 29, 1, p. 20-31 12 p.

Research output: Contribution to journalArticle

Kruppel-Like Transcription Factors
Neoplastic Stem Cells
Glioblastoma
Transcription Factors
Stem Cells

PTEN reconstitution alters glioma responses to c-Met pathway inhibition

Rory Goodwin, C., Lal, B., Ho, S., Woodard, C. L., Zhou, X., Taeger, A., Xia, S. & Laterra, J. Oct 2011 In : Anti-Cancer Drugs. 22, 9, p. 905-912 8 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Glioma
Heterografts
Growth
Receptor Protein-Tyrosine Kinases

Regulation of glioblastoma stem cells by retinoic acid: Role for Notch pathway inhibition

Ying, M., Wang, S., Sang, Y., Sun, P., Lal, B., Goodwin, C. R., Guerrero-Cazares, H., Quinones-Hinojosa, A., Laterra, J. & Xia, S. Aug 4 2011 In : Oncogene. 30, 31, p. 3454-3467 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Tretinoin
Stem Cells
Neoplastic Stem Cells
Down-Regulation

Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression

Bhang, H. E. C., Gabrielson, K. L., Laterra, J., Fisher, P. B. & Pomper, M. G. Jan 2011 In : Nature Medicine. 17, 1, p. 123-129 7 p.

Research output: Contribution to journalArticle

Gene expression
Tumors
Genes
Gene Expression
Imaging techniques
2010

Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation

Goodwin, C. R., Lal, B., Zhou, X., Ho, S., Xia, S., Taeger, A., Murray, J. & Laterra, J. Apr 1 2010 In : Cancer Research. 70, 7, p. 2932-2941 10 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Cell Movement
Glioma
Growth
Small Interfering RNA

FasL gene knock-down therapy enhances the antiglioma immune response

Jansen, T., Tyler, B., Mankowski, J. L., Recinos, V. R., Pradilla, G., Legnani, F., Laterra, J. & Olivi, A. May 2010 In : Neuro-Oncology. 12, 5, p. 482-489 8 p.

Research output: Contribution to journalArticle

Gene Knockdown Techniques
Glioma
Neoplasms
T-Lymphocytes
Therapeutics

Molecular therapy targeting Sonic hedgehog and hepatocyte growth factor signaling in a mouse model of medulloblastoma

Coon, V., Laukert, T., Pedone, C. A., Laterra, J., Kim, K. J. & Fults, D. W. Sep 2010 In : Molecular Cancer Therapeutics. 9, 9, p. 2627-2636 10 p.

Research output: Contribution to journalArticle

Medulloblastoma
Hepatocyte Growth Factor
Hedgehogs
Therapeutics
Neutralizing Antibodies

Neuro-oncology: Unmasking the multiforme in glioblastoma

Goodwin, C. R. & Laterra, J. Jun 2010 In : Nature Reviews Neurology. 6, 6, p. 304-305 2 p.

Research output: Contribution to journalArticle

Genomic Library
Glioblastoma
Brain Neoplasms

Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults

Chaichana, K. L., Kosztowski, T., Niranjan, A. N. I., Olivi, A., Weingart, J. D., Laterra, J., Brem, H. & Quiñones-Hinojosa, A. Aug 2010 In : Journal of Neurosurgery. 113, 2, p. 286-292 7 p.

Research output: Contribution to journalArticle

Astrocytoma
Survival
Recurrence
Neoplasms
Craniotomy

Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas: Clinical article

Chaichana, K. L., McGirt, M. J., Laterra, J., Olivi, A. & Quiñones-Hinojosa, A. Jan 2010 In : Journal of Neurosurgery. 112, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

Glioma
Recurrence
Neoplasms
Astrocytoma
Oligodendroglioma