Jeffrey D Rothstein

Professor

1979 …2020
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Research Output 1979 2020

2020

Hydrogen peroxide triggers an increase in cell surface expression of system xc in cultured human glioma cells

Chase, L. A., VerHeulen Kleyn, M., Schiller, N. T., King, A. G., Flores, G., Engelsman, S. B., Bowles, C., Smith, S. L., Robinson, A. E. & Rothstein, J., Mar 2020, In : Neurochemistry International. 134, 104648.

Research output: Contribution to journalArticle

Glioma
Hydrogen Peroxide
Glutathione
Cystine
Cell Membrane
2019

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Chew, J., Cook, C., Gendron, T. F., Jansen-West, K., Del Rosso, G., Daughrity, L. M., Castanedes-Casey, M., Kurti, A., Stankowski, J. N., Disney, M. D., Rothstein, J. D., Dickson, D. W., Fryer, J. D., Zhang, Y. J. & Petrucelli, L., Feb 15 2019, In : Molecular neurodegeneration. 14, 1, 1 p.

Research output: Contribution to journalArticle

TDP-43 Proteinopathies
Dipeptides
RNA
Proteins
Antisense RNA

Analyzing progression of motor and speech impairment in ALS

Agurto, C., Pietrowicz, M., Eyigoz, E. K., Mosmiller, E., Baxi, E., Rothstein, J. D., Roy, P., Berry, J., Maragakis, N. J., Ahmad, O., Cecchi, G. A. & Norel, R., Jul 2019, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., p. 6097-6102 6 p. 8857300. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Amyotrophic Lateral Sclerosis
Mobile Applications
Vital Capacity
Biomarkers
Application programs

CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation

Cheng, W., Wang, S., Zhang, Z., Morgens, D. W., Hayes, L. R., Lee, S., Portz, B., Xie, Y., Nguyen, B. V., Haney, M. S., Yan, S., Dong, D., Coyne, A. N., Yang, J., Xian, F., Cleveland, D. W., Qiu, Z., Rothstein, J. D., Shorter, J., Gao, F. B. & 2 others, Bassik, M. C. & Sun, S., Dec 4 2019, In : Neuron. 104, 5, p. 885-898.e8

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
RNA Helicases
Dipeptides
RNA
Antisense RNA

Erratum: Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease (Neuron (2018) 99(5) (925–940.e7), (S0896627318306378) (10.1016/j.neuron.2018.07.039))

Eftekharzadeh, B., Daigle, J. G., Kapinos, L. E., Coyne, A., Schiantarelli, J., Carlomagno, Y., Cook, C., Miller, S. J., Dujardin, S., Amaral, A. S., Grima, J. C., Bennett, R. E., Tepper, K., DeTure, M., Vanderburg, C. R., Corjuc, B. T., DeVos, S. L., Gonzalez, J. A., Chew, J., Vidensky, S. & 10 others, Gage, F. H., Mertens, J., Troncoso, J., Mandelkow, E., Salvatella, X., Lim, R. Y. H., Petrucelli, L., Wegmann, S., Rothstein, J. D. & Hyman, B. T., Jan 16 2019, In : Neuron. 101, 2, 1 p.

Research output: Contribution to journalComment/debate

tau Proteins
Cell Nucleus Active Transport
Names
Publications
Alzheimer Disease

FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes

Savchenko, E., Teku, G. N., Boza-Serrano, A., Russ, K., Berns, M., Deierborg, T., Lamas, N. J., Wichterle, H., Rothstein, J. D., Henderson, C. E., Vihinen, M. & Roybon, L., Jul 3 2019, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Fibroblast Growth Factors
Astrocytes
Stem Cells
Amino Acid Transport System X-AG
Fibroblast Growth Factor 2

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin

Miller, S. J., Philips, T., Kim, N., Dastgheyb, R., Chen, Z., Hsieh, Y. C., Daigle, J. G., Datta, M., Chew, J., Vidensky, S., Pham, J. T., Hughes, E. G., Robinson, M. B., Sattler, R., Tomer, R., Suk, J. S., Bergles, D. E., Haughey, N., Pletnikov, M., Hanes, J. S. & 1 others, Rothstein, J. D., Jan 1 2019, In : Nature neuroscience.

