Jikui Shen

Research Associate

20012020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Sustained delivery of acriflavine from the suprachoroidal space provides long term suppression of choroidal neovascularization

Hackett, S. F., Fu, J., Kim, Y. C., Tsujinaka, H., Shen, J., Lima e Silva, R., Khan, M., Hafiz, Z., Wang, T., Shin, M., Anders, N. M., He, P., Ensign, L. M., Hanes, J. & Campochiaro, P. A., Jun 2020, In : Biomaterials. 243, 119935.

Research output: Contribution to journalArticle

Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles

Tsujinaka, H., Fu, J., Shen, J., Yu, Y., Hafiz, Z., Kays, J., McKenzie, D., Cardona, D., Culp, D., Peterson, W., Gilger, B. C., Crean, C. S., Zhang, J. Z., Kanan, Y., Yu, W., Cleland, J. L., Yang, M., Hanes, J. & Campochiaro, P. A., Dec 1 2020, In : Nature communications. 11, 1, 694.

Research output: Contribution to journalArticle

Open Access
2019

A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling

Mirando, A. C., Shen, J., Formica, R., Chu, Z., Sass, N. C., Lorenc, V. E., Green, J., Campochiaro, P. A., Popel, A. S. & Pandey, N., Feb 21 2019, In : JCI insight. 4, 4

Research output: Contribution to journalArticle

Open Access
2018

ATN-161 as an integrin α5β1 antagonist depresses ocular neovascularization by promoting new vascular endothelial cell apoptosis

Sui, A., Zhong, Y., Demetriades, A. M., Shen, J., Su, T., Yao, Y., Gao, Y., Zhu, Y., Shen, X. & Xie, B., Aug 22 2018, In : Medical Science Monitor. 24, p. 5860-5873 14 p.

Research output: Contribution to journalArticle

Endocan blockade suppresses experimental ocular neovascularization in mice

Su, T., Zhong, Y., Demetriades, A. M., Shen, J., Sui, A., Yao, Y., Gao, Y., Zhu, Y., Shen, X. & Xie, B., Feb 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 930-939 10 p.

Research output: Contribution to journalArticle

Mousetap, a Novel Technique to Collect Uncontaminated Vitreous or Aqueous and Expand Usefulness of Mouse Models

Fortmann, S. D., Lorenc, V. E., Shen, J., Hackett, S. F. & Campochiaro, P. A., Dec 1 2018, In : Scientific Reports. 8, 1, 6371.

Research output: Contribution to journalArticle

VEGF/VEGFR2 blockade does not cause retinal atrophy in AMD-relevant models

Long, D., Kanan, Y., Shen, J., Hackett, S. F., Liu, Y., Hafiz, Z., Khan, M., Lu, L. & Campochiaro, P. A., May 17 2018, In : JCI insight. 3, 10

Research output: Contribution to journalArticle

Open Access
2017

AAV8-antiVEGFfab Ocular Gene Transfer for Neovascular Age-Related Macular Degeneration

Liu, Y., Fortmann, S. D., Shen, J., Wielechowski, E., Tretiakova, A., Yoo, S., Kozarsky, K., Wang, J., Wilson, J. M. & Campochiaro, P. A., Jan 1 2017, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration

Ding, K., Eaton, L., Bowley, D., Rieser, M., Chang, Q., Harris, M. C., Clabbers, A., Dong, F., Shen, J., Hackett, S. F., Touw, D. S., Bixby, J., Zhong, S., Benatuil, L., Bose, S., Grinnell, C., Preston, G. M., Iyer, R., Sadhukhan, R., Marchie, S. & 6 others, Overmeyer, G., Ghayur, T., van Riet, D. A., Tang, S., Campochario, P. A. & Gu, J., Feb 17 2017, In : mAbs. 9, 2, p. 269-284 16 p.

Research output: Contribution to journalArticle

Reversible retinal vessel closure from VEGF-induced leukocyte plugging

Liu, Y., Shen, J., Fortmann, S. D., Wang, J., Vestweber, D. & Campochiaro, P. A., Sep 21 2017, In : JCI insight. 2, 18

Research output: Contribution to journalArticle

Open Access
2016

The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization

Zeng, M., Shen, J., Liu, Y., Lu, L. Y., Ding, K., Fortmann, S. D., Khan, M., Wang, J., Hackett, S. F., Semenza, G. L. & Campochiaro, P. A., Dec 21 2016, (Accepted/In press) In : Journal of Molecular Medicine. p. 1-13 13 p.

