James Handa

Professor

1987 …2020

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2020

ADVERSE EVENTS OF THE ARGUS II RETINAL PROSTHESIS: Incidence, Causes, and Best Practices for Managing and Preventing Conjunctival Erosion

Rizzo, S., Barale, P. O., Ayello-Scheer, S., Devenyi, R. G., Delyfer, M. N., Korobelnik, J. F., Rachitskaya, A., Yuan, A., Jayasundera, K. T., Zacks, D. N., Handa, J. T., Montezuma, S. R., Koozekanani, D., Stanga, P. E., da Cruz, L., Walter, P., Augustin, A. J., Chizzolini, M., Olmos de Koo, L. C., Ho, A. C. & 25 others, Kirchhof, B., Hahn, P., Vajzovic, L., Iezzi, R., Gaucher, D., Arevalo, J. F., Gregori, N. Z., Grisanti, S., Özmert, E., Yoon, Y. H., Kokame, G. T., Lim, J. I., Szurman, P., de Juan, E., Rezende, F. A., Salzmann, J., Richard, G., Huang, S. S., Merlini, F., Patel, U., Cruz, C., Greenberg, R. J., Justus, S., Cinelli, L. & Humayun, M. S., Feb 1 2020, In : Retina (Philadelphia, Pa.). 40, 2, p. 303-311 9 p.

Research output: Contribution to journalArticle

Clarin-1 expression in adult mouse and human retina highlights a role of Müller glia in Usher syndrome

Xu, L., Bolch, S. N., Santiago, C. P., Dyka, F. M., Akil, O., Lobanova, E. S., Wang, Y., Martemyanov, K. A., Hauswirth, W. W., Smith, W. C., Handa, J. T., Blackshaw, S., Ash, J. D. & Dinculescu, A., Feb 1 2020, In : Journal of Pathology. 250, 2, p. 195-204 10 p.

Research output: Contribution to journalArticle

Open Access

LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target

Choudhary, M., Ismail, E. N., Yao, P. L., Tayyari, F., Radu, R. A., Nusinowitz, S., Boulton, M. E., Apte, R. S., Ruberti, J. W., Handa, J. T., Tontonoz, P. & Malek, G., Jan 1 2020, In : JCI Insight. 5, 1, e131928.

Research output: Contribution to journalArticle

Open Access

Quantitative Ocular Ultrasound Findings in Microbial Keratitis-Associated Endophthalmitis

Viruni, N., Zhang, A. Y., Wang, X., Handa, J. T. & Liu, T. Y. A., Jan 1 2020, (Accepted/In press) In : Ophthalmology Retina.

Research output: Contribution to journalArticle

2019

A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

Handa, J. T., Bowes Rickman, C., Dick, A. D., Gorin, M. B., Miller, J. W., Toth, C. A., Ueffing, M., Zarbin, M. & Farrer, L. A., Dec 1 2019, In : Nature communications. 10, 1, 3347.

Research output: Contribution to journalArticle

Open Access

Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease

Yazdankhah, M., Shang, P., Ghosh, S., Bhutto, I. A., Stepicheva, N., Grebe, R., Hose, S., Weiss, J., Luo, T., Mishra, S., Riazuddin, S. A., Ghosh, A., Handa, J. T., Lutty, G. A., Zigler, J. S. & Sinha, D., Jan 1 2019, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration

Ghosh, S., Padmanabhan, A., Vaidya, T., Watson, A. M., Bhutto, I. A., Hose, S., Shang, P., Stepicheva, N., Yazdankhah, M., Weiss, J., Das, M., Gopikrishna, S., Aishwarya, Yadav, N., Berger, T., Mak, T. W., Xia, S., Qian, J., Lutty, G. A., Jayagopal, A. & 6 others, Zigler, J. S., Sethu, S., Handa, J. T., Watkins, S. C., Ghosh, A. & Sinha, D., Dec 1 2019, In : Communications biology. 2, 1, 348.

