Joel Kleinman

Research output

Research output per year 1973 1981 1990 1991 1992 1993 1994 2003 2004 2005 2006 2008 2011 2012 2014 2015 2016 2018 2019 2020 2022 2023 2024

• 335 Article
• 17 Review article
• 16 Comment/debate
• 10 Letter
• 4 More
  • 2 Chapter
  • 1 Editorial
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2024

  Human archetypal pluripotent stem cells differentiate into trophoblast stem cells via endogenous BMP5/7 induction without transitioning through naive state

  Tietze, E., Barbosa, A. R., Araujo, B., Euclydes, V., Spiegelberg, B., Cho, H. J., Lee, Y. K., Wang, Y., McCord, A., Lorenzetti, A., Feltrin, A., van de Leemput, J., Di Carlo, P., Ursini, G., Benjamin, K. J., Brentani, H., Kleinman, J. E., Hyde, T. M., Erwin, J., McKay, R., & 4 othersShin, J. H., Sawada, T., Paquola, A. C. M. & Erwin, J. A., Dec 2024, In: Scientific reports. 14, 1, 3291.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pluripotent Stem Cells 100%
  • Stem Cells 62%
  • Bone Morphogenetic Protein 4 36%
  • rho-Associated Kinases 10%
  • Amnion 10%

• The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

  Weber, L. M., Divecha, H. R., Tran, M. N., Kwon, S. H., Spangler, A., Montgomery, K. D., Tippani, M., Bharadwaj, R., Kleinman, J. E., Page, S. C., Hyde, T. M., Collado-Torres, L., Maynard, K., Martinowich, K. & Hicks, S., Jan 24 2024, In: eLife. 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • Locus Coeruleus 72%
  • Disorder 51%
  • Norepinephrine 36%
  • Gene Expression 36%
• 2023

  Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football

  Iverson, G. L., Jamshidi, P., Fisher-Hubbard, A. O., Deep-Soboslay, A., Hyde, T. M., Kleinman, J. E., deJong, J. L., Shepherd, C. E., Hazrati, L. N. & Castellani, R. J., 2023, In: Frontiers in Neurology. 14, 1143882.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chronic Traumatic Encephalopathy 100%
  • Football 72%
  • Suicide 21%
  • Mood Disorders 13%
  • Sports 8%

• Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions

  Pergola, G., Parihar, M., Sportelli, L., Bharadwaj, R., Borcuk, C., Radulescu, E., Bellantuono, L., Blasi, G., Chen, Q., Kleinman, J. E., Wang, Y., Sripathy, S. R., Maher, B., Monaco, A., Rossi, F., Shin, J. H., Hyde, T., Bertolino, A. & Weinberger, D., Apr 2023, In: Science Advances. 9, 15, eade2812.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Consensus 100%
  • Schizophrenia 85%
  • Brain 51%
  • Genes 42%
  • Neurodevelopmental Disorders 15%

• Erratum: A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan (Cell Stem Cell (2022) 29(11) (1594–1610.e8), (S1934590922004180), (10.1016/j.stem.2022.09.010))

  Su, Y., Zhou, Y., Bennett, M. L., Li, S., Carceles-Cordon, M., Lu, L., Huh, S., Jimenez-Cyrus, D., Kennedy, B. C., Kessler, S. K., Viaene, A. N., Helbig, I., Gu, X., Kleinman, J. E., Hyde, T., Weinberger, D. R., Nauen, D. W., Song, H. & Ming, G. L., Jan 5 2023, In: Cell stem cell. 30, 1, p. 113 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Atlases 100%
  • Transcriptome 85%
  • Longevity 83%
  • Neuroglia 82%
  • Hippocampus 74%

• Investigating trait variability of gene coexpression network architecture in brain by controlling for genomic risk of schizophrenia

  Radulescu, E., Chen, Q., Pergola, G., Di Carlo, P., Han, S., Shin, J. H., Hyde, T. M., Kleinman, J. E. & Weinberger, D. R., Oct 13 2023, In: PLoS genetics. 19, 10, e1010989.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • schizophrenia 100%
  • gene regulatory networks 80%
  • Gene Regulatory Networks 78%
  • genomics 72%
  • brain 65%

• Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

  Chen, F., Wang, X., Jang, S. K., Quach, B. C., Weissenkampen, J. D., Khunsriraksakul, C., Yang, L., Sauteraud, R., Albert, C. M., Allred, N. D. D., Arnett, D. K., Ashley-Koch, A. E., Barnes, K. C., Barr, R. G., Becker, D. M., Bielak, L. F., Bis, J. C., Blangero, J., Boorgula, M. P., Chasman, D. I., & 70 othersChavan, S., Chen, Y. D. I., Chuang, L. M., Correa, A., Curran, J. E., David, S. P., Fuentes, L. D. L., Deka, R., Duggirala, R., Faul, J. D., Garrett, M. E., Gharib, S. A., Guo, X., Hall, M. E., Hawley, N. L., He, J., Hobbs, B. D., Hokanson, J. E., Hsiung, C. A., Hwang, S. J., Hyde, T. M., Irvin, M. R., Jaffe, A. E., Johnson, E. O., Kaplan, R., Kardia, S. L. R., Kaufman, J. D., Kelly, T. N., Kleinman, J. E., Kooperberg, C., Lee, I. T., Levy, D., Lutz, S. M., Manichaikul, A. W., Martin, L. W., Marx, O., McGarvey, S. T., Minster, R. L., Moll, M., Moussa, K. A., Naseri, T., North, K. E., Oelsner, E. C., Peralta, J. M., Peyser, P. A., Psaty, B. M., Rafaels, N., Raffield, L. M., Reupena, M. S., Rich, S. S., Rotter, J. I., Schwartz, D. A., Shadyab, A. H., Sheu, W. H. H., Sims, M., Smith, J. A., Sun, X., Taylor, K. D., Telen, M. J., Watson, H., Weeks, D. E., Weir, D. R., Yanek, L. R., Young, K. A., Young, K. L., Zhao, W., Hancock, D. B., Jiang, B., Vrieze, S. & Liu, D. J., Feb 2023, In: Nature genetics. 55, 2, p. 291-300 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tobacco Use 76%
  • Transcriptome 66%
  • Quantitative Trait Loci 61%
  • Genome-Wide Association Study 50%
  • Statistics 37%

• Orthogonal approaches required to measure proteasome composition and activity in mammalian brain tissue

  Türker, F., Bharadwaj, R. A., Kleinman, J. E., Weinberger, D., Hyde, T. M., White, C. J., Williams, D. & Margolis, S. S., Jun 2023, In: Journal of Biological Chemistry. 299, 6, 104811.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteasome Endopeptidase Complex 100%
  • Brain 46%
  • Alzheimer Disease 14%
  • Macromolecular Substances 13%
  • Parahippocampal Gyrus 11%

• Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response

  PTSD Working Group of the Psychiatric Genomics Consortium, Traumatic Stress Brain Research Group & PTSD BrainOmics Project of the PsychENCODE Consortium, Oct 1 2023, In: The American journal of psychiatry. 180, 10, p. 739-754 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Expression Profiling 100%
  • Post-Traumatic Stress Disorders 95%
  • Prefrontal Cortex 87%
  • Gene Expression 58%
  • RNA Sequence Analysis 48%

• SUFI: an automated approach to spectral unmixing of fluorescent multiplex images captured in mouse and post-mortem human brain tissues

  Sadashivaiah, V., Tippani, M., Page, S. C., Kwon, S. H., Bach, S. V., Bharadwaj, R. A., Hyde, T., Kleinman, J. E., Jaffe, A. & Maynard, K., Dec 2023, In: BMC Neuroscience. 24, 1, 6.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fluorescence 100%
  • Brain 60%
  • RNA 56%
  • Optical Imaging 44%
  • Fluorescent Dyes 42%

• Sutton’s Law

  Kleinman, J. E. & Hyde, T. M., Jul 2023, In: American Journal of Psychiatry. 180, 7, p. 465-466 2 p.

