Research Output 1992 2017

2017

Characterization of elite suppressors cell-associated HIV-1 mRNA at baseline and with T cell activation

Pohlmyer, C. W., Bullen, C. K., Martin, A. R., Laird, G. M., Chioma, S. U., Walker-Sperling, V. E. K. & Blankson, J. N. Jun 1 2017 In : Yale Journal of Biology and Medicine. 90, 2, p. 331-336 6 p.

Research output: Contribution to journalArticle

HIV-1
T-Lymphocytes
Messenger RNA
T-cells
Ionomycin

Intracellular HIV-1 rna and CD4+ t cell activation in patients starting antiretrovirals

El-Diwany, R., Breitwieser, F. P., Soliman, M., Skaist, A. M., Srikrishna, G., Blankson, J. N., Ray, S. C., Wheelan, S. J., Thomas, D. L. & Balagopal, A. Mar 29 2017 In : AIDS.

Research output: Contribution to journalArticle

HIV-1
T-Lymphocytes
RNA
Gene Expression
HLA-DR Antigens

The effect of Ingenol-B on the suppressive capacity of elite suppressor HIV-specific CD8+ T cells

Kwaa, A. K., Goldsborough, K., Walker-Sperling, V. E., Pianowski, L. F., Gama, L. & Blankson, J. N. May 1 2017 In : PLoS ONE. 12, 5, 0174516

Research output: Contribution to journalArticle

T-lymphocytes
HIV
T-Lymphocytes
T-cells
HIV long-term survivors

Weak HIV Antibody Responses in Perinatally-Infected Young Adults

Kirkpatrick, A. R., Unsal, A. B., Blankson, J. N., Moore, R. D., Quinn, T. C., Hadigan, C. & Laeyendecker, O. Jun 23 2017 In : Pediatric Infectious Disease Journal.

Research output: Contribution to journalArticle

HIV Antibodies
Antibody Formation
Young Adult
HIV
Incidence
2016
Immunoenzyme Techniques
HIV
Incidence
Infection
CD4 Lymphocyte Count

Factors Associated With the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller

Walker-Sperling, V. E., Pohlmeyer, C. W., Veenhuis, R. T., May, M., Luna, K. A., Kirkpatrick, A. R., Laeyendecker, O., Cox, A. L., Carrington, M., Bailey, J. R., Arduino, R. C. & Blankson, J. N. Jul 6 2016 In : EBioMedicine.

Research output: Contribution to journalArticle

HIV-1
Blood Flow Velocity
Bulimia
T-cells
Natural Killer Cells

HIV Impairs Lung Epithelial Integrity and Enters the Epithelium to Promote Chronic Lung Inflammation

Brune, K. A., Ferreira, F., Mandke, P., Chau, E., Aggarwal, N. R., D'alessio, F. R., Lambert, A. A., Kirk, G., Blankson, J., Drummond, M. B., Tsibris, A. M. & Sidhaye, V. K. Mar 1 2016 In : PLoS One. 11, 3, e0149679

Research output: Contribution to journalArticle

epithelial cells
lungs
Pneumonia
Epithelium
HIV

Immune control despite protracted lymphopenia after chemoradiation in an elite controller

Reiss, K. A., Jackson, D. C., Piotrowski, A., Grossman, S. & Blankson, J. N. Jan 1 2016 In : Open Forum Infectious Diseases. 3, 1, ofw016

Research output: Contribution to journalArticle

Lymphopenia
Viral Load
Small Cell Lung Carcinoma
HIV-1

Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "meet the Experts" 2015 Workshop Summary

Akkina, R., Allam, A., Balazs, A. B., Blankson, J. N., Burnett, J. C., Casares, S., Garcia, J. V., Hasenkrug, K. J., Kashanchi, F., Kitchen, S. G., Klein, F., Kumar, P., Luster, A. D., Poluektova, L. Y., Rao, M., Sanders-Beer, B. E., Shultz, L. D. & Zack, J. A. Feb 1 2016 In : AIDS Research and Human Retroviruses. 32, 2, p. 109-119 11 p.

Research output: Contribution to journalArticle

National Institute of Allergy and Infectious Diseases (U.S.)
HIV
Education
HLA Antigens
Myeloid Cells

Short Communication: HIV Controller T Cells Effectively Inhibit Viral Replication in Alveolar Macrophages

Walker-Sperling, V. E., Merlo, C. A., Buckheit, R. W., Lambert, A., Tarwater, P., Kirk, G. D., Drummond, M. B. & Blankson, J. N. Nov 1 2016 In : AIDS Research and Human Retroviruses. 32, 10-11, p. 1097-1099 3 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
HIV
T-Lymphocytes
HIV-1
Macrophages

The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication

Walker-Sperling, V. E., Pohlmeyer, C. W., Tarwater, P. M. & Blankson, J. N. Jan 25 2016 In : EBioMedicine.

