James Handa

Professor-Fac

1987 …2018
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Macular Degeneration Medicine & Life Sciences
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Oxidative Stress Medicine & Life Sciences
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Research Output 1987 2018

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

Ghosh, S., Shang, P., Terasaki, H., Stepicheva, N., Hose, S., Yazdankhah, M., Weiss, J., Sakamoto, T., Bhutto, I. A., Xia, S., Zigler, J. S., Kannan, R., Qian, J., Handa, J. T. & Sinha, D., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD104-AMD113

Research output: Contribution to journalArticle

Crystallins
Epithelial-Mesenchymal Transition
Macular Degeneration
Vimentin
Cadherins

ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

Wang, J., Zibetti, C., Shang, P., Sripathi, S. R., Zhang, P., Cano, M., Hoang, T., Xia, S., Ji, H., Merbs, S. L., Zack, D. J., Handa, J. T., Sinha, D., Blackshaw, S. & Qian, J., Dec 1 2018, In : Nature Communications. 9, 1, 1364

Research output: Contribution to journalArticle

accessibility
analysis
pathology
risk factor
footprint

Oxidative stress induces an interactive decline in Wnt and Nrf2 signaling in degenerating retinal pigment epithelium

Ebrahimi, K. B., Cano, M., Rhee, J., Datta, S., Wang, L. & Handa, J. T., Aug 1 2018, In : Antioxidants and Redox Signaling. 29, 4, p. 389-407 19 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Oxidative Stress
Macular Degeneration
High Fat Diet
Geographic Atrophy

Quantifying the Rate of Ellipsoid Zone Loss in Stargardt Disease

Cai, C. X., Light, J. G. & Handa, J. T., Feb 1 2018, In : American Journal of Ophthalmology. 186, p. 1-9 9 p.

Research output: Contribution to journalArticle

Optical Coherence Tomography
Retinal Pigment Epithelium
Disease Progression
Retrospective Studies
Outcome Assessment (Health Care)
Macular Degeneration
Hemorrhage
Visual Acuity
Vascular Endothelial Growth Factor A
Injections