1983 …2020

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2020
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2019

Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response

Caballero-Eraso, C., Shin, M. K., Pho, H., Kim, L. J., Pichard, L. E., Wu, Z. J., Gu, C., Berger, S., Pham, L., Yeung, H. Y. B., Shirahata, M., Schwartz, A. R., Tang, W. Y. W., Sham, J. S. K. & Polotsky, V. Y., Jan 1 2019, In : Journal of Physiology. 597, 1, p. 151-172 22 p.

Research output: Contribution to journalArticle

Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body

Shin, M. K., Eraso, C. C., Mu, Y. P., Gu, C., Yeung, B. H. Y., Kim, L. J., Liu, X. R., Wu, Z. J., Paudel, O., Pichard, L. E., Shirahata, M., Tang, W. Y., Sham, J. S. K. & Polotsky, V. Y., Nov 8 2019, In : Circulation research. 125, 11, p. 989-1002 14 p.

Research output: Contribution to journalArticle

2018

Intraluminal pressure triggers myogenic response via activation of calcium spark and calcium-activated chloride channel in rat renal afferent arteriole

Yip, K. P., Balasubramanian, L., Kan, C., Wang, L., Liu, R., Ribeiro-Silva, L. & Sham, J., Dec 1 2018, In : American Journal of Physiology - Renal Physiology. 315, 6, p. F1592-F1600

Research output: Contribution to journalArticle

Magnesium attenuates endothelin-1-induced vasoreactivity and enhances vasodilatation in mouse pulmonary arteries: Modulation by chronic hypoxic pulmonary hypertension

Mu, Y. P., Huang, Q. H., Zhu, J. L., Zheng, S. Y., Yan, F. R., Zhuang, X. L., Sham, J. & Lin, M. J., Jan 1 2018, (Accepted/In press) In : Experimental Physiology.

Research output: Contribution to journalArticle

2016

Aberrant DNA methylation of phosphodiestarase 4D alters airway smooth muscle cell phenotypes

Lin, A. H. Y., Shang, Y., Mitzner, W. A., Sham, J. & Tang, W-Y., Feb 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 54, 2, p. 241-249 9 p.

Research output: Contribution to journalArticle

Conformation of ryanodine receptor-2 gates store-operated calcium entry in rat pulmonary arterial myocytes

Lin, A. H. Y., Sun, H., Paudel, O., Lin, M. J. & Sham, J., 2016, In : Cardiovascular Research. 111, 1, p. 94-104 11 p.

Research output: Contribution to journalArticle

Increase in caveolae and caveolin-1 expression modulates agonist-induced contraction and store- and receptor-operated Ca2+ entry in pulmonary arteries of pulmonary hypertensive rats

Jiao, H. X., Mu, Y. P., Gui, L. X., Yan, F. R., Lin, D. C., Sham, J. & Lin, M. J., Jan 29 2016, (Accepted/In press) In : Vascular Pharmacology.

Research output: Contribution to journalArticle

2015

CD38 mediates angiotensin II-induced intracellular Ca2+ release in rat pulmonary arterial smooth muscle cells

Lee, S., Paudel, O., Jiang, Y., Yang, X. R. & Sham, J. S. K., Mar 1 2015, In : American journal of respiratory cell and molecular biology. 52, 3, p. 332-341 10 p.

Research output: Contribution to journalArticle

Extracellular Adenosine Diphosphate Ribose Mobilizes Intracellular Ca 2+ via Purinergic-Dependent Ca 2+ Pathways in Rat Pulmonary Artery Smooth Muscle Cells

Huang, C., Hu, J., Subedi, K. P., Lin, A. H. Y., Paudel, O., Ran, P. & Sham, J. S. K., Nov 1 2015, In : Cellular Physiology and Biochemistry. 37, 5, p. 2043-2059 17 p.

Research output: Contribution to journalArticle

Ginsenoside Rb1 attenuates agonist-induced contractile response via inhibition of store-operated calcium entry in pulmonary arteries of normal and pulmonary hypertensive rats

Wang, R. X., He, R. L., Jiao, H. X., Dai, M., Mu, Y. P., Hu, Y., Wu, Z. J., Sham, J. S. K. & Lin, M. J., Apr 6 2015, In : Cellular Physiology and Biochemistry. 35, 4, p. 1467-1481 15 p.

Research output: Contribution to journalArticle

2014

Alterations of the lung methylome in allergic airway hyper-responsiveness

Cheng, R. Y., Shang, Y., Limjunyawong, N., Dao, T., Das, S., Rabold, R., Sham, J. S., Mitzner, W. & Tang, W. Y., Apr 1 2014, In : Environmental and molecular mutagenesis. 55, 3, p. 244-255 12 p.

Research output: Contribution to journalArticle

Classical transient receptor potential 1 and 6 contribute to hypoxic pulmonary hypertension through differential regulation of pulmonary vascular functions

Xia, Y., Yang, X. R., Fu, Z., Paudel, O., Abramowitz, J., Birnbaumer, L. & Sham, J. S. K., Jan 1 2014, In : Hypertension. 63, 1, p. 173-180 8 p.