Research output: Contribution to journalArticle

Open Access

Photic generation of 11-cis-retinal in bovine retinal pigment epithelium

Zhang, J., Choi, E. H., Tworak, A., Salom, D., Leinonen, H., Sander, C. L., Hoang, T. V., Handa, J. T., Seth Blackshaw, X., Palczewska, G., Kiser, P. D. & Krzysztof Palczewski, X., Dec 13 2019, In : Journal of Biological Chemistry. 294, 50, p. 19137-19154 18 p.

Research output: Contribution to journalArticle

The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration

Getter, T., Suh, S., Hoang, T., Handa, J. T., Dong, Z., Ma, X., Chen, Y., Blackshaw, S. & Palczewski, K., Jun 14 2019, In : Journal of Biological Chemistry. 294, 24, p. 9461-9475 15 p.

Research output: Contribution to journalArticle

2018

A role for βA3/A1-crystallin in type 2 EMT of RPE cells occurring in dry age-related Macular degeneration

Ghosh, S., Shang, P., Terasaki, H., Stepicheva, N., Hose, S., Yazdankhah, M., Weiss, J., Sakamoto, T., Bhutto, I. A., Xia, S., Zigler, J. S., Kannan, R., Qian, J., Handa, J. T. & Sinha, D., Mar 2018, In : Investigative Ophthalmology and Visual Science. 59, 4, p. AMD104-AMD113

Research output: Contribution to journalArticle

ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

Wang, J., Zibetti, C., Shang, P., Sripathi, S. R., Zhang, P., Cano, M., Hoang, T., Xia, S., Ji, H. K., Merbs, S. L., Zack, D. J., Handa, J., Sinha, D., Blackshaw, S. & Qian, J., Dec 1 2018, In : Nature Communications. 9, 1, 1364.

Research output: Contribution to journalArticle

Oxidative stress induces an interactive decline in Wnt and Nrf2 signaling in degenerating retinal pigment epithelium

Ebrahimi, K. B., Cano, M., Rhee, J., Datta, S., Wang, L. & Handa, J., Aug 1 2018, In : Antioxidants and Redox Signaling. 29, 4, p. 389-407 19 p.

Research output: Contribution to journalArticle

Quantifying the Rate of Ellipsoid Zone Loss in Stargardt Disease

Cai, C. X., Light, J. G. & Handa, J., Feb 1 2018, In : American Journal of Ophthalmology. 186, p. 1-9 9 p.

Research output: Contribution to journalArticle

Retinal Anatomy and Electrode Array Position in Retinitis Pigmentosa Patients After Argus II Implantation: An International Study

Gregori, N. Z., Callaway, N. F., Hoeppner, C., Yuan, A., Rachitskaya, A., Feuer, W., Ameri, H., Arevalo, J. F., Augustin, A. J., Birch, D. G., Dagnelie, G., Grisanti, S., Davis, J. L., Hahn, P., Handa, J., Ho, A. C., Huang, S. S., Humayun, M. S., Iezzi, R., Jayasundera, K. T. & 12 others, Kokame, G. T., Lam, B. L., Lim, J. I., Mandava, N., Montezuma, S. R., Olmos de Koo, L., Szurman, P., Vajzovic, L., Wiedemann, P., Weiland, J., Yan, J. & Zacks, D. N., Sep 1 2018, In : American Journal of Ophthalmology. 193, p. 87-99 13 p.

Research output: Contribution to journalArticle

Shortest Distance From Fovea to Subfoveal Hemorrhage Border Is Important in Patients With Neovascular Age-related Macular Degeneration

Kherani, S., Scott, A., Wenick, A., Zimmer Galler, I. E., Brady, C. J., Sodhi, A., Meyerle, C., Solomon, S., Shaukat, R., Channa, R., Adeyemo, O., Handa, J., Wang, J. & Campochiaro, P. A., May 1 2018, In : American Journal of Ophthalmology. 189, p. 86-95 10 p.

