JIKUI Shen

2022

Advanced Functions Embedded in the Second Version of Database, Global Evaluation of SARS-CoV-2/hCoV-19 Sequences 2

Li, K., Wang, A. K. Y., Liu, S., Fang, S., Lu, A. Z., Shen, J., Yang, L., Hu, C. D., Yang, K. & Wan, J., Apr 11 2022, In: Frontiers in Medicine. 9, 813964.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

GESS: A database of global evaluation of SARS-CoV-2/hCoV-19 sequences

Fang, S., Li, K., Shen, J., Liu, S., Liu, J., Yang, L., Hu, C. D. & Wan, J., Jan 8 2021, In: Nucleic acids research. 49, D1, p. D706-D714

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Proteosomal degradation impairs transcytosis of AAV vectors from suprachoroidal space to retina

Ding, K., Shen, J., Hackett, S., Khan, M. & Campochiaro, P. A., Dec 2021, In: Gene Therapy. 28, 12, p. 740-747 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Updated SARS-CoV-2 single nucleotide variants and mortality association

Fang, S., Liu, S., Shen, J., Lu, A. Z., Wang, A. K. Y., Zhang, Y., Li, K., Liu, J., Yang, L., Hu, C. D. & Wan, J., Dec 2021, In: Journal of Medical Virology. 93, 12, p. 6525-6534 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Genetic Spectrum and Distinct Evolution Patterns of SARS-CoV-2

Liu, S., Shen, J., Fang, S., Li, K., Liu, J., Yang, L., Hu, C. D. & Wan, J., Sep 25 2020, In: Frontiers in Microbiology. 11, 593548.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Inhibiting NF-κB signaling activation reduces retinal neovascularization by promoting a polarization shift in macrophages

Sui, A., Chen, X., Demetriades, A. M., Shen, J., Cai, Y., Yao, Y., Yao, Y., Zhu, Y., Shen, X. & Xie, B., Jun 2020, In: Investigative Ophthalmology and Visual Science. 61, 6, 4.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1β/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model

Sui, A., Chen, X., Shen, J., Demetriades, A. M., Yao, Y., Yao, Y., Zhu, Y., Shen, X. & Xie, B., Oct 1 2020, In: Cell Death and Disease. 11, 10, 901.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases

Kureshi, R., Zhu, A., Shen, J., Tzeng, S. Y., Astrab, L. R., Sargunas, P. R., Green, J. J., Campochiaro, P. A. & Spangler, J. B., Oct 1 2020, In: Cellular and Molecular Bioengineering. 13, 5, p. 405-418 14 p.

Research output: Contribution to journal › Article › peer-review

Suprachoroidal gene transfer with nonviral nanoparticles

Shen, J., Kim, J., Tzen, S. Y., Ding, K., Hafiz, Z., Long, D., Wang, J., Gree, J. J. & Campochia, P. A., Jul 2020, In: Science Advances. 6, 27, eaba1606.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Sustained delivery of acriflavine from the suprachoroidal space provides long term suppression of choroidal neovascularization

Hackett, S. F., Fu, J., Kim, Y. C., Tsujinaka, H., Shen, J., Lima e Silva, R., Khan, M., Hafiz, Z., Wang, T., Shin, M., Anders, N. M., He, P., Ensign, L. M., Hanes, J. & Campochiaro, P. A., Jun 2020, In: Biomaterials. 243, 119935.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles

Tsujinaka, H., Fu, J., Shen, J., Yu, Y., Hafiz, Z., Kays, J., McKenzie, D., Cardona, D., Culp, D., Peterson, W., Gilger, B. C., Crean, C. S., Zhang, J. Z., Kanan, Y., Yu, W., Cleland, J. L., Yang, M., Hanes, J. & Campochiaro, P. A., Dec 1 2020, In: Nature communications. 11, 1, 694.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2019

AAV8-vectored suprachoroidal gene transfer produces widespread ocular transgene expression

Ding, K., Shen, J., Hafiz, Z., Hackett, S. F., e Silva, R. L., Khan, M., Lorenc, V. E., Chen, D., Chadha, R., Zhang, M., van Everen, S., Buss, N., Fiscella, M., Danos, O. & Campochiaro, P. A., Nov 1 2019, In: Journal of Clinical Investigation. 129, 11, p. 4901-4911 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling

Mirando, A. C., Shen, J., Silva, R. L. E., Chu, Z., Sass, N. C., Lorenc, V. E., Green, J. J., Campochiaro, P. A., Popel, A. S. & Pandey, N. B., Feb 21 2019, In: JCI Insight. 4, 4

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2018

AAV8-antiVEGFfab Ocular Gene Transfer for Neovascular Age-Related Macular Degeneration

Liu, Y., Fortmann, S. D., Shen, J., Wielechowski, E., Tretiakova, A., Yoo, S., Kozarsky, K., Wang, J., Wilson, J. M. & Campochiaro, P. A., Feb 7 2018, In: Molecular Therapy. 26, 2, p. 542-549 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

ATN-161 as an integrin α5β1 antagonist depresses ocular neovascularization by promoting new vascular endothelial cell apoptosis

Sui, A., Zhong, Y., Demetriades, A. M., Shen, J., Su, T., Yao, Y., Gao, Y., Zhu, Y., Shen, X. & Xie, B., Aug 22 2018, In: Medical Science Monitor. 24, p. 5860-5873 14 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Endocan blockade suppresses experimental ocular neovascularization in mice

Su, T., Zhong, Y., Demetriades, A. M., Shen, J., Sui, A., Yao, Y., Gao, Y., Zhu, Y., Shen, X. & Xie, B., Feb 2018, In: Investigative Ophthalmology and Visual Science. 59, 2, p. 930-939 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Mousetap, a Novel Technique to Collect Uncontaminated Vitreous or Aqueous and Expand Usefulness of Mouse Models

Fortmann, S. D., Lorenc, V. E., Shen, J., Hackett, S. F. & Campochiaro, P. A., Dec 1 2018, In: Scientific reports. 8, 1, 6371.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

VEGF/VEGFR2 blockade does not cause retinal atrophy in AMD-relevant models

Long, D., Kanan, Y., Shen, J., Hackett, S. F., Liu, Y., Hafiz, Z., Khan, M., Lu, L. & Campochiaro, P. A., May 17 2018, In: JCI Insight. 3, 10

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2017

Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration

Ding, K., Eaton, L., Bowley, D., Rieser, M., Chang, Q., Harris, M. C., Clabbers, A., Dong, F., Shen, J., Hackett, S. F., Touw, D. S., Bixby, J., Zhong, S., Benatuil, L., Bose, S., Grinnell, C., Preston, G. M., Iyer, R., Sadhukhan, R., Marchie, S., & 6 othersOvermeyer, G., Ghayur, T., van Riet, D. A., Tang, S., Campochario, P. A. & Gu, J., Feb 17 2017, In: mAbs. 9, 2, p. 269-284 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Reversible retinal vessel closure from VEGF-induced leukocyte plugging

Liu, Y., Shen, J., Fortmann, S. D., Wang, J., Vestweber, D. & Campochiaro, P. A., Sep 21 2017, In: JCI Insight. 2, 18, e95530.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization

Zeng, M., Shen, J., Liu, Y., Lu, L. Y., Ding, K., Fortmann, S. D., Khan, M., Wang, J., Hackett, S. F., Semenza, G. L. & Campochiaro, P. A., Apr 1 2017, In: Journal of Molecular Medicine. 95, 4, p. 417-429 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2014

Antagonism of PDGF-BB suppresses subretinal neovascularization and enhances the effects of blocking VEGF-A

Dong, A., Seidel, C., Snell, D., Ekawardhani, S., Ahlskog, J. K. J., Baumann, M., Shen, J., Iwase, T., Tian, J., Stevens, R., Hackett, S. F., Stumpp, M. T. & Campochiaro, P. A., Jul 2014, In: Angiogenesis. 17, 3, p. 553-562 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Improvement and optimization of standards for a preclinical animal test model of laser induced choroidal neovascularization

Zhu, Y., Lu, Q., Shen, J., Zhang, L., Gao, Y., Shen, X. & Xie, B., Apr 29 2014, In: PloS one. 9, 4, e94743.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: Reciprocal suppression with VEGF

Shen, J., Choy, D. F., Yoshida, T., Iwase, T., Hafiz, G., Xie, B., Hackett, S. F., Arron, J. R. & Campochiaro, P. A., Aug 2014, In: Journal of Cellular Physiology. 229, 8, p. 974-983 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

