James Eshleman

Professor

1988 …2020

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8-Hydroxyguanosine repair is defective in some microsatellite stable colorectal cancer cells

Parker, A. R., O'Meally, R. N., Oliver, D. H., Hua, L., Nelson, W. G., DeWeese, T. L. & Eshleman, J. R., Dec 15 2002, In : Cancer Research. 62, 24, p. 7230-7233 4 p.

Research output: Contribution to journalArticle

Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences

Fujiwara, T., Stolker, J. M., Watanabe, T., Rashid, A., Longo, P., Eshleman, J. R., Booker, S., Lynch, H. T., Jass, J. R., Green, J. S., Kim, H., Jen, J., Vogelstein, B. & Hamilton, S. R., Oct 1998, In : American Journal of Pathology. 153, 4, p. 1063-1078 16 p.

Research output: Contribution to journalArticle

A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts

Springer, S., Wang, Y., Dal Molin, M., Masica, D. L., Jiao, Y., Kinde, I., Blackford, A., Raman, S. P., Wolfgang, C. L., Tomita, T., Niknafs, N., Douville, C., Ptak, J., Dobbyn, L., Allen, P. J., Klimstra, D. S., Schattner, M. A., Schmidt, C. M., Yip-Schneider, M., Cummings, O. W. & 47 others, Brand, R. E., Zeh, H. J., Singhi, A. D., Scarpa, A., Salvia, R., Malleo, G., Zamboni, G., Falconi, M., Jang, J. Y., Kim, S. W., Kwon, W., Hong, S. M., Song, K. B., Kim, S. C., Swan, N., Murphy, J., Geoghegan, J., Brugge, W., Fernandez-Del Castillo, C., Mino-Kenudson, M., Schulick, R., Edil, B. H., Adsay, V., Paulino, J., Van Hooft, J., Yachida, S., Nara, S., Hiraoka, N., Yamao, K., Hijioka, S., Van Der Merwe, S., Goggins, M., Canto, M. I., Ahuja, N., Hirose, K., Makary, M., Weiss, M. J., Cameron, J., Pittman, M., Eshleman, J. R., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Karchin, R., Hruban, R. H., Vogelstein, B. & Lennon, A. M., Nov 2015, In : Gastroenterology. 149, 6, p. 1501-1510 10 p.

Research output: Contribution to journalArticle

Advancements in the development of hif-1a-activated protein switches for use in enzyme prodrug therapy e114032

Wright, R. C., Khakhar, A., Eshleman, J. R. & Ostermeier, M., Nov 26 2014, In : PloS one. 9, 11, 014032.

Research output: Contribution to journalArticle

A gene amplified in a transformed mouse cell line undergoes complex transcriptional processing and encodes a nuclear protein

Snyder, L. C., Trusko, S. P., Freeman, N., Eshleman, J. R., Fakharzadeh, S. S. & George, D. L., Jan 1 1988, In : Journal of Biological Chemistry. 263, 32, p. 17150-17158 9 p.

Research output: Contribution to journalArticle

Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas

Jinawath, N., Shiao, M. S., Norris, A., Murphy, K., Klein, A., Yonescu, R., Iacobuzio-Donahue, C., Meeker, A. K., Jinawath, A., Yeo, C. J., Eshleman, J., Hruban, R. H., Brody, J. R., Griffin, C. A. & Harada, S., May 1 2017, In : Genes Chromosomes and Cancer. 56, 5, p. 427-435 9 p.

Research output: Contribution to journalArticle

A molecular fraction collecting tool for the ABI 310 automated sequencer

Lin, M. T., Rich, R. G., Shipley, R. F., Hafez, M. J., Tseng, L. H., Murphy, K. M., Gocke, C. D. & Eshleman, J. R., Nov 2007, In : Journal of Molecular Diagnostics. 9, 5, p. 598-603 6 p.