Research output: Contribution to journalArticle

2017

3-DOF Force-Sensing Motorized Micro-Forceps for Robot-Assisted Vitreoretinal Surgery

Gonenc, B., Chamani, A., Handa, J., Gehlbach, P., Taylor, R. H. & Iordachita, I., Jun 1 2017, In : IEEE Sensors Journal. 17, 11, p. 3526-3541 16 p., 7903591.

Research output: Contribution to journalArticle

Melanoma subtypes demonstrate distinct PD-L1 expression profiles

Kaunitz, G. J., Cottrell, T. R., Lilo, M., Muthappan, V., Esandrio, J., Berry, S., Xu, H., Ogurtsova, A., Anders, R. A., Fischer, A. H., Kraft, S., Gerstenblith, M. R., Thompson, C. L., Honda, K., Cuda, J. D., Eberhart, C. G., Handa, J., Lipson, E. & Taube, J. M., Sep 1 2017, In : Laboratory Investigation. 97, 9, p. 1063-1071 9 p.

Research output: Contribution to journalArticle

STARGARDT DISEASE: Beyond Flecks and Atrophy

Light, J. G., Fard, M. A., Yaseri, M., Aiyetan, P., Handa, J. & Ebrahimi, K. B., Jan 17 2017, (Accepted/In press) In : Retina.

Research output: Contribution to journalArticle

The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling

Shang, P., Valapala, M., Grebe, R., Hose, S., Ghosh, S., Bhutto, I. A., Handa, J., Lutty, G. A., Lu, L., Wan, J., Qian, J., Sergeev, Y., Puertollano, R., Zigler, J. S., Xu, G. T. & Sinha, D., 2017, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

Datta, S., Cano, M., Ebrahimi, K., Wang, L. & Handa, J., 2017, (Accepted/In press) In : Progress in Retinal and Eye Research.

Research output: Contribution to journalArticle

2016

Five-Year Safety and Performance Results from the Argus II Retinal Prosthesis System Clinical Trial

da Cruz, L., Dorn, J. D., Humayun, M. S., Dagnelie, G., Handa, J., Barale, P. O., Sahel, J. A., Stanga, P. E., Hafezi, F., Safran, A. B., Salzmann, J., Santos, A., Birch, D., Spencer, R., Cideciyan, A. V., de Juan, E., Duncan, J. L., Eliott, D., Fawzi, A., Olmos de Koo, L. C. & 7 others, Ho, A. C., Brown, G., Haller, J., Regillo, C., Del Priore, L. V., Arditi, A. & Greenberg, R. J., Oct 1 2016, In : Ophthalmology. 123, 10, p. 2248-2254 7 p.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

Hu, K., Babapoor-Farrokhran, S., Rodrigues, M., Deshpande, M., Puchner, B., Kashiwabuchi, F., Hassan, S. J., Asnaghi, L., Handa, J. T., Merbs, S., Eberhart, C. G., Semenza, G. L., Montaner, S. & Sodhi, A., Jan 1 2016, In : Oncotarget. 7, 7, p. 7816-7828 13 p.

Research output: Contribution to journalArticle

Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation

Wang, L., Cano, M., Datta, S., Wei, H., Ebrahimi, K. B., Gorashi, Y., Garlanda, C. & Handa, J. T., Dec 1 2016, In : Journal of Pathology. 240, 4, p. 495-506 12 p.

Research output: Contribution to journalArticle

Pro-permeability Factors in Diabetic Macular Edema; The Diabetic Macular Edema Treated with Ozurdex Trial

Campochiaro, P. A., Hafiz, G., Mir, T. A., Scott, A., Zimmer Galler, I. E., Shah, S. M., Wenick, A., Brady, C. J., Han, I., He, L., Channa, R., Poon, D., Meyerle, C., Aronow, M. B., Sodhi, A., Handa, J., Kherani, S., Han, Y., Sophie, R., Wang, G. & 1 others, Qian, J., Aug 1 2016, In : American Journal of Ophthalmology. 168, p. 13-23 11 p.

