Research Output 1981 2017

2017

RNA sequencing of esophageal adenocarcinomas identifies novel fusion transcripts, including NPC1-MELK, arising from a complex chromosomal rearrangement

Wang, Z., Cheng, Y., Abraham, J. M., Yan, R., Liu, X., Chen, W., Ibrahim, S., Schroth, G. P., Ke, X., He, Y. & Meltzer, S. J. 2017 (Accepted/In press) In : Cancer.

Research output: Research - peer-reviewArticle

RNA Sequence Analysis
Leucine Zippers
Adenocarcinoma
Phosphotransferases
Mothers

The novel fusion transcript NR5A2-KLHL29FT is generated by an insertion at the KLHL29 locus

Sun, Z., Ke, X., Salzberg, S. L., Kim, D., Antonescu, V., Cheng, Y., Huang, B., Song, J. H., Abraham, J. M., Ibrahim, S., Tian, H. & Meltzer, S. J. 2017 (Accepted/In press) In : Cancer.

Research output: Research - peer-reviewArticle

Cytoplasmic and Nuclear Receptors
Colonic Neoplasms
Epithelium
Neoplasms
RNA Sequence Analysis
2016

Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression

Huang, B., Song, J. H., Cheng, Y., Abraham, J. M., Ibrahim, S., Sun, Z., Ke, X. & Meltzer, S. J. Feb 15 2016 (Accepted/In press) In : Oncogene.

Research output: Research - peer-reviewArticle

Long Noncoding RNA
Antisense RNA
Stomach Neoplasms
Neoplasms
Keratin-7
2015

Phosphorus-32, a clinically available drug, inhibits cancer growth by inducing DNA double-strand breakage

Cheng, Y., Kiess, A. P., Herman, J. M., Pomper, M. G., Meltzer, S. J. & Abraham, J. M. Jun 1 2015 In : PLoS One. 10, 6, 0128152

Research output: Research - peer-reviewArticle

radionuclides
isotopes
electrons
phosphorus
drugs
2014

Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells

Yang, X., Song, J. H., Cheng, Y., Wu, W., Bhagat, T., Yu, Y., Abraham, J. M., Ibrahim, S., Ravich, W., Roland, B. C., Khashab, M., Singh, V. K., Shin, E. J., Yang, X., Verma, A. K., Meltzer, S. J. & Mori, Y. Jun 1 2014 In : Gut. 63, 6, p. 881-890 10 p.

Research output: Research - peer-reviewArticle

Long Noncoding RNA
Adenocarcinoma
RNA Sequence Analysis
Biological Assay
Small Interfering RNA
2013

Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma

Wu, W., Bhagat, T. D., Yang, X., Song, J. H., Cheng, Y., Agarwal, R., Abraham, J. M., Ibrahim, S., Bartenstein, M., Hussain, Z., Suzuki, M., Yu, Y., Chen, W., Eng, C., Greally, J., Verma, A. & Meltzer, S. J. May 2013 In : Gastroenterology. 144, 5

Research output: Research - peer-reviewArticle

Long Noncoding RNA
Barrett Esophagus
Adenocarcinoma
DNA
Methylation

MicroRNA-224 negatively regulates p21 expression during late neoplastic progression in inflammatory bowel disease

Olaru, A. V., Yamanaka, S., Vazquez, C., Mori, Y., Cheng, Y., Abraham, J. M., Bayless, T. M., Harpaz, N., Selaru, F. M. & Meltzer, S. J. Mar 2013 In : Inflammatory Bowel Diseases. 19, 3, p. 471-480 10 p.

Research output: Research - peer-reviewArticle

MicroRNAs
Inflammatory Bowel Diseases
Neoplasms
Cell Cycle
Messenger RNA
2012

[32P]ATP inhibits the growth of xenografted tumors in nude mice

Cheng, Y., Senthamizhchelvan, S., Agarwal, R., Green, G. M., Mease, R. C., Sgouros, G., Huso, D. L., Pomper, M. G., Meltzer, S. J. & Abraham, J. M. May 15 2012 In : Cell cycle (Georgetown, Tex.). 11, 10, p. 1878-1882 5 p.

