Joel Daniel Greenspan

Research Associate

1977 …2020

Research output per year

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Research Output

2020

Pain Sensitivity Modifies Risk of Injury-Related Temporomandibular Disorder

Sharma, S., Ohrbach, R., Fillingim, R. B., Greenspan, J. D. & Slade, G., May 1 2020, In : Journal of Dental Research. 99, 5, p. 530-536 7 p.

Research output: Contribution to journalArticle

Open Access
2019

A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway

Khoury, S., Piltonen, M. H., Ton, A. T., Cole, T., Samoshkin, A., Smith, S. B., Belfer, I., Slade, G. D., Fillingim, R. B., Greenspan, J. D., Ohrbach, R., Maixner, W., Neely, G. G., Serohijos, A. W. R. & Diatchenko, L., Aug 2019, In : Annals of neurology. 86, 2, p. 168-180 13 p.

Research output: Contribution to journalArticle

Anatomical selectivity in overlap of chronic facial and bodily pain

Slade, G. D., Rosen, J. D., Ohrbach, R., Greenspan, J. D., Fillingim, R. B., Parisien, M., Khoury, S., Diatchenko, L., Maixner, W. & Bair, E., May 1 2019, In : Pain Reports. 4, 3, e729.

Research output: Contribution to journalArticle

Open Access

Clinical predictors of persistent temporomandibular disorder in people with first-onset temporomandibular disorder: A prospective case-control study

Meloto, C. B., Slade, G. D., Lichtenwalter, R. N., Bair, E., Rathnayaka, N., Diatchenko, L., Greenspan, J. D., Maixner, W., Fillingim, R. B. & Ohrbach, R., Jul 1 2019, In : Journal of the American Dental Association. 150, 7, p. 572-581.e10

Research output: Contribution to journalArticle

Decreased grey matter volume in mTBI patients with post-traumatic headache compared to headache-free mTBI patients and healthy controls: a longitudinal MRI study

Burrowes, S. A. B., Rhodes, C. S., Meeker, T. J., Greenspan, J. D., Gullapalli, R. P. & Seminowicz, D. A., Jan 1 2019, In : Brain Imaging and Behavior.

Research output: Contribution to journalArticle

Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males

Smith, S. B., Parisien, M., Bair, E., Belfer, I., Chabot-Doré, A. J., Gris, P., Khoury, S., Tansley, S., Torosyan, Y., Zaykin, D. V., Bernhardt, O., De Oliveira Serrano, P., Gracely, R. H., Jain, D., Järvelin, M. R., Kaste, L. M., Kerr, K. F., Kocher, T., Lähdesmäki, R., Laniado, N. & 21 others, Laurie, C. C., Laurie, C. A., Männikkö, M., Meloto, C. B., Nackley, A. G., Nelson, S. C., Pesonen, P., Ribeiro-Dasilva, M. C., Rizzatti-Barbosa, C. M., Sanders, A. E., Schwahn, C., Sipilä, K., Sofer, T., Teumer, A., Mogil, J. S., Fillingim, R. B., Greenspan, J. D., Ohrbach, R., Slade, G. D., Maixner, W. & Diatchenko, L., Mar 1 2019, In : Pain. 160, 3, p. 579-591 13 p.

Research output: Contribution to journalArticle

Incident injury is strongly associated with subsequent incident temporomandibular disorder: Results from the OPPERA study

Sharma, S., Wactawski-Wende, J., Lamonte, M. J., Zhao, J., Slade, G. D., Bair, E., Greenspan, J. D., Fillingim, R. B., Maixner, W. & Ohrbach, R., Jul 1 2019, In : Pain. 160, 7, p. 1551-1561 11 p.

Research output: Contribution to journalArticle

Non-invasive motor cortex neuromodulation reduces secondary hyperalgesia and enhances activation of the descending pain modulatory network

Meeker, T. J., Keaser, M. L., Khan, S. A., Gullapalli, R. P., Seminowicz, D. A. & Greenspan, J. D., Jan 1 2019, In : Frontiers in Neuroscience. 13, MAY, 467.

Research output: Contribution to journalArticle

Open Access

Premorbid and concurrent predictors of TMD onset and persistence

Ohrbach, R., Slade, G. D., Bair, E., Rathnayaka, N., Diatchenko, L., Greenspan, J. D., Maixner, W. & Fillingim, R. B., Jan 1 2019, (Accepted/In press) In : European Journal of Pain (United Kingdom).

