Jed W Fahey

Assistant Professor

1980 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. T. & Fahey, J. W., Dec 1 2020, In : Scientific reports. 10, 1, 5822.

Research output: Contribution to journalArticle

Open Access
2019

A strategy to deliver precise oral doses of the glucosinolates or isothiocyanates from moringa oleifera leaves for use in clinical studies

Fahey, J. W., Wade, K. L., Stephenson, K. K., Shi, Y., Liu, H., Panjwani, A. A., Warrick, C. R. & Olson, M. E., Jul 2019, In : Nutrients. 11, 7, 1547.

Research output: Contribution to journalArticle

Open Access

Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration

Fahey, J. W., Wade, K. L., Stephenson, K. K., Panjwani, A. A., Liu, H., Cornblatt, G., Cornblatt, B. S., Ownby, S. L., Fuchs, E., Holtzclaw, W. D. & Cheskin, L. J., Jun 29 2019, In : Nutrients. 11, 7

Research output: Contribution to journalArticle

Open Access

Broccoli or sulforaphane: Is it the source or dose that matters?

Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 6 2019, In : Molecules. 24, 19, 3593.

Research output: Contribution to journalReview article

Open Access

Compartmentalization of anti-oxidant and anti-inflammatory gene expression in current and former smokers with COPD

Sidhaye, V., Holbrook, J. T., Burke, A., Sudini, K. R., Sethi, S., Criner, G. J., Fahey, J. W., Berenson, C. S., Jacobs, M. R., Thimmulappa, R., Wise, R. A. & Biswal, S., Aug 20 2019, In : Respiratory research. 20, 1, 190.

Research output: Contribution to journalArticle

Open Access

Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China

Chen, J. G., Johnson, J., Egner, P., Ng, D., Zhu, J., Wang, J. B., Xue, X. F., Sun, Y., Zhang, Y. H., Lu, L. L., Chen, Y. S., Wu, Y., Zhu, Y. R., Carmella, S., Hecht, S., Jacobson, L., Muñoz, A., Kensler, K., Rule, A., Fahey, J. & 2 others, Kensler, T. & Groopman, J., Sep 1 2019, In : American Journal of Clinical Nutrition. 110, 3, p. 675-684 10 p.

Research output: Contribution to journalArticle

Open Access

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., Mar 2019, In : PloS one. 14, 3, e0213095.

Research output: Contribution to journalArticle

Open Access
2018

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi

Tahata, S., Singh, S. V., Lin, Y., Hahm, E. R., Beumer, J. H., Christner, S. M., Rao, U. N., Sander, C., Tarhini, A. A., Tawbi, H., Ferris, L. K., Wilson, M., Rose, A., Dietz, C. M., Hughes, E., Fahey, J. W., Leachman, S. A., Cassidy, P. B., Butterfield, L. H., Zarour, H. M. & 1 others, Kirkwood, J. M., Jul 2018, In : Cancer Prevention Research. 11, 7, p. 429-437 9 p.

Research output: Contribution to journalArticle

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli

Bent, S., Lawton, B., Warren, T., Widjaja, F., Dang, K., Fahey, J. W., Cornblatt, B., Kinchen, J. M., Delucchi, K. & Hendren, R. L., May 30 2018, In : Molecular Autism. 9, 1, 35.

Research output: Contribution to journalArticle

Isothiocyanates: Translating the Power of Plants to People

Palliyaguru, D. L., Yuan, J. M., Kensler, T. W. & Fahey, J. W., Sep 2018, In : Molecular Nutrition and Food Research. 62, 18, 1700965.

Research output: Contribution to journalReview article

Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1

Dayalan Naidu, S., Suzuki, T., Yamamoto, M., Fahey, J. W. & Dinkova-Kostova, A. T., Sep 2018, In : Molecular Nutrition and Food Research. 62, 18, 1700908.

Research output: Contribution to journalReview article

The Diversity of Chemoprotective Glucosinolates in Moringaceae (Moringa spp.)

Fahey, J. W., Olson, M. E., Stephenson, K. K., Wade, K. L., Chodur, G. M., Odee, D., Nouman, W., Massiah, M., Alt, J., Egner, P. & Hubbard, W. C., Dec 1 2018, In : Scientific Reports. 8, 1, 7994.