Research output: Contribution to journalArticle

Astrocytes
Neurons
Dendrites
Spine
Dendritic Spines

Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging

Jha, M. K., Lee, Y., Russell, K. A., Yang, F., Dastgheyb, R. M., Deme, P., Ament, X. H., Chen, W., Liu, Y., Guan, Y., Polydefkis, M. J., Hoke, A., Haughey, N. J., Rothstein, J. D. & Morrison, B. M., Jan 1 2019, (Accepted/In press) In : Glia.

Research output: Contribution to journalArticle

Schwann Cells
Maintenance
Peripheral Nerves
Myelin-Associated Glycoprotein
Nerve Growth Factor Receptor

Prospective natural history study of C9orf72 ALS clinical characteristics and biomarkers

Alzheimer's Disease Neuroimaging Initiative, Oct 22 2019, In : Neurology. 93, 17, p. e1605-e1617

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Natural History
Biomarkers
Dipeptides
DNA

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

The ITALSGEN Consortium & The International ALS Genomics Consortium, Apr 1 2019, In : Annals of neurology. 85, 4, p. 470-481 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Genome-Wide Association Study
Linkage Disequilibrium
Random Allocation
Smoking

The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model

Katt, M. E., Mayo, L. N., Ellis, S. E., Machairaki, V., Rothstein, J. D., Cheng, L. & Searson, P. C., Jul 15 2019, In : Fluids and Barriers of the CNS. 16, 1, 20.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Blood-Brain Barrier
Neurodegenerative Diseases
Mutation
Poisons
2018

ALSUntangled 41: “Eric Is Winning”

THE ALSUNTANGLED GROUP, Jan 2 2018, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19, 1-2, p. 157-160 4 p.

Research output: Contribution to journalArticle

ALSUntangled 43: copper

THE ALSUNTANGLED GROUP, Jul 3 2018, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19, 5-6, p. 472-476 5 p.

Research output: Contribution to journalArticle

Copper

Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model

Miller, S. J., Glatzer, J. C., Hsieh, Y. C. & Rothstein, J. D., Jan 1 2018, (Accepted/In press) In : Journal of Neurogenetics.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Astrocytes
Spinal Cord
Motor Neuron Disease
Neuroglia

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

Research output: Contribution to journalArticle

Kinesin
Genome
Mutation
Genes
Genome-Wide Association Study

Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells

Perkins, E. M., Clarkson, Y. L., Suminaite, D., Lyndon, A. R., Tanaka, K., Rothstein, J. D., Skehel, P. A., Wyllie, D. J. A. & Jackson, M., Jan 1 2018, In : Human Molecular Genetics. 27, 15, p. 2614-2627 14 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Purkinje Cells
Amino Acid Transport Systems
Excitatory Amino Acids
N-Methyl-D-Aspartate Receptors

Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis

Hoye, M. L., Regan, M. R., Jensen, L. A., Lake, A. M., Reddy, L. V., Vidensky, S., Richard, J-P., Maragakis, N. J., Rothstein, J. D., Dougherty, J. D. & Miller, T. M., Sep 1 2018, In : Brain : a journal of neurology. 141, 9, p. 2561-2575 15 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
MicroRNAs
Astrocytes
Excitatory Amino Acid Transporter 2

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

Zhang, K., Daigle, J. G., Cunningham, K. M., Coyne, A. N., Ruan, K., Grima, J. C., Bowen, K. E., Wadhwa, H., Yang, P., Rigo, F., Taylor, J. P., Gitler, A. D., Rothstein, J. D. & Lloyd, T., Jan 1 2018, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Neurodegenerative diseases
Defects
Neurodegenerative Diseases
Heat-Shock Proteins