Research output: Contribution to journalArticle

Racial/ethnic differences in experimental pain sensitivity and associated factors – Cardiovascular responsiveness and psychological status

Kim, H. J., Greenspan, J. D., Ohrbach, R., Fillingim, R. B., Maixner, W., Renn, C. L., Johantgen, M., Zhu, S. & Dorsey, S. G., Apr 1 2019, In : PloS one. 14, 4, e0215534.

Research output: Contribution to journalArticle

Open Access
2018

Characteristics Associated With High-Impact Pain in People With Temporomandibular Disorder: A Cross-Sectional Study

Miller, V. E., Poole, C., Golightly, Y., Barrett, D., Chen, D. G., Ohrbach, R., Greenspan, J. D., Fillingim, R. B. & Slade, G. D., Jan 1 2018, (Accepted/In press) In : Journal of Pain.

Research output: Contribution to journalArticle

Long-term changes in biopsychosocial characteristics related to temporomandibular disorder: findings from the OPPERA study

Fillingim, R. B., Slade, G. D., Greenspan, J. D., Dubner, R., Maixner, W., Bair, E. & Ohrbach, R., Nov 1 2018, In : Pain. 159, 11, p. 2403-2413 11 p.

Research output: Contribution to journalArticle

Quantitative Sensory Testing and Current Perception Threshold Testing in Patients With Chronic Pain Following Lower Extremity Fracture

Griffioen, M. A., Greenspan, J. D., Johantgen, M., Von Rueden, K., O’Toole, R. V., Dorsey, S. G. & Renn, C. L., Jan 1 2018, In : Biological Research for Nursing. 20, 1, p. 16-24 9 p.

Research output: Contribution to journalArticle

2017

Acute Pain Characteristics in Patients with and without Chronic Pain following Lower Extremity Injury

Griffioen, M. A., Greenspan, J. D., Johantgen, M., Von Rueden, K., O'Toole, R. V., Dorsey, S. G. & Renn, C. L., Feb 1 2017, In : Pain Management Nursing. 18, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes

Parisien, M., Khoury, S., Chabot-Doré, A. J., Sotocinal, S. G., Slade, G. D., Smith, S. B., Fillingim, R. B., Ohrbach, R., Greenspan, J. D., Maixner, W., Mogil, J. S., Belfer, I. & Diatchenko, L., May 30 2017, In : Cell Reports. 19, 9, p. 1940-1952 13 p.

Research output: Contribution to journalArticle

Epiregulin and EGFR interactions are involved in pain processing

Martin, L. J., Smith, S. B., Khoutorsky, A., Magnussen, C. A., Samoshkin, A., Sorge, R. E., Cho, C., Yosefpour, N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khuong, T. M., Mir, E., Gibson, D. G., Wieskopf, J. S., Sotocinal, S. G., Austin, J. S., Meloto, C. B., Gitt, J. H., Gkogkas, C. & 14 others, Sonenberg, N., Greenspan, J. D., Fillingim, R. B., Ohrbach, R., Slade, G. D., Knott, C., Dubner, R., Nackley, A. G., Ribeiro-Da-Silva, A., Neely, G. G., Maixner, W., Zaykin, D. V., Mogil, J. S. & Diatchenko, L., Sep 1 2017, In : Journal of Clinical Investigation. 127, 9, p. 3353-3366 14 p.

Research output: Contribution to journalArticle

Pain reduction due to novel sensory-motor training in Complex Regional Pain Syndrome I – A pilot study

Schmid, A. C., Schwarz, A., Gustin, S. M., Greenspan, J. D., Hummel, F. C. & Birbaumer, N., Apr 1 2017, In : Scandinavian Journal of Pain. 15, p. 30-37 8 p.

Research output: Contribution to journalArticle

Racial and ethnic differences in experimental pain sensitivity: Systematic review and meta-analysis

Kim, H. J., Yang, G. S., Greenspan, J. D., Downton, K. D., Griffith, K. A., Renn, C. L., Johantgen, M. & Dorsey, S. G., Feb 1 2017, In : Pain. 158, 2, p. 194-211 18 p.