Research output: Research - peer-reviewArticle

Nude Mice
Adenosine Triphosphate
Growth
Neoplasms
Antineoplastic Agents

Epigenomic program of Barrett's-associated neoplastic progression reveals possible involvement of insulin signaling pathways

Agarwal, R., Jin, Z., Yang, J., Mori, Y., Song, J. H., Kumar, S., Sato, M., Cheng, Y., Olaru, A. V., Abraham, J. M., Verma, A. & Meltzer, S. J. Feb 2012 In : Endocrine-Related Cancer. 19, 1

Research output: Research - peer-reviewArticle

Neoplastic Gene Expression Regulation
Insulin-Like Growth Factor Binding Proteins
CpG Islands
Barrett Esophagus
Gene Expression Profiling

LARP7 is a potential tumor suppressor gene in gastric cancer

Cheng, Y., Jin, Z., Agarwal, R., Ma, K., Yang, J., Ibrahim, S., Olaru, A. V., David, S., Ashktorab, H., Smoot, D. T., Duncan, M. D., Hutcheon, D. F., Abraham, J. M., Meltzer, S. J. & Mori, Y. Jul 2012 In : Laboratory Investigation. 92, 7, p. 1013-1019 7 p.

Research output: Research - peer-reviewArticle

Tumor Suppressor Genes
Stomach Neoplasms
Stomach
Peptide Elongation Factors
Transcription Factors

Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancers

Olaru, A. V., Cheng, Y., Agarwal, R., Yang, J., David, S., Abraham, J. M., Yu, W., Kwon, J. H., Lazarev, M., Brant, S. R., Marohn, M. R., Hutcheon, D. F., Harpaz, N., Meltzer, S. J. & Mori, Y. Apr 2012 In : Inflammatory Bowel Diseases. 18, 4, p. 641-648 8 p.

Research output: Research - peer-reviewArticle

CpG Islands
Inflammatory Bowel Diseases
Methylation
Colorectal Neoplasms
Phenotype
2011

Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation

Olaru, A. V., Selaru, F. M., Mori, Y., Vazquez, C., David, S., Paun, B., Cheng, Y., Jin, Z., Yang, J., Agarwal, R., Abraham, J. M., Dassopoulos, T., Harris, M., Bayless, T. M., Kwon, J., Harpaz, N., Livak, F. & Meltzer, S. J. Jan 2011 In : Inflammatory Bowel Diseases. 17, 1, p. 221-231 11 p.

Research output: Research - peer-reviewArticle

MicroRNAs
Inflammatory Bowel Diseases
Neoplasms
Hypoxia-Inducible Factor 1
Inflammation

MicroRNA-192 and-215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro

Jin, Z., Selaru, F. M., Cheng, Y., Kan, T., Agarwal, R., Mori, Y., Olaru, A. V., Yang, J., David, S., Hamilton, J. P., Abraham, J. M., Harmon, J., Duncan, M., Montgomery, E. A. & Meltzer, S. J. Mar 31 2011 In : Oncogene. 30, 13, p. 1577-1585 9 p.

Research output: Research - peer-reviewArticle

Activated-Leukocyte Cell Adhesion Molecule
MicroRNAs
Stomach Neoplasms
In Vitro Techniques
Stomach

Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer

Ito, T., Sato, F., Kan, T., Cheng, Y., David, S., Agarwal, R., Paun, B. C., Jin, Z., Olaru, A. V., Hamilton, J. P., Selaru, F. M., Yang, J., Matsumura, N., Shimizu, K., Abraham, J. M., Shimada, Y., Mori, Y. & Meltzer, S. J. Nov 1 2011 In : International Journal of Cancer. 129, 9, p. 2134-2146 13 p.

Research output: Research - peer-reviewArticle

Esophageal Neoplasms
Cell Proliferation
polo-like kinase 1
Luciferases
MicroRNAs

Strong inhibition of xenografted tumor growth by low-level doses of [ 32P]ATP

Cheng, Y., Yang, J., Agarwal, R., Green, G. M., Mease, R. C., Pomper, M. G., Meltzer, S. J. & Abraham, J. M. Jun 2011 In : Oncotarget. 2, 6, p. 461-466 6 p.