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease

Eftekharzadeh, B., Daigle, J. G., Kapinos, L. E., Coyne, A., Schiantarelli, J., Carlomagno, Y., Cook, C., Miller, S. J., Dujardin, S., Amaral, A. S., Grima, J. C., Bennett, R. E., Tepper, K., DeTure, M., Vanderburgh, C. R., Corjuc, B. T., DeVos, S. L., Gonzalez, J. A., Chew, J., Vidensky, S. & 10 others, Gage, F. H., Mertens, J., Troncoso, J. C., Mandelkow, E., Salvatella, X., Lim, R. Y. H., Petrucelli, L., Wegmann, S., Rothstein, J. D. & Hyman, B. T., Sep 5 2018, In : Neuron. 99, 5, p. 925-940.e7

Research output: Contribution to journalArticle

Nuclear Pore
tau Proteins
Cell Nucleus Active Transport
Alzheimer Disease
Nuclear Pore Complex Proteins

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., Kuleshov, M. V., Ma'ayan, A., Stathias, V., Terryn, R., Cooper, D., Forlin, M., Koleti, A., Vidovic, D., Chung, C., Schürer, S. C. & 87 others, Vasiliauskas, J., Pilarczyk, M., Shamsaei, B., Fazel, M., Ren, Y., Niu, W., Clark, N. A., White, S., Mahi, N., Zhang, L., Kouril, M., Reichard, J. F., Sivaganesan, S., Medvedovic, M., Meller, J., Koch, R. J., Birtwistle, M. R., Iyengar, R., Sobie, E. A., Azeloglu, E. U., Kaye, J., Osterloh, J., Haston, K., Kalra, J., Finkbiener, S., Li, J., Milani, P., Adam, M., Escalante-Chong, R., Sachs, K., Lenail, A., Ramamoorthy, D., Fraenkel, E., Daigle, G., Hussain, U., Coye, A., Rothstein, J. D., Sareen, D., Ornelas, L., Banuelos, M., Mandefro, B., Ho, R., Svendsen, C. N., Lim, R. G., Stocksdale, J., Casale, M. S., Thompson, T. G., Wu, J., Thompson, L. M., Dardov, V., Venkatraman, V., Matlock, A., Van Eyk, J. E., Jaffe, J. D., Papanastasiou, M., Subramanian, A., Golub, T. R., Erickson, S. D., Fallahi-Sichani, M., Hafner, M., Gray, N. S., Lin, J. R., Mills, C. E., Muhlich, J. L., Niepel, M., Shamu, C. E., Williams, E. H., Wrobel, D., Sorger, P. K., Heiser, L. M., Gray, J. W., Korkola, J. E., Mills, G. B., LaBarge, M., Feiler, H. S., Dane, M. A., Bucher, E., Nederlof, M., Sudar, D., Gross, S., Kilburn, D. F., Smith, R., Devlin, K., Margolis, R., Derr, L., Lee, A. & Pillai, A., Jan 24 2018, In : Cell Systems. 6, 1, p. 13-24 12 p.

Research output: Contribution to journalReview article

Cataloging
Libraries
Inborn Genetic Diseases
Molecular Imaging
Neurodegenerative Diseases
2017
3D printers
Molds
Photons
Microscopy
Microscopic examination

ALSUntangled 38: L-serine

THE ALSUNTANGLED GROUP, Jan 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 1-2, p. 148-151 4 p.

Research output: Contribution to journalArticle

ALSUntangled No. 36: Accilion

THE ALSUNTANGLED GROUP, Jan 2 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 1-2, p. 142-147 6 p.

Research output: Contribution to journalArticle

ALSUntangled No. 37: Inosine*

THE ALSUNTANGLED GROUP, Apr 3 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, 3-4, p. 309-312 4 p.