Research output: Contribution to journalArticle

HIV
T-Lymphocytes
T-cells
Protein Kinase C
Inborn Errors Amino Acid Metabolism

What can we do to reduce the viral reservoir in HIV-1-infected individuals?

Pohlmeyer, C. W., Walker-Sperling, V. E. & Blankson, J. N. Jul 1 2016 In : Future Microbiology. 11, 7, p. 839-842 4 p.

Research output: Contribution to journalReview article

HIV-1
2015

A human immunodeficiency virus controller with a large population of CD4+CD8+ double-positive T cells

Durand, C. M., Buckheit, R. W., Salgado, M., Pohlmeyer, C. W., Walker-Sperling, V. E., Hegarty, R. W., Ambinder, R. F. & Blankson, J. N. 2015 In : Open Forum Infectious Diseases. 2, 2, ofv039

Research output: Contribution to journalArticle

HIV
T-Lymphocytes
Antiviral Agents
HIV-1

A murine viral outgrowth assay to detect residual HIV type 1 in patients with undetectable viral loads

Metcalf Pate, K. A. , Pohlmeyer, C. W. , Walker-Sperling, V. E. , Foote, J. B. , Najarro, K. M. , Cryer, C. G. , Salgado, M. , Gama, L. , Engle, E. L. , Shirk, E. N. , Queen, S. E. , Chioma, S. , Vermillion, M. S. , Bullock, B. , Li, M. , Lyons, C. E. , Adams, R. J. , Zink, M. C. , Clements, J. E. , Mankowski, J. L. & 1 others Blankson, J. N. Nov 1 2015 In : Journal of Infectious Diseases. 212, 9, p. 1387-1396 10 p.

Research output: Contribution to journalArticle

Viral Load
HIV-1
HIV
Simian immunodeficiency virus
T-Lymphocytes

Hospitalization rates and reasons among HIV elite controllers and persons with medically controlled HIV infection

Crowell, T. A., Gebo, K. A., Blankson, J. N., Korthuis, P. T., Yehia, B. R., Rutstein, R. M., Moore, R. D., Sharp, V., Nijhawan, A. E., Mathews, W. C., Hanau, L. H., Corales, R. B., Beil, R., Somboonwit, C., Edelstein, H., Allen, S. L. & Berry, S. A. Jun 1 2015 In : Journal of Infectious Diseases. 211, 11, p. 1692-1702 11 p.

Research output: Contribution to journalArticle

Hospitalization
HIV
Infection
Viremia
CD4 Lymphocyte Count

Medroxyprogesterone acetate increases HIV-1 infection of unstimulated peripheral blood mononuclear cells in vitro

Sampah, M. E. S., Laird, G. M., Blankson, J. N., Siliciano, R. F. & Coleman, J. S. Jun 19 2015 In : AIDS. 29, 10, p. 1137-1146 10 p.

Research output: Contribution to journalArticle

Medroxyprogesterone Acetate
HIV Infections
HIV-1
Blood Cells
In Vitro Techniques

Reactivation kinetics of HIV-1 and susceptibility of reactivated latently infected CD4+ T cells to HIV-1-specific CD8+ T cells

Walker-Sperling, V. E. K., Cohen, V. J., Tarwater, P. M. & Blankson, J. N. 2015 In : Journal of Virology. 89, 18, p. 9631-9638 8 p.

Research output: Contribution to journalArticle

T-lymphocytes
HIV-1
T-Lymphocytes
Human immunodeficiency virus 1
cells
2014

Candida Esophagitis in a human immunodeficiency virus-1-positive elite controller with hepatitis C virus cirrhosis

Chen, A., Shieh, E., Brinkley, S. & Blankson, J. N. 2014 In : Open Forum Infectious Diseases. 1, 3, ofu111

Research output: Contribution to journalArticle

Esophagitis
Opportunistic Infections
CD4 Lymphocyte Count
Coinfection
Candida

Comparative analysis of the capacity of elite suppressor CD4+ and CD8+ T cells to inhibit HIV-1 replication in monocyte-derived macrophages

Walker-Sperling, V. E. K., Buckheit, R. W. & Blankson, J. N. Sep 1 2014 In : Journal of Virology. 88, 17, p. 9789-9798 10 p.