Research output: Research - peer-reviewArticle

Adenosine Triphosphate
Growth
Neoplasms
Nude Mice
Intravenous Injections
2009

A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus

Jin, Z. , Cheng, Y. , Gu, W. , Zheng, Y. , Sato, F. , Mori, Y. , Olaru, A. V. , Paun, B. C. , Yang, J. , Kan, T. , Ito, T. , Hamilton, J. P. , Selaru, F. M. , Agarwal, R. , David, S. , Abraham, J. M. , Wolfsen, H. C. , Wallace, M. B. , Shaheen, N. J. , Washington, K. & 10 others Wang, J., Canto, M. I., Bhattacharyya, A., Nelson, M. A., Wagner, P. D., Romero, Y., Wang, K. K., Feng, Z., Sampliner, R. E. & Meltzer, S. J. May 15 2009 In : Cancer Research. 69, 10, p. 4112-4115 4 p.

Research output: Research - peer-reviewArticle

Barrett Esophagus
Validation Studies
Methylation
Biomarkers
ROC Curve

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3

Selaru, F. M. , Olaru, A. V. , Kan, T. , David, S. , Cheng, Y. , Mori, Y. , Yang, J. , Paun, B. , Jin, Z. , Agarwal, R. , Hamilton, J. P. , Abraham, J. , Georgiades, C. , Alvarez, H. , Vivekanandan, P. , Yu, W. , Maitra, A. , Torbenson, M. , Thuluvath, P. J. , Gores, G. J. & 3 others LaRusso, N. F., Hruban, R. & Meltzer, S. J. May 2009 In : Hepatology. 49, 5, p. 1595-1601 7 p.

Research output: Research - peer-reviewArticle

Tissue Inhibitor of Metalloproteinase-3
Cholangiocarcinoma
MicroRNAs
Cell Death
Reverse Transcriptase Polymerase Chain Reaction

Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells

Agarwal, R., Mori, Y., Cheng, Y., Jin, Z., Olaru, A. V., Hamilton, J. P., David, S., Selaru, F. M., Yang, J., Abraham, J. M., Montgomery, E., Morin, P. J. & Meltzer, S. J. Nov 24 2009 In : PLoS One. 4, 11, e8002

Research output: Research - peer-reviewArticle

Methylation
Genetic Promoter Regions
Cells
Tissue
stomach neoplasms

The miR-106b-25 Polycistron, Activated by Genomic Amplification, Functions as an Oncogene by Suppressing p21 and Bim

Kan, T., Sato, F., Ito, T., Matsumura, N., David, S., Cheng, Y., Agarwal, R., Paun, B. C., Jin, Z., Olaru, A. V., Selaru, F. M., Hamilton, J. P., Yang, J., Abraham, J. M., Mori, Y. & Meltzer, S. J. May 2009 In : Gastroenterology. 136, 5, p. 1689-1700 12 p.

Research output: Research - peer-reviewArticle

Oncogenes
Messenger RNA
Barrett Esophagus
MicroRNAs
Adenocarcinoma
2008

Generation of small 32P-labeled peptides as a potential approach to colorectal cancer therapy

Abraham, J. M., Cheng, Y., Hamilton, J. P., Paun, B., Jin, Z., Agarwal, R., Kan, T., David, S., Olaru, A., Yang, J., Ito, T., Selaru, F. M., Mori, Y. & Meltzer, S. J. Jun 25 2008 In : PLoS One. 3, 6, e2508

Research output: Research - peer-reviewArticle

colorectal neoplasms
peptides
therapeutics
Colorectal Neoplasms
Peptides

Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression

Jin, Z., Hamilton, J. P., Yang, J., Mori, Y., Olaru, A., Sato, F., Ito, T., Kan, T., Cheng, Y., Paun, B., David, S., Beer, D. G., Agarwal, R., Abraham, J. M. & Meltzer, S. J. Jan 1 2008 In : Cancer Epidemiology Biomarkers and Prevention. 17, 1, p. 111-117 7 p.

Research output: Research - peer-reviewArticle

Protein Kinases
Biomarkers
Adenocarcinoma
Barrett Esophagus
Esophagus

Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma

Ito, T., Shimada, Y., Kan, T., David, S., Cheng, Y., Mori, Y., Agarwal, R., Paun, B., Jin, Z., Olaru, A., Hamilton, J. P., Yang, J., Abraham, J. M., Meltzer, S. J. & Sato, F. May 1 2008 In : Cancer Research. 68, 9, p. 3214-3224 11 p.