Research output: Contribution to journalArticle

c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA

Liu, J., Hu, J., Ludlow, A. T., Pham, J. T., Shay, J. W., Rothstein, J. D. & Corey, D. R., Feb 16 2017, In : Cell Chemical Biology. 24, 2, p. 141-148 8 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 9
Chromosomes
Open Reading Frames
RNA
Molecules

Edaravone: A new drug approved for ALS

Rothstein, J. D., Nov 2 2017, In : Cell. 171, 4, 1 p.

Research output: Contribution to journalShort survey

Amyotrophic Lateral Sclerosis
Riluzole
Neurodegenerative diseases
Oxidants
Pharmaceutical Preparations

Mutant Huntingtin Disrupts the Nuclear Pore Complex

Grima, J. C., Daigle, J. G., Arbez, N., Cunningham, K. C., Zhang, K., Ochaba, J., Geater, C., Morozko, E., Stocksdale, J., Glatzer, J. C., Pham, J. T., Ahmed, I., Peng, Q., Wadhwa, H., Pletnikova, O., Troncoso, J. C., Duan, W., Snyder, S. H., Ranum, L. P. W., Thompson, L. M. & 3 others, Lloyd, T., Ross, C. A. & Rothstein, J. D., Apr 5 2017, In : Neuron. 94, 1, p. 93-107.e6

Research output: Contribution to journalArticle

Nuclear Pore
Nuclear Pore Complex Proteins
Cell Nucleus Active Transport
Huntington Disease
Neurons

Neurodegenerative disease: Two-for-one on potential therapies

Zhang, K. & Rothstein, J. D., Apr 20 2017, In : Nature. 544, 7650, p. 302-303 2 p.

Research output: Contribution to journalShort survey

nervous system disorder
disease treatment
molecular analysis
Nervous System Diseases
Neurodegenerative Diseases

Oligodendroglia: Metabolic supporters of neurons

Philips, T. & Rothstein, J. D., Sep 1 2017, In : Journal of Clinical Investigation. 127, 9, p. 3271-3280 10 p.

Research output: Contribution to journalReview article

Oligodendroglia
Neurons
Energy Transfer
Myelin Sheath
Pyruvic Acid

Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis

C9ORF72 Neurofilament Study Group, Jul 1 2017, In : Annals of Neurology. 82, 1, p. 139-146 8 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Amyotrophic Lateral Sclerosis
Biomarkers
Survival
Cerebrospinal Fluid

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

Gendron, T. F., Chew, J., Stankowski, J. N., Hayes, L., Zhang, Y. J., Prudencio, M., Carlomagno, Y., Daughrity, L. M., Jansen-West, K., Perkerson, E. A., O'Raw, A., Cook, C., Pregent, L., Belzil, V., Van Blitterswijk, M., Tabassian, L. J., Lee, C. W., Yue, M., Tong, J., Song, Y. & 59 others, Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Rademakers, R., Fryer, J. D., Rush, B. K., Pedraza, O., Caputo, A. M., Desaro, P., Palmucci, C., Robertson, A., Heckman, M. G., Diehl, N. N., Wiggs, E., Tierney, M., Braun, L., Farren, J., Lacomis, D., Ladha, S., Fournier, C. N., McCluskey, L. F., Elman, L. B., Toledo, J. B., McBride, J. D., Tiloca, C., Morelli, C., Poletti, B., Solca, F., Prelle, A., Wuu, J., Jockel-Balsarotti, J., Rigo, F., Ambrose, C., Datta, A., Yang, W., Raitcheva, D., Antognetti, G., McCampbell, A., Van Swieten, J. C., Miller, B. L., Boxer, A. L., Brown, R. H., Bowser, R., Miller, T. M., Trojanowski, J. Q., Grossman, M., Berry, J. D., Hu, W. T., Ratti, A., Traynor, B. J., Disney, M. D., Benatar, M., Silani, V., Glass, J. D., Floeter, M. K., Rothstein, J. D., Boylan, K. B. & Petrucelli, L., Mar 29 2017, In : Science Translational Medicine. 9, 383, eaai7866.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
RNA
Proteins
Antisense Oligonucleotides
Therapeutics
2016

ALSUntangled No. 34: GM604

THE ALSUNTANGLED GROUP, Nov 16 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 7-8, p. 617-621 5 p.