  Research output: Contribution to journal › Editorial › peer-review
• 2022

  Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways

  Zandi, P. P., Jaffe, A. E., Goes, F. S., Burke, E. E., Collado-Torres, L., Huuki-Myers, L., Seyedian, A., Lin, Y., Seifuddin, F., Pirooznia, M., Ross, C. A., Kleinman, J. E., Weinberger, D. R. & Hyde, T. M., Mar 2022, In: Nature neuroscience. 25, 3, p. 381-389 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Gyrus Cinguli 100%
  • Amygdala 96%
  • Bipolar Disorder 93%
  • Transcriptome 89%
  • Down-Regulation 67%

• Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability

  Brain Somatic Mosaicism Network, Jul 9 2022, In: Science. 377, 6605, p. 511-517 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Mutation 100%
  • Autistic Disorder 89%
  • Brain 87%
  • Transcription Factors 44%
  • Virus Integration 40%

• Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes

  The BrainSeq Consortium, Nov 2022, In: Nature neuroscience. 25, 11, p. 1559-1568 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Caudate Nucleus 100%
  • Transcriptome 79%
  • Antipsychotic Agents 78%
  • Schizophrenia 70%
  • Genes 34%

• A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan

  Su, Y., Zhou, Y., Bennett, M. L., Li, S., Carceles-Cordon, M., Lu, L., Huh, S., Jimenez-Cyrus, D., Kennedy, B. C., Kessler, S. K., Viaene, A. N., Helbig, I., Gu, X., Kleinman, J. E., Hyde, T. M., Weinberger, D. R., Nauen, D. W., Song, H. & Ming, G. L., Nov 3 2022, In: Cell stem cell. 29, 11, p. 1594-1610.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Atlases 100%
  • Transcriptome 85%
  • Longevity 83%
  • Neuroglia 82%
  • Hippocampus 74%

• Decoding Shared Versus Divergent Transcriptomic Signatures Across Cortico-Amygdala Circuitry in PTSD and Depressive Disorders

  Traumatic Stress Brain Research Group, Sep 1 2022, In: The American journal of psychiatry. 179, 9, p. 673-686 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Depressive Disorder 100%
  • Amygdala 96%
  • Post-Traumatic Stress Disorders 95%
  • GABAergic Neurons 29%
  • Genes 19%

• Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders

  Zhou, J., Chen, Q., Braun, P. R., Perzel Mandell, K. A., Jaffe, A. E., Tan, H. Y., Hyde, T. M., Kleinman, J. E., Potash, J. B., Shinozaki, G., Weinberger, D. R. & Han, S., Aug 23 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 34, e2206069119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deep Learning 100%
  • DNA Methylation 71%
  • Inborn Genetic Diseases 67%
  • Mental Disorders 59%
  • Quantitative Trait Loci 45%

• Genetics and Brain Transcriptomics of Completed Suicide

  Punzi, G., Ursini, G., Chen, Q., Radulescu, E., Tao, R., Huuki, L. A., Di Carlo, P., Collado-Torres, L., Heon Shin, J., Catanesi, R., Jaffe, A. E., Hyde, T. M., Kleinman, J. E., Mackay, T. F. C. & Weinberger, D. R., Mar 2022, In: American Journal of Psychiatry. 179, 3, p. 226-241 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Completed Suicide 100%
  • Suicide 64%
  • Brain 34%
  • Mental Disorders 21%
  • Metabolic Activation 10%

• Molecular landscapes of human hippocampal immature neurons across lifespan

  Zhou, Y., Su, Y., Li, S., Kennedy, B. C., Zhang, D. Y., Bond, A. M., Sun, Y., Jacob, F., Lu, L., Hu, P., Viaene, A. N., Helbig, I., Kessler, S. K., Lucas, T., Salinas, R. D., Gu, X., Chen, H. I., Wu, H., Kleinman, J. E., Hyde, T. M., & 4 othersNauen, D. W., Weinberger, D. R., Ming, G. L. & Song, H., Jul 21 2022, In: Nature. 607, 7919, p. 527-533 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Longevity 100%
  • Neurons 68%
  • Hippocampus 33%
  • Neurogenesis 29%
  • Alzheimer Disease 21%

• Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus

  Perzel Mandell, K. A., Eagles, N. J., Deep-Soboslay, A., Tao, R., Han, S., Wilton, R., Szalay, A. S., Hyde, T. M., Kleinman, J. E., Jaffe, A. E. & Weinberger, D. R., Apr 2022, In: Molecular psychiatry. 27, 4, p. 2061-2067 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Caudate Nucleus 100%
  • Antipsychotic Agents 78%
  • Phenotype 51%
  • Gene Expression 51%
  • DNA Methylation 34%

• TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein

  Zaharija, B., Odorčić, M., Hart, A., Samardžija, B., Marreiros, R., Prikulis, I., Juković, M., Hyde, T. M., Kleinman, J. E., Korth, C. & Bradshaw, N. J., Oct 2022, In: International journal of molecular sciences. 23, 19, 11048.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • schizophrenia 100%
  • Proteins 53%
  • Agglomeration 50%
  • Disorder 50%
  • amino acids 48%

• Variation in TAF1 Expression in Female Carrier-Induced Pluripotent Stem Cells and Human Brain Ontogeny Has Implications for Adult Neostriatum Vulnerability in X-Linked Dystonia Parkinsonism

  D’ignazio, L., Jacomini, R. S., Qamar, B., Benjamin, K. J. M., Arora, R., Sawada, T., Evans, T. A., Diffenderfer, K. E., Pankonin, A. R., Hendriks, W. T., Hyde, T. M., Kleinman, J. E., Weinberger, D. R., Bragg, D. C., Paquola, A. C. M. & Erwin, J. A., Jul 1 2022, In: eNeuro. 9, 4, ENEURO.0129-22.2022.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dystonia 3, Torsion, X-Linked 100%
  • Neostriatum 72%
  • Induced Pluripotent Stem Cells 59%
  • Brain 25%
  • Short Interspersed Nucleotide Elements 21%
• 2021

  Epigenome-wide study of brain DNA methylation following acute opioid intoxication

  Shu, C., Sosnowski, D. W., Tao, R., Deep-Soboslay, A., Kleinman, J. E., Hyde, T. M., Jaffe, A. E., Sabunciyan, S. & Maher, B. S., Apr 1 2021, In: Drug and alcohol dependence. 221, 108658.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epigenome 100%
  • DNA Methylation 79%
  • Opioid-Related Disorders 78%
  • Opioid Analgesics 71%
  • Netrin-1 50%

• Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers

  Markunas, C. A., Semick, S. A., Quach, B. C., Tao, R., Deep-Soboslay, A., Carnes, M. U., Bierut, L. J., Hyde, T. M., Kleinman, J. E., Johnson, E. O., Jaffe, A. E. & Hancock, D. B., Feb 2021, In: Neuropsychopharmacology. 46, 3, p. 554-560 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nucleus Accumbens 100%
  • Non-Smokers 93%
  • DNA Methylation 90%
  • Smokers 78%
  • Smoking 66%
  1 Scopus citations

• Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

  Perzel Mandell, K. A., Eagles, N. J., Wilton, R., Price, A. J., Semick, S. A., Collado-Torres, L., Ulrich, W. S., Tao, R., Han, S., Szalay, A. S., Hyde, T. M., Kleinman, J. E., Weinberger, D. R. & Jaffe, A. E., Dec 1 2021, In: Nature communications. 12, 1, 5251.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • schizophrenia 100%
  • methylation 92%
  • sequencing 79%
  • genome 76%
  • Quantitative Trait Loci 73%

• Publisher Correction: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex (Nature Neuroscience, (2021), 24, 3, (425-436), 10.1038/s41593-020-00787-0)

  Maynard, K. R., Collado-Torres, L., Weber, L. M., Uytingco, C., Barry, B. K., Williams, S. R., Catallini, J. L., Tran, M. N., Besich, Z., Tippani, M., Chew, J., Yin, Y., Kleinman, J. E., Hyde, T. M., Rao, N., Hicks, S. C., Martinowich, K. & Jaffe, A. E., Apr 2021, In: Nature neuroscience. 24, 4, p. 612 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Peer Review 100%
  • Neurosciences 86%
  • Transcriptome 74%
  • Prefrontal Cortex 72%
  • Gene Expression 48%
  1 Scopus citations

• Single molecule in situ hybridization reveals distinct localizations of schizophrenia risk-related transcripts SNX19 and AS3MT in human brain

  Takahashi, Y., Maynard, K. R., Tippani, M., Jaffe, A. E., Martinowich, K., Kleinman, J. E., Weinberger, D. R. & Hyde, T. M., Jul 2021, In: Molecular psychiatry. 26, 7, p. 3536-3547 12 p.