Research output: Research - peer-reviewArticle

Pituitary Neoplasms
Cell Movement
Lymph Nodes
Neoplasm Metastasis
Esophageal Squamous Cell Carcinoma

Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors

Jin, Z., Cheng, Y., Olaru, A., Kan, T., Yang, J., Paun, B., Ito, T., Hamilton, J. P., David, S., Agarwal, R., Selaru, F. M., Sato, F., Abraham, J. M., Beer, D. G., Mori, Y., Shimada, Y. & Meltzer, S. J. Nov 15 2008 In : International Journal of Cancer. 123, 10, p. 2331-2336 6 p.

Research output: Research - peer-reviewArticle

Barrett Esophagus
Methylation
Adenocarcinoma
Esophageal Squamous Cell Carcinoma
Esophagus

Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features

Sato, F. , Jin, Z. , Schulmann, K. , Wang, J. , Greenwald, B. D. , Ito, T. , Kan, T. , Hamilton, J. P. , Yang, J. , Paun, B. , David, S. , Olaru, A. , Cheng, Y. , Mori, Y. , Abraham, J. M. , Yfantis, H. G. , Wu, T. T. , Fredericksen, M. B. , Wang, K. K. , Canto, M. & 3 others Romero, Y., Feng, Z. & Meltzer, S. J. Apr 2 2008 In : PLoS One. 3, 4, e1890

Research output: Research - peer-reviewArticle

esophagus
epigenetics
Barrett Esophagus
Epigenomics
adenocarcinoma
2007

Hypermethylation of tachykinin-1 is a potential biomarker in human esophageal cancer

Jin, Z., Olaru, A., Yang, J., Sato, F., Cheng, Y., Kan, T., Mori, Y., Mantzur, C., Paun, B., Hamilton, J. P., Ito, T., Wang, S., David, S., Agarwal, R., Beer, D. G., Abraham, J. M. & Meltzer, S. J. Nov 1 2007 In : Clinical Cancer Research. 13, 21, p. 6293-6300 8 p.

Research output: Research - peer-reviewArticle

Tachykinins
Esophageal Neoplasms
Biomarkers
Barrett Esophagus
Methylation

Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma

Jin, Z., Mori, Y., Yang, J., Sato, F., Ito, T., Cheng, Y., Paun, B., Hamilton, J. P., Kan, T., Olaru, A., David, S., Agarwal, R., Abraham, J. M., Beer, D., Montgomery, E. & Meltzer, S. J. Sep 20 2007 In : Oncogene. 26, 43, p. 6332-6340 9 p.

Research output: Research - peer-reviewArticle

Loss of Heterozygosity
Methylation
Adenocarcinoma
Chromosomes
Polymerase Chain Reaction

Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells

Abraham, J. M., Sato, F., Cheng, Y., Paun, B., Kan, T., Olaru, A., Jin, Z., Yang, J., Agarwal, R., David, S., Hamilton, J. P., Ito, T., Mori, Y. & Meltzer, S. J. Oct 3 2007 In : PLoS One. 2, 10, e964

Research output: Research - peer-reviewArticle

radionuclides
colorectal neoplasms
neoplasms
neoplasm cells
Radioisotopes
2006

A Genome-Wide Search Identifies Epigenetic Silencing of Somatostatin, Tachykinin-1, and 5 Other Genes in Colon Cancer

Mori, Y., Cai, K., Cheng, Y., Wang, S., Paun, B., Hamilton, J. P., Jin, Z., Sato, F., Berki, A. T., Kan, T., Ito, T., Mantzur, C., Abraham, J. M. & Meltzer, S. J. Sep 2006 In : Gastroenterology. 131, 3, p. 797-808 12 p.

Research output: Research - peer-reviewArticle

Tachykinins
Somatostatin
Epigenomics
Colonic Neoplasms
Methylation

Mutational and LOH analyses of the chromosome 4q region in esophageal adenocarcinoma

Sterian, A., Kan, T., Berki, A. T., Mori, Y., Olaru, A., Schulmann, K., Sato, F., Wang, S., Paun, B., Cai, K., Hamilton, J. P., Abraham, J. M. & Meltzer, S. J. Jul 2006 In : Oncology. 70, 3, p. 168-172 5 p.