Research output: Contribution to journalArticle

T-lymphocytes
HIV-1
Macrophages
T-Lymphocytes
macrophages

Evolution of an attenuated HIV-1 isolate in an elite suppressor

Salgado, M., Gandhi, S., Buckheit, R. W., Berkenblit, G. V. & Blankson, J. N. Mar 1 2014 In : AIDS Research and Human Retroviruses. 30, 3, p. 284-288 5 p.

Research output: Contribution to journalArticle

Reading Frames
HIV-1
Nonsense Codon
Viremia
Virus Replication

Failure to identify HIV-infected individuals in a clinical trial using a single HIV rapid test for screening

Piwowar-Manning, E., Fogel, J., Laeyendecker, O., Wolf, S., Cummings, V., Marzinke, M., Clarke, W., Breaud, A., Wendel, S., Wang, L., Swanson, P., Hackett, J., Mannheimer, S., Del Rio, C., Kuo, I., Harawa, N., Koblin, B., Moore, R., Blankson, J. & Eshleman, S. Jan 1 2014 In : HIV Clinical Trials. 15, 2, p. 62-68 7 p.

Research output: Contribution to journalArticle

Clinical Trials
HIV
HIV Infections
Infection
HIV-2
HIV-1
Infection

HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon

Chattergoon, M. A., Latanich, R., Quinn, J., Winter, M. E., Buckheit, R. W., Blankson, J. N., Pardoll, D. & Cox, A. L. 2014 In : PLoS Pathogens. 10, 5, e1004082

Research output: Contribution to journalArticle

Inflammasomes
Interferon Type I
Toll-Like Receptors
Monocytes
Macrophages

HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice

Salgado, M., Swanson, M. D., Pohlmeyer, C. W., Buckheit, R. W., Wu, J., Archin, N. M., Williams, T. M., Margolis, D. M., Siliciano, R. F., Garcia, J. V. & Blankson, J. N. 2014 In : Journal of Virology. 88, 6, p. 3340-3352 13 p.

Research output: Contribution to journalArticle

viruses
HIV long-term survivors
HLA-B Antigens
HIV-1
T-Lymphocytes

Long-term control of viral replication in a group O, human immunodeficiency virus Type 1-infected individual

Buckheit, R. W., Sexauer, S. B., Sedaghat, A. R., Wilke, C. O., Laeyendecker, O., Basseth, C. R. & Blankson, J. N. Jun 1 2014 In : AIDS Research and Human Retroviruses. 30, 6, p. 511-513 3 p.

Research output: Contribution to journalArticle

HIV-1

Sprouty-2 regulates HIV-specific T cell polyfunctionality

Chiu, Y. L., Shan, L., Huang, H., Haupt, C., Bessell, C., Canaday, D. H., Zhang, H., Ho, Y. C., Powell, J. D., Oelke, M., Margolick, J. B., Blankson, J. N., Griffin, D. E. & Schneck, J. P. Jan 2 2014 In : Journal of Clinical Investigation. 124, 1, p. 198-208 11 p.

Research output: Contribution to journalArticle

HIV-2
T-Lymphocytes
HIV
Antigens
MAP Kinase Signaling System
2013

CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants

Pohlmeyer, C. W., Buckheit, R. W., Siliciano, R. F. & Blankson, J. N. Dec 12 2013 In : Retrovirology. 10, 1, 152

Research output: Contribution to journalArticle

HLA-B Antigens
HIV-1
T-Lymphocytes
Mutation
Epitopes
HIV Antibodies
Antibody Affinity
HIV-1
Anti-Idiotypic Antibodies
HIV
HIV-1
T-Lymphocytes
HLA-B Antigens
HIV Infections
Limit of Detection

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay

Laird, G. M., Eisele, E. E., Rabi, S. A., Lai, J., Chioma, S., Blankson, J. N., Siliciano, J. D. & Siliciano, R. F. May 2013 In : PLoS Pathogens. 9, 5, e1003398

Research output: Contribution to journalArticle

HIV-1
T-Lymphocytes
Clinical Trials
Costs and Cost Analysis
Proviruses

The implications of viral reservoirs on the elite control of HIV-1 infection

Buckheit, R. W., Salgado, M., Martins, K. O. & Blankson, J. N. Mar 2013 In : Cellular and Molecular Life Sciences. 70, 6, p. 1009-1019 11 p.

Research output: Contribution to journalArticle

HIV Infections
HIV-1
Viruses
Infection
Defective Viruses

XReplication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure

Ho, Y. C., Shan, L., Hosmane, N. N., Wang, J., Laskey, S. B., Rosenbloom, D. I. S., Lai, J., Blankson, J. N., Siliciano, J. D. & Siliciano, R. F. Oct 24 2013 In : Cell. 155, 3

Research output: Contribution to journalArticle

Proviruses
HIV-1
T-Lymphocytes
T-cells
HIV Infections
2012

Developing strategies for HIV-1 eradication

Durand, C. M., Blankson, J. N. & Siliciano, R. F. Nov 2012 In : Trends in Immunology. 33, 11, p. 554-562 9 p.