Research output: Contribution to journalArticle

Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation

Gingras, M. C., Covington, K. R., Chang, D. K., Donehower, L. A., Gill, A. J., Ittmann, M. M., Creighton, C. J., Johns, A. L., Shinbrot, E., Dewal, N., Fisher, W. E., Pilarsky, C., Grützmann, R., Overman, M. J., Jamieson, N. B., Van Buren, G., Drummond, J., Walker, K., Hampton, O. A., Xi, L. & 158 others, Muzny, D. M., Doddapaneni, H., Lee, S. L., Bellair, M., Hu, J., Han, Y., Dinh, H. H., Dahdouli, M., Samra, J. S., Bailey, P., Waddell, N., Pearson, J. V., Harliwong, I., Wang, H., Aust, D., Oien, K. A., Hruban, R. H., Hodges, S. E., McElhany, A., Saengboonmee, C., Duthie, F. R., Grimmond, S. M., Biankin, A. V., Wheeler, D. A., Gibbs, R. A., Jones, M. D., Mawson, A., Scarlett, C. J., Brancato, M. A. L., Rowe, S. J., Simpson, S. H., Smith Martyn, M., Thomas, M. T., Chantrill, L. A., Chin, V. T., Angela, C., Cowley, M. J., Humphris, J. L., Mead, S., Nagrial, A. M., Pajic, M., Pettit, J., Pinese, M., Rooman, I., Wu, J., Tao, J., DiPietro, R., Watson, C., Steinmann, A., Lee, H. C., Wong, R., Pinho, A. V., Giry-Laterriere, M., Daly, R. J., Musgrove, E. A., Sutherland, R. L., Kassahn, K. S., Miller, D. K., Wilson, P. J., Patch, A. M., Song, S., Idrisoglu, S., Nourse, C., Nourbakhsh, E., Manning, S., Wani, S., Gongora, M., Anderson, M., Holmes, O., Leonard, C., Taylor, D., Wood, S., Xu, C., Nones, K., Fink, L. J., Christ, A., Bruxner, T., Cloonan, N., Newell, F., Quinn, M., Nagaraj, S., Kazakoff, S., Waddell, N., Krisnan, K., Queelly, Wood, D., Pavlakis, N., Guminski, A., Toon, C., Asghari, R., Merrett, N. D., Pavey, D., Das, A., Cosman, P. H., Ismail, K., O'Connnor, C., Lam, V. W., McLeod, D., Pleass, H. C., Richardson, A., James, V., Kench, J. G., Cooper, C. L., Joseph, D., Sandroussi, C., Crawford, M., Gallagher, J., Texler, M., Forest, C., Laycock, A., Epari, K. P., Ballal, M., Fletcher, D. R., Mukhedkar, S., Spry, N. A., DeBoer, B., Chai, M., Zeps, N., Beilin, M., Feeney, K., Nguyen, N. Q., Ruszkiewicz, A. R., Worthley, C., Tan, C. P., Debrencini, T., Chen, J., Brooke-Smith, M. E., Papangelis, V., Tang, H., Barbour, A. P., Clouston, A. D., Martin, P., O'Rourke, T. J., Chiang, A., Fawcett, J. W., Slater, K., Yeung, S., Hatzifotis, M., Hodgkinson, P., Christophi, C., Nikfarjam, M., Mountain, A., Eshleman, J. R., Maitra, A., Iacobuzio-Donahue, C. A., Schulick, R. D., Wolfgang, C. L., Morgan, R. A., Hodgin, M., Scarpa, A., Lawlor, R. T., Beghelli, S., Corbo, V., Scardoni, M., Bassi, C., Tempero, M. A., Glasgow, G. & Graham, J. S., Feb 2 2016, In : Cell Reports. 14, 4, p. 907-919 13 p.