Research output: Research - peer-reviewArticle

Loss of Heterozygosity
Adenocarcinoma
Chromosomes
Tumor Suppressor Genes
Neoplasms

Polo-like kinase and survivin are esophageal tumor-specific promoters

Sato, F., Abraham, J. M., Yin, J., Kan, T., Ito, T., Mori, Y., Hamilton, J. P., Jin, Z., Cheng, Y., Paun, B., Berki, A. T., Wang, S., Shimada, Y. & Meltzer, S. J. Apr 7 2006 In : Biochemical and Biophysical Research Communications. 342, 2, p. 465-471 7 p.

Research output: Research - peer-reviewArticle

Carcinogens
Phosphotransferases
Genes
Tumors
Esophageal Neoplasms

Promoter Methylation and Response to Chemotherapy and Radiation in Esophageal Cancer

Hamilton, J. P., Sato, F., Greenwald, B. D., Suntharalingam, M., Krasna, M. J., Edelman, M. J., Doyle, A., Berki, A. T., Abraham, J. M., Mori, Y., Kan, T., Mantzur, C., Paun, B., Wang, S., Ito, T., Jin, Z. & Meltzer, S. J. Jun 2006 In : Clinical Gastroenterology and Hepatology. 4, 6, p. 701-708 8 p.

Research output: Research - peer-reviewArticle

Esophageal Neoplasms
Methylation
Radiation
Drug Therapy
Genes

Reprimo methylation is a potential biomarkerof Barrett's-associated esophageal neoplastic progression

Hamilton, J. P., Sato, F., Jin, Z., Greenwald, B. D., Ito, T., Mori, Y., Paun, B. C., Kan, T., Cheng, Y., Wang, S., Yang, J., Abraham, J. M. & Meltzer, S. J. Nov 15 2006 In : Clinical Cancer Research. 12, 22, p. 6637-6642 6 p.

Research output: Research - peer-reviewArticle

Methylation
Esophagus
Deoxycytidine
Polymerase Chain Reaction
Esophageal Squamous Cell Carcinoma

Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis

Wang, S. , Zhan, M. , Yin, J. , Abraham, J. M. , Mori, Y. , Sato, F. , Xu, Y. , Olaru, A. , Berki, A. T. , Li, H. , Schulmann, K. , Kan, T. , Hamilton, J. P. , Paun, B. , Yu, M. M. , Jin, Z. , Cheng, Y. , Ito, T. , Mantzur, C. , Greenwald, B. D. & 1 others Meltzer, S. J. Jun 1 2006 In : Oncogene. 25, 23, p. 3346-3356 11 p.

Research output: Research - peer-reviewArticle

Barrett Esophagus
Adenocarcinoma
Genes
Esophagus
Neoplasms
2005

Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk

Schulmann, K., Sterian, A., Berki, A., Yin, J., Sato, F., Xu, Y., Olaru, A., Wang, S., Mori, Y., Deacu, E., Hamilton, J., Kan, T., Krasna, M. J., Beer, D. G., Pepe, M. S., Abraham, J. M., Feng, Z., Schmiegel, W., Greenwald, B. D. & Meltzer, S. J. Jun 9 2005 In : Oncogene. 24, 25, p. 4138-4148 11 p.

Research output: Research - peer-reviewArticle

Barrett Esophagus
Adenocarcinoma
Methylation
Odds Ratio
Confidence Intervals

Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability

Schulmann, K., Mori, Y., Croog, V., Yin, J., Olaru, A., Sterian, A., Sato, F., Wang, S., Xu, Y., Deacu, E., Berki, A. T., Hamilton, J. P., Kan, T., Abraham, J. M., Schmiegel, W., Harpaz, N. & Meltzer, S. J. Jul 2005 In : Gastroenterology. 129, 1, p. 74-85 12 p.

Research output: Research - peer-reviewArticle

Microsatellite Instability
Inflammatory Bowel Diseases
Phenotype
Neoplasms
N-methylsuccinimide
2004

Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-β response pathway genes

Deacu, E., Mori, Y., Sato, F., Yin, J., Olaru, A., Sterian, A., Xu, Y., Wang, S., Schulmann, K., Berki, A., Kan, T., Abraham, J. M. & Meltzer, S. J. Nov 1 2004 In : Cancer Research. 64, 21, p. 7690-7696 7 p.