Research output: Contribution to journalArticle

Robotic Vitreoretinal Surgery

Channa, R., Iordachita, I. & Handa, J., Nov 23 2016, (Accepted/In press) In : Retina.

Research output: Contribution to journalArticle

2015

Concise review: Using stem cells to prevent the progression of myopia - A concept

Janowski, M., Bulte, J. W. M., Handa, J. T., Rini, D. & Walczak, P., Jul 1 2015, In : Stem Cells. 33, 7, p. 2104-2113 10 p.

Research output: Contribution to journalArticle

EMT-associated factors promote invasive properties of uveal melanoma cells

Asnaghi, L., Gezgin, G., Tripathy, A., Handa, J. T., Merbs, S. L., van der Velden, P. A., Jager, M. J., Harbour, J. W. & Eberhart, C. G., Aug 25 2015, In : Molecular vision. 21, p. 919-929 11 p.

Research output: Contribution to journalArticle

Lipoprotein(A) with an intact lysine binding site protects the retina from an age-related macular degeneration phenotype in mice (an American ophthalmological society thesis)

Handa, J. T., Tagami, M., Ebrahimi, K., Leibundgut, G., Janiak, A., Witztum, J. L. & Tsimikas, S., Jan 1 2015, In : Transactions of the American Ophthalmological Society. 113, p. T5-1-T5-22

Research output: Contribution to journalArticle

Long-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind

Ho, A. C., Humayun, M. S., Dorn, J. D., Da Cruz, L., Dagnelie, G., Handa, J., Barale, P. O., Sahel, J. A., Stanga, P. E., Hafezi, F., Safran, A. B., Salzmann, J., Santos, A., Birch, D., Spencer, R., Cideciyan, A. V., De Juan, E., Duncan, J. L., Eliott, D., Fawzi, A. & 8 others, Olmos De Koo, L. C., Brown, G. C., Haller, J. A., Regillo, C. D., Del Priore, L. V., Arditi, A., Geruschat, D. R. & Greenberg, R. J., Aug 1 2015, In : Ophthalmology. 122, 8, p. 1547-1554 8 p.

Research output: Contribution to journalArticle

Rescuing trafficking mutants of the ATP-binding cassette protein, ABCA4, with small molecule correctors as a treatment for Stargardt eye disease

Sabirzhanova, I., Lopes Pacheco, M., Rapino, D., Grover, R., Handa, J. T., Guggino, W. B. & Cebotaru, L., Aug 7 2015, In : Journal of Biological Chemistry. 290, 32, p. 19743-19755 13 p.

Research output: Contribution to journalArticle

2014

A submillimetric 3-DOF force sensing instrument with integrated fiber bragg grating for retinal microsurgery

He, X., Handa, J., Gehlbach, P., Taylor, R. & Iordachita, I., Feb 1 2014, In : IEEE Transactions on Biomedical Engineering. 61, 2, p. 522-534 13 p., 6609063.

Research output: Contribution to journalArticle

Automated image alignment and segmentation to follow progression of geographic atrophy in age-related macular degeneration

Ramsey, D. J., Sunness, J. S., Malviya, P., Applegate, C., Hager, G. D. & Handa, J. T., Jul 2014, In : Retina. 34, 7, p. 1296-1307 12 p.

Research output: Contribution to journalArticle

Hypoxia promotes uveal melanoma invasion through enhanced notch and MAPK activation

Asnaghi, L., Lin, M. H., Lim, K. S., Lim, K. J., Tripathy, A., Wendeborn, M., Merbs, S. L., Handa, J. T., Sodhi, A., Bar, E. E. & Eberhart, C. G., Aug 28 2014, In : PloS one. 9, 8, e105372.