Research output: Contribution to journalArticle

2014

Antagonism of PDGF-BB suppresses subretinal neovascularization and enhances the effects of blocking VEGF-A

Dong, A., Seidel, C., Snell, D., Ekawardhani, S., Ahlskog, J. K. J., Baumann, M., Shen, J., Iwase, T., Tian, J., Stevens, R., Hackett, S. F., Stumpp, M. T. & Campochiaro, P. A., Jul 2014, In : Angiogenesis. 17, 3, p. 553-562 10 p.

Research output: Contribution to journalArticle

Improvement and optimization of standards for a preclinical animal test model of laser induced choroidal neovascularization

Zhu, Y., Lu, Q., Shen, J., Zhang, L., Gao, Y., Shen, X. & Xie, B., Apr 29 2014, In : PloS one. 9, 4, e94743.

Research output: Contribution to journalArticle

Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: Reciprocal suppression with VEGF

Shen, J., Choy, D. F., Yoshida, T., Iwase, T., Hafiz, G., Xie, B., Hackett, S. F., Arron, J. R. & Campochiaro, P. A., Aug 2014, In : Journal of Cellular Physiology. 229, 8, p. 974-983 10 p.

Research output: Contribution to journalArticle

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

Shen, J., Frye, M., Lee, B. L., Reinardy, J. L., McClung, J. M., Ding, K., Kojima, M., Xia, H., Seidel, C., Lima E Silva, R., Dong, A., Hackett, S. F., Wang, J., Howard, B. W., Vestweber, D., Kontos, C. D., Peters, K. G. & Campochiaro, P. A., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4564-4576 13 p.

Research output: Contribution to journalArticle

2013

Sustained delivery of a HIF-1 antagonist for ocular neovascularization

Iwase, T., Fu, J., Yoshida, T., Muramatsu, D., Miki, A., Hashida, N., Lu, L., Oveson, B., Lima E Silva, R., Seidel, C., Yang, M., Connelly, S., Shen, J., Han, B., Wu, M., Semenza, G. L., Hanes, J. & Campochiaro, P. A., Nov 13 2013, In : Journal of Controlled Release. 172, 3, p. 625-633 9 p.

Research output: Contribution to journalArticle

Topical Pazopanib Blocks VEGF-induced vascular leakage and neovascularization in the mouse retina but is ineffective in the rabbit

Iwase, T., Oveson, B. C., Hashida, N., e Silva, R. L., Shen, J., Krauss, A. H., Gale, D. C., Adamson, P. & Campochiaro, P. A., Jan 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 503-511 9 p.

Research output: Contribution to journalArticle

VEGF Receptor Blockade Markedly Reduces Retinal Microglia/Macrophage Infiltration into Laser-Induced CNV

Huang, H., Parlier, R., Shen, J. K., Lutty, G. A. & Vinores, S. A., Aug 20 2013, In : PloS one. 8, 8, e71808.

Research output: Contribution to journalArticle

2011

Blockade of VEGFR1 and 2 suppresses pathological angiogenesis and vascular leakage in the eye

Huang, H., Shen, J. & Vinores, S. A., 2011, In : PLoS One. 6, 6, e21411.

Research output: Contribution to journalArticle

Vascular endothelial growth factor-B gene transfer exacerbates retinal and choroidal neovascularization and vasopermeability without promoting inflammation

Zhong, X., Huang, H., Shen, J., Zacchigna, S., Zentilin, L., Giacca, M. & Vinores, S. A., Mar 7 2011, In : Molecular vision. 17, p. 492-507 16 p.

Research output: Contribution to journalArticle

2010

Agents that bind annexin A2 suppress ocular neovascularization

Lima E Silva, R., Shen, J., Gong, Y. Y., Seidel, C. P., Hackett, S. F., Kesavan, K., Jacoby, D. B. & Campochiaro, P. A., Dec 1 2010, In : Journal of Cellular Physiology. 225, 3, p. 855-864 10 p.

Research output: Contribution to journalArticle

Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization

Yoshida, T., Zhang, H., Iwase, T., Shen, J., Semenza, G. L. & Campochiaro, P. A., Jun 1 2010, In : FASEB Journal. 24, 6, p. 1759-1767 9 p.

Research output: Contribution to journalArticle

Parstatin suppresses ocular neovascularization and inflammation

Huang, H., Vasilakis, P., Zhong, X., Shen, J., Geronatsiou, K., Papadaki, H., Maragoudakis, M. E., Gartaganis, S. P., Vinores, S. A. & Tsopanoglou, N. E., Nov 2010, In : Investigative Ophthalmology and Visual Science. 51, 11, p. 5825-5832 8 p.

Research output: Contribution to journalArticle

2009

Blockade of Sphingosine-1- Phosphate Reduces Macrophage Influx and Retinal and Choroidal Neovascularization

Bing, X. I. E., Shen, J., Dong, A., Rashid, A., Stoller, G. & Campochiaro, P. A., Jan 1 2009, In : Journal of Cellular Physiology. 218, 1, p. 192-198 7 p.