Research output: Research - peer-reviewArticle

Type II Activin Receptors
Transforming Growth Factor beta
Colonic Neoplasms
Growth
Genes

An Unsupervised Approach to Identify Molecular Phenotypic Components Influencing Breast Cancer Features

Selaru, F. M., Yin, J., Olaru, A., Mori, Y., Xu, Y., Epstein, S. H., Sato, F., Deacu, E., Wang, S., Sterian, A., Fulton, A., Abraham, J. M., Shibata, D., Baquet, C., Stass, S. A. & Meltzer, S. J. Mar 1 2004 In : Cancer Research. 64, 5, p. 1584-1588 5 p.

Research output: Research - peer-reviewArticle

Estrogen Receptors
Breast Neoplasms
African Americans
Principal Component Analysis
Neoplasms

Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression

Kimos, M. C., Wang, S., Borkowski, A., Yang, G. Y., Yang, C. S., Perry, K., Olaru, A., Deacu, E., Sterian, A., Cottrell, J., Papadimitriou, J., Sisodia, L., Selaru, F. M., Mori, Y., Xu, Y., Yin, J., Abraham, J. M. & Meltzer, S. J. Sep 1 2004 In : International Journal of Cancer. 111, 3, p. 415-417 3 p.

Research output: Research - peer-reviewArticle

Cornified Envelope Proline-Rich Proteins
Proliferating Cell Nuclear Antigen
Biomarkers
Epithelium
Staining and Labeling

Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

Mori, Y., Yin, J., Sato, F., Sterian, A., Simms, L. A., Selaru, F. M., Schulmann, K., Xu, Y., Olaru, A., Wang, S., Deacu, E., Abraham, J. M., Young, J., Leggett, B. A. & Meltzer, S. J. Apr 1 2004 In : Cancer Research. 64, 7, p. 2434-2438 5 p.

Research output: Research - peer-reviewArticle

Microsatellite Instability
Epigenomics
Colon
Carcinogenesis
Genes
2003

An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma

Wang, S., Mori, Y., Sato, F., Yin, J., Xu, Y., Zou, T. T., Olaru, A., Kimos, M. C., Perry, K., Selaru, F. M., Deacu, E., Sun, M., Shi, Y. C., Shibata, D., Abraham, J. M., Greenwald, B. D. & Meltzer, S. J. Jan 23 2003 In : Oncogene. 22, 3, p. 467-470 4 p.

Research output: Research - peer-reviewArticle

Loss of Heterozygosity
Carcinoma
Genes
Neoplasms
Messenger RNA

Loss of Heterozygosity and Mutational Analyses of the ACTRII Gene Locus in Human Colorectal Tumors

Olaru, A., Mori, Y., Yin, J., Wang, S., Kimos, M. C., Perry, K., Xu, Y., Sato, F., Selaru, F. M., Deacu, E., Sterian, A., Shibata, D., Abraham, J. M. & Meltzer, S. J. Dec 2003 In : Laboratory Investigation. 83, 12, p. 1867-1871 5 p.

Research output: Research - peer-reviewArticle

Loss of Heterozygosity
Colorectal Neoplasms
Genes
Neoplasms
N-methylsuccinimide

The impact of microsatellite instability on the molecular phenotype of colorectal tumors

Mori, Y., Selaru, F. M., Sato, F., Yin, J., Simms, L. A., Xu, Y., Olaru, A., Deacu, E., Wang, S., Taylor, J. M., Young, J., Leggett, B., Jass, J. R., Abraham, J. M., Shibata, D. & Meltzer, S. J. Aug 1 2003 In : Cancer Research. 63, 15, p. 4577-4582 6 p.

Research output: Research - peer-reviewArticle

Microsatellite Instability
Colorectal Neoplasms
Phenotype
N-methylsuccinimide
Neoplasms
2002

Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma

Sato, F., Shibata, D., Harpaz, N., Xu, Y., Yin, J., Mori, Y., Wang, S., Olaru, A., Deacu, E., Selaru, F. M., Kimos, M. C., Hytiroglou, P., Young, J., Leggett, B., Gazdar, A. F., Toyooka, S., Abraham, J. M. & Meltzer, S. J. Dec 1 2002 In : Cancer Research. 62, 23, p. 6820-6822 3 p.