  Research output: Contribution to journal › Article › peer-review

  • In Situ Hybridization 100%
  • Schizophrenia 89%
  • Brain 53%
  • Neurons 40%
  • Prefrontal Cortex 39%

• Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain

  Tran, M. N., Maynard, K. R., Spangler, A., Huuki, L. A., Montgomery, K. D., Sadashivaiah, V., Tippani, M., Barry, B. K., Hancock, D. B., Hicks, S. C., Kleinman, J. E., Hyde, T. M., Collado-Torres, L., Jaffe, A. E. & Martinowich, K., Oct 6 2021, In: Neuron. 109, 19, p. 3088-3103.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gene Expression Profiling 100%
  • Reward 93%
  • Brain 47%
  • Nucleus Accumbens 45%
  • Amygdala 27%

• Suicide in Older Adult Men Is Not Related to a Personal History of Participation in Football

  Iverson, G. L., Deep-Soboslay, A., Hyde, T. M., Kleinman, J. E., Erskine, B., Fisher-Hubbard, A., deJong, J. L. & Castellani, R. J., Nov 26 2021, In: Frontiers in Neurology. 12, 745824.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Football 100%
  • Suicide 78%
  • Mood Disorders 12%
  • Substance-Related Disorders 11%
  • Sports 11%

• Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

  Maynard, K. R., Collado-Torres, L., Weber, L. M., Uytingco, C., Barry, B. K., Williams, S. R., Catallini, J. L., Tran, M. N., Besich, Z., Tippani, M., Chew, J., Yin, Y., Kleinman, J. E., Hyde, T. M., Rao, N., Hicks, S. C., Martinowich, K. & Jaffe, A. E., Mar 2021, In: Nature neuroscience. 24, 3, p. 425-436 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcriptome 100%
  • Prefrontal Cortex 98%
  • Gene Expression 65%
  • RNA Sequence Analysis 60%
  • Neurosciences 58%
  2 Scopus citations
• 2020

  Association of missense mutation in FOLH1 with decreased NAAG levels and impaired working memory circuitry and cognition

  Zink, C. F., Barker, P. B., Sawa, A., Weinberger, D. R., Wang, M., Quillian, H., Ulrich, W. S., Chen, Q., Jaffe, A. E., Kleinman, J. E., Hyde, T. M., Prettyman, G. E., Giegerich, M., Carta, K., van Ginkel, M. & Bigos, K. L., Dec 2020, In: American Journal of Psychiatry. 177, 12, p. 1129-1139 11 p.

  Research output: Contribution to journal › Article › peer-review

  • isospaglumic acid 100%
  • Hydrolases 71%
  • Missense Mutation 62%
  • Folic Acid 59%
  • Short-Term Memory 56%
  5 Scopus citations

• Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia

  Tao, R., Li, C., Jaffe, A. E., Shin, J. H., Deep-Soboslay, A., Yamin, R., Weinberger, D. R., Hyde, T. M. & Kleinman, J. E., Dec 1 2020, In: Translational psychiatry. 10, 1, 158.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cannabinoid Receptors 100%
  • Cannabis 84%
  • DNA Methylation 78%
  • Prefrontal Cortex 71%
  • Endocannabinoids 64%
  4 Scopus citations

• Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex

  Perzel Mandell, K. A., Price, A. J., Wilton, R., Collado-Torres, L., Tao, R., Eagles, N. J., Szalay, A. S., Hyde, T., Weinberger, D. R., Kleinman, J. E. & Jaffe, A., 2020, In: Epigenetics. p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Methylation 100%
  • Methylation 91%
  • Epigenomics 35%
  • Brain 29%
  • hydrogen sulfite 25%
  3 Scopus citations

• Characterizing the nuclear and cytoplasmic transcriptomes in developing and mature human cortex uncovers new insight into psychiatric disease gene regulation

  Price, A. J., Hwang, T., Tao, R., Burke, E. E., Rajpurohit, A., Shin, J. H., Hyde, T. M., Kleinman, J. E., Jaffe, A. E. & Weinberger, D. R., 2020, In: Genome research. 30, 1, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcriptome 100%
  • Mental Disorders 88%
  • Brain 53%
  • Genes 43%
  • RNA 37%
  6 Scopus citations

• Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome

  Semick, S. A., Collado-Torres, L., Markunas, C. A., Shin, J. H., Deep-Soboslay, A., Tao, R., Huestis, M. A., Bierut, L. J., Maher, B. S., Johnson, E. O., Hyde, T. M., Weinberger, D. R., Hancock, D. B., Kleinman, J. E. & Jaffe, A. E., Dec 2020, In: Molecular psychiatry. 25, 12, p. 3267-3277 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontal Lobe 100%
  • Transcriptome 98%
  • Smoking 77%
  • Mothers 67%
  • Pregnancy 64%
  2 Scopus citations

• Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

  Burke, E. E., Chenoweth, J. G., Shin, J. H., Collado-Torres, L., Kim, S. K., Micali, N., Wang, Y., Colantuoni, C., Straub, R. E., Hoeppner, D. J., Chen, H. Y., Sellers, A., Shibbani, K., Hamersky, G. R., Diaz Bustamante, M., Phan, B. D. N., Ulrich, W. S., Valencia, C., Jaishankar, A., Price, A. J., & 17 othersRajpurohit, A., Semick, S. A., Bürli, R. W., Barrow, J. C., Hiler, D. J., Page, S. C., Martinowich, K., Hyde, T. M., Kleinman, J. E., Berman, K. F., Apud, J. A., Cross, A. J., Brandon, N. J., Weinberger, D. R., Maher, B. J., McKay, R. D. G. & Jaffe, A. E., Dec 1 2020, In: Nature communications. 11, 1, 462.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rosette Crystal 100%
  • signatures 57%
  • Donor 48%
  • cells 38%
  • Induced Pluripotent Stem Cells 26%
  16 Scopus citations

• Generation of four postmortem dura-derived iPS cell lines from four control individuals with genotypic and brain-region-specific transcriptomic data available through the BrainSEQ consortium.

  Sawada, T., Benjamin, K. J. M., Brandtjen, A. C., Tietze, E., Allen, S. J., Paquola, A. C. M., Kleinman, J. E., Hyde, T. M. & Erwin, J. A., Jul 2020, In: Stem Cell Research. 46, 101806.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Induced Pluripotent Stem Cells 100%
  • Cell Line 52%
  • Fibroblasts 43%
  • Brain 43%
  • Germ Layers 37%

• Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

  Radulescu, E., Jaffe, A. E., Straub, R. E., Chen, Q., Shin, J. H., Hyde, T. M., Kleinman, J. E. & Weinberger, D. R., Apr 1 2020, In: Molecular psychiatry. 25, 4, p. 791-804 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Schizophrenia 100%
  • Brain 60%
  • Genes 49%
  • Gene Expression 18%
  • RNA-Seq 17%
  25 Scopus citations

• Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain

  Clark, M. B., Wrzesinski, T., Garcia, A. B., Hall, N. A. L., Kleinman, J. E., Hyde, T., Weinberger, D. R., Harrison, P. J., Haerty, W. & Tunbridge, E. M., Jan 1 2020, In: Molecular psychiatry. 25, 1, p. 37-47 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Psychiatry 100%
  • L-type calcium channel alpha(1C) 78%
  • Nanopore Sequencing 76%
  • Brain 66%
  • RNA Splicing 60%
  27 Scopus citations

• NurR1 and ERR1 modulate the expression of genes of a DRD2 coexpression network enriched for schizophrenia risk

  Torretta, S., Rampino, A., Basso, M., Pergola, G., Carlo, P. D., Shin, J. H., Kleinman, J. E., Hyde, T. M., Weinberger, D. R., Masellis, R., Blasi, G., Pennuto, M. & Bertolino, A., Jan 22 2020, In: Journal of Neuroscience. 40, 4, p. 932-941 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Schizophrenia 100%
  • Gene Expression 73%
  • Antipsychotic Agents 24%
  • Prefrontal Cortex 24%
  • Genes 21%
  2 Scopus citations

• Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk

  Jaffe, A. E., Hoeppner, D. J., Saito, T., Blanpain, L., Ukaigwe, J., Burke, E. E., Collado-Torres, L., Tao, R., Tajinda, K., Maynard, K. R., Tran, M. N., Martinowich, K., Deep-Soboslay, A., Shin, J. H., Kleinman, J. E., Weinberger, D. R., Matsumoto, M. & Hyde, T. M., 2020, (Accepted/In press) In: Nature neuroscience.

  Research output: Contribution to journal › Article › peer-review

  • Dentate Gyrus 100%
  • Gene Expression Profiling 94%
  • Schizophrenia 74%
  • Hippocampus 73%
  • Transcriptome 42%
  15 Scopus citations

• Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19)

  The BrainSeq Consortium, Apr 1 2020, In: Molecular psychiatry. 25, 4, p. 831-843 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Sorting Nexins 100%
  • Schizophrenia 49%
  • Exons 25%
  • Epigenomics 10%
  • Alleles 8%
  14 Scopus citations

• Sex differences in the transcription of glutamate transporters in major depression and suicide.