Research output: Contribution to journalArticle

Nicotine elevated intracellular Ca2+ in rat airway smooth muscle cells via activating and up-regulating α7-nicotinic acetylcholine receptor

Jiang, Y., Dai, A., Zhou, Y., Peng, G., Hu, G., Li, B., Sham, J. S. K. & Ran, P., Feb 2014, In : Cellular Physiology and Biochemistry. 33, 2, p. 389-401 13 p.

Research output: Contribution to journalArticle

2013

Down-regulation of TRPM8 in pulmonary arteries of pulmonary hypertensive rats

Liu, X. R., Liu, Q., Chen, G. Y., Hu, Y., Sham, J. S. K. & Lin, M. J., Jul 2013, In : Cellular Physiology and Biochemistry. 31, 6, p. 892-904 13 p.

Research output: Contribution to journalArticle

Epigenetic alterations by DNA methylation in house dust mite-induced airway hyperresponsiveness

Shang, Y., Das, S., Rabold, R., Sham, J. S. K., Mitzner, W. & Tang, W. Y., Aug 1 2013, In : American journal of respiratory cell and molecular biology. 49, 2, p. 279-287 9 p.

Research output: Contribution to journalArticle

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Activates Global and Heterogeneous Local Ca2 Signals from NAADP- and Ryanodine Receptor-gated Ca2 Stores in Pulmonary Arterial Myocytes

Jiang, Y. L., Lin, A. H. Y., Xia, Y., Lee, S., Paudel, O., Sun, H., Yang, X. R., Ran, P. & Sham, J. S. K., Apr 12 2013, In : Journal of Biological Chemistry. 288, 15, p. 10381-10394 14 p.

Research output: Contribution to journalArticle

Remanent cell traction force in renal vascular smooth muscle cells induced by integrin-mediated mechanotransduction

Balasubramanian, L., Lo, C. M., Sham, J. S. K. & Yip, K. P., Feb 15 2013, In : American Journal of Physiology - Cell Physiology. 304, 4, p. C382-C391

Research output: Contribution to journalArticle

TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension

Xia, Y., Fu, Z., Hu, J., Huang, C., Paudel, O., Cai, S., Liedtke, W. & Sham, J. S. K., Oct 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 7, p. C704-C715

Research output: Contribution to journalArticle

2012

Chronic hypoxia-induced upregulation of Ca 2+-activated Cl - channel in pulmonary arterial myocytes: A mechanism contributing to enhanced vasoreactivity

Sun, H., Xia, Y., Paudel, O., Yang, X. R. & Sham, J. S. K., Aug 1 2012, In : Journal of Physiology. 590, 15, p. 3507-3521 15 p.

Research output: Contribution to journalArticle

Enhanced store-operated Ca 2+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats

Liu, X. R., Zhang, M. F., Yang, N., Liu, Q., Wang, R. X., Cao, Y. N., Yang, X. R., Sham, J. S. K. & Lin, M. J., Jan 1 2012, In : American Journal of Physiology - Cell Physiology. 302, 1, p. C77-C87

Research output: Contribution to journalArticle

Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension

Yang, X. R., Lin, A. H. Y., Hughes, J. M., Flavahan, N. A., Cao, Y. N., Liedtke, W. & Sham, J. S. K., Mar 1 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 302, 6, p. L555-L568

Research output: Contribution to journalArticle

2011

Alteration of pulmonary artery integrin levels in chronic hypoxia and monocrotaline-induced pulmonary hypertension

Umesh, A., Paudel, O., Cao, Y. N., Myers, A. C. & Sham, J. S. K., Oct 1 2011, In : Journal of Vascular Research. 48, 6, p. 525-537 13 p.

Research output: Contribution to journalArticle

2010

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction

Deshpande, D. A., Wang, W. C. H., McIlmoyle, E. L., Robinett, K. S., Schillinger, R. M., An, S. S., Sham, J. S. K. & Liggett, S. B., Nov 1 2010, In : Nature medicine. 16, 11, p. 1299-1304 6 p.

Research output: Contribution to journalArticle

2007

Hydrogen peroxide-induced Ca2+ mobilization in pulmonary arterial smooth muscle cells

Lin, M. J., Yang, X. R., Cao, Y. N. & Sham, J. S. K., Jun 1 2007, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, 6, p. L1598-L1608

Research output: Contribution to journalArticle

Integrin-mediated mechanotransduction in renal vascular smooth muscle cells: Activation of calcium sparks

Balasubramanian, L., Ahmed, A., Lo, C. M., Sham, J. S. K. & Yip, K. P., Oct 1 2007, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 293, 4, p. R1586-R1594

Research output: Contribution to journalArticle

2006

Attenuation of mitochondrial, but not cytosolic, Ca2+ overload reduces myocardial injury induced by ischemia and reperfusion

Cao, C. M., Yan, W. Y., Liu, J., WL Kam, K., Zhan, S. Z., Sham, J. S. K. & Wong, T. M., Jul 1 2006, In : Acta Pharmacologica Sinica. 27, 7, p. 911-918 8 p.