Research output: Research - peer-reviewArticle

Ulcerative Colitis
Methylation
Colorectal Neoplasms
Genes
Carcinogenesis

Activation of the esophagin promoter during esophageal epithelial cell differentiation

Smolinski, K. N., Abraham, J. M., Souza, R. F., Yin, J., Wang, S., Xu, Y., Zou, T. T., Kong, D., Fleisher, A. S. & Meltzer, S. J. 2002 In : Genomics. 79, 6, p. 875-880 6 p.

Research output: Research - peer-reviewArticle

Cornified Envelope Proline-Rich Proteins
Cell Differentiation
Epithelial Cells
Genetic Promoter Regions
Calcium

Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon

Zou, T. T., Selaru, F. M., Xu, Y., Shustova, V., Yin, J., Mori, Y., Shibata, D., Sato, F., Wang, S., Olaru, A., Deacu, E., Liu, T. C., Abraham, J. M. & Meltzer, S. J. Jul 18 2002 In : Oncogene. 21, 31, p. 4855-4862 8 p.

Research output: Research - peer-reviewArticle

Oligonucleotide Array Sequence Analysis
Colonic Neoplasms
Genes
Colon
RNA

Artificial Neural Networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer

Xu, Y., Selaru, F. M., Yin, J., Zou, T. T., Shustova, V., Mori, Y., Sato, F., Liu, T. C., Olaru, A., Wang, S., Kimos, M. C., Perry, K., Desai, K., Greenwald, B. D., Krasna, M. J., Shibata, D., Abraham, J. M. & Meltzer, S. J. Jun 15 2002 In : Cancer Research. 62, 12, p. 3493-3497 5 p.

Research output: Research - peer-reviewArticle

Barrett Esophagus
Gene Regulatory Networks
Esophageal Neoplasms
Oligonucleotide Array Sequence Analysis
Transcriptome

Artificial neural networks distinguish among subtypes of neoplastic colorectal lesions

Selaru, F. M., Xu, Y., Yin, J., Zou, T., Liu, T. C., Mori, Y., Abraham, J. M., Sato, F., Wang, S., Twigg, C., Olaru, A., Shustova, V., Leytin, A., Hytiroglou, P., Shibata, D., Harpaz, N. & Meltzer, S. J. 2002 In : Gastroenterology. 122, 3, p. 606-613 8 p.

Research output: Research - peer-reviewArticle

Clone Cells
Cluster Analysis
Complementary DNA
Oligonucleotide Array Sequence Analysis
Inflammatory Bowel Diseases

Global gene expression profiling in Barrett's esophagus and esophageal cancer: A comparative analysis using cDNA microarrays

Selaru, F. M., Zou, T., Xu, Y., Shustova, V., Yin, J., Mori, Y., Sato, F., Wang, S., Olaru, A., Shibata, D., Greenwald, B. D., Krasna, M. J., Abraham, J. M. & Meltzer, S. J. Jan 17 2002 In : Oncogene. 21, 3, p. 475-478 4 p.

Research output: Research - peer-reviewArticle

Barrett Esophagus
Gene Expression Profiling
Esophageal Neoplasms
Oligonucleotide Array Sequence Analysis
Computational Biology

Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas

Shibata, D. M., Sato, F., Mori, Y., Perry, K., Yin, J., Wang, S., Xu, Y., Olaru, A., Selaru, F., Spring, K., Young, J., Abraham, J. M. & Meltzer, S. J. Oct 15 2002 In : Cancer Research. 62, 20, p. 5637-5640 4 p.

Research output: Research - peer-reviewArticle

Microsatellite Instability
Stomach
Adenocarcinoma
Neoplasms
Methylation

Hypermethylation of the p14ARF gene in ulcerative colitis-associated colorectal carcinogenesis

Sato, F., Harpaz, N., Shibata, D., Xu, Y., Yin, J., Mori, Y., Zou, T. T., Wang, S., Desai, K., Leytin, A., Selaru, F. M., Abraham, J. M. & Meltzer, S. J. 2002 In : Cancer Research. 62, 4, p. 1148-1151 4 p.

Research output: Research - peer-reviewArticle

Tumor Suppressor Protein p14ARF
Ulcerative Colitis
Carcinogenesis
Genes
Methylation