Research output: Contribution to journalArticle

ALSUntangled No. 35: Hyperbaric Oxygen Therapy*

THE ALSUNTANGLED GROUP, Nov 16 2016, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17, 7-8, p. 622-624 3 p.

Research output: Contribution to journalArticle

Astroglia in thick tissue with super resolution and cellular reconstruction

Miller, S. J. & Rothstein, J. D., Aug 1 2016, In : PLoS One. 11, 8, e0160391.

Research output: Contribution to journalArticle

astrocytes
Astrocytes
Brain
Tissue
brain

Astroglial transcriptome dysregulation in early disease of an ALS mutant SOD1 mouse model

Miller, S. J., Zhang, P., Glatzer, J. & Rothstein, J. D., Nov 30 2016, (Accepted/In press) In : Journal of Neurogenetics. p. 1-12 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Transcriptome
Astrocytes
Neurodegenerative Diseases
Disease Progression

C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC

Hayes, L. & Rothstein, J. D., May 4 2016, In : Neuron. 90, 3, p. 427-431 5 p.

Research output: Contribution to journalArticle

Transgenic Mice

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Zhang, Y. J., Gendron, T. F., Grima, J. C., Sasaguri, H., Jansen-West, K., Xu, Y. F., Katzman, R. B., Gass, J., Murray, M. E., Shinohara, M., Lin, W. L., Garrett, A., Stankowski, J. N., Daughrity, L., Tong, J., Perkerson, E. A., Yue, M., Chew, J., Castanedes-Casey, M., Kurti, A. & 16 others, Wang, Z. S., Liesinger, A. M., Baker, J. D., Jiang, J., Lagier-Tourenne, C., Edbauer, D., Cleveland, D. W., Rademakers, R., Boylan, K. B., Bu, G., Link, C. D., Dickey, C. A., Rothstein, J. D., Dickson, D. W., Fryer, J. D. & Petrucelli, L., Mar 21 2016, (Accepted/In press) In : Nature Neuroscience.

Research output: Contribution to journalArticle

Nucleocytoplasmic Transport Proteins
Cell Nucleus Active Transport
Pathology
Ubiquitinated Proteins
Xeroderma Pigmentosum

Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology

Zhang, P., Haidet-Phillips, A. M., Pham, J. T., Lee, Y., Huo, Y., Tienari, P. J., Maragakis, N. J., Sattler, R. & Rothstein, J. D., Jan 1 2016, In : GLIA. 64, 1, p. 63-75 13 p.

Research output: Contribution to journalArticle

Glial Fibrillary Acidic Protein
Zinc Fingers
Astrocytes
Fibroblasts
Technology

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations

Le, N. T. T., Chang, L., Kovlyagina, I., Georgiou, P., Safren, N., Braunstein, K. E., Kvarta, M. D., Dyke, A. M. V., Legates, T. A., Philips, T., Morrison, B., Thompson, S. M., Puche, A. C., Gould, T. D., Rothstein, J. D., Wong, P. C. & Monteiro, M. J., Nov 22 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 47, p. E7580-E7589

Research output: Contribution to journalArticle

Frontotemporal Dementia
Motor Neuron Disease
Memory Disorders
Pathology
Mutation

Nucleocytoplasmic transport in C9orf72-mediated ALS/FTD

Zhang, K., Grima, J. C., Rothstein, J. D. & Lloyd, T., Apr 25 2016, In : Nucleus. 7, 2, p. 132-137 6 p.