Research output: Contribution to journalArticle

Analysis of hematopoietic stem cell transplant engraftment: Use of loss or gain of microsatellite alleles to identify residual hematopoietic malignancy

Lin, M. T., Tseng, L. H., Beierl, K., Harada, S., Hafez, M. J., Eshleman, J. R. & Gocke, C. D., Dec 1 2011, In : Diagnostic Molecular Pathology. 20, 4, p. 194-202 9 p.

Research output: Contribution to journalArticle

Analysis of polymorphisms and haplotype structure of the human thymidylate synthase genetic region: A tool for pharmacogenetic studies

Ghosh, S., Hossain, M. Z., Borges, M., Goggins, M. G., Ingersoll, R. G., Eshleman, J. R., Klein, A. P. & Kern, S. E., Apr 5 2012, In : PloS one. 7, 4, e34426.

Research output: Contribution to journalArticle

A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer

Boland, C. R., Thibodeau, S. N., Hamilton, S. R., Sidransky, D., Eshleman, J. R., Burt, R. W., Meltzer, S. J., Rodriguez-Bigas, M. A., Fodde, R., Ranzani, G. N. & Srivastava, S., Nov 15 1998, In : Cancer Research. 58, 22, p. 5248-5257 10 p.

Research output: Contribution to journalArticle

An early lesion in hepatic carcinogenesis: Loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region

Sun, M., Eshleman, J. R., Ferrell, L. D., Jacobs, G., Sudilovsky, E. C., Tuthill, R., Hussein, M. R. & Sudilovsky, O., Jan 1 2001, In : Hepatology. 33, 6, p. 1415-1424 10 p.

Research output: Contribution to journalArticle

A New Fast Phasing Method Based On Haplotype Subtraction

Mocci, E., Debeljak, M., Klein, A. P. & Eshleman, J. R., May 2019, In : Journal of Molecular Diagnostics. 21, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

An Inactivating Mutation in HDAC2 Leads to Dysregulation of Apoptosis Mediated by APAF1

Hanigan, C. L., van Engeland, M., De Bruine, A. P., Wouters, K. A., Weijenberg, M. P., Eshleman, J. R. & Herman, J. G., Nov 2008, In : Gastroenterology. 135, 5, p. 1654-1664.e2

Research output: Contribution to journalArticle

An in vivo platform for translational drug development in pancreatic cancer

Rubio-Viqueira, B., Jimeno, A., Cusatis, G., Zhang, X., Iacobuzio-Donahue, C., Karikari, C., Shi, C., Danenberg, K., Danenberg, P. V., Kuramochi, H., Tanaka, K., Singh, S., Salimi-Moosavi, H., Bouraoud, N., Amador, M. L., Altiok, S., Kulesza, P., Yeo, C., Messersmith, W., Eshleman, J. & 3 others, Hruban, R. H., Maitra, A. & Hidalgo, M., Aug 1 2006, In : Clinical Cancer Research. 12, 15, p. 4652-4661 10 p.

Research output: Contribution to journalArticle

A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts

Masica, D. L., Molin, M. D., Wolfgang, C., Tomita, T., Ostovaneh, M. R., Blackford, A., Moran, R. A., Law, J. K., Barkley, T., Goggins, M. S., Canto, M., Pittman, M., Eshleman, J., Ali, S. Z., Fishman, E. K., Kamel, I. R., Raman, S. P., Zaheer, A., Ahuja, N., Makary, M. A. & 16 others, Weiss, M. J., Hirose, K., Cameron, J. L., Rezaee, N., He, J., Ahn, Y. J., Wu, W., Wang, Y., Springer, S., Diaz, L. L., Papadopoulos, N., Hruban, R. H., Kinzler, K. W., Vogelstein, B., Karchin, R. & O'Broin-Lennon, A. M., 2017, In : Journal of the American Medical Informatics Association. 24, 1, p. 145-152 8 p.

Research output: Contribution to journalArticle

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.