Research output: Contribution to journalArticle

Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa

Usui, S., Komeima, K., Lee, S. Y., Jo, Y. J., Ueno, S., Rogers, B. S., Wu, Z., Shen, J., Lu, L., Oveson, B. C., Rabinovitch, P. S. & Campochiaro, P. A., Mar 18 2009, In : Molecular Therapy. 17, 5, p. 778-786 9 p.

Research output: Contribution to journalArticle

Inflammatory cytokine expression on the ocular surface in the Botulium toxin B induced murine dry eye model.

Zhu, L., Shen, J., Zhang, C., Park, C. Y., Kohanim, S., Yew, M., Parker, J. S. & Chuck, R. S., 2009, In : Molecular vision. 15, p. 250-258 9 p.

Research output: Contribution to journalArticle

Oxidative stress promotes ocular neovascularization

Dong, A., Xie, B., Shen, J., Yoshida, T., Yokoi, K., Hackett, S. F. & Campochiaro, P. A., Jun 1 2009, In : Journal of Cellular Physiology. 219, 3, p. 544-552 9 p.

Research output: Contribution to journalArticle

2008

An Adam15 amplification loop promotes vascular endothelial growth factor-induced ocular neovascularization

Xie, B., Shen, J., Dong, A., Swaim, M., Hackett, S. F., Wyder, L., Worpenberg, S., Barbieri, S. & Campochiaro, P. A., Aug 2008, In : FASEB Journal. 22, 8, p. 2775-2783 9 p.

Research output: Contribution to journalArticle

Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa

Komeima, K., Usui, S., Shen, J., Rogers, B. S. & Campochiaro, P. A., Sep 15 2008, In : Free Radical Biology and Medicine. 45, 6, p. 905-912 8 p.

Research output: Contribution to journalArticle

MicroRNAs regulate ocular neovascularization

Shen, J. K., Yang, X., Xie, B., Chen, Y., Swaim, M., Hackett, S. F. & Campochiaro, P. A., Jul 2008, In : Molecular Therapy. 16, 7, p. 1208-1216 9 p.

Research output: Contribution to journalArticle

2007

Differential sensitivity of cones to iron-mediated oxidative damage

Rogers, B. S., Symons, R. C. A., Komeima, K., Shen, J. K., Xiao, W., Swaim, M. E., Yuan, Y. G., Kachi, S. & Campochiaro, P. A., Jan 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 1, p. 438-445 8 p.

Research output: Contribution to journalArticle

Increased expression of glial cell line-derived neurotrophic factor protects against oxidative damage-induced retinal degeneration

Dong, A., Shen, J., Krause, M., Hackett, S. F. & Campochiaro, P. A., Nov 1 2007, In : Journal of Neurochemistry. 103, 3, p. 1041-1052 12 p.

Research output: Contribution to journalArticle

In vivo immunostaining demonstrates macrophages associate with growing and regressing vessels

Shen, J., Xie, B., Dong, A., Swaim, M., Hackett, S. F. & Campochiaro, P. A., Sep 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 9, p. 4335-4341 7 p.

Research output: Contribution to journalArticle

Oxidative damage in age-related macular degeneration

Shen, J. K., Dong, A., Hackett, S. F., Bell, W. R., Green, W. R. & Campochiaro, P. A., Oct 1 2007, In : Histology and Histopathology. 22, 10-12, p. 1301-1308 8 p.

Research output: Contribution to journalArticle

The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization

Lima E Silva, R., Shen, J., Hackett, S. F., Kachi, S., Akiyama, H., Kiuchi, K., Yokoi, K., Hatara, M. C., Lauer, T., Aslam, S., Gong, Y. Y., Xiao, W. H., Khu, N. H., Thut, C. & Campochiaro, P. A., Oct 1 2007, In : FASEB Journal. 21, 12, p. 3219-3230 12 p.

Research output: Contribution to journalArticle

TNF-α is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage

Vinores, S. A., Xiao, W. H., Shen, J. K. & Campochiaro, P. A., Jan 1 2007, In : Journal of Neuroimmunology. 182, 1-2, p. 73-79 7 p.

Research output: Contribution to journalArticle

Vegf or EphA2 antisense polyamide-nucleic acids; vascular localization and suppression of retinal neovascularization

Shen, J., Xie, B., Hatara, C. M., Hackett, S. F. & Campochiaro, P. A., Nov 2007, In : Molecular Therapy. 15, 11, p. 1924-1930 7 p.