  Powers, B., Joyce, C., Kleinman, J. E., Hyde, T. M., Ajilore, O., Leow, A. & Sodhi, M. S., Dec 1 2020, In: Journal of Affective Disorders. 277, p. 244-252 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Amino Acid Transport System X-AG 100%
  • suicide 70%
  • Sex Characteristics 70%
  • Suicide 69%
  • Prefrontal Cortex 31%
• 2019

  African-American and Caucasian participation in postmortem human brain donation for neuropsychiatric research

  Deep-Soboslay, A., Mighdoll, M. I., Jaffe, A. E., Thomas, S. B., Herman, M. M., Sirovatka, J., King, J. P., Fowler, D. R., Zulauf, D., DiAngelo, C., Hyde, T. M. & Kleinman, J. E., Oct 1 2019, In: PloS one. 14, 10, e0222565.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • African Americans 100%
  • Brain 52%
  • Biomedical Research 35%
  • Coroners and Medical Examiners 30%
  • Tissue Donors 18%

• Association of a Noncoding RNA Postmortem With Suicide by Violent Means and In Vivo With Aggressive Phenotypes

  Punzi, G., Ursini, G., Viscanti, G., Radulescu, E., Shin, J. H., Quarto, T., Catanesi, R., Blasi, G., Jaffe, A. E., Deep-Soboslay, A., Hyde, T. M., Kleinman, J. E., Bertolino, A. & Weinberger, D. R., Mar 1 2019, In: Biological psychiatry. 85, 5, p. 417-424 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Untranslated RNA 100%
  • Suicide 81%
  • Phenotype 53%
  • Gene Regulatory Networks 38%
  • Long Noncoding RNA 38%
  5 Scopus citations

• Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq

  The BrainSeq Consortium¶, Jun 2019, In: PloS one. 14, 6, e0217765.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Allelic Imbalance 100%
  • Quantitative Trait Loci 83%
  • RNA-Seq 77%
  • Brain 32%
  • Single Nucleotide Polymorphism 27%

• Correction: Temporal dynamics of miRNAs in human DLPFC and its association with miRNA dysregulation in schizophrenia (Translational Psychiatry, (2019), 9, 1, (196), 10.1038/s41398-019-0538-y)

  Hu, Z., Gao, S., Lindberg, D., Panja, D., Wakabayashi, Y., Li, K., Kleinman, J. E., Zhu, J. & Li, Z., Dec 1 2019, In: Translational psychiatry. 9, 1, 237.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Names 100%
  • MicroRNAs 88%
  • Schizophrenia 85%
  • Psychiatry 78%
  1 Scopus citations

• Correction: DLPFC transcriptome defines two molecular subtypes of schizophrenia (Translational Psychiatry, (2019), 9, 1, (147), 10.1038/s41398-019-0472-z)

  Bowen, E. F. W., Burgess, J. L., Granger, R., Kleinman, J. E. & Rhodes, C. H., Dec 1 2019, In: Translational psychiatry. 9, 1, 169.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Transcriptome 100%
  • Schizophrenia 88%
  • Psychiatry 80%

• Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation

  Price, A. J., Collado-Torres, L., Ivanov, N. A., Xia, W., Burke, E. E., Shin, J. H., Tao, R., Ma, L., Jia, Y., Hyde, T. M., Kleinman, J. E., Weinberger, D. R. & Jaffe, A. E., Sep 26 2019, In: Genome biology. 20, 1, 196.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • methylation 100%
  • Human Development 90%
  • DNA methylation 88%
  • DNA Methylation 82%
  • Methylation 75%
  20 Scopus citations

• DLPFC transcriptome defines two molecular subtypes of schizophrenia

  Bowen, E. F. W., Burgess, J. L., Granger, R., Kleinman, J. E. & Rhodes, C. H., Dec 1 2019, In: Translational psychiatry. 9, 1, 147.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcriptome 100%
  • Prefrontal Cortex 98%
  • Schizophrenia 88%
  • Gene Expression 27%
  • Genes 25%
  4 Scopus citations