Research output: Contribution to journalReview article

2016

Acute low back pain: Differential somatosensory function and gene expression compared with healthy no-pain controls

Starkweather, A. R., Ramesh, D., Lyon, D. E., Siangphoe, U., Deng, X., Sturgill, J., Heineman, A., Elswick, R. K., Dorsey, S. G. & Greenspan, J., Jan 1 2016, In : Clinical Journal of Pain. 32, 11, p. 933-939 7 p.

Research output: Contribution to journalArticle

Causal Mediation in the Development of Painful Temporomandibular Disorder

Sanders, A. E., Akinkugbe, A. A., Fillingim, R. B., Ohrbach, R., Greenspan, J. D., Maixner, W., Bair, E. & Slade, G. D., Sep 9 2016, (Accepted/In press) In : Journal of Pain.

Research output: Contribution to journalArticle

Characteristics of Patients with Lower Extremity Trauma with Improved and Not Improved Pain During Hospitalization: A Pilot Study

Griffioen, M. A., Johantgen, M., Von Rueden, K., Greenspan, J. D., Dorsey, S. G. & Renn, C. L., Feb 1 2016, In : Pain Management Nursing. 17, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Comparison of Low Back Pain Recovery and Persistence: A Descriptive Study of Characteristics at Pain Onset

Starkweather, A. R., Lyon, D. E., Kinser, P., Heineman, A., Sturgill, J. L., Deng, X., Siangphoe, U., Elswick, R. K., Greenspan, J. & Dorsey, S. G., Jul 1 2016, In : Biological Research For Nursing. 18, 4, p. 401-410 10 p.

Research output: Contribution to journalArticle

Demographic Predictors of Pain Sensitivity: Results From the OPPERA Study

Ostrom, C., Bair, E., Maixner, W., Dubner, R., Fillingim, R. B., Ohrbach, R., Slade, G. D. & Greenspan, J. D., May 27 2016, (Accepted/In press) In : Journal of Pain.

Research output: Contribution to journalArticle

Identification of clusters of individuals relevant to temporomandibular disorders and other chronic pain conditions: The OPPERA study

Bair, E., Gaynor, S., Slade, G. D., Ohrbach, R., Fillingim, R. B., Greenspan, J. D., Dubner, R., Smith, S. B., Diatchenko, L. & Maixner, W., Jun 1 2016, In : Pain. 157, 6, p. 1266-1278 13 p.

Research output: Contribution to journalArticle

Methods to measure peripheral and central sensitization using quantitative sensory testing: A focus on individuals with low back pain

Starkweather, A. R., Heineman, A., Storey, S., Rubia, G., Lyon, D. E., Greenspan, J. D. & Dorsey, S. G., Feb 1 2016, In : Applied Nursing Research. 29, p. 237-241 5 p.

Research output: Contribution to journalArticle

Modification of COMT-dependent pain sensitivity by psychological stress and sex

Meloto, C. B., Bortsov, A. V., Bair, E., Helgeson, E., Ostrom, C., Smith, S. B., Dubner, R., Slade, G. D., Fillingim, R. B., Greenspan, J. D., Ohrbach, R., Maixner, W., McLean, S. A. & Diatchenko, L., Apr 1 2016, In : Pain. 157, 4, p. 858-867 10 p.

Research output: Contribution to journalArticle

Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal)

Schmid, A. C., Chien, J. H., Greenspan, J. D., Garonzik, I., Weiss, N., Ohara, S. & Lenz, F., May 1 2016, In : Journal of Neurophysiology. 115, 5, p. 2421-2433 13 p.

Research output: Contribution to journalReview article

Painful Temporomandibular Disorder: Decade of Discovery from OPPERA Studies

Dubner, R., Slade, G. D., Ohrbach, R., Greenspan, J. D., Fillingim, R. B., Bair, E., Sanders, A. E., Dubner, R., Diatchenko, L., Meloto, C. B., Smith, S. & Maixner, W., Sep 1 2016, In : Journal of Dental Research. 95, 10, p. 1084-1092 9 p.

Research output: Contribution to journalReview article

Temporal change in headache and its contribution to the risk of developing first-onset temporomandibular disorder in the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) study

Tchivileva, I. E., Ohrbach, R., Fillingim, R. B., Greenspan, J. D., Maixner, W. & Slade, G. D., Oct 20 2016, In : Pain. 158, 1, p. 120-129 10 p.