Research output: Contribution to journalArticle

2006

En masse nascent transcription analysis to elucidate regulatory transcription factors

Fan, J., Zhan, M., Shen, J., Matindale, J. L., Yang, X., Kawai, T. & Gorospe, M., Apr 10 2006, In : Nucleic acids research. 34, 5, p. 1492-1500 9 p.

Research output: Contribution to journalArticle

Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development

Vinores, S. A., Xiao, W. H., Aslam, S., Shen, J., Oshima, Y., Nambu, H., Liu, H., Carmeliet, P. & Campochiaro, P. A., Mar 1 2006, In : Journal of Cellular Physiology. 206, 3, p. 749-758 10 p.

Research output: Contribution to journalArticle

Recombinant non-collagenous domain of α2(IV) collagen causes involution of choroidal neovascularization by inducing apoptosis

Formica, R., Kachi, S., Akiyama, H., Shen, J., Aslam, S., Gong, Y. Y., Khu, N. H., Hatara, M. C., Boutaud, A., Peterson, R. & Campochiaro, P. A., Jul 2006, In : Journal of Cellular Physiology. 208, 1, p. 161-166 6 p.

Research output: Contribution to journalArticle

Retinal degeneration from oxidative damage

Cingolani, C., Rogers, B., Lu, L., Kachi, S., Shen, J. K. & Campochiaro, P. A., Feb 15 2006, In : Free Radical Biology and Medicine. 40, 4, p. 660-669 10 p.

Research output: Contribution to journalArticle

Superoxide dismutase 1 protects retinal cells from oxidative damage

Dong, A., Shen, J., Krause, M., Akiyama, H., Hackett, S. F., Lai, H. & Campochiaro, P. A., Sep 1 2006, In : Journal of Cellular Physiology. 208, 3, p. 516-526 11 p.

Research output: Contribution to journalArticle

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1

Shen, J., Samul, R., Silva, R. L., Akiyama, H., Liu, H., Saishin, Y., Hackett, S. F., Zinnen, S., Kossen, K., Fosnaugh, K., Vargeese, C., Gomez, A., Bouhana, K., Aitchison, R., Pavco, P. & Campochiaro, P. A., Feb 1 2006, In : Gene Therapy. 13, 3, p. 225-234 10 p.

Research output: Contribution to journalArticle

Trans-scleral delivery of polyamine analogs for ocular neovascularization

Lima e Silva, R., Kachi, S., Akiyama, H., JiKui Shen, S., Hatara, M. C., Aslam, S., Gong, Y. Y., Khu, N. H., Lauer, T. W., Hackett, S. F., Marton, L. J. & Campochiaro, P. A., Nov 1 2006, In : Experimental eye research. 83, 5, p. 1260-1267 8 p.

Research output: Contribution to journalArticle

Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization

Shen, J. K., Yang, X. R., Xiao, W. H., Hackett, S. F., Sato, Y. & Campochiaro, P. A., Apr 1 2006, In : FASEB Journal. 20, 6, p. 723-725 3 p.

Research output: Contribution to journalArticle

2005

Activation of microglia and chemokines in light-induced retinal degeneration

Zhang, C., Shen, J. K., Lam, T. T., Zeng, H. Y., Chiang, S. K., Yang, F. & Tso, M. O. M., Oct 27 2005, In : Molecular vision. 11, p. 887-895 9 p.

Research output: Contribution to journalArticle

Different effects of angiopoietin-2 in different vascular beds: New vessels are most sensitive

Oshima, Y., Oshima, S., Nambu, H., Kachi, S., Takahashi, K., Umeda, N., Shen, J. K., Dong, A., Apte, R. S., Duh, E., Hackett, S. F., Okoye, G., Ishibashi, K., Handa, J., Melia, M., Wiegand, S., Yancopoulos, G., Zack, D. J. & Campochiaro, P. A., Jun 1 2005, In : FASEB Journal. 19, 8, p. 963-965 3 p.

Research output: Contribution to journalArticle

Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa

Shen, J., Yang, X., Dong, A., Petters, R. M., Peng, Y. W., Wong, F. & Campochiaro, P. A., Jun 1 2005, In : Journal of Cellular Physiology. 203, 3, p. 457-464 8 p.

Research output: Contribution to journalArticle

Vascular targeting of ocular neovascularization with a vascular endothelial growth factor121/gelonin chimeric protein

Akiyama, H., Mohamedali, K. A., Lima E Silva, R., Kachi, S., Shen, J. K., Hatara, C., Umeda, N., Hackett, S. F., Aslam, S., Krause, M., Lai, H., Rosenblum, M. G. & Campochiaro, P. A., Dec 1 2005, In : Molecular Pharmacology. 68, 6, p. 1543-1550 8 p.

Research output: Contribution to journalArticle