Research output: Contribution to journalArticle

Wild and domesticated Moringa oleifera differ in taste, glucosinolate composition, and antioxidant potential, but not myrosinase activity or protein content

Chodur, G. M., Olson, M. E., Wade, K. L., Stephenson, K. K., Nouman, W., Garima & Fahey, J. W., Dec 1 2018, In : Scientific Reports. 8, 1, 7995.

Research output: Contribution to journalArticle

2017

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane

Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In : Trends in Food Science and Technology. 69, p. 257-269 13 p.

Research output: Contribution to journalReview article

Moringa oleifera: A review of the medicinal potential

Fahey, J. W., May 9 2017, 1st International Symposium on Moringa. International Society for Horticultural Science, Vol. 1158. p. 209-224 16 p. (Acta Horticulturae; vol. 1158).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency

Fahey, J. W., Wade, K. L., Wehage, S. L., Holtzclaw, W. D., Liu, H., Talalay, P., Fuchs, E. & Stephenson, K. K., 2017, (Accepted/In press) In : Molecular Nutrition and Food Research.

Research output: Contribution to journalArticle

Sulforaphane for the chemoprevention of bladder cancer: Molecular mechanism targeted approach

Leone, A., Diorio, G., Sexton, W., Schell, M., Alexandrow, M., Fahey, J. W. & Kumar, N. B., Jan 1 2017, In : Oncotarget. 8, 21, p. 35412-35424 13 p.

Research output: Contribution to journalReview article

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Axelsson, A. S., Tubbs, E., Mecham, B., Chacko, S., Nenonen, H. A., Tang, Y., Fahey, J. W., Derry, J. M. J., Wollheim, C. B., Wierup, N., Haymond, M. W., Friend, S. H., Mulder, H. & Rosengren, A. H., Jun 14 2017, In : Science Translational Medicine. 9, 394, 4477.

Research output: Contribution to journalArticle

2016

An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma

An, S. S., Mitzner, W., Tang, W. Y., Ahn, K., Yoon, A. R., Huang, J., Kilic, O., Yong, H. M., Fahey, J. W., Kumar, S., Biswal, S., Holgate, S. T., Panettieri, R. A., Solway, J. & Liggett, S. B., Jul 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 1, p. 294-297.e4

Research output: Contribution to journalArticle

Biomarker-guided strategy for treatment of autism spectrum disorder (ASD)

Liu, H., Talalay, P. & Fahey, J. W., May 1 2016, In : CNS and Neurological Disorders - Drug Targets. 15, 5, p. 602-613 12 p.

Research output: Contribution to journalArticle

Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: A randomized, double-blind, placebo controlled trial

Wise, R. A., Holbrook, J. T., Criner, G., Sethi, S., Rayapudi, S., Sudini, K. R., Sugar, E., Burke, A., Thimmulappa, R., Singh, A., Talalay, P., Fahey, J. W., Berenson, C. S., Jacobs, M. R., Biswal, S., Leatherman, G., Daniel, M., Thurman, A., Marchetti, N., Kim, V. & 25 others, Shenoy, K., Smith, H., Rosario, M., Bolla, S., Mandapati, C., Eberhardt, E., Kruzel, R., Kumar, S., Noel, S., Beselman, A., Amend-Libercci, D., Ewing, C., Hart, A., Lears, A., Nowakowski, D., Prusakowski, N., Shade, D., Yasin, R., Brown, E., Wang, L., O'Connor, G., Strange, C., Wendt, C., Punturieri, A. & Viviano, L. W., Nov 1 2016, In : PLoS One. 11, 11, e0163716.

Research output: Contribution to journalArticle

Leaf protein and mineral concentrations across the "Miracle tree" genus moringa

Olson, M. E., Sankaran, R. P., Fahey, J. W., Grusak, M. A., Odee, D. & Nouman, W., Jul 1 2016, In : PLoS One. 11, 7, e0159782.

Research output: Contribution to journalArticle

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma

Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A. T., May 24 2016, In : Scientific reports. 6, 25804.