Research output: Contribution to journalComment/debate

Cell Nucleus Active Transport
Frontotemporal Dementia
Mutation
Frontotemporal Dementia With Motor Neuron Disease

Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST

Perkins, E. M., Suminaite, D., Clarkson, Y. L., Lee, S. K., Lyndon, A. R., Rothstein, J. D., Wyllie, D. J. A., Tanaka, K. & Jackson, M., 2016, In : Human Molecular Genetics. 25, 20, p. 4448-4461 14 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Spectrin
Purkinje Cells
Amino Acid Transport System X-AG
AMPA Receptors

Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex

Valera, A. M., Binda, F., Pawlowski, S. A., Dupont, J. L., Casella, J. F., Rothstein, J. D., Poulain, B. & Isope, P., Mar 16 2016, In : eLife. 5, MARCH2016, e09862.

Research output: Contribution to journalArticle

Cerebellar Cortex
Animals
Purkinje Cells
Cells
Communication

The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons

Ehmsen, J. T., Liu, Y., Wang, Y., Paladugu, N., Johnson, A. E., Rothstein, J. D., du Lac, S., Mattson, M. P. & Hoke, A., Oct 19 2016, In : Scientific Reports. 6, 35592.

Research output: Contribution to journalArticle

Motor Neurons
Glycine
Spinal Cord
Stiff-Person Syndrome
Amino Acid Transport Systems

The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease

Haeusler, A. R., Donnelly, C. J. & Rothstein, J. D., Jun 1 2016, In : Nature Reviews Neuroscience. 17, 6, p. 383-395 13 p.

Research output: Contribution to journalReview article

Chromosomes, Human, Pair 9
Neurodegenerative Diseases
Open Reading Frames
Nucleotides
Poisons

The transcription factor Pax6 contributes to the induction of GLT-1 expression in astrocytes through an interaction with a distal enhancer element

Ghosh, M., Lane, M., Krizman, E., Sattler, R., Rothstein, J. D. & Robinson, M. B., Jan 1 2016, In : Journal of Neurochemistry. 136, 2, p. 262-275 14 p.

Research output: Contribution to journalArticle

Astrocytes
Transcription Factors
Neurons
Amino Acid Transport System X-AG
Small Interfering RNA
2015

A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells

Li, Y., Balasubramanian, U., Cohen, D., Zhang, P., Mosmiller, E., Sattler, R., Maragakis, N. J. & Rothstein, J. D., Mar 11 2015, In : PLoS One. 10, 3, e0118266.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem cells
Libraries
mutation
Mutation

ALSUntangled: Introducing the table of evidence

ALSUntangled Group, Mar 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 1-2, p. 142-145 4 p.

Research output: Contribution to journalArticle

ALSUntangled No. 29: MitoQ

The Alsuntangled Lsuntangled Grouproup, Aug 27 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 5-6, p. 427-429 3 p.

Research output: Contribution to journalArticle

Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model

Choi, I. Y., Lim, H. T., Estrellas, K., Mula, J., Cohen, T. V., Zhang, Y., Donnelly, C. J., Richard, J-P., Kim, Y. J., Kim, H., Kazuki, Y., Oshimura, M., Li, H. L., Hotta, A., Rothstein, J. D., Maragakis, N. J., Wagner, K. R. & Lee, G., Sep 9 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
Myoblasts
Phenotype
Chemical compounds
Stem cells

Human endogenous retrovirus-K contributes to motor neuron disease

Li, W., Lee, M. H., Henderson, L., Tyagi, R., Bachani, M., Steiner, J., Campanac, E., Hoffman, D. A., Geldern, G. V., Johnson, K., Maric, D., Morris, H. D., Lentz, M., Pak, K., Mammen, A., Ostrow, L., Rothstein, J. D. & Nath, A., Sep 30 2015, In : Science Translational Medicine. 7, 307

Research output: Contribution to journalArticle

Endogenous Retroviruses
Motor Neuron Disease
Neurons
Amyotrophic Lateral Sclerosis
Anterior Horn Cells