Research output: Contribution to journalArticle

HIV-1
Highly Active Antiretroviral Therapy
HIV Infections
T-Lymphocytes
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation
HIV-1

Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

Buckheit, R. W., Allen, T. G., Alme, A., Salgado, M., O'Connell, K. A., Huculak, S., Falade-Nwulia, O., Williams, T. M., Gallant, J. E., Siliciano, R. F. & Blankson, J. N. 2012 In : Nature Communications. 3, 1697

Research output: Contribution to journalArticle

Electroretinography
Blood Flow Velocity
human immunodeficiency virus
HIV-1
controllers

Inhibitory potential of subpopulations of CD8+ T cells in HIV-1-infected elite suppressors

Buckheit, R. W., Salgado, M., Silciano, R. F. & Blankson, J. N. Dec 2012 In : Journal of Virology. 86, 24, p. 13679-13688 10 p.

Research output: Contribution to journalArticle

T-lymphocytes
HIV-1
T-Lymphocytes
virus replication
Human immunodeficiency virus 1
Mycobacterium tuberculosis
HIV
T-Lymphocytes
cells
Endrin
CD4 Lymphocyte Count
Viral Load
MicroRNAs
HIV-1
T-Lymphocytes

Residual Viremia and Viral Reservoirs in Elite Controllers

Buckheit, R. W. & Blankson, J. N. 2012 Models of Protection Against HIV/SIV. Elsevier Inc., p. 253-271 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Viremia
Infection
Electroretinography
Bulimia
Viral Load

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

Shan, L., Deng, K., Shroff, N. S., Durand, C. M., Rabi, S. A., Yang, H. C., Zhang, H., Margolick, J. B., Blankson, J. N. & Siliciano, R. F. Mar 23 2012 In : Immunity. 36, 3, p. 491-501 11 p.

Research output: Contribution to journalArticle

HIV-1
Viruses
T-Lymphocytes
Highly Active Antiretroviral Therapy
Viral Cytopathogenic Effect
2011
Virion
HIV-1
T-Lymphocytes
Viruses
Infection

Circulating monocytes are not a major reservoir of HIV-1 in elite suppressors

Spivak, A. M., Salgado, M., Alireza Rabi, S., O'Connell, K. A. & Blankson, J. N. Oct 2011 In : Journal of Virology. 85, 19, p. 10399-10403 5 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
Monocytes
HIV long-term survivors
monocytes

HIV type 1-mediated downregulation of HLA-B*57/B*5801 proteins on elite suppressor CD4+ T cells

Sampah, M. E. S., Ceccato, C. M. & Blankson, J. N. Feb 1 2011 In : AIDS Research and Human Retroviruses. 27, 2, p. 183-186 4 p.

Research output: Contribution to journalArticle

HLA-B Antigens
HIV-1
Down-Regulation
T-Lymphocytes
Proteins

Immunopathogenesis of Human Immunodeficiency Virus Infection

Blankson, J. N. & Siliciano, R. F. Jul 2011 Goldman's Cecil Medicine: Twenty Fourth Edition. Elsevier Inc., Vol. 2, p. 2175-2177 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

AIDS

Killing the messenger to maintain control of HIV

Blankson, J. N. Aug 2011 In : Nature Medicine. 17, 8, p. 927-928 2 p.

Research output: Contribution to journalArticle

HIV
Highly Active Antiretroviral Therapy
HIV-1
T-Lymphocytes
Viral Load
HIV Infections
Interleukins
Hepacivirus
African Americans
HIV-1
Genotype

Spontaneous resolution of HIV-associated nephropathy in an elite controller

Blankson, J. N., Basseth, C. R., Kuperman, M. & Fine, D. M. May 15 2011 In : AIDS. 25, 8, p. 1135-1137 3 p.

Research output: Contribution to journalArticle

AIDS-Associated Nephropathy

Sustained elite suppression of replication competent HIV-1 in a patient treated with rituximab based chemotherapy

Gaillard, S., Dinoso, J. B., Marsh, J. A., DeZern, A. E., O'Connell, K. A., Spivak, A. M., Alwood, K., Durand, C. M., Ambinder, R. F. & Blankson, J. N. Jul 2011 In : Journal of Clinical Virology. 51, 3, p. 195-198 4 p.

Research output: Contribution to journalArticle

HIV-1
Drug Therapy
Plasmapheresis
Vincristine
Prednisone