Shen, J., Frye, M., Lee, B. L., Reinardy, J. L., McClung, J. M., Ding, K., Kojima, M., Xia, H., Seidel, C., Lima E Silva, R., Dong, A., Hackett, S. F., Wang, J., Howard, B. W., Vestweber, D., Kontos, C. D., Peters, K. G. & Campochiaro, P. A., Oct 1 2014, In: Journal of Clinical Investigation. 124, 10, p. 4564-4576 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

118 Scopus citations

2013

Sustained delivery of a HIF-1 antagonist for ocular neovascularization

Iwase, T., Fu, J., Yoshida, T., Muramatsu, D., Miki, A., Hashida, N., Lu, L., Oveson, B., Lima E Silva, R., Seidel, C., Yang, M., Connelly, S., Shen, J., Han, B., Wu, M., Semenza, G. L., Hanes, J. & Campochiaro, P. A., 2013, In: Journal of Controlled Release. 172, 3, p. 625-633 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Topical Pazopanib Blocks VEGF-induced vascular leakage and neovascularization in the mouse retina but is ineffective in the rabbit

Iwase, T., Oveson, B. C., Hashida, N., e Silva, R. L., Shen, J., Krauss, A. H., Gale, D. C., Adamson, P. & Campochiaro, P. A., Jan 2013, In: Investigative Ophthalmology and Visual Science. 54, 1, p. 503-511 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

VEGF Receptor Blockade Markedly Reduces Retinal Microglia/Macrophage Infiltration into Laser-Induced CNV

Huang, H., Parlier, R., Shen, J. K., Lutty, G. A. & Vinores, S. A., Aug 20 2013, In: PloS one. 8, 8, e71808.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

2011

Blockade of VEGFR1 and 2 suppresses pathological angiogenesis and vascular leakage in the eye

Huang, H., Shen, J. & Vinores, S. A., 2011, In: PloS one. 6, 6, e21411.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

Vascular cell-adhesion molecule-1 plays a central role in the proangiogenic effects of oxidative stress

Dong, A., Shen, J., Zeng, M. B. & Campochiaro, P. A., Aug 30 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. 14614-14619 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Vascular endothelial growth factor-B gene transfer exacerbates retinal and choroidal neovascularization and vasopermeability without promoting inflammation

Zhong, X., Huang, H., Shen, J., Zacchigna, S., Zentilin, L., Giacca, M. & Vinores, S. A., 2011, In: Molecular vision. 17, p. 492-507 16 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

2010

Agents that bind annexin A2 suppress ocular neovascularization

Lima E Silva, R., Shen, J., Gong, Y. Y., Seidel, C. P., Hackett, S. F., Kesavan, K., Jacoby, D. B. & Campochiaro, P. A., Dec 2010, In: Journal of Cellular Physiology. 225, 3, p. 855-864 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization

Yoshida, T., Zhang, H., Iwase, T., Shen, J., Semenza, G. L. & Campochiaro, P. A., Jun 2010, In: FASEB Journal. 24, 6, p. 1759-1767 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

89 Scopus citations

Parstatin suppresses ocular neovascularization and inflammation

Huang, H., Vasilakis, P., Zhong, X., Shen, J. K., Geronatsiou, K., Papadaki, H., Maragoudakis, M. E., Gartaganis, S. P., Vinores, S. A. & Tsopanoglou, N. E., Nov 2010, In: Investigative Ophthalmology and Visual Science. 51, 11, p. 5825-5832 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2009

Blockade of Sphingosine-1- Phosphate Reduces Macrophage Influx and Retinal and Choroidal Neovascularization

Bing, X. I. E., Shen, J., Dong, A., Rashid, A., Stoller, G. & Campochiaro, P. A., Jan 2009, In: Journal of Cellular Physiology. 218, 1, p. 192-198 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

72 Scopus citations

Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa

Usui, S., Komeima, K., Lee, S. Y., Jo, Y. J., Ueno, S., Rogers, B. S., Wu, Z., Shen, J., Lu, L., Oveson, B. C., Rabinovitch, P. S. & Campochiaro, P. A., 2009, In: Molecular Therapy. 17, 5, p. 778-786 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

91 Scopus citations

Inflammatory cytokine expression on the ocular surface in the Botulium toxin B induced murine dry eye model.

