James Handa

Professor

1987 …2019
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Fingerprint Dive into the research topics where James Handa is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Macular Degeneration Medicine & Life Sciences
Retinal Pigments Medicine & Life Sciences
Retinal Pigment Epithelium Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Bruch Membrane Medicine & Life Sciences
Oxidative Stress Medicine & Life Sciences
Retina Medicine & Life Sciences
Vitreoretinal Surgery Medicine & Life Sciences

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Research Output 1987 2019

A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

Handa, J., Bowes Rickman, C., Dick, A. D., Gorin, M. B., Miller, J. W., Toth, C. A., Ueffing, M., Zarbin, M. & Farrer, L. A., Dec 1 2019, In : Nature communications. 10, 1, 3347.

Research output: Contribution to journalArticle

Open Access
Systems Biology
degeneration
Macular Degeneration
biology
therapy
Retinal Vein Occlusion
Macular Edema
Vascular Endothelial Growth Factor A
Visual Acuity
Edema

Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease

Yazdankhah, M., Shang, P., Ghosh, S., Bhutto, I. A., Stepicheva, N., Grebe, R., Hose, S., Weiss, J., Luo, T., Mishra, S., Riazuddin, S. A., Ghosh, A., Handa, J. T., Lutty, G. A., Zigler, J. S. & Sinha, D., Jan 1 2019, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Fetal Diseases
Autophagy
Epidermal Growth Factor Receptor
Phosphotransferases
Astrocytes

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration

Ghosh, S., Padmanabhan, A., Vaidya, T., Watson, A. M., Bhutto, I. A., Hose, S., Shang, P., Stepicheva, N., Yazdankhah, M., Weiss, J., Das, M., Gopikrishna, S., Aishwarya, Yadav, N., Berger, T., Mak, T. W., Xia, S., Qian, J., Lutty, G. A., Jayagopal, A. & 6 others, Zigler, J. S., Sethu, S., Handa, J. T., Watkins, S. C., Ghosh, A. & Sinha, D., Dec 1 2019, In : Communications Biology. 2, 1, 348.

Research output: Contribution to journalArticle

Open Access
Lipocalins
Macular Degeneration
Pathology
retina
Infiltration

The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration

Getter, T., Suh, S., Hoang, T., Handa, J., Dong, Z., Ma, X., Chen, Y., Blackshaw, S. & Palczewski, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 24, p. 9461-9475 15 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Toxicity
Calcium
Retina
Assays