Alhopuro, P., Parker, A. R., Lehtonen, R., Enholm, S., Järvinen, H. J., Mecklin, J. P., Karhu, A., Eshleman, J. R. & Aaltonen, L. A., Oct 2005, In : Human mutation. 26, 4, 1 p.

Research output: Contribution to journalArticle

Anti-gene padlocks eliminate Escherichia coli based on their genotype

Shi, C., Parker, A. R., Hua, L., Morrell, C. N., Lee, S. C., Bandaru, V., Dumler, J. S., Wu, T. C. & Eshleman, J. R., Feb 1 2008, In : Journal of Antimicrobial Chemotherapy. 61, 2, p. 262-272 11 p.

Research output: Contribution to journalArticle

A pilot study of prostate-specific membrane antigen (PSMA) dynamics in men undergoing treatment for advanced prostate cancer

Paller, C., Piana, D., Eshleman, J., Riel, S., Denmeade, S. R., Isaacsson Velho, P., Rowe, S., Pomper, M. G., Antonarakis, E., Luo, J. & Eisenberger, M., Jan 1 2019, In : Prostate. 79, 14, p. 1597-1603 7 p.

Research output: Contribution to journalArticle

Application of traditional clinical pathology quality control techniques to molecular pathology

Liang, S. L., Lin, M. T., Hafez, M. J., Gocke, C. D., Murphy, K. M., Sokoll, L. J. & Eshleman, J. R., Mar 2008, In : Journal of Molecular Diagnostics. 10, 2, p. 142-146 5 p.

Research output: Contribution to journalArticle

A protein therapeutic modality founded on molecular regulation

Wright, C. M., Wright, R. C., Eshleman, J. R. & Ostermeier, M., Sep 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 39, p. 16206-16211 6 p.

Research output: Contribution to journalArticle

A single nucleotide primer extension assay to detect the APC I1307K gene variant

Murphy, K. M., Geiger, T., Hafez, M. J., Eshleman, J. R., Griffin, C. A. & Berg, K. D., Nov 2003, In : Journal of Molecular Diagnostics. 5, 4, p. 222-226 5 p.

Research output: Contribution to journalArticle

Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers

Aragon Han, P., Kim, H. S., Cho, S., Fazeli, R., Najafian, A., Khawaja, H., McAlexander, M., Dy, B., Sorensen, M., Aronova, A., Sebo, T. J., Giordano, T. J., Fahey, T. J., Thompson, G. B., Gauger, P. G., Somervell, H., Bishop, J. A., Eshleman, J., Schneider, E. B., Witwer, K. W. & 2 others, Umbricht, C. B. & Zeiger, M. A., Apr 1 2016, In : Thyroid. 26, 4, p. 532-542 11 p.

Research output: Contribution to journalArticle

A subgroup of microsatellite stable colorectal cancers has elevated mutation rates and different responses to alkylating and oxidising agents

Parker, A. R., Leonard, C. P., Hua, L., Francis, R. O., Dhara, S., Maitra, A. & Eshleman, J. R., Apr 19 2004, In : British journal of cancer. 90, 8, p. 1666-1671 6 p.

Research output: Contribution to journalArticle

ATM mutations in patients with hereditary pancreatic cancer

Roberts, N. J., Jiao, Y., Yu, J., Kopelovich, L., Petersen, G. M., Bondy, M. L., Gallinger, S., Schwartz, A. G., Syngal, S., Cote, M. L., Axilbund, J., Schulick, R., Ali, S. Z., Eshleman, J. R., Velculescu, V. E., Goggins, M., Vogelstein, B., Papadopoulos, N., Hruban, R. H., Kinzler, K. W. & 1 others, Klein, A. P., Jan 1 2012, In : Cancer discovery. 2, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

A virtual pyrogram generator to resolve complex pyrosequencing results

Chen, G., Olson, M. T., O'Neill, A., Norris, A., Beierl, K., Harada, S., Debeljak, M., Rivera-Roman, K., Finley, S., Stafford, A., Gocke, C. D., Lin, M. T. & Eshleman, J. R., Mar 1 2012, In : Journal of Molecular Diagnostics. 14, 2, p. 149-159 11 p.