Research output: Contribution to journalArticle

Hypoxic pulmonary hypertension: Role of superoxide and NADPH oxidase (gp91phox)

Liu, J. Q., Zelko, I. N., Erbynn, E. M., Sham, J. S. K. & Folz, R. J., Jan 1 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 290, 1, p. L2-L10

Research output: Contribution to journalArticle

Integrin ligands mobilize Ca2+ from ryanodine receptor-gated stores and lysosome-related acidic organelles in pulmonary arterial smooth muscle cells

Umesh, A., Thompson, M. A., Chini, E. N., Yip, K. P. & Sham, J. S. K., Nov 10 2006, In : Journal of Biological Chemistry. 281, 45, p. 34312-34323 12 p.

Research output: Contribution to journalArticle

2005

Multiple ryanodine receptor subtypes and heterogeneous ryanodine receptor-gated Ca2+ stores in pulmonary arterial smooth muscle cells

Yang, X. R., Lin, M. J., Yip, K. P., Jeyakumar, L. H., Fleischer, S., Leung, G. P. H. & Sham, J. S. K., Aug 1 2005, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 289, 2 33-2, p. L338-L348

Research output: Contribution to journalArticle

Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability

Becker, P. M., Waltenberger, J., Yachechko, R., Mirzapoiazova, T., Sham, J. S. K., Lee, C. G., Elias, J. A. & Verin, A. D., Jun 24 2005, In : Circulation research. 96, 12, p. 1257-1265 9 p.

Research output: Contribution to journalArticle

2004

Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: A novel mechanism of hypoxic pulmonary hypertension

Lin, M. J., Leung, G. P. H., Zhang, W. M., Yang, X. R., Yip, K. P., Tse, C. M. & Sham, J. S. K., Sep 3 2004, In : Circulation research. 95, 5, p. 496-505 10 p.

Research output: Contribution to journalArticle

Endothelin-1 and IP3 induced Ca2+ sparks in pulmonary arterial smooth muscle cells

Zhang, W. M., Lin, M. J. & Sham, J. S. K., Nov 1 2004, In : Journal of cardiovascular pharmacology. 44, SUPPL. 1, p. S121-S124

Research output: Contribution to journalArticle

2003

ET-1 activates Ca2+ sparks in PASMC: Local Ca2+ signaling between inositol trisphosphate and ryanodine receptors

Zhang, W. M., Yip, K. P., Lin, M. J., Shimoda, L. A., Li, W. H. & Sham, J. S. K., Sep 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 3 29-3, p. L680-L690

Research output: Contribution to journalArticle

Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries

Liu, J. Q., Sham, J. S. K., Shimoda, L. A., Kuppusamy, P. & Sylvester, J. T., Aug 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 2 29-2, p. L322-L333

Research output: Contribution to journalArticle

Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-β in human bronchial epithelial cells

Wang, L., Cummings, R., Zhao, Y., Kazlauskas, A., Sham, J. K. S., Morris, A., Georas, S., Brindley, D. N. & Natarajan, V., Oct 10 2003, In : Journal of Biological Chemistry. 278, 41, p. 39931-39940 10 p.

Research output: Contribution to journalArticle

The isolated polycystin-1 cytoplasmic COOH terminus prolongs ATP-stimulated Cl- conductance through increased Ca2+ entry

Wildman, S. S., Hooper, K. M., Turner, C. M., Sham, J. S. K., Lakatta, E. G., King, B. F., Unwin, R. J. & Sutters, M., Dec 1 2003, In : American Journal of Physiology - Renal Physiology. 285, 6 54-6, p. F1168-F1178

Research output: Contribution to journalArticle

2002

Acute and chronic hypoxic pulmonary vasoconstriction: A central role for endothelin-1?

Shimoda, L. A., Sham, J. S. K., Liu, Q. & Sylvester, J. T., Aug 22 2002, In : Respiratory Physiology and Neurobiology. 132, 1, p. 93-106 14 p.

Research output: Contribution to journalArticle

Effects of pharmacological preconditioning with U50488H on calcium homeostasis in rat ventricular myocytes subjected to metabolic inhibition and anoxia

Ho, J. C. S., Wu, S., Kam, K. W. L., Sham, J. S. K. & Wong, T. M., Nov 1 2002, In : British Journal of Pharmacology. 137, 6, p. 739-748 10 p.

Research output: Contribution to journalArticle

Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle

Zhou, L., Burnett, A. L., Huang, P. L., Becker, L. C., Kuppusamy, P., Kass, D. A., Kevin Donahue, J., Proud, D., Sham, J. S. K., Dawson, T. M. & Xu, K. Y., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 294, 5, p. 1030-1035 6 p.

Research output: Contribution to journalArticle

2001

Inhibition of voltage-gated K+ currents by endothelin-1 in human pulmonary arterial myocytes

Shimoda, L. A., Sylvester, J. T., Booth, G. M., Shimoda, T. H., Sonya, M., Undem, B. J. & Sham, J. S. K., Dec 17 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 5 25-5, p. L1115-L1122

Research output: Contribution to journalArticle