Research output: Contribution to journalArticle

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response

Valapala, M., Edwards, M., Hose, S., Grebe, R., Bhutto, I. A., Cano, M., Berger, T., Mak, T. W., Wawrousek, E., Handa, J. T., Lutty, G. A., Samuel Zigler, J. & Sinha, D., Dec 1 2014, In : Aging Cell. 13, 6, p. 1091-1094 4 p.

Research output: Contribution to journalArticle

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

Valapala, M., Wilson, C., Hose, S., Bhutto, I. A., Grebe, R., Dong, A., Greenbaum, S., Gu, L., Sengupta, S., Cano, M., Hackett, S., Xu, G., Lutty, G. A., Dong, L., Sergeev, Y., Handa, J. T., Campochiaro, P., Wawrousek, E., Zigler, J. S. & Sinha, D., Mar 2014, In : Autophagy. 10, 3, p. 480-496 17 p.

Research output: Contribution to journalArticle

NRF2 plays a protective role in diabetic retinopathy in mice

Xu, Z., Wei, Y., Gong, J., Cho, H., Park, J. K., Sung, E. R., Huang, H., Wu, L., Eberhart, C., Handa, J. T., Du, Y., Kern, T. S., Thimmulappa, R., Barber, A. J., Biswal, S. & Duh, E. J., Jan 1 2014, In : Diabetologia. 57, 1, p. 204-213 10 p.

Research output: Contribution to journalArticle

Nrf2 signaling is impaired in the aging RPE given an oxidative insult

Sachdeva, M. M., Cano, M. & Handa, J. T., Feb 1 2014, In : Experimental eye research. 119, p. 111-114 4 p.

Research output: Contribution to journalArticle

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells

Wang, L., Kondo, N., Cano, M., Ebrahimi, K., Yoshida, T., Barnett, B. P., Biswal, S. & Handa, J. T., May 2014, In : Free Radical Biology and Medicine. 70, p. 155-166 12 p.

Research output: Contribution to journalArticle

Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells

Cano, M., Wang, L., Wan, J., Barnett, B. P., Ebrahimi, K., Qian, J. & Handa, J. T., Apr 1 2014, In : Free Radical Biology and Medicine. 69, p. 1-14 14 p.

Research output: Contribution to journalArticle

Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells

Chen, C., Cano, M., Wang, J. J., Li, J., Huang, C., Yu, Q., Herbert, T. P., Handa, J. T. & Zhang, S. X., May 10 2014, In : Antioxidants and Redox Signaling. 20, 14, p. 2091-2106 16 p.

Research output: Contribution to journalArticle

T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration

Cruz-Guilloty, F., Saeed, A. M., Duffort, S., Cano, M., Ebrahimi, K. B., Ballmick, A., Tan, Y., Wang, H., Laird, J. M., Salomon, R. G., Handa, J. T. & Perez, V. L., Feb 19 2014, In : PloS one. 9, 2, e88201.

Research output: Contribution to journalArticle

2013

A force-sensing microsurgical instrument that detects forces below human tactile sensation

Sunshine, S., Balicki, M., He, X., Olds, K., Kang, J., Gehlbach, P., Taylor, R., Iordachita, I. & Handa, J. T., Jan 1 2013, In : Retina. 33, 1, p. 200-206 7 p.

Research output: Contribution to journalArticle

A role for Jag2 in promoting uveal melanoma dissemination and growth

Asnaghi, L., Handa, J. T., Merbs, S. L., Harbour, J. W. & Eberhart, C. G., Jan 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 295-306 12 p.

Research output: Contribution to journalArticle

Auditory force feedback substitution improves surgical precision during simulated ophthalmic surgery

Cutler, N., Balicki, M., Finkelstein, M., Wang, J., Gehlbach, P., McGready, J., Iordachita, I., Taylor, R. & Handa, J. T., Feb 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 1316-1324 9 p.

Research output: Contribution to journalArticle