Research output: Contribution to journalArticle

2015

COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain

Slade, G. D., Sanders, A. E., Ohrbach, R., Bair, E., Maixner, W., Greenspan, J. D., Fillingim, R. B., Smith, S. & Diatchenko, L., Sep 24 2015, In : Journal of Dental Research. 94, 9, p. 1187-1195 9 p.

Research output: Contribution to journalArticle

COMT gene locus: New functional variants

Meloto, C. B., Segall, S. K., Smith, S., Parisien, M., Shabalina, S. A., Rizzatti-Barbosa, C. M., Gauthier, J., Tsao, D., Convertino, M., Piltonen, M. H., Slade, G. D., Fillingim, R. B., Greenspan, J. D., Ohrbach, R., Knott, C., Maixner, W., Zaykin, D., Dokholyan, N. V., Reenila, I., Mannisto, P. T. & 1 others, Diatchenko, L., Oct 2015, In : Pain. 156, 10, p. 2072-2083 12 p.

Research output: Contribution to journalArticle

Controversies in the mechanism of central pain

Chien, J. H., Kim, J. H., Cheng, J. J., Liu, C. C., Greenspan, J. D. & Lenz, F. A., May 28 2015, The Brain Adapting with Pain: Contribution of Neuroimaging Technology to Pain Mechanisms. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Subjective Sleep Quality Deteriorates Before Development of Painful Temporomandibular Disorder

Sanders, A. E., Akinkugbe, A. A., Bair, E., Fillingim, R. B., Greenspan, J. D., Ohrbach, R., Dubner, R., Maixner, W. & Slade, G. D., Dec 4 2015, (Accepted/In press) In : Journal of Pain.

Research output: Contribution to journalArticle

2014

Intersession reliability of fMRI activation for heat pain and motor tasks

Quiton, R. L., Keaser, M. L., Zhuo, J., Gullapalli, R. P. & Greenspan, J. D., 2014, In : NeuroImage: Clinical. 5, p. 309-321 13 p.

Research output: Contribution to journalArticle

Motor cortex stimulation suppresses cortical responses to noxious hindpaw stimulation after spinal cord lesion in rats

Jiang, L., Ji, Y., Voulalas, P. J., Keaser, M., Xu, S., Gullapalli, R. P., Greenspan, J. & Masri, R., Jan 1 2014, In : Brain Stimulation. 7, 2, p. 182-189 8 p.

Research output: Contribution to journalArticle

Pressure pain thresholds fluctuate with, but do not usefully predict, the clinical course of painful temporomandibular disorder

Slade, G. D., Sanders, A. E., Ohrbach, R., Fillingim, R. B., Dubner, R., Gracely, R. H., Bair, E., Maixner, W. & Greenspan, J. D., Oct 1 2014, In : Pain. 155, 10, p. 2134-2143 10 p.

Research output: Contribution to journalArticle

2013

Chronic temporomandibular disorders are not necessarily associated with a compromised endogenous analgesic system

Garrett, P. H., Sarlani, E., Grace, E. G. & Greenspan, J. D., Jan 1 2013, In : Journal of Oral and Facial Pain and Headache. 27, 2, p. 142-150 9 p.

Research output: Contribution to journalArticle

Clinical orofacial characteristics associated with risk of first-onset TMD: The OPPERA prospective cohort study

Ohrbach, R., Bair, E., Fillingim, R. B., Gonzalez, Y., Gordon, S. M., Lim, P. F., Ribeiro-Dasilva, M., Diatchenko, L., Dubner, R., Greenspan, J. D., Knott, C., Maixner, W., Smith, S. B. & Slade, G. D., Dec 2013, In : Journal of Pain. 14, 12 SUPPL., p. T33-T50

Research output: Contribution to journalArticle

Facial pain with localized and widespread manifestations: Separate pathways of vulnerability

Slade, G. D., Smith, S. B., Zaykin, D. V., Tchivileva, I. E., Gibson, D. G., Yuryev, A., Mazo, I., Bair, E., Fillingim, R., Ohrbach, R., Greenspan, J., Maixner, W. & Diatchenko, L., Nov 2013, In : Pain. 154, 11, p. 2335-2343 9 p.