Research output: Contribution to journalArticle

Prevention of carcinogen-induced oral cancer by sulforaphane

Bauman, J. E., Zang, Y., Sen, M., Li, C., Wang, L., Egner, P., Fahey, J. W., Normolle, D. P., Grandis, J. R., Kensler, T. W. & Johnson, D. E., Jul 1 2016, In : Cancer Prevention Research. 9, 7, p. 547-557 11 p.

Research output: Contribution to journalArticle

Randomized, split-body, single-blinded clinical trial of topical broccoli sprout extract: Assessing the feasibility of its use in keratin-based disorders

Kerns, M. L., Guss, L., Fahey, J. W., Cohen, B. A., Hakim, J. M. C., Sung, S., Lu, R. G. & Coulombe, P. A., 2016, (Accepted/In press) In : Journal of the American Academy of Dermatology.

Research output: Contribution to journalArticle

The multifaceted role of sulforaphane in protection against uv radiation-mediated skin damage

Benedict, A. L., Knatko, E. V., Kostov, R. V., Zhang, Y., Higgins, M., Kalra, S., Fahey, J. W., Ibbotson, S. H., Proby, C. M., Talalay, P. & Dinkova-Kostova, A. T., Jan 1 2016, Broccoli: Cultivation, Nutritional Properties and Effects on Health. Nova Science Publishers, Inc., p. 185-208 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Brassica: Characteristics and Properties

Fahey, J. W., Sep 14 2015, Encyclopedia of Food and Health. Elsevier Inc., p. 469-477 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Flavor misattribution: A novel approach to improving compliance and blinding in food-based clinical interventions

Bierwirth, J. E., Oftedal, K. N., Civille, G. V. & Fahey, J. W., Jan 1 2015, In : NFS Journal. 1, p. 24-30 7 p.

Research output: Contribution to journalArticle

Glucosinolates from the Brassica Vegetables and Their Health Effects

Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., Sep 14 2015, Encyclopedia of Food and Health. Elsevier Inc., p. 248-255 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T. J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 1 2015, In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

Research output: Contribution to journalArticle

Sulforaphane bioavailability from glucoraphanin-rich broccoli: Control by active endogenous myrosinase

Fahey, J. W., Holtzclaw, W. D., Wehage, S. L., Wade, K. L., Stephenson, K. K. & Talalay, P., Nov 2 2015, In : PloS one. 10, 11, e0140963.

Research output: Contribution to journalArticle

Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways

Brown, R. H., Reynolds, C., Brooker, A., Talalay, P. & Fahey, J. W., Sep 15 2015, In : Respiratory research. 16, 1, 106.

Research output: Contribution to journalArticle

2014

Dietary amelioration of Helicobacter infection

Fahey, J. W., Stephenson, K. K. & Wallace, A. J., Dec 12 2014, In : Nutrition Research. 35, 6, p. 461-473 13 p.

Research output: Contribution to journalReview article

Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: Results of a randomized clinical trial in China

Egner, P. A., Chen, J. G., Zarth, A. T., Ng, D. K., Wang, J. B., Kensler, K. H., Jacobson, L. P., Muñoz, A., Johnson, J. L., Groopman, J. D., Fahey, J. W., Talalay, P., Zhu, J., Chen, T. Y., Qian, G. S., Carmella, S. G., Hecht, S. S. & Kensler, T. W., Aug 2014, In : Cancer Prevention Research. 7, 8, p. 813-823 11 p.

Research output: Contribution to journalArticle

Sulforaphane treatment of autism spectrum disorder (ASD)

Singh, K., Connors, S. L., Macklin, E. A., Smith, K. D., Fahey, J. W., Talalay, P. & Zimmerman, A. W., Oct 28 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15550-15555 6 p.

Research output: Contribution to journalArticle

2013

Health span extension through green chemoprevention

Fahey, J. W. & Kensler, T. W., Jan 1 2013, In : Virtual Mentor. 15, 4, p. 311-318 8 p.

Research output: Contribution to journalReview article

Keap1-Nrf2 signaling: A target for cancer prevention by sulforaphane

Kensler, T. W., Egner, P. A., Agyeman, A. S., Visvanathan, K., Groopman, J. D., Chen, J. G., Chen, T. Y., Fahey, J. W. & Talalay, P., Mar 18 2013, Natural Products in Cancer Prevention and Therapy. Pezzuto, J. & Suh, N. (eds.). p. 163-178 16 p. (Topics in Current Chemistry; vol. 329).