Zhu, L., Shen, J., Zhang, C., Park, C. Y., Kohanim, S., Yew, M., Parker, J. S. & Chuck, R. S., 2009, In: Molecular vision. 15, p. 250-258 9 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Oxidative stress promotes ocular neovascularization

Dong, A., Xie, B., Shen, J., Yoshida, T., Yokoi, K., Hackett, S. F. & Campochiaro, P. A., Jun 2009, In: Journal of Cellular Physiology. 219, 3, p. 544-552 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

100 Scopus citations

2008

An Adam15 amplification loop promotes vascular endothelial growth factor-induced ocular neovascularization

Xie, B., Shen, J., Dong, A., Swaim, M., Hackett, S. F., Wyder, L., Worpenberg, S., Barbieri, S. & Campochiaro, P. A., Aug 2008, In: FASEB Journal. 22, 8, p. 2775-2783 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa

Komeima, K., Usui, S., Shen, J., Rogers, B. S. & Campochiaro, P. A., Sep 15 2008, In: Free Radical Biology and Medicine. 45, 6, p. 905-912 8 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

MicroRNAs regulate ocular neovascularization

Shen, J. K., Yang, X., Xie, B., Chen, Y., Swaim, M., Hackett, S. F. & Campochiaro, P. A., Jul 2008, In: Molecular Therapy. 16, 7, p. 1208-1216 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

184 Scopus citations

2007

Differential sensitivity of cones to iron-mediated oxidative damage

Rogers, B. S., Symons, R. C. A., Komeima, K., Shen, J. K., Xiao, W., Swaim, M. E., Yuan, Y. G., Kachi, S. & Campochiaro, P. A., Jan 2007, In: Investigative Ophthalmology and Visual Science. 48, 1, p. 438-445 8 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Increased expression of glial cell line-derived neurotrophic factor protects against oxidative damage-induced retinal degeneration

Dong, A., Shen, J., Krause, M., Hackett, S. F. & Campochiaro, P. A., Nov 2007, In: Journal of Neurochemistry. 103, 3, p. 1041-1052 12 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

In vivo immunostaining demonstrates macrophages associate with growing and regressing vessels

Shen, J., Xie, B., Dong, A., Swaim, M., Hackett, S. F. & Campochiaro, P. A., Sep 2007, In: Investigative Ophthalmology and Visual Science. 48, 9, p. 4335-4341 7 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Oxidative damage in age-related macular degeneration

Shen, J. K., Dong, A., Hackett, S. F., Bell, W. R., Green, W. R. & Campochiaro, P. A., Oct 2007, In: Histology and Histopathology. 22, 10-12, p. 1301-1308 8 p.

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization

Lima E Silva, R., Shen, J., Hackett, S. F., Kachi, S., Akiyama, H., Kiuchi, K., Yokoi, K., Hatara, M. C., Lauer, T., Aslam, S., Gong, Y. Y., Xiao, W. H., Khu, N. H., Thut, C. & Campochiaro, P. A., Oct 2007, In: FASEB Journal. 21, 12, p. 3219-3230 12 p.

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

TNF-α is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage

Vinores, S. A., Xiao, W. H., Shen, J. K. & Campochiaro, P. A., Jan 2007, In: Journal of Neuroimmunology. 182, 1-2, p. 73-79 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

Vegf or EphA2 antisense polyamide-nucleic acids; vascular localization and suppression of retinal neovascularization

Shen, J., Xie, B., Hatara, C. M., Hackett, S. F. & Campochiaro, P. A., Nov 2007, In: Molecular Therapy. 15, 11, p. 1924-1930 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2006

En masse nascent transcription analysis to elucidate regulatory transcription factors

Fan, J., Zhan, M., Shen, J., Matindale, J. L., Yang, X., Kawai, T. & Gorospe, M., 2006, In: Nucleic acids research. 34, 5, p. 1492-1500 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development

Vinores, S. A., Xiao, W. H., Aslam, S., Shen, J., Oshima, Y., Nambu, H., Liu, H., Carmeliet, P. & Campochiaro, P. A., Mar 2006, In: Journal of Cellular Physiology. 206, 3, p. 749-758 10 p.

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

JIKUI Shen

Research output

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