Research output: Contribution to journalArticle

General health status and incidence of first-onset temporomandibular disorder: The OPPERA prospective cohort study

Sanders, A. E., Slade, G. D., Bair, E., Fillingim, R. B., Knott, C., Dubner, R., Greenspan, J. D., Maixner, W. & Ohrbach, R., Dec 2013, In : Journal of Pain. 14, 12 SUPPL., p. T51-T62

Research output: Contribution to journalArticle

Genetic variants associated with development of TMD and its intermediate phenotypes: The genetic architecture of TMD in the OPPERA prospective cohort study

Smith, S. B., Mir, E., Bair, E., Slade, G. D., Dubner, R., Fillingim, R. B., Greenspan, J. D., Ohrbach, R., Knott, C., Weir, B., Maixner, W. & Diatchenko, L., Dec 2013, In : Journal of Pain. 14, 12 SUPPL., p. T91-T101

Research output: Contribution to journalArticle

Multivariable modeling of phenotypic risk factors for first-onset TMD: The OPPERA prospective cohort study

Bair, E., Ohrbach, R., Fillingim, R. B., Greenspan, J. D., Dubner, R., Diatchenko, L., Helgeson, E., Knott, C., Maixner, W. & Slade, G. D., Dec 2013, In : Journal of Pain. 14, 12 SUPPL., p. T102-T115

Research output: Contribution to journalArticle

Pain sensitivity and autonomic factors associated with development of TMD: The OPPERA prospective cohort study

Greenspan, J. D., Slade, G. D., Bair, E., Dubner, R., Fillingim, R. B., Ohrbach, R., Knott, C., Diatchenko, L., Liu, Q. & Maixner, W., Dec 2013, In : Journal of Pain. 14, 12 SUPPL., p. T63-T74.e6

Research output: Contribution to journalArticle

Preclinical episodes of orofacial pain symptoms and their association with health care behaviors in the OPPERA prospective cohort study

Slade, G. D., Sanders, A. E., Bair, E., Brownstein, N., Dampier, D., Knott, C., Fillingim, R., Maixner, W. O., Smith, S., Greenspan, J., Dubner, R. & Ohrbach, R., May 2013, In : Pain. 154, 5, p. 750-760 11 p.

Research output: Contribution to journalArticle

Psychological factors associated with development of TMD: The OPPERA prospective cohort study

Fillingim, R. B., Ohrbach, R., Greenspan, J. D., Knott, C., Diatchenko, L., Dubner, R., Bair, E., Baraian, C., MacK, N., Slade, G. D. & Maixner, W., Dec 2013, In : Journal of Pain. 14, 12 SUPPL., p. T75-T90

Research output: Contribution to journalArticle

Signs and symptoms of first-onset TMD and sociodemographic predictors of its development: The OPPERA prospective cohort study

Slade, G. D., Bair, E., Greenspan, J. D., Dubner, R., Fillingim, R. B., Diatchenko, L., Maixner, W., Knott, C. & Ohrbach, R., Dec 2013, In : Journal of Pain. 14, 12 SUPPL., p. T20-T32.e3

Research output: Contribution to journalArticle

Sleep apnea symptoms and risk of temporomandibular disorder: OPPERA cohort

Sanders, A. E., Essick, G. K., Fillingim, R., Knott, C., Ohrbach, R., Greenspan, J. D., Diatchenko, L., Maixner, W., Dubner, R., Bair, E., Miller, V. E. & Slade, G. D., May 20 2013, In : Journal of Dental Research. 92, SUPPL. 7, p. 70S-77S

Research output: Contribution to journalArticle

Study protocol, sample characteristics, and loss to follow-up: The OPPERA prospective cohort study

Bair, E., Brownstein, N. C., Ohrbach, R., Greenspan, J. D., Dubner, R., Fillingim, R. B., Maixner, W., Smith, S. B., Diatchenko, L., Gonzalez, Y., Gordon, S. M., Lim, P. F., Ribeiro-Dasilva, M., Dampier, D., Knott, C. & Slade, G. D., Dec 2013, In : Journal of Pain. 14, 12 SUPPL., p. T2-T19

Research output: Contribution to journalArticle