Research output: Chapter in Book/Report/Conference proceedingChapter

Prevention of liver cancer in Qidong, China: Lessons from aflatoxin biomarker studies

Egner, P. A., Wang, J. B., Zhu, Y. R., Jacobson, L. P., Ng, D., Muñoz, A., Fahey, J. W., Chen, J. G., Chen, T. Y., Qian, G. S., Groopman, J. D. & Kensler, T. W., Sep 1 2013, In : Progress in Chemistry. 25, 9, p. 1454-1461 8 p.

Research output: Contribution to journalArticle

Structure-activity analysis of flavonoids: Direct and indirect antioxidant, and antiinflammatory potencies and toxicities

Tsuji, P. A., Stephenson, K. K., Wade, K. L., Liu, H. & Fahey, J. W., Oct 7 2013, In : Nutrition and Cancer. 65, 7, p. 1014-1025 12 p.

Research output: Contribution to journalArticle

Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates

Fahey, J. W., Stephenson, K. K., Wade, K. L. & Talalay, P., May 24 2013, In : Biochemical and Biophysical Research Communications. 435, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

2012

Black cohosh: Coming full circle?

Johnson, T. L. & Fahey, J. W., Jun 14 2012, In : Journal of Ethnopharmacology. 141, 3, p. 775-779 5 p.

Research output: Contribution to journalReview article

Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China

Kensler, T. W., Ng, D., Carmella, S. G., Chen, M., Jacobson, L. P., Muñoz, A., Egner, P. A., Chen, J. G., Qian, G. S., Chen, T. Y., Fahey, J. W., Talalay, P., Groopman, J. D., Yuan, J. M. & Hecht, S. S., Jan 9 2012, In : Carcinogenesis. 33, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

Notes from the field: "Green" chemoprevention as frugal medicine

Fahey, J. W., Talalay, P. & Kensler, T. W., Feb 1 2012, In : Cancer Prevention Research. 5, 2, p. 179-188 10 p.

Research output: Contribution to journalShort survey

Protection of humans by plant glucosinolates: Efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora

Fahey, J. W., Wehage, S. L., Holtzclaw, W. D., Kensler, T. W., Egner, P. A., Shapiro, T. A. & Talalay, P., Apr 1 2012, In : Cancer Prevention Research. 5, 4, p. 603-611 9 p.

Research output: Contribution to journalArticle

2011

Bioavailability of sulforaphane from two broccoli sprout beverages: Results of a short-term, cross-over clinical trial in Qidong, China

Egner, P. A., Chen, J. G., Wang, J. B., Wu, Y., Sun, Y., Lu, J. H., Zhu, J., Zhang, Y. H., Chen, Y. S., Friesen, M. D., Jacobson, L. P., Muñoz, A., Ng, D., Qian, G. S., Zhu, Y. R., Chen, T. Y., Botting, N. P., Zhang, Q., Fahey, J. W., Talalay, P. & 2 others, Groopman, J. D. & Kensler, T. W., Mar 1 2011, In : Cancer Prevention Research. 4, 3, p. 384-395 12 p.

Research output: Contribution to journalArticle

Broccoli (brassica oleracea var. italica) sprouts and extracts rich in glucosinolates and isothiocyanates affect cholesterol metabolism and genes involved in lipid homeostasis in hamsters

Rodríguez-Cantú, L. N., Gutiérrez-Uribe, J. A., Arriola-Vucovich, J., Díaz-De La Garza, R. I., Fahey, J. W. & Serna-Saldivar, S. O., Feb 23 2011, In : Journal of Agricultural and Food Chemistry. 59, 4, p. 1095-1103 9 p.

Research output: Contribution to journalArticle

Moringa oleifera: Un árbol multiusos para las zonas tropicales secas

Translated title of the contribution: Moringa oleifera: A multipurpose tree for the dry tropicsOlson, M. E. & Fahey, J. W., Dec 1 2011, In : Revista Mexicana de Biodiversidad. 82, 4, p. 1071-1082 12 p.

Research output: Contribution to journalArticle