Research output: Contribution to journalArticle

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice

Jurcak, N. R., Rucki, A. A., Muth, S., Thompson, E., Sharma, R., Ding, D., Zhu, Q., Eshleman, J., Anders, R. A., Jaffee, E., Fujiwara, K. & Zheng, L., Sep 1 2019, In : Gastroenterology. 157, 3, p. 838-850.e6

Research output: Contribution to journalArticle

Benign nodal nevi frequently harbor the activating V600E BRAF mutation

Taube, J. M., Begum, S., Shi, C., Eshleman, J. R. & Westra, W. H., Apr 1 2009, In : American Journal of Surgical Pathology. 33, 4, p. 568-571 4 p.

Research output: Contribution to journalArticle

Biphenotypic Differentiation of Pancreatic Cancer in 3-Dimensional Culture

Matsushita, Y., Smith, B., Delannoy, M., Trujillo, M. A., Chianchiano, P., McMillan, R., Kamiyama, H., Liang, H., Thompson, E. D., Hruban, R. H., Matsui, W., Wood, L. D., Roberts, N. J. & Eshleman, J. R., Oct 1 2019, In : Pancreas. 48, 9, p. 1225-1231 7 p.

Research output: Contribution to journalArticle

Both Transforming Growth Factor-β and Substrate Release Are Inducers of Apoptosis in a Human Colon Adenoma Cell Line

Wang, C. Y., Eshleman, J. R., Willson, J. K. V., Markowitz, S., Wang, C. Y., Willson, J. K. V., Markowitz, S. & Eshleman, J. R., Nov 1 1995, In : Cancer Research. 55, 21, p. 5101-5105 5 p.

Research output: Contribution to journalArticle

BRAF pyrosequencing analysis aided by a lookup table

Olson, M. T., Harrington, C., Beierl, K., Chen, G., Thiess, M., O'Neill, A., Taube, J. M., Zeiger, M. A., Lin, M. T. & Eshleman, J. R., May 1 2014, In : American journal of clinical pathology. 141, 5, p. 639-647 9 p.

Research output: Contribution to journalArticle

Brief report: Transmission of a T-cell lymphoma by allogeneic bone marrow transplantation

Berg, K. D., Brinster, N. K., Huhn, K. M., Goggins, M. G., Jones, R. J., Makary, A., Murphy, K. M., Griffin, C. A., Rosenblum-Vos, L. S., Borowitz, M. J., Nousari, H. C. & Eshleman, J. R., Nov 15 2001, In : New England Journal of Medicine. 345, 20, p. 1458-1463 6 p.

Research output: Contribution to journalArticle

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Australian Pancreatic Genome Initiative (APGI), Dec 1 2019, In : Nature communications. 10, 1, 3637.

Research output: Contribution to journalArticle

Open Access

Capillary electrophoresis artifact due to eosin: Implications for the interpretation of molecular diagnostic assays

Murphy, K. M., Berg, K. D., Geiger, T., Hafez, M., Flickinger, K. A., Cooper, L., Pearson, P. & Eshleman, J. R., Feb 2005, In : Journal of Molecular Diagnostics. 7, 1, p. 143-148 6 p.

Research output: Contribution to journalArticle

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair

Parker, A. R., Sieber, O. M., Shi, C., Hua, L., Takao, M., Tomlinson, I. P. & Eshleman, J. R., Nov 1 2005, In : Carcinogenesis. 26, 11, p. 2010-2018 9 p.

Research output: Contribution to journalArticle

Challenges posed to pathologists in the detection of KRAS mutations in colorectal cancers

Dudley, J., Tseng, L. H., Rooper, L., Harris, M., Haley, L., Chen, G., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Feb 1 2015, In : Archives of Pathology and Laboratory Medicine. 139, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

Eshleman, J. R., Casey, G., Kochera, M. E., Sedwick, W. D., Swinler, S. E., Veigl, M. L., Willson, J. K. V., Schwartz, S. & Markowitz, S. D., Aug 13 1998, In : Oncogene. 17, 6, p. 719-725 7 p.

Research output: Contribution to journalArticle

Open Access

Circulating tumor DNA as a clinical test in resected pancreatic cancer

Groot, V. P., Mosier, S., Javed, A. A., Teinor, J. A., Gemenetzis, G., Ding, D., Haley, L. M., Yu, J., Burkhart, R. A., Hasanain, A., Debeljak, M., Kamiyama, H., Narang, A., Laheru, D. A., Zheng, L., Lin, M. T., Gocke, C. D., Fishman, E. K., Hruban, R. H., Goggins, M. G. & 7 others, Quintus Molenaar, I., Cameron, J. L., Weiss, M. J., Velculescu, V. E., He, J., Wolfgang, C. L. & Eshleman, J. R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4973-4984 12 p.

Research output: Contribution to journalArticle

Clinical detection and categorization of uncommon and concomitant mutations involving BRAF

Zheng, G., Tseng, L. H., Chen, G., Haley, L., Illei, P., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Oct 24 2015, In : BMC cancer. 15, 1, 779.

Research output: Contribution to journalArticle

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

Sausen, M., Phallen, J., Adleff, V., Jones, S., Leary, R. J., Barrett, M. T., Anagnostou, V., Parpart-Li, S., Murphy, D., Li, Q. K., Hruban, C. A., Scharpf, R. B., White, J. R., O'Dwyer, P. J., Allen, P. J., Eshleman, J., Thompson, C. B., Klimstra, D. S., Linehan, D. C., Maitra, A. & 6 others, Hruban, R. H., Diaz, L. A., Von Hoff, D. D., Johansen, J. S., Drebin, J. A. & Velculescu, V. E., Jul 7 2015, In : Nature Communications. 6, 7686.

Research output: Contribution to journalArticle

Open Access

Clinical mutational profiling of 1006 lung cancers by next generation sequencing

Illei, P. B., Belchis, D., Tseng, L. H., Nguyen, D., De Marchi, F., Haley, L., Riel, S., Beierl, K., Zheng, G., Brahmer, J. R., Askin, F. B., Gocke, C. D., Eshleman, J. R., Forde, P. M. & Lin, M. T., Jan 1 2017, In : Oncotarget. 8, 57, p. 96684-96696 13 p.

Research output: Contribution to journalArticle

Clinical validation of coexisting activating mutations within EGFR, mitogen-activated protein kinase, and phosphatidylinositol 3-kinase pathways in lung cancers

De Marchi, F., Haley, L., Fryer, H., Ibrahim, J., Beierl, K., Zheng, G., Gocke, C., Eshleman, J., Belchis, D. A., Illei, P. B. & Lin, M-T., Feb 1 2019, In : Archives of Pathology and Laboratory Medicine. 143, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

Clinical validation of coexisting driver mutations in colorectal cancers

Zheng, G., Tseng, L. H., Haley, L., Ibrahim, J., Bynum, J., Xian, R., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Apr 2019, In : Human pathology. 86, p. 12-20 9 p.

Research output: Contribution to journalArticle

Clinical validation of KRAS, BRAF, and EGFR mutation detection using next-generation sequencing

Lin, M. T., Mosier, S. L., Thiess, M., Beierl, K. F., Debeljak, M., Tseng, L. H., Chen, G., Yegnasubramanian, S., Ho, H., Cope, L., Wheelan, S. J., Gocke, C. D. & Eshleman, J. R., Jun 2014, In : American journal of clinical pathology. 141, 6, p. 856-866 11 p.

Research output